-
1
-
-
41049100303
-
FIG4, Charcot-Marie-Tooth disease, and hypopigmentation: a role for phosphoinositides in melanosome biogenesis?
-
Marks MS. FIG4, Charcot-Marie-Tooth disease, and hypopigmentation: a role for phosphoinositides in melanosome biogenesis? Pigment Cell Melanoma Res 2008: 21: 11-14.
-
(2008)
Pigment Cell Melanoma Res
, vol.21
, pp. 11-14
-
-
Marks, M.S.1
-
2
-
-
52949149668
-
Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics.
-
Huizing M, Helip-Wooley A, Westbroek W, Gunay-Aygun M, Gahl WA. Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics. Annu Rev Genomics Hum Genet 2008: 9: 359-386.
-
(2008)
Annu Rev Genomics Hum Genet
, vol.9
, pp. 359-386
-
-
Huizing, M.1
Helip-Wooley, A.2
Westbroek, W.3
Gunay-Aygun, M.4
Gahl, W.A.5
-
3
-
-
34250012834
-
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.
-
Nachury MV, Loktev AV, Zhang Q et al. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 2007: 129: 1201-1213.
-
(2007)
Cell
, vol.129
, pp. 1201-1213
-
-
Nachury, M.V.1
Loktev, A.V.2
Zhang, Q.3
-
4
-
-
78751656754
-
Role of Rab GTPases in membrane traffic and cell physiology.
-
Hutagalung AH, Novick PJ. Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 2011: 91: 119-149.
-
(2011)
Physiol Rev
, vol.91
, pp. 119-149
-
-
Hutagalung, A.H.1
Novick, P.J.2
-
5
-
-
0025363426
-
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.
-
Chavrier P, Parton RG, Hauri HP, Simons K, Zerial M. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell 1990: 62: 317-329.
-
(1990)
Cell
, vol.62
, pp. 317-329
-
-
Chavrier, P.1
Parton, R.G.2
Hauri, H.P.3
Simons, K.4
Zerial, M.5
-
6
-
-
33747447033
-
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.
-
Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol 2006: 173: 767-780.
-
(2006)
J Cell Biol
, vol.173
, pp. 767-780
-
-
Pellinen, T.1
Arjonen, A.2
Vuoriluoto, K.3
Kallio, K.4
Fransen, J.A.5
Ivaska, J.6
-
7
-
-
2342570334
-
Rab14 is involved in membrane trafficking between the Golgi complex and endosomes.
-
Junutula JR, De Maziere AM, Peden AA et al. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Mol Biol Cell 2004: 15: 2218-2229.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2218-2229
-
-
Junutula, J.R.1
De Maziere, A.M.2
Peden, A.A.3
-
8
-
-
0037155909
-
rab4 regulates transport to the apical plasma membrane in Madin-Darby canine kidney cells.
-
Mohrmann K, Leijendekker R, Gerez L, van Der Sluijs P. rab4 regulates transport to the apical plasma membrane in Madin-Darby canine kidney cells. J Biol Chem 2002: 277: 10474-10481.
-
(2002)
J Biol Chem
, vol.277
, pp. 10474-10481
-
-
Mohrmann, K.1
Leijendekker, R.2
Gerez, L.3
van Der Sluijs, P.4
-
9
-
-
0034282387
-
Rab15 differentially regulates early endocytic trafficking.
-
Zuk PA, Elferink LA. Rab15 differentially regulates early endocytic trafficking. J Biol Chem 2000: 275: 26754-26764.
-
(2000)
J Biol Chem
, vol.275
, pp. 26754-26764
-
-
Zuk, P.A.1
Elferink, L.A.2
-
10
-
-
0032951298
-
Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells.
-
Casanova JE, Wang X, Kumar R et al. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell 1999: 10: 47-61.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 47-61
-
-
Casanova, J.E.1
Wang, X.2
Kumar, R.3
-
11
-
-
0035202869
-
Rab22a affects the morphology and function of the endocytic pathway.
-
Mesa R, Salomon C, Roggero M, Stahl PD, Mayorga LS. Rab22a affects the morphology and function of the endocytic pathway. J Cell Sci 2001: 114: 4041-4049.
