Large ARF guanine nucleotide exchange factors in membrane trafficking

Cellular and Molecular Life Sciences

Volumn 65, Issue 21, 2008, Pages 3433-3445

  Anders, N ^a   Jurgens G ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

ARF GTPases; ARF GEF interactors; Brefeldin A (BFA); Large ARF guanine nucleotide exchange factors (ARF GEFs); Membrane traffic

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; BREFELDIN A; COATOMER PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MEMBRANE PROTEIN; MYCOTOXIN;

ARABIDOPSIS; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELL ORGANELLE; CELL STRUCTURE; CELLULAR DISTRIBUTION; DIMERIZATION; ENTEROVIRUS; ENZYME ACTIVATION; EUKARYOTIC CELL; HUMAN; INTRACELLULAR TRANSPORT; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; PSEUDOMONAS SYRINGAE; REGULATORY MECHANISM; REVIEW; SACCHAROMYCES CEREVISIAE; TRANSPORT KINETICS; VIRUS VIRULENCE;

ADP-RIBOSYLATION FACTORS; ANIMALS; ARABIDOPSIS PROTEINS; BIOLOGICAL TRANSPORT; BREFELDIN A; CELL COMPARTMENTATION; CELL MEMBRANE; ENZYME ACTIVATION; EUKARYOTIC CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HOST-PATHOGEN INTERACTIONS; HUMANS; MEMBRANE PROTEINS; PLANT PROTEINS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSPORT VESICLES;

EUKARYOTA; MAMMALIA;

EID: 55549089615     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-8227-7     Document Type: Review

References (117)

