Synthetic single-framework antibody library integrated with rapid affinity maturation by VL shuffling

Protein Engineering, Design and Selection

Volumn 24, Issue 9, 2011, Pages 691-700

  Brockmann, E C ^a   Akter, S ^a   Savukoski, T ^a   Huovinen, T ^a   Lehmusvuori, A ^a   Leivo, J ^a   Saavalainen, O ^a,d   Azhayev, A ^b,c   Lovgren T ^a   Hellman, J ^a   Lamminmaki U ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c Metkinen Chemistry Oy   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

affinity maturation; phage display; recombination; scFv antibody fragment; synthetic library

Indexed keywords

AFFINITY MATURATION; PHAGE DISPLAY; RECOMBINATION; SCFV ANTIBODY FRAGMENTS; SYNTHETIC LIBRARY;

BINDING ENERGY; CLONING; DISSOCIATION; ENZYMES; GENES;

ANTIBODIES;

ANTIBODY; IMMUNOGLOBULIN; LYSOZYME; SYNTHETIC PEPTIDE;

ANTIBODY LIBRARY; ARTICLE; DOMAIN SHUFFLING; GENE; MATURATION; MUTAGENESIS; PRIORITY JOURNAL; RAPID AFFINITY MATURATION;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; DNA SHUFFLING; HUMANS; MOLECULAR SEQUENCE DATA; MURAMIDASE; MUTAGENESIS; PEPTIDE LIBRARY; PROTEIN ENGINEERING; PROTEIN FOLDING; REPRODUCIBILITY OF RESULTS; SINGLE-CHAIN ANTIBODIES;

EID: 80052328890     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr023     Document Type: Article

References (53)