-
(2001)
J Cell Sci
, vol.114
, pp. 4041-4049
-
-
Mesa, R.1
Salomon, C.2
Roggero, M.3
Stahl, P.D.4
Mayorga, L.S.5
-
12
-
-
0030751653
-
Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles.
-
Calhoun BC, Goldenring JR. Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles. Biochem J 1997: 325: 559-564.
-
(1997)
Biochem J
, vol.325
, pp. 559-564
-
-
Calhoun, B.C.1
Goldenring, J.R.2
-
13
-
-
0242363236
-
Characterization of the in vitro retrograde transport of MPR46.
-
Medigeshi GR, Schu P. Characterization of the in vitro retrograde transport of MPR46. Traffic 2003: 4: 802-811.
-
(2003)
Traffic
, vol.4
, pp. 802-811
-
-
Medigeshi, G.R.1
Schu, P.2
-
14
-
-
2442509574
-
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.
-
Seaman MN. Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol 2004: 165: 111-122.
-
(2004)
J Cell Biol
, vol.165
, pp. 111-122
-
-
Seaman, M.N.1
-
15
-
-
0035906951
-
Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.
-
Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR. Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. Science 2001: 292: 1373-1376.
-
(2001)
Science
, vol.292
, pp. 1373-1376
-
-
Carroll, K.S.1
Hanna, J.2
Simon, I.3
Krise, J.4
Barbero, P.5
Pfeffer, S.R.6
-
16
-
-
34447550833
-
Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation.
-
Kong C, Su X, Chen PI, Stahl PD. Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. J Biol Chem 2007: 282: 15294-15301.
-
(2007)
J Biol Chem
, vol.282
, pp. 15294-15301
-
-
Kong, C.1
Su, X.2
Chen, P.I.3
Stahl, P.D.4
-
17
-
-
0345829921
-
Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-TRE.
-
Martinu L, Santiago-Walker A, Qi H, Chou MM. Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-TRE. J Biol Chem 2002: 277: 50996-51002.
-
(2002)
J Biol Chem
, vol.277
, pp. 50996-51002
-
-
Martinu, L.1
Santiago-Walker, A.2
Qi, H.3
Chou, M.M.4
-
18
-
-
0035162703
-
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking.
-
Burke P, Schooler K, Wiley HS. Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell 2001: 12: 1897-1910.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 1897-1910
-
-
Burke, P.1
Schooler, K.2
Wiley, H.S.3
-
19
-
-
67650540827
-
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
-
Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. J Biol Chem 2009: 284: 18115-18128.
-
(2009)
J Biol Chem
, vol.284
, pp. 18115-18128
-
-
Rashid, S.1
Pilecka, I.2
Torun, A.3
Olchowik, M.4
Bielinska, B.5
Miaczynska, M.6
-
20
-
-
45549087226
-
Regulation of endosome dynamics by Rab5 and Huntingtin-HAP40 effector complex in physiological versus pathological conditions.
-
Pal A, Severin F, Hopfner S, Zerial M. Regulation of endosome dynamics by Rab5 and Huntingtin-HAP40 effector complex in physiological versus pathological conditions. Methods Enzymol 2008: 438: 239-257.
-
(2008)
Methods Enzymol
, vol.438
, pp. 239-257
-
-
Pal, A.1
Severin, F.2
Hopfner, S.3
Zerial, M.4
-
21
-
-
66449123730
-
Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration.
-
Vanlandingham PA, Ceresa BP. Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration. J Biol Chem 2009: 284: 12110-12124.
-
(2009)
J Biol Chem
, vol.284
, pp. 12110-12124
-
-
Vanlandingham, P.A.1
Ceresa, B.P.2
-
22
-
-
78650114245
-
Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.
-
Tabata K, Matsunaga K, Sakane A, Sasaki T, Noda T, Yoshimori T. Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain. Mol Biol Cell 2010: 21: 4162-4172.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 4162-4172
-
-
Tabata, K.1
Matsunaga, K.2
Sakane, A.3
Sasaki, T.4
Noda, T.5
Yoshimori, T.6
-
23
-
-
34147150205
-
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans.
