Light chain shuffling of a high affinity antibody results in a drift in epitope recognition

Molecular Immunology

Volumn 33, Issue 1, 1996, Pages 47-56

  Ohlin, Mats ^a   Owman, Henrik ^a   Mach, Michael ^b   Borrebaeck, Carl A K ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Antibody specificity; Cytomegalovirus; Glycoprotein B (gB); Human monoclonal antibody; Phage display technology

Indexed keywords

EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; VIRUS ANTIBODY;

ANTIBODY AFFINITY; ARTICLE; CYTOMEGALOVIRUS; DNA SEQUENCE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; PHAGE DISPLAY; PRIORITY JOURNAL;

CYTOMEGALOVIRUS;

EID: 0029981792     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/0161-5890(95)00123-9     Document Type: Article

References (45)

1. Azuma J., Kurimoto T., Tsuji S., Mochizuki N., Fujinaga S., Matsumoto Y. and Masuho Y. (1991) Phase I study on human monoclonal antibody against cytomegalovirus: pharmacokinetics and immunogenicity. J. Immunother. 10, 278-285.
2. Barbas III C. F., Bain J. D., Hoekstra D. M. and Lerner R. A. (1992) Semisynthetic combinatorial antibody libraries: A chemical solution to the diversity problem. Proc. natn. Acad. Sci. USA 89, 4457-4461.
3. Barbas III C. F., Collet T. A., Amberg W., Roben P., Binley J. M., Hoekstra D., Cababa D., Jones T. M., Williamson R. A., Pilkington G. R., Haigwood N. L., Cabezas E., Satterthwait A. C., Sanz I. and Burton D. R. (1993) Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries. J. Mol. Biol. 230, 812-823.
4. Broliden P. A., Ljunggren K., Hinkula J., Norrby E., Akerblom L. and Wahren B. (1990) A monoclonal antibody to the human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization. J. Virol. 64, 936-940.
5. Broliden P. A., Rudén U., Ouattara A. S., deThé G., Sølver E., Trojnar J. and Wahren B. (1991) Specific synthetic peptides for detection of and discrimination between HIV-1 and HIV-2 infection. J. Acq. Imm. Def. Syn. 4, 952-958.
6. Burton D. R., Barbas III C. F., Persson M. A. A., Koenig S., Chanock R. M. and Lerner R. A. (1991) A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc. natn. Acad. Sci. USA 88, 10134-10137.
7. Cavacini L. A., Enes C. L., Power J., Duval M. and Posner. M. R. (1994) Effect of antibody valency on interaction with cell-surface expressed HIV-1 and viral neutralization. J. Immun. 152, 2538-2545.
8. Cranage M. P., Kouzarides T., Bankier A. T., Satchwell S., Weston K., Tomlinson P., Barrell B., Hart H., Bell S. E., Minson A. C. and Smith G. L. (1986) Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus. EMBO J. 5, 3057-3063.
9. Gram H., Marconi L.-A., Barbas III C. F., Collet T. A., Lerner R. A. and Kang A. S. (1992) In vitro selection and affinity maturation of antibodies from a naive combinatorial library. Proc. natn. Acad. Sci. USA 89, 3576-3580.
10. Griffiths A. D., Malmqvist M., Marks J. D., Bye J. M., Embleton M. J., McCafferty J., Baier M., Holliger K. P., Gorick B. D., Hughes-Jones N. C., Hoogenboom H. R. and Winter G. (1993) Human anti-self antibodies with high specificity from phage display libraries. EMBO J. 12, 725-34.
11. Griffiths A. D., Williams S. C., Hartley O., Tomlinson I. M., Waterhouse P., Crosby W. L., Kontermann R. E., Jones P. T., Low N. M., Allison T. J., Prospero T. D., Hoogenboom H. R., Nissim A., Cox J. P. L., Harrison J. L., Zaccolo M., Gherardi E. and Winter G. (1994) Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13, 3245-3260.
12. Hawkins R. E., Russell S. J. and Winter G. (1992) Selection of phage antibodies by binding affinity. Mimicking affinity maturation. J. Mol. Biol. 226, 889-896.
13. Hieter P. A., Maizel J. V. Jr and Leder P. (1982) Evolution of human immunoglobulin κ J region genes. J. Biol. Chem. 257, 1516-1522.
14. H gene segments rearranged in vitro. J. Mol. Biol. 227, 381-388.
15. Huse W. D., Sastrym L., Iversom S. A., Kang A. S., Alting-Mees M., Burton D., Benkovic S. J. and Lerner R. A. (1989) Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246, 1275-1281.
16. Huston J. S., Levinson D., Mudgett-Hunter M., Tai M.-S., Novotny J., Margolies M. N., Ridge R. J., Bruccoleri R. E., Haber E., Crea R. and Oppermann H. (1988) Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. natn. Acad. Sci. USA 85, 5879-5883.
17. Ichihara Y., Matsuoka H. and Kurosawa Y. (1988) Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J. 7, 4141-4150.
18. Jaume J. C., Costante G., Portolano S., McLachlan S. M. and Rapoport B. (1994) Recombinant thyroid peroxidase-specific autoantibodies. I. How diverse is the pool of heavy and light chains in immunoglobulin gene libraries constructed from thyroid tissue-infiltrating plasma cells. Endocrinology 135, 16-24.
19. Kabat E. A., Wu T. T., Perry H. M., Gottesman K. S. and Foeller C. (1991) Sequences of Immunological Interest, 5th edition. NIH Publication No. 91-3242, National Institutes of Public Health, Bethesda, MD, U.S.A.