1. Arndt, K.M., Muller, K.M. and Pluckthun, A. (1998) Biochemistry, 37, 12918-12926.
2. Azriel-Rosenfeld, R., Valensi, M. and Benhar, I. (2004) J. Mol. Biol., 335, 177-192.
3. Bebenek, K. and Kunkel, T.A. (1989) Nucleic Acids Res., 17, 5408.
4. Brockmann, E.C., Cooper, M., Strömsten, N., Vehniäinen, M. and Saviranta, P. (2005) J. Immunol. Methods, 296, 159-170.
5. Cardoso, D.F., Nato, F., England, P., Ferreira, M.L., Vaughan, T.J., Mota, I., Mazie, J.C., Choumet, V. and Lafaye, P. (2000) Scand. J. Immunol., 51, 337-344.
6. Collis, A.V., Brouwer, A.P. and Martin, A.C. (2003) J. Mol. Biol., 325, 337-354.
7. de Haard, H.J., van Neer, N., Reurs, A., Hufton, S.E., Roovers, R.C., Henderikx, P., de Bruine, A.P., Arends, J.W. and Hoogenboom, H.R. (1999) J. Biol. Chem., 274, 18218-18230.
8. Ewert, S., Huber, T., Honegger, A. and Pluckthun, A. (2003) J. Mol. Biol., 325, 531-553.
9. Fellouse, F.A., Esaki, K., Birtalan, S., et al. (2007) J. Mol. Biol., 373, 924-940.
10. Gonzalez-Techera, A., Umpierrez-Failache, M., Cardozo, S., Obal, G., Pritsch, O., Last, J.A., Gee, S.J., Hammock, B.D. and Gonzalez-Sapienza, G. (2008) Bioconjug. Chem., 19, 993-1000.
11. Gram, H., Marconi, L.A., Barbas, C.F., 3rd, Collet, T.A., Lerner, R.A. and Kang, A.S. (1992) Proc. Natl Acad. Sci. USA, 89, 3576-3580.
12. Griffiths, A.D., Malmqvist, M., Marks, J.D., Bye, J.M., Embleton, M.J., McCafferty, J., Baier, M., Holliger, K.P., Gorick, B.D. and Hughes-Jones, N.C. (1993) EMBO J., 12, 725-734.
13. Griffiths, A.D., Williams, S.C., Hartley, O., Tomlinson, I.M., Waterhouse, P., Crosby, W.L., Kontermann, R.E., Jones, P.T., Low, N.M. and Allison, T.J. (1994) EMBO J., 13, 3245-3260.
14. Hawkins, R.E., Russell, S.J. and Winter, G. (1992) J. Mol. Biol., 226, 889-896.
15. Hoet, R.M., Cohen, E.H., Kent, R.B., et al. (2005) Nat. Biotechnol., 23, 344-348.
16. Honegger, A. and Pluckthun, A. (2001) J. Mol. Biol., 309, 657-670.
17. Horton, R.D. and Lord, S.T. (1986) Nucleic Acids Res., 14, 5112.
18. Huovinen, T., Sanmark, H., Ylä-Pelto, J., Vehniäinen, M. and Lamminmaki, U. (2010) Mol. Biotechnol., 44, 221-231.
19. Knappik, A., Ge, L., Honegger, A., Pack, P., Fischer, M., Wellnhofer, G., Hoess, A., Wolle, J., Pluckthun, A. and Virnekas, B. (2000) J. Mol. Biol., 296, 57-86.
20. Korpimäki, T., Brockmann, E.C., Kuronen, O., Saraste, M., Lamminmäki, U. and Tuomola, M. (2004) J. Agr. Food. Chem., 52, 40-47.
21. Krebber, A., Bornhauser, S., Burmester, J., Honegger, A., Willuda, J., Bosshard, H.R. and Plückthun, A. (1997) J. Immunol. Methods, 201, 35-55.
22. Kunkel, T.A. (1985) Proc. Natl Acad. Sci. USA, 82, 488-492.
23. Kunkel, T.A., Roberts, J.D. and Zakour, R.A. (1987) Methods Enzymol., 154, 367-382.
24. Lee, C.V., Liang, W.C., Dennis, M.S., Eigenbrot, C., Sidhu, S.S. and Fuh, G. (2004) J. Mol. Biol., 340, 1073-1093.
25. Lu, D., Shen, J., Vil, M.D., Zhang, H., Jimenez, X., Bohlen, P., Witte, L. and Zhu, Z. (2003) J. Biol. Chem., 278, 43496-43507.
26. MacCallum, R.M., Martin, A.C. and Thornton, J.M. (1996) J. Mol. Biol., 262, 732-745.
27. Marks, J.D., Hoogenboom, H.R., Bonnert, T.P., McCafferty, J., Griffiths, A.D. and Winter, G. (1991) J. Mol. Biol., 222, 581-597.
28. Marks, J.D., Griffiths, A.D., Malmqvist, M., Clackson, T.P., Bye, J.M. and Winter, G. (1992) Biotechnology (NY), 10, 779-783.
29. Nagy, Z.A., Hubner, B., Löhning, C., et al. (2002) Nat. Med., 8, 801-807.
30. Nemazee, D., Martensson, A. and Verkoczy, L. (2002) Semin. Immunol., 14, 191-198; discussion 222-224.
31. Ohlin, M. and Borrebaeck, C.A. (1996) Mol. Immunol., 33, 583-592.
32. Ohlin, M., Owman, H., Mach, M. and Borrebaeck, C.A. (1996) Mol. Immunol., 33, 47-56.
33. Osbourn, J.K., Field, A., Wilton, J., Derbyshire, E., Earnshaw, J.C., Jones, P.T., Allen, D. and McCafferty, J. (1996) Immunotechnology, 2, 181-196.
34. Persson, H., Wallmark, H., Ljungars, A., Hallborn, J. and Ohlin, M. (2008) Protein Eng. Des. Sel., 21, 485-493.
35. Pini, A., Viti, F., Santucci, A., Carnemolla, B., Zardi, L., Neri, P. and Neri, D. (1998) J. Biol. Chem., 273, 21769-21776.
36. Rojas, G., Lamdan, H., Padron, S., Munoz, Y., Ayala, M. and Gavilondo, J.V. (2005) Biochem. Biophys. Res. Commun., 336, 1207-1213.
37. Rothe, C., Urlinger, S., Löhning, C., et al. (2008) J. Mol. Biol., 376, 1182-1200.
38. Schier, R., Bye, J., Apell, G., McCall, A., Adams, G.P., Malmqvist, M., Weiner, L.M. and Marks, J.D. (1996) J. Mol. Biol., 255, 28-43.
39. Schofield, D.J., et al. (2007) Genome Biol., 8, R254.
40. Sheets, M.D., Amersdorfer, P., Finnern, R., Sargent, P., Lindquist, E., Schier, R., Hemingsen, G., Wong, C., Gerhart, J.C. and Marks, J.D. (1998) Proc. Natl Acad. Sci. USA, 95, 6157-6162.
41. Shi, L., Wheeler, J.C., Sweet, R.W., et al. (2010) J. Mol. Biol., 397, 385-396.
42. Sidhu, S.S., Lowman, H.B., Cunningham, B.C. and Wells, J.A. (2000) Methods Enzymol., 328, 333-363.
43. Sidhu, S.S., Li, B., Chen, Y., Fellouse, F.A., Eigenbrot, C. and Fuh, G. (2004) J. Mol. Biol., 338, 299-310.
44. Sivanandam, A.S., Mohan, S., Kapur, S., Kita, H., Lau, K.H., Bagi, G., Baylink, D.J. and Qin, X. (2004) Arch. Biochem. Biophys., 423, 343-350.
45. Söderlind, E., Strandberg, L., Jirholt, P., et al. (2000) Nat. Biotechnol., 18, 852-856.
46. Steidl, S., Ratsch, O., Brocks, B., Durr, M. and Thomassen-Wolf, E. (2008) Mol. Immunol., 46, 135-144.
47. Vaughan, T.J., Williams, A.J., Pritchard, K., Osbourn, J.K., Pope, A.R., Earnshaw, J.C., McCafferty, J., Hodits, R.A., Wilton, J. and Johnson, K.S. (1996) Nat. Biotechnol., 14, 309-314.
48. Virnekas, B., Ge, L., Plückthun, A., Schneider, K.C., Wellnhofer, G. and Moroney, S.E. (1994) Nucleic Acids Res., 22, 5600-5607.
49. Wassman, C.D., Tam, P.Y., Lathrop, R.H. and Weiss, G.A. (2004) Nucleic Acids Res., 32, 6407-6413.
50. Yagodkin, A., Azhayev, A., Roivainen, J., Antopolsky, M., Kayushin, A., Korosteleva, M., Miroshnikov, A., Randolph, J. and Mackie, H. (2007) Nucleosides Nucleotides Nucleic Acids, 26, 473-497.
51. Yang, W.P., Green, K., Pinz-Sweeney, S., Briones, A.T., Burton, D.R. and Barbas, C.F., 3rd (1995) J. Mol. Biol., 254, 392-403.
52. Zahnd, C., Spinelli, S., Luginbühl, B., Amstutz, P., Cambillau, C. and Plückthun, A. (2004) J. Biol. Chem., 279, 18870-18877.
53. Zemlin, M., Klinger, M., Link, J., Zemlin, C., Bauer, K., Engler, J.A., Schroeder, H.W., Jr and Kirkham, P.M. (2003) J. Mol. Biol., 334, 733-749.