-
Van Wesenbeeck L, Odgren PR, Coxon FP et al. Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest 2007: 117: 919-930.
-
(2007)
J Clin Invest
, vol.117
, pp. 919-930
-
-
Van Wesenbeeck, L.1
Odgren, P.R.2
Coxon, F.P.3
-
24
-
-
0242268528
-
Human VPS34 and p150 are Rab7 interacting partners.
-
Stein MP, Feng Y, Cooper KL, Welford AM, Wandinger-Ness A. Human VPS34 and p150 are Rab7 interacting partners. Traffic 2003: 4: 754-771.
-
(2003)
Traffic
, vol.4
, pp. 754-771
-
-
Stein, M.P.1
Feng, Y.2
Cooper, K.L.3
Welford, A.M.4
Wandinger-Ness, A.5
-
25
-
-
58149471951
-
Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease.
-
Skwarek LC, Boulianne GL. Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease. Dev Cell 2009: 16: 12-20.
-
(2009)
Dev Cell
, vol.16
, pp. 12-20
-
-
Skwarek, L.C.1
Boulianne, G.L.2
-
26
-
-
78650419576
-
Rab7: role of its protein interaction cascades in endo-lysosomal traffic.
-
Wang T, Ming Z, Xiaochun W, Hong W. Rab7: role of its protein interaction cascades in endo-lysosomal traffic. Cell Signal 2011: 23: 516-521.
-
(2011)
Cell Signal
, vol.23
, pp. 516-521
-
-
Wang, T.1
Ming, Z.2
Xiaochun, W.3
Hong, W.4
-
27
-
-
54249096642
-
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking.
-
Cao C, Backer JM, Laporte J, Bedrick EJ, Wandinger-Ness A. Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol Biol Cell 2008: 19: 3334-3346.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 3334-3346
-
-
Cao, C.1
Backer, J.M.2
Laporte, J.3
Bedrick, E.J.4
Wandinger-Ness, A.5
-
28
-
-
0040973364
-
A novel Rab9 effector required for endosome-to-TGN transport.
-
Diaz E, Schimmoller F, Pfeffer SR. A novel Rab9 effector required for endosome-to-TGN transport. J Cell Biol 1997: 138: 283-290.
-
(1997)
J Cell Biol
, vol.138
, pp. 283-290
-
-
Diaz, E.1
Schimmoller, F.2
Pfeffer, S.R.3
-
29
-
-
74949090299
-
An overview of the molecular mechanism of autophagy.
-
In: Levine B, Yoshimori T, Deretic V, eds. Berlin, Heidelberg: Springer-Verlag
-
Yang Z, Klionsky DJ. An overview of the molecular mechanism of autophagy. In: Levine B, Yoshimori T, Deretic V, eds. Autophagy in infection and immunity. Berlin, Heidelberg: Springer-Verlag, 2009: 1-32.
-
(2009)
Autophagy in infection and immunity.
, pp. 1-32
-
-
Yang, Z.1
Klionsky, D.J.2
-
30
-
-
84934441448
-
Autophagosome and phagosome.
-
Deretic V. Autophagosome and phagosome. Methods Mol Biol 2008: 445: 1-10.
-
(2008)
Methods Mol Biol
, vol.445
, pp. 1-10
-
-
Deretic, V.1
-
31
-
-
33751115464
-
Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest.
-
Kyei GB, Vergne I, Chua J et al. Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest. EMBO J 2006: 25: 5250-5259.
-
(2006)
EMBO J
, vol.25
, pp. 5250-5259
-
-
Kyei, G.B.1
Vergne, I.2
Chua, J.3
-
32
-
-
3242877218
-
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells.
-
Gutierrez MG, Munafo DB, Beron W, Colombo MI. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 2004: 117: 2687-2697.
-
(2004)
J Cell Sci
, vol.117
, pp. 2687-2697
-
-
Gutierrez, M.G.1
Munafo, D.B.2
Beron, W.3
Colombo, M.I.4
-
33
-
-
0034714098
-
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.
-
Pereira-Leal JB, Seabra MC. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J Mol Biol 2000: 301: 1077-1087.