1. Gillingham, A. K. and Munro, S. (2007). The Small G Proteins of the Arf Family and Their Regulators. Annu Rev Cell Dev Biol.
2. D'Souza-Schorey, C. and Chavrier, P. (2006). ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol 7, 347-58.
3. Myers, K. R. and Casanova, J. E. (2008). Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends Cell Biol 18, 184-92.
4. Cox, R., Mason-Gamer, R. J., Jackson, C. L. and Segev, N. (2004). Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Mol Biol Cell 15, 1487-505.
5. Mouratou, B., Biou, V., Joubert, A., Cohen, J., Shields, D. J., Geldner, N., Jurgens, G., Melancon, P., and Cherfils, J. (2005). The domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein Arf. BMC Genomics 6, 20.
6. Gillingham, A. K. and Munro, S. (2007). Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. PLoS ONE 2, e842.
7. Casanova, J. E. (2007). Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic 8, 1476-85.
8. Richter, S., Geldner, N., Schrader, J., Wolters, H., Stierhof, Y. D., Rios, G., Koncz, C., Robinson, D. G., and Jurgens, G. (2007). Functional diversification of closely related ARF-GEFs in protein secretion and recycling. Nature 448, 488-92.
9. Teh, O. K. and Moore, I. (2007). An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells. Nature 448, 493-6.
10. Wang, J., Huang, Y., Fang, M., Zhang, Y., Zheng, Z., Zhao, Y. and Su, W. (2002). Brefeldin A, a cytotoxin produced by Paecilomyces sp. and Aspergillus clavatus isolated from Taxus mairei and Torreya grandis. FEMS Immunol Med Microbiol 34, 51-7.
11. Zeghouf, M., Guibert, B., Zeeh, J. C. and Cherfils, J. (2005). Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors. Biochem Soc Trans 33, 1265-8.
12. Renault, L., Guibert, B. and Cherfils, J. (2003). Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor. Nature 426, 525-30.
13. Peyroche, A., Antonny, B., Robineau, S., Acker, J., Cherfils, J. and Jackson, C. L. (1999). Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain. Mol Cell 3, 275-85.
14. Donaldson, J. G., Finazzi, D. and Klausner, R. D. (1992). Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature 360, 350-2.
15. Mossessova, E., Corpina, R. A. and Goldberg, J. (2003). Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell 12, 1403-11.
16. Sata, M., Moss, J. and Vaughan, M. (1999). Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors. Proc Natl Acad Sci USA 96, 2752-7.
17. Geldner, N., Anders, N., Wolters, H., Keicher, J., Kornberger, W., Muller, P., Delbarre, A., Ueda, T., Nakano, A., and Jurgens, G. (2003). The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth. Cell 112, 219-30.
18. Donaldson, J. G., Lippincott-Schwartz, J., Bloom, G. S., Kreis, T. E. and Klausner, R. D. (1990). Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action. J Cell Biol 111, 2295-306.
19. Robinson, M. S. and Kreis, T. E. (1992). Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: effects of brefeldin A and G protein activators. Cell 69, 129-38.
20. Klausner, R. D., Donaldson, J. G. and Lippincott-Schwartz, J. (1992). Brefeldin A: insights into the control of membrane traffic and organelle structure. J Cell Biol 116, 1071-80.
21. Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S. and Klausner, R. D. (1989). Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell 56,801-13.
22. Lippincott-Schwartz, J., Donaldson, J. G., Schweizer, A., Berger, E. G., Hauri, H. P., Yuan, L. C. and Klausner, R. D. (1990). Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway. Cell 60, 821-36.
23. Doms, R. W., Russ, G. and Yewdell, J. W. (1989). Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum. J Cell Biol 109, 61-72.
24. Lippincott-Schwartz, J., Yuan, L., Tipper, C., Amherdt, M., Orci, L. and Klausner, R. D. (1991). Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67, 601-16.
25. Wood, S. A., Park, J. E. and Brown, W. J. (1991). Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes. Cell 67, 591-600.
26. Ritzenthaler, C., Nebenfuhr, A., Movafeghi, A., Stussi-Garaud, C., Behnia, L., Pimpl, P., Staehelin, L. A. and Robinson, D. G. (2002). Reevaluation of the effects of brefeldin A on plant cells using tobacco Bright Yellow 2 cells expressing Golgi-targeted green fluorescent protein and COPI antisera. Plant Cell 14, 237-61.
