Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms

Biochemical Journal

Volumn 428, Issue 1, 2010, Pages 47-54

  Zhu, Yanjuan ^a   Kodvawala, Ahmer ^a   Hui, David Y ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Apolipoprotein E (apoE); Atherosclerosis; c Jun N terminal kinase (JNK); Inflammation; Lipoprotein receptor; Macrophage

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E (APOE); C-JUN N-TERMINAL KINASE; C-JUN N-TERMINAL KINASE (JNK); CELL SURFACES; CYTOKINE PRODUCTION; HEPARIN SULFATES; INFLAMMATORY RESPONSE; INHIBITORY EFFECT; LIPOPOLYSACCHARIDES; LIPOPROTEIN RECEPTORS; LYSINE RESIDUES; MACROPHAGE ACTIVATION; MONOCYTE-MACROPHAGES; NECROSIS FACTORS; PROTEOGLYCANS; RECEPTOR BINDING; RECEPTOR-BINDING DOMAINS; TANDEM REPEATS; TOLL-LIKE RECEPTORS;

AMINO ACIDS; CELL CULTURE; GLYCOPROTEINS; PATHOLOGY; PHOSPHORYLATION;

MACROPHAGES;

APOLIPOPROTEIN E; HEPARIN DERIVATIVE; HEPARIN LYASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LYSINE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE ACTIVATION; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RECEPTOR BINDING; TANDEM REPEAT; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; METABOLISM; SIGNAL TRANSDUCTION;

MURINAE;

ANIMALS; APOLIPOPROTEINS E; CELLS, CULTURED; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MICE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 77953401752     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100016     Document Type: Article

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