-
(2000)
J Mol Biol
, vol.301
, pp. 1077-1087
-
-
Pereira-Leal, J.B.1
Seabra, M.C.2
-
34
-
-
8444243363
-
Targeting Rab GTPases to distinct membrane compartments.
-
Pfeffer S, Aivazian D. Targeting Rab GTPases to distinct membrane compartments. Nat Rev Mol Cell Biol 2004: 5: 886-896.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 886-896
-
-
Pfeffer, S.1
Aivazian, D.2
-
35
-
-
0028067898
-
Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.
-
Alexandrov K, Horiuchi H, Steele-Mortimer O, Seabra MC, Zerial M. Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. EMBO J 1994: 13: 5262-5273.
-
(1994)
EMBO J
, vol.13
, pp. 5262-5273
-
-
Alexandrov, K.1
Horiuchi, H.2
Steele-Mortimer, O.3
Seabra, M.C.4
Zerial, M.5
-
36
-
-
0035575616
-
Rab GTPases: specifying and deciphering organelle identity and function.
-
Pfeffer SR. Rab GTPases: specifying and deciphering organelle identity and function. Trends Cell Biol 2001: 11: 487-491.
-
(2001)
Trends Cell Biol
, vol.11
, pp. 487-491
-
-
Pfeffer, S.R.1
-
37
-
-
22944444569
-
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
-
Eathiraj S, Pan X, Ritacco C, Lambright DG. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature 2005: 436: 415-419.
-
(2005)
Nature
, vol.436
, pp. 415-419
-
-
Eathiraj, S.1
Pan, X.2
Ritacco, C.3
Lambright, D.G.4
-
38
-
-
25144476558
-
TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7.
-
Zhang XM, Walsh B, Mitchell CA, Rowe T. TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7. Biochem Biophys Res Commun 2005: 335: 154-161.
-
(2005)
Biochem Biophys Res Commun
, vol.335
, pp. 154-161
-
-
Zhang, X.M.1
Walsh, B.2
Mitchell, C.A.3
Rowe, T.4
-
39
-
-
0030158607
-
New insights into the pathogenesis of choroideremia: a tale of two REPs.
-
Seabra MC. New insights into the pathogenesis of choroideremia: a tale of two REPs. Ophthalmic Genet 1996: 17: 43-46.
-
(1996)
Ophthalmic Genet
, vol.17
, pp. 43-46
-
-
Seabra, M.C.1
-
40
-
-
17344369362
-
Mutations in GDI1 are responsible for X-linked non-specific mental retardation.
-
D'Adamo P, Menegon A, Lo Nigro C et al. Mutations in GDI1 are responsible for X-linked non-specific mental retardation. Nat Genet 1998: 19: 134-139.
-
(1998)
Nat Genet
, vol.19
, pp. 134-139
-
-
D'Adamo, P.1
Menegon, A.2
Lo Nigro, C.3
-
41
-
-
79955000748
-
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.
-
Hou X, Hagemann N, Schoebel S et al. A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J 2011: 30: 1659-1670.
-
(2011)
EMBO J
, vol.30
, pp. 1659-1670
-
-
Hou, X.1
Hagemann, N.2
Schoebel, S.3
-
42
-
-
46749153756
-
Characterization of pip5k3 fleck corneal dystrophy-linked gene in zebrafish.
-
Boisset G, Polok BK, Schorderet DF. Characterization of pip5k3 fleck corneal dystrophy-linked gene in zebrafish. Gene Expr Patterns 2008: 8: 404-410.
-
(2008)
Gene Expr Patterns
, vol.8
, pp. 404-410
-
-
Boisset, G.1
Polok, B.K.2
Schorderet, D.F.3
-
43
-
-
69349094765
-
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.
-
Bielas SL, Silhavy JL, Brancati F et al. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet 2009: 41: 1032-1036.
-
(2009)
Nat Genet
, vol.41
, pp. 1032-1036
-
-
Bielas, S.L.1
Silhavy, J.L.2
Brancati, F.3
-
44
-
-
79551634466
-
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
-
Otto EA, Ramaswami G, Janssen S et al. Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy. J Med Genet 2011: 48: 105-116.