27. Tse, Y. C., Lo, S. W., Hillmer, S., Dupree, P. and Jiang, L. (2006). Dynamic response of prevacuolar compartments to brefeldin a in plant cells. Plant Physiol 142, 1442-59.
28. Vogel, J. P., Lee, J. N., Kirsch, D. R., Rose, M. D. and Sztul, E. S. (1993). Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae. J Biol Chem 268, 3040-3.
29. Graham, T. R., Scott, P. A. and Emr, S. D. (1993). Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway. Embo J 12, 869-77.
30. Rambourg, A., Clermont, Y., Jackson, C. L. and Kepes, F. (1995). Effects of brefeldin A on the three-dimensional structure of the Golgi apparatus in a sensitive strain of Saccharomyces cerevisiae. Anat Rec 241, 1-9.
31. Hunziker, W., Whitney, J. A. and Mellman, I. (1991). Selective inhibition of transcytosis by brefeldin A in MDCK cells. Cell 67, 617-27.
32. Beraud-Dufour, S., Paris, S., Chabre, M. and Antonny, B. (1999). Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange. J Biol Chem 274, 37629-36.
33. Beraud-Dufour, S., Robineau, S., Chardin, P., Paris, S., Chabre, M., Cherfils,J. and Antonny, B. (1998). A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.Embo J 17,3651-9.
34. Goldberg, J. (1998). Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell 95, 237-48.
35. Cherfils, J. and Melancon, P. (2005). On the action of Brefeldin Aon Sec7-stimulated membrane-recruitment and GDP/GTP exchange of Arf proteins. Biochem Soc Trans 33, 635-8.
36. Robineau, S., Chabre, M. and Antonny, B. (2000). Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain. Proc Natl Acad Sci USA 97, 9913-8.
37. Zeeh, J. C., Zeghouf, M., Grauffel, C., Guibert, B., Martin, E., Dejaegere, A. and Cherfils, J. (2006). Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains. J Biol Chem 281, 11805-14.
38. Deitz, S. B., Rambourg, A., Kepes, F. and Franzusoff, A. (2000). Sec7p directs the transitions required for yeast Golgi biogenesis. Traffic 1, 172-83.
39. Spang, A., Herrmann, J. M., Hamamoto, S. and Schekman, R. (2001). The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Mol Biol Cell 12, 1035-45.
40. Achstetter, T., Franzusoff, A., Field, C. and Schekman, R. (1988). SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus. J Biol Chem 263, 11711-7.
41. Franzusoff, A., Redding, K., Crosby, J., Fuller, R. S. and Schekman, R. (1991). Localization of components involved in protein transport and processing through the yeast Golgi apparatus. J Cell Biol 112, 27-37.
42. Preuss, D., Mulholland, J., Franzusoff, A., Segev, N. and Botstein, D. (1992). Characterization of the Saccharomyces Golgi complex through the cell cycle by immunoelectron microscopy. Mol Biol Cell 3, 789-803.
43. Franzusoff, A. and Schekman, R. (1989). Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation. Embo J 8, 2695-702.
44. Wang, C. W., Hamamoto, S., Orci, L. and Schekman, R. (2006). Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J Cell Biol 174, 973-83.
45. Peyroche, A., Paris, S. and Jackson, C. L. (1996). Nucleotide exchange on ARF mediated by yeast Gea1 protein. Nature 384, 479-81.
46. Peyroche, A., Courbeyrette, R., Rambourg, A. and Jackson, C. L. (2001). The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast. J Cell Sci 114, 2241-53.
47. Park, S. K., Hartnell, L. M. and Jackson, C. L. (2005). Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes. Mol Biol Cell 16, 3786-99.
48. Sata, M., Donaldson, J. G., Moss, J. and Vaughan, M. (1998). Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors. Proc Natl Acad Sci USA 95, 4204-8.
49. Zakrzewska, E., Perron, M., Laroche, A. and Pallotta, D. (2003). Arole for GEA1 and GEA2 in the organization of the actin cytoskeleton in Saccharomyces cerevisiae. Genetics 165, 985-95.
50. Claude, A., Zhao, B. P. and Melancon, P. (2003). Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity. Biochem Biophys Res Commun 303, 160-9.
51. Manolea, F., Claude, A., Chun, J., Rosas, J. and Melancon, P. (2008). Distinct Functions for Arf Guanine Nucleotide Exchange Factors at the Golgi Complex: GBF1 and BIGs Are Required for Assembly and Maintenance of the Golgi Stack and trans-Golgi Network, Respectively. Mol Biol Cell 19, 523-35.