20. Larrick J. W., Danielsson L., Brenner C. A., Wallace E. F., Abrahamson M., Fry K. E. and Borrebaeck C. A. K. (1989) Polymerase chain reaction using mixed primers: cloning of human monoclonal antibody variable region genes from single hybridoma cells. BioTechnology 7, 934-938.
21. Lehner R., Stamminger T. and Mach M. (1991) Comparative sequence analysis of human cytomegalovirus strains. J. Clin. Microbiol. 29, 2494-2502.
22. Malmborg A.-C., Michaëlsson A., Ohlin M., Jansson B. and Borrebaeck C. A. K. (1992) Real time analysis of antibody-antigen reaction kinetics. Scand. J. Immun. 35, 643-650.
23. Marks J. D., Hoogenboom H. R., Bonnert T. P., McCafferty J., Griffiths A. D. and Winter G. (1991) By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 22, 581-597.
24. McCafferty J., Griffiths A. D., Winter G. and Chiswell D. J. (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552-554.
25. Meyer H., Masuho Y. and Mach M. (1990) The gp116 of the gp58/116 complex of human cytomegalovirus represents the amino-terminal part of the precursor molecule and contains a neutralizing epitope. J. Gen. Virol. 71, 2443-2450.
26. Meyer H., Sundqvist V.-A., Pereira L. and Mach M. (1992) Glycoprotein gp116 of human cytomegalovirus contains epitopes for strain-common and strain-specific antibodies. J. Gen. Virol. 73, 2375-2383.
27. Ohizumi Y., Suzuki H., Matsumoto Y.-I., Masuho Y. and Numazaki Y. (1992) Neutralizing mechanism of two human monoclonal antibodies against human cytomegalovirus glycoprotein 130/55. J. Gen. Virol. 73, 2705-2707.
28. Ohlin M. and Borrebaeck C. A. K. (1993) Production of human monoclonal antibodies. In Methods of Immunological Analysis Vol. 2 (Edited by Masseyeff R. F., Albert W. H. and Staines N. A.), pp. 298-325. VCH Verlagsgesellschaft mbH, Weinheim, Germany.
29. Ohlin M., Owman H., Rioux J. D., Newkirk M. M. and Borrebaeck C. A. K. (1994) Restricted variable region gene usage and possible rheumatoid factor relationship among human monoclonal antibodies specific for the AD-1 epitope on cytomegalovirus glycoprotein B. Molec. Immun. 31, 983-991.
30. Ohlin M., Sundqvist V.-A., Mach M., Wahren B. and Borrebaeck C. A. K. (1993) Fine specificity of the human immune response to the major neutralization epitopes expressed bon cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. J. Virol. 67, 703-710.
31. Olee T., Yang P.-M., Siminovitch K. A., Olsen N. J., Hillson J. L., Wu J., Kozin F., Carson D. A. and Chen P. P. (1991) Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J. Clin. Invest. 88, 193-203.
32. Padlan E. A., Abergel C. and Tipper J. P. (1995) Identification of specificity-determining residues in antibodies. FASEB J. 9, 133-139.
33. κ locus. Nucleic Acids Res. 12, 9229-9236.
34. Potter H. (1993) Application of electroporation in recombinant DNA technology. Meth. Enzymol. 217, 461-478.
35. Rapoport B., Portolano S. and McLachlan S. M. (1995) Combinatorial libraries: new insights into human organ-specific autoantibodies. Immun. Today 16, 43-49.
36. Rosenblum J. S. and Barbas III C. F. (1995) Synthetic antibodies. In Antibody Engineering. 2nd Edition (Edited by Borrebaeck C. A. K.), pp. 89-116. Oxford University Press, New York.
37. Schmidt T. G. M. and Skerra A. (1993) The random peptide library-assisted engineering of a C-terminal affinity peptide, useful for the detection and purification of a functional Ig Fv fragment. Prot. Eng. 6, 109-122.
38. Schroeder H. W., Hillson J. L. and Perlmutter R. M. (1987) Early restriction in the human antibody repertoire. Science 238, 791-793.
39. Silvestri M., Jäderling F., Rudén U., Ohlin M. and Sundqvist V.-A. (1993) Fine specificity and neutralizing activity of human serum antibodies directed to the major antigenic region on gp116 of human cytomegalovirus. Serodiag. Immunother. Infect. Dis. 5, 209-216.
40. Skinner M. A., Langlois A. J., McDanal C. B., McDougal J. S., Bolognesi D. P. and Matthews T. J. (1988) Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4. J. Virol. 62, 4195-4200.
41. Spaete R. R., Gehrz R. C. and Landini M. P. (1994) Human cytomegalovirus structural proteins. J. Gen. Virol. 75, 3287-3308.
42. Sällberg M., Rudén U., Magnius L. O., Norrby E. and Wahren B. (1991) Rapid "tea-bag" peptide synthesis using 9-fluorenylmethoxycarbonyl (Fmoc) protected amino acids applied for antigenic mapping of viral proteins. Immun. Lett. 30, 59-68.
43. Söderlind E., Simonsson Lagerkvist A. C., Dueñas M., Malmborg A.-C., Ayala M., Danielsson L. and Borrebaeck C. A. K. (1993) Chaperonin assisted phage display of antibody fragments on filamentous bacteriophages. BioTechnology 11, 503-507.
44. VanCott T. C., Bethke F. R., Polonis V. R., Gorny M. K., Zolla-Pazner S., Redfield R. R. and Birx D. L. (1994) Dissociation rate of antibody-gp120 binding interactions is predictive of V3-mediated neutralization of HIV-1. J. Immun. 153, 449-459.
45. Williamson R. A., Burioni R., Sanna P. P., Partridge L. J., Barbas III C. F. and Burton D. R. (1993) Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries. Proc. natn. Acad. Sci. USA 90, 4141-4145.