-
(2011)
J Med Genet
, vol.48
, pp. 105-116
-
-
Otto, E.A.1
Ramaswami, G.2
Janssen, S.3
-
45
-
-
77953970326
-
The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2).
-
Syx D, Malfait F, Van Laer L et al. The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2). Hum Genet 2010: 128: 79-88.
-
(2010)
Hum Genet
, vol.128
, pp. 79-88
-
-
Syx, D.1
Malfait, F.2
Van Laer, L.3
-
46
-
-
68249083253
-
RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome.
-
Basel-Vanagaite L, Sarig O, Hershkovitz D et al. RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome. Am J Hum Genet 2009: 85: 254-263.
-
(2009)
Am J Hum Genet
, vol.85
, pp. 254-263
-
-
Basel-Vanagaite, L.1
Sarig, O.2
Hershkovitz, D.3
-
47
-
-
23444435692
-
Alsin is partially associated with centrosome in human cells.
-
Millecamps S, Gentil BJ, Gros-Louis F, Rouleau G, Julien JP. Alsin is partially associated with centrosome in human cells. Biochim Biophys Acta 2005: 1745: 84-100.
-
(2005)
Biochim Biophys Acta
, vol.1745
, pp. 84-100
-
-
Millecamps, S.1
Gentil, B.J.2
Gros-Louis, F.3
Rouleau, G.4
Julien, J.P.5
-
48
-
-
79952317005
-
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation.
-
Otomo A, Kunita R, Suzuki-Utsunomiya K, Ikeda JE, Hadano S. Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation. FEBS Lett 2011: 585: 730-736.
-
(2011)
FEBS Lett
, vol.585
, pp. 730-736
-
-
Otomo, A.1
Kunita, R.2
Suzuki-Utsunomiya, K.3
Ikeda, J.E.4
Hadano, S.5
-
50
-
-
69049112930
-
Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.
-
Lai C, Xie C, Shim H, Chandran J, Howell BW, Cai H. Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin. Mol Brain 2009: 2: 23.
-
(2009)
Mol Brain
, vol.2
, pp. 23
-
-
Lai, C.1
Xie, C.2
Shim, H.3
Chandran, J.4
Howell, B.W.5
Cai, H.6
-
51
-
-
79952325543
-
Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: implications for human motor neuron disease.
-
Palmisano R, Golfi P, Heimann P et al. Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: implications for human motor neuron disease. BMC Neurosci 2011: 12: 24.
-
(2011)
BMC Neurosci
, vol.12
, pp. 24
-
-
Palmisano, R.1
Golfi, P.2
Heimann, P.3
-
52
-
-
45549098629
-
Rab GTPases and their roles in brain neurons and glia.
-
Ng EL, Tang BL. Rab GTPases and their roles in brain neurons and glia. Brain Res Rev 2008: 58: 236-246.
-
(2008)
Brain Res Rev
, vol.58
, pp. 236-246
-
-
Ng, E.L.1
Tang, B.L.2
-
53
-
-
65249141171
-
Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus.
-
del Toro D, Alberch J, Lazaro-Dieguez F et al. Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus. Mol Biol Cell 2009: 20: 1478-1492.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1478-1492
-
-
del Toro, D.1
Alberch, J.2
Lazaro-Dieguez, F.3
-
54
-
-
71949120013
-
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
-
Li X, Standley C, Sapp E et al. Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol 2009: 29: 6106-6116.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 6106-6116
-
-
Li, X.1
Standley, C.2
Sapp, E.3
-
55
-
-
77249158951
-
Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.
-
Nagabhushana A, Chalasani ML, Jain N et al. Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant. BMC Cell Biol 2010: 11: 4.
-
(2010)
BMC Cell Biol
, vol.11
, pp. 4
-
-
Nagabhushana, A.1
Chalasani, M.L.2
Jain, N.3
-
56
-
-
9744254471
-
Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway.
-
Luiro K, Yliannala K, Ahtiainen L et al. Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway. Hum Mol Genet 2004: 13: 3017-3027.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 3017-3027
-
-
Luiro, K.1
Yliannala, K.2
Ahtiainen, L.3
-
57
-
-
24644494640
-
Protein transduction of Rab9 in Niemann-Pick C cells reduces cholesterol storage.