52. Zhao, X., Lasell, T. K. and Melancon, P. (2002). Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Mol Biol Cell 13, 119-33.
53. Garcia-Mata, R., Szul, T., Alvarez, C. and Sztul, E. (2003). ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1. Mol Biol Cell 14, 2250-61.
54. Kawamoto, K., Yoshida, Y., Tamaki, H., Torii, S., Shinotsuka, C., Yamashina, S. and Nakayama, K. (2002). GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat. Traffic 3, 483-95.
55. Zhao, X., Claude, A., Chun, J., Shields, D. J., Presley, J. F. and Melancon, P. (2006). GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic. J Cell Sci 119, 3743-53.
56. Citterio, C., Vichi, A., Pacheco-Rodriguez, G., Aponte, A. M., Moss, J. and Vaughan, M. (2008). Unfolded protein response and cell death after depletion of brefeldin Ainhibited guanine nucleotide-exchange protein GBF1. Proc Natl Acad Sci USA 105, 2877-82.
57. Lefrancois, S. and McCormick, P. J. (2007). The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes. Traffic 8, 1440-51.
58. Shinotsuka, C., Waguri, S., Wakasugi, M., Uchiyama, Y. and Nakayama, K. (2002). Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. Biochem Biophys Res Commun 294, 254-60.
59. Ishizaki, R., Shin, H. W., Mitsuhashi, H. and Nakayama, K. (2008). Redundant Roles of BIG2 and BIG1, Guanine-nucleotide Exchange Factors for ARFs in Membrane Traffic between the TGN and endosomes. Mol Biol Cell.
60. Shinotsuka, C., Yoshida, Y., Kawamoto, K., Takatsu, H. and Nakayama, K. (2002). Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation. J Biol Chem 277, 9468-73.
61. Shen, X.,Hong, M. S., Moss, J. and Vaughan, M. (2007). BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1. Proc Natl Acad Sci USA 104, 1230-5.
62. Islam, A., Shen, X., Hiroi, T., Moss, J., Vaughan, M. and Levine, S. J. (2007). The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles. J Biol Chem 282, 9591-9.
63. Shen, X., Xu, K. F., Fan, Q., Pacheco-Rodriguez, G., Moss, J. and Vaughan, M. (2006). Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake. Proc Natl Acad Sci USA 103, 2635-40.
64. Charych, E. I., Yu, W., Miralles, C. P., Serwanski, D. R., Li, X., Rubio, M. and De Blas, A. L. (2004). The brefeldin Ainhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors. J Neurochem 90, 173-89.
65. Xu, K. F., Shen, X., Li, H., Pacheco-Rodriguez, G., Moss, J. and Vaughan, M. (2005). Interaction of BIG2, a brefeldin Ainhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. Proc Natl Acad Sci USA 102, 2784-9.
66. Sheen, V. L., Ganesh, V. S., Topcu, M., Sebire, G., Bodell, A., Hill, R. S., Grant, P. E., Shugart, Y. Y., Imitola, J., Khoury, S. J., Guerrini, R., and Walsh, C. A. (2004). Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat Genet 36, 69-76.
67. Claude, A., Zhao, B. P., Kuziemsky, C. E., Dahan, S., Berger, S. J., Yan, J. P., Armold, A.D., Sullivan, E. M., and Melancon, P. (1999). GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. J Cell Biol 146, 71 -84.
68. Niu, T. K., Pfeifer, A. C., Lippincott-Schwartz, J. and Jackson, C. L. (2005). Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi. Mol Biol Cell 16, 1213-22.
69. Szul, T., Grabski, R., Lyons, S., Morohashi, Y., Shestopal, S., Lowe, M. and Sztul, E. (2007). Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking. J Cell Sci 120, 3929-40.
70. Togawa, A., Morinaga, N., Ogasawara, M., Moss, J. and Vaughan, M. (1999). Purification and cloning of a brefeldin Ainhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. J Biol Chem 274, 12308-15.
71. Morinaga, N., Adamik, R., Moss, J. and Vaughan, M. (1999). Brefeldin A inhibited activity of the sec7 domain of p200, a mammalian guanine nucleotide-exchange protein for ADP-ribosylation factors. J Biol Chem 274, 17417-23.
72. Mansour, S. J., Skaug, J., Zhao, X.H., Giordano, J., Scherer, S. W. and Melancon, P. (1999). p200 ARF-GEP1: a Golgilocalized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A. Proc Natl Acad Sci USA 96, 7968-73.
73. Shin, H. W., Morinaga, N., Noda, M. and Nakayama, K. (2004). BIG2, a guanine nucleotide exchange factor for ADPribosylation factors: its localization to recycling endosomes and implication in the endosome integrity. Mol Biol Cell 15, 5283-94.
