Interferon-β-1 b and interferon-γ have similar inhibitory effects on apolipoprotein-E production in the monocyte/macrophage

Multiple Sclerosis

Volumn 8, Issue 2, 2002, Pages 124-129

  O’Toole, Daniel ^a   Love, W C ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Apolipoprotein E; Interferon beta; Interferon gamma; Monocytes; Multiple sclerosis

Indexed keywords

ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN E; CARRIER PROTEIN; CELL PROTEIN; CHOLESTEROL; GAMMA INTERFERON; INTERFERON BETA SERINE; LIPID; MESSENGER RNA; RECOMBINANT CYTOKINE; BETA INTERFERON; BETA1A INTERFERON; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; BLOOD DONOR; CELL LINE; CEREBROSPINAL FLUID; CONTROLLED STUDY; CONVALESCENCE; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MULTIPLE SCLEROSIS; NERVE FIBER REGENERATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RELAPSE; REMISSION; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; DRUG INTERACTION; GENETICS; METABOLISM; PROTEIN PROCESSING;

APOLIPOPROTEINS E; CELLS, CULTURED; DRUG INTERACTIONS; GENOTYPE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERFERON-BETA; MACROPHAGES; MONOCYTES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0036009152     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1191/1352458502ms784oa     Document Type: Article

References (43)

1. Methylprednisolone therapy in multiple sclerosis: A profile of adverse effects
2. The modifications of T-lymphocyte cell subpopulations in patients with beta-interferon intracavitary treatment
3. Mechanisms of interferon beta action in multiple sclerosis
4. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
5. Counteracting effect of IFN-beta on IFN-gamma-induced proliferation of human astrocytes in culture
6. In vitro TNF-alpha, IL-2 and IFN-gamma production as markers of relapses in multiple sclerosis
7. Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms
8. Homing to central nervous system vasculature by antigen-specific lymphocytes: II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination
9. Uptake of lipoproteins for axonal growth of sympathetic neurons
10. Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis
11. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets
12. Apolipoproteins and lipoproteins in human plasma: An overview
13. Physiology and pathology of the lipid transport in the brain
14. Astrocytes synthesize apolipoprotein E and metabolise apolipoprotein E-containing lipoproteins
15. Novel large apolipoprotein E-containing lipoproteins of density 1.006-1.060 g/ml in human cerebrospinal fluid
16. Apolipoprotein E and Alzheimer’s disease. A rapidly expanding field with medical and epidemiological consequences
17. Genetics and brain injury: Apolipoprotein E
18. Changes in cerebrospinal fluid IgG and apolipoprotein E indices in patients with multiple sclerosis during demyelination and remyelination
19. Apolipoprotein E in animal models of CNS injury and in Alzheimer’s disease
20. Expression of apolipoprotein E during nerve degeneration and regeneration
21. Preliminary observations on APOE epsilon4 allele and progression of disability in multiple sclerosis
22. Association of the APOE epsilon4 allele with disease activity in multiple sclerosis
23. Apo-E and risk of cognitive impairment in multiple sclerosis
24. Apolipoprotein E and multiple sclerosis: A biochemical and genetic investigation
25. No association between Apo-E ε4 allele and outcome and susceptibility in primary progressive multiple sclerosis
26. Apo-E epsilon 2-4 and -491 polymorphisms are not associated with MS
27. Apo E genotypes in multiple sclerosis, Parkinson’s disease, schwannomas and late-onset Alzheimer’s disease
28. Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: Evidence for a major influence on the clinical presentation and prognosis
29. Separation of leukocytes from blood and bone marrow
30. Isolation of adherent monocytes from human blood
31. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples
32. RNA quantitation by fluorescent based solution assay: Ribogreen reagent characterisation
33. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
34. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
35. Protein transfer to nitrocellulose filters. A simple method for quantitation of single proteins in complex mixtures
36. Apolipoprotein-E genotyping by one-stage PCR
37. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth
38. Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor
39. Apolipoprotein E suppresses glial cell secretion of TNF alpha
40. Cytokine regulation of macrophage apo E secretion: Opposing effects of GM-CSF and TGF-beta