-
Narita K, Choudhury A, Dobrenis K et al. Protein transduction of Rab9 in Niemann-Pick C cells reduces cholesterol storage. FASEB J 2005: 19: 1558-1560.
-
(2005)
FASEB J
, vol.19
, pp. 1558-1560
-
-
Narita, K.1
Choudhury, A.2
Dobrenis, K.3
-
58
-
-
53849117085
-
Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor.
-
Metcalf DJ, Calvi AA, Seaman MN, Mitchison HM, Cutler DF. Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor. Traffic 2008: 9: 1905-1914.
-
(2008)
Traffic
, vol.9
, pp. 1905-1914
-
-
Metcalf, D.J.1
Calvi, A.A.2
Seaman, M.N.3
Mitchison, H.M.4
Cutler, D.F.5
-
59
-
-
68849107901
-
The emerging role of the RAB25 small GTPase in cancer.
-
Agarwal R, Jurisica I, Mills GB, Cheng KW. The emerging role of the RAB25 small GTPase in cancer. Traffic 2009: 10: 1561-1568.
-
(2009)
Traffic
, vol.10
, pp. 1561-1568
-
-
Agarwal, R.1
Jurisica, I.2
Mills, G.B.3
Cheng, K.W.4
-
60
-
-
66149115113
-
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.
-
Tzaban S, Massol RH, Yen E et al. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol 2009: 185: 673-684.
-
(2009)
J Cell Biol
, vol.185
, pp. 673-684
-
-
Tzaban, S.1
Massol, R.H.2
Yen, E.3
-
61
-
-
0035914343
-
Identification and characterization of a family of Rab11-interacting proteins.
-
Hales CM, Griner R, Hobdy-Henderson KC et al. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem 2001: 276: 39067-39075.
-
(2001)
J Biol Chem
, vol.276
, pp. 39067-39075
-
-
Hales, C.M.1
Griner, R.2
Hobdy-Henderson, K.C.3
-
62
-
-
9144271680
-
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
-
Cheng KW, Lahad JP, Kuo WL et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med 2004: 10: 1251-1256.
-
(2004)
Nat Med
, vol.10
, pp. 1251-1256
-
-
Cheng, K.W.1
Lahad, J.P.2
Kuo, W.L.3
-
63
-
-
78751470917
-
Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent.
-
Lapierre LA, Caldwell CM, Higginbotham JN et al. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken) 2011: 68: 97-111.
-
(2011)
Cytoskeleton (Hoboken)
, vol.68
, pp. 97-111
-
-
Lapierre, L.A.1
Caldwell, C.M.2
Higginbotham, J.N.3
-
64
-
-
32344443827
-
Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system.
-
Lapierre LA, Goldenring JR. Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system. Methods Enzymol 2005: 403: 715-723.
-
(2005)
Methods Enzymol
, vol.403
, pp. 715-723
-
-
Lapierre, L.A.1
Goldenring, J.R.2
-
65
-
-
77949756773
-
Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.
-
Nam KT, Lee HJ, Smith JJ et al. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest 2010: 120: 840-849.
-
(2010)
J Clin Invest
, vol.120
, pp. 840-849
-
-
Nam, K.T.1
Lee, H.J.2
Smith, J.J.3
-
66
-
-
34848816931
-
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
-
Caswell PT, Spence HJ, Parsons M et al. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 2007: 13: 496-510.
-
(2007)
Dev Cell
, vol.13
, pp. 496-510
-
-
Caswell, P.T.1
Spence, H.J.2
Parsons, M.3
-
67
-
-
0037371509
-
Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy.
-
Verhoeven K, De Jonghe P, Coen K et al. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am J Hum Genet 2003: 72: 722-727.
-
(2003)
Am J Hum Genet
, vol.72
, pp. 722-727
-
-
Verhoeven, K.1
De Jonghe, P.2
Coen, K.3
-
68
-
-
78650130133
-
Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.