74. Mayer, U., Büttner, G., and Jürgens, G. (1993). Apical-basal pattern formation in the Arabidopsis embryo: studies on the role of the gnom gene. Development 117, 149-162.
75. Shevell,D. E., Leu, W. M., Gillmor, C. S., Xia, G., Feldmann, K. A. and Chua, N. H. (1994). EMB30 is essential for normal cell division, cell expansion, and cell adhesion in Arabidopsis and encodes a protein that has similarity to Sec7. Cell 77, 1051-62.
76. Kleine-Vehn, J., Dhonukshe, P., Sauer, M., Brewer, P. B., Wisniewska, J., Paciorek, T., Benkova, E. and Friml, J. (2008). ARF GEF-Dependent Transcytosis and Polar Delivery of PIN Auxin Carriers in Arabidopsis. Curr Biol 18, 526-31.
77. Geldner, N., Richter, S., Vieten, A., Marquardt, S., Torres-Ruiz, R. A., Mayer, U. and Jurgens, G. (2004). The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth. Development 131, 389-400.
78. Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., Offringa, R. and Jurgens, G. (2003). Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis. Nature 426, 147-53.
79. Wang, L., Liao, F. L., Zhu, L., Peng, X. B. and Sun, M. X. (2008). NtGNL1 is involved in embryonic cell division patterning, root elongation, and pollen tube growth in tobacco. New Phytol.
80. Nomura, K., Debroy, S., Lee, Y.H., Pumplin, N., Jones, J. and He, S. Y. (2006). Abacterial virulence protein suppresses host innate immunity to cause plant disease. Science 313, 220-3.
81. Pagnussat, G. C., Yu, H. J., Ngo, Q. A., Rajani, S.,Mayalagu, S., Johnson, C. S., Capron, A., Xie, L. F., Ye, D., and Sundaresan, V. (2005). Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis. Development 132, 603-14.
82. Nielsen, M., Albrethsen, J., Larsen, FH., Skriver, K. (2006). The Arabidopsis ADP-ribosylation factor (ARF) and ARF-like (ARL) system and its regulation by BIG2, a large ARF-GEF. Plant Science 171, 707-717.
83. Grebe, M., Gadea, J., Steinmann, T., Kientz, M., Rahfeld, J. U., Salchert, K., Koncz, C. and Jurgens, G. (2000). A conserved domain of the arabidopsis GNOM protein mediates subunit interaction and cyclophilin 5 binding. Plant Cell 12, 343-56.
84. Yamaji, R., Adamik, R., Takeda, K., Togawa, A., Pacheco-Rodriguez, G., Ferrans, V. J., Moss, J. and Vaughan, M. (2000). Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. Proc Natl Acad Sci USA 97, 2567-72.
85. Anders, N., Nielsen, M., Keicher, J., Stierhof, Y.D., Furutani, M., Tasaka, M., Skriver, K. and Jurgens, G. (2008). Membrane Association of the Arabidopsis ARF Exchange Factor GNOM Involves Interaction of Conserved Domains. Plant Cell, 20(1):142-51.
86. Morinaga, N., Tsai, S. C., Moss, J. and Vaughan, M. (1996). Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain. Proc Natl Acad Sci USA 93, 12856-60.
87. Ramaen, O., Joubert, A., Simister, P., Belgareh-Touze, N., Olivares-Sanchez, M. C., Zeeh, J. C., Chantalat, S., Golinelli-Cohen, M. P., Jackson, C. L., Biou, V., and Cherfils, J. (2007). Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors. J Biol Chem 282, 28834-42.
88. Garcia-Mata, R. and Sztul, E. (2003). The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor. EMBO Rep 4, 320-5.
89. Amor, J. C., Harrison, D. H., Kahn, R. A. and Ringe, D. (1994). Structure of the human ADP-ribosylation factor 1 complexed with GDP. Nature 372, 704-8.
90. Greasley, S. E., Jhoti, H., Teahan, C., Solari, R., Fensome, A., Thomas, G.M., Cockcroft, S. and Bax, B. (1995). The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed toGDP determined from two different crystal forms. Nat Struct Biol 2, 797-806.
91. Zhao, L., Helms, J. B., Brunner, J. and Wieland, F. T. (1999). GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. J Biol Chem 274, 14198-203.
92. Li, H., Adamik, R., Pacheco-Rodriguez, G., Moss, J. and Vaughan, M. (2003). Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). Proc Natl Acad Sci USA 100, 1627-32.
93. Wessels, E., Duijsings, D., Lanke, K. H., Melchers, W. J., Jackson, C. L. and van Kuppeveld, F. J. (2007). Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1. J Virol 81, 5238-45.
94. Padilla, P. I., Chang, M. J., Pacheco-Rodriguez, G., Adamik, R., Moss, J. and Vaughan, M. (2003). Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. Proc Natl Acad Sci USA 100, 2322-7.