-
BasuRay S, Mukherjee S, Romero E, Wilson MC, Wandinger-Ness A. Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling. PLoS One 2010: 5: e15351.
-
(2010)
PLoS One
, vol.5
-
-
BasuRay, S.1
Mukherjee, S.2
Romero, E.3
Wilson, M.C.4
Wandinger-Ness, A.5
-
69
-
-
77950686629
-
Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.
-
McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum Mol Genet 2010: 19: 1033-1047.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 1033-1047
-
-
McCray, B.A.1
Skordalakes, E.2
Taylor, J.P.3
-
70
-
-
0035865135
-
Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes.
-
Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C. Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J 2001: 20: 683-693.
-
(2001)
EMBO J
, vol.20
, pp. 683-693
-
-
Cantalupo, G.1
Alifano, P.2
Roberti, V.3
Bruni, C.B.4
Bucci, C.5
-
71
-
-
34247874425
-
Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.
-
Sakane A, Hatakeyama S, Sasaki T. Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. Biochem Biophys Res Commun 2007: 357: 1058-1064.
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 1058-1064
-
-
Sakane, A.1
Hatakeyama, S.2
Sasaki, T.3
-
72
-
-
0034722890
-
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.
-
Sebti SM, Hamilton AD. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies. Oncogene 2000: 19: 6584-6593.
-
(2000)
Oncogene
, vol.19
, pp. 6584-6593
-
-
Sebti, S.M.1
Hamilton, A.D.2
-
73
-
-
0035930612
-
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.
-
Coxon FP, Helfrich MH, Larijani B et al. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem 2001: 276: 48213-48222.
-
(2001)
J Biol Chem
, vol.276
, pp. 48213-48222
-
-
Coxon, F.P.1
Helfrich, M.H.2
Larijani, B.3
-
74
-
-
35348839555
-
Zoledronic acid - a multiplicity of anti-cancer action.
-
Yuasa T, Kimura S, Ashihara E, Habuchi T, Maekawa T. Zoledronic acid - a multiplicity of anti-cancer action. Curr Med Chem 2007: 14: 2126-2135.
-
(2007)
Curr Med Chem
, vol.14
, pp. 2126-2135
-
-
Yuasa, T.1
Kimura, S.2
Ashihara, E.3
Habuchi, T.4
Maekawa, T.5
-
75
-
-
0026731811
-
rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.
-
Kinsella BT, Maltese WA. rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids. J Biol Chem 1992: 267: 3940-3945.
-
(1992)
J Biol Chem
, vol.267
, pp. 3940-3945
-
-
Kinsella, B.T.1
Maltese, W.A.2
-
76
-
-
77953612448
-
A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases.
-
Ali BR, Nouvel I, Leung KF, Hume AN, Seabra MC. A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases. Biochem Biophys Res Commun 2010: 397: 34-41.
-
(2010)
Biochem Biophys Res Commun
, vol.397
, pp. 34-41
-
-
Ali, B.R.1
Nouvel, I.2
Leung, K.F.3
Hume, A.N.4
Seabra, M.C.5
-
77
-
-
77957896645
-
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
-
Fletcher S, Keaney EP, Cummings CG et al. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. J Med Chem 2010: 53: 6867-6888.
-
(2010)
J Med Chem
, vol.53
, pp. 6867-6888
-
-
Fletcher, S.1
Keaney, E.P.2
Cummings, C.G.3
-
78
-
-
0030762010
-
Functional protein prenylation is required for the brefeldin A-dependent retrograde transport from the Golgi apparatus to the endoplasmic reticulum.
-
Ivessa NE, Gravotta D, De Lemos-Chiarandini C, Kreibich G. Functional protein prenylation is required for the brefeldin A-dependent retrograde transport from the Golgi apparatus to the endoplasmic reticulum. J Biol Chem 1997: 272: 20828-20834.
-
(1997)
J Biol Chem
, vol.272
, pp. 20828-20834
-
-
Ivessa, N.E.1
Gravotta, D.2
De Lemos-Chiarandini, C.3
Kreibich, G.4
-
79
-
-
77949734021
-
ADP-ribosylation factors modulate the cell surface transport of G protein-coupled receptors.
-
Dong C, Zhang X, Zhou F et al. ADP-ribosylation factors modulate the cell surface transport of G protein-coupled receptors. J Pharmacol Exp Ther 2010: 333: 174-183.
-
(2010)
J Pharmacol Exp Ther
, vol.333
, pp. 174-183
-
-
Dong, C.1
Zhang, X.2
Zhou, F.3
-
80
-
-
55549089615
-
Large ARF guanine nucleotide exchange factors in membrane trafficking.
-
Anders N, Jurgens G. Large ARF guanine nucleotide exchange factors in membrane trafficking. Cell Mol Life Sci 2008: 65: 3433-3445.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 3433-3445
-
-
Anders, N.1
Jurgens, G.2
-
81
-
-
78349274356
-
LG186: an inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells.
-
Boal F, Guetzoyan L, Sessions RB et al. LG186: an inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells. Traffic 2010: 11: 1537-1551.
-
(2010)
Traffic
, vol.11
, pp. 1537-1551
-
-
Boal, F.1
Guetzoyan, L.2
Sessions, R.B.3
-
82
-
-
33746326517
-
Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
-
Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y. Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Curr Top Med Chem 2006: 6: 1109-1116.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1109-1116
-
-
Nassar, N.1
Cancelas, J.2
Zheng, J.3
Williams, D.A.4
Zheng, Y.5
-
83
-
-
77949351405
-
Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay.
-
Surviladze Z, Waller A, Wu Y et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. J Biomol Screen 2010: 15: 10-20.
-
(2010)
J Biomol Screen
, vol.15
, pp. 10-20
-
-
Surviladze, Z.1
Waller, A.2
Wu, Y.3
-
84
-
-
84882573644
-
-
Three small molecule pan activator families of Ras-related GTPases. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); PMID: 21433375.
-
Surviladze Z, Ursu O, Miscioscia F et al. Three small molecule pan activator families of Ras-related GTPases. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010: PMID: 21433375.
-
(2010)
-
-
Surviladze, Z.1
Ursu, O.2
Miscioscia, F.3
-
86
-
-
3242788185
-
Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.
-
Hao Y, Creson T, Zhang L et al. Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J Neurosci 2004: 24: 6590-6599.
-
(2004)
J Neurosci
, vol.24
, pp. 6590-6599
-
-
Hao, Y.1
Creson, T.2
Zhang, L.3
-
87
-
-
78149353040
-
The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway.
-
Yamauchi J, Torii T, Kusakawa S et al. The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway. J Neurosci Res 2010: 88: 3189-3197.
-
(2010)
J Neurosci Res
, vol.88
, pp. 3189-3197
-
-
Yamauchi, J.1
Torii, T.2
Kusakawa, S.3
-
88
-
-
0037389276
-
Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 protein.
-
Wiegand V, Chang TY, Strauss JF, Fahrenholz F, Gimpl G. Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 protein. FASEB J 2003: 17: 782-784.
-
(2003)
FASEB J
, vol.17
, pp. 782-784
-
-
Wiegand, V.1
Chang, T.Y.2
Strauss, J.F.3
Fahrenholz, F.4
Gimpl, G.5
-
89
-
-
0036734602
-
Modulation of cellular cholesterol transport and homeostasis by Rab11.
-
Holtta-Vuori M, Tanhuanpaa K, Mobius W, Somerharju P, Ikonen E. Modulation of cellular cholesterol transport and homeostasis by Rab11. Mol Biol Cell 2002: 13: 3107-3122.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 3107-3122
-
-
Holtta-Vuori, M.1
Tanhuanpaa, K.2
Mobius, W.3
Somerharju, P.4
Ikonen, E.5
-
90
-
-
67650089619
-
Cyclodextrins promote protein aggregation posing risks for therapeutic applications.
-
Wang MS, Boddapati S, Sierks MR. Cyclodextrins promote protein aggregation posing risks for therapeutic applications. Biochem Biophys Res Commun 2009: 386: 526-531.
-
(2009)
Biochem Biophys Res Commun
, vol.386
, pp. 526-531
-
-
Wang, M.S.1
Boddapati, S.2
Sierks, M.R.3
|