95. Nigam, S. K., Jin, Y. J., Jin, M. J., Bush, K. T., Bierer, B. E. and Burakoff, S. J. (1993). Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum. Biochem J 294 (Pt 2), 511-5.
96. Steinmann, T., Geldner, N., Grebe, M., Mangold, S., Jackson, C. L., Paris, S., Galweiler, L., Palme, K., and Jurgens, G. (1999). Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF. Science 286, 316-8.
97. Szul, T., Garcia-Mata, R., Brandon, E., Shestopal, S., Alvarez, C. and Sztul, E. (2005). Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1. Traffic 6, 374-85.
98. Chantalat, S., Courbeyrette, R., Senic-Matuglia, F., Jackson, C. L., Goud, B. and Peyroche, A. (2003). A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p. Mol Biol Cell 14, 2357-71.
99. Chantalat, S., Park, S. K., Hua, Z., Liu, K., Gobin, R., Peyroche, A., Rambourg, A., Graham, T. R., and Jackson, C. L. (2004). The Arf activator Gea2p and the P-type ATPase Drs2p interact at the Golgi in Saccharomyces cerevisiae. J Cell Sci 117, 711-22.
100. Monetta, P., Slavin, I., Romero, N. and Alvarez, C. (2007). Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association. Mol Biol Cell 18, 2400-10.
101. Alvarez, C., Garcia-Mata, R., Brandon, E. and Sztul, E. (2003). COPI recruitment is modulated by a Rab1b-dependent mechanism. Mol Biol Cell 14, 2116-27.
102. Jones, S., Jedd, G., Kahn, R. A., Franzusoff, A., Bartolini, F. and Segev, N. (1999). Genetic interactions in yeast between Ypt GTPases and Arf guanine nucleotide exchangers. Genetics 152, 1543-56.
103. Grosshans, B. L., Ortiz, D. and Novick, P. (2006). Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA 103, 11821-7.
104. Kuroda, F., Moss, J. and Vaughan, M. (2007). Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. Proc Natl Acad Sci USA 104, 3201-6.
105. Franzusoff, A., Lauze, E. and Howell, K. E. (1992). Immuno-isolation of Sec7p-coated transport vesicles from the yeast secretory pathway. Nature 355, 173-5.
106. Martin, M. E., Hidalgo, J., Rosa, J. L., Crottet, P. and Velasco, A. (2000). Effect of protein kinase A activity on the association of ADP-ribosylation factor 1 to golgi membranes. J Biol Chem 275, 19050-9.
107. Ishizaki, R., Shin, H. W., Iguchi-Ariga, S. M., Ariga, H. and Nakayama, K. (2006). AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors. Genes Cells 11, 949-59.
108. Miyamoto, T., Oshiro, N., Yoshino, K., Nakashima, A., Eguchi, S., Takahashi, M., Ono, Y., Kikkawa, U., and Yonezawa, K. (2008). AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus. J Biol Chem 283, 4430-8.
109. Padilla, P. I., Pacheco-Rodriguez, G., Moss, J. and Vaughan, M. (2004). Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. Proc Natl Acad Sci USA 101, 2752-7.
110. Citterio, C., Jones, H. D., Pacheco-Rodriguez, G., Islam, A., Moss, J. andVaughan, M. (2006). Effect of protein kinaseAon accumulation of brefeldin A-inhibited guanine nucleotideexchange protein 1 (BIG1) in HepG2 cell nuclei. Proc Natl Acad Sci USA 103, 2683-8.
111. Saeki, N., Tokuo, H. and Ikebe, M. (2005). BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. J Biol Chem 280, 10128-34.
112. Wessels, E., Duijsings, D., Niu, T. K., Neumann, S., Oorschot, V. M., de Lange, F., Lanke, K. H., Klumperman, J., Henke, A., Jackson, C. L., Melchers, W. J., and van Kuppeveld, F. J. (2006). A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1. Dev Cell 11, 191-201.
113. Wessels, E., Duijsings, D., Lanke, K. H., van Dooren, S. H., Jackson, C. L., Melchers, W. J. and van Kuppeveld, F. J. (2006). Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment. J Virol 80, 11852-60.
114. Belov,G.A., Altan-Bonnet, N., Kovtunovych, G., Jackson, C. L., Lippincott-Schwartz, J. and Ehrenfeld, E. (2007). Hijacking components of the cellular secretory pathway for replication of poliovirus RNA. J Virol 81, 558-67.
115. Nagai, H., Kagan, J. C., Zhu, X., Kahn, R. A. and Roy, C. R. (2002). A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science 295, 679-82.
116. Amor, J. C., Swails, J., Zhu, X., Roy, C. R., Nagai, H., Ingmundson, A., Cheng, X. and Kahn, R. A. (2005). The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. J Biol Chem 280, 1392-400.
117. Wolf, J. R., Lasher, R. S. and Franzusoff, A. (1996). The putative membrane anchor protein for yeast Sec7p recruitment. Biochem Biophys Res Commun 224, 126-33.