Haplotype exclusion and receptor editing: Irreconcilable differences?

Seminars in Immunology

Volumn 14, Issue 3, 2002, Pages 191-198

  Nemazee, David ^a   Mårtensson, Annica ^a   Verkoczy, Laurent ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Allelic exclusion; Haplotype; Monospecificity; Receptor editing

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ALLELIC EXCLUSION; ARTICLE; B LYMPHOCYTE; GENE REARRANGEMENT; GENE STRUCTURE; GENETIC RECOMBINATION; HAPLOTYPE; HUMAN; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; RECEPTOR EDITING; T LYMPHOCYTE; ALLELE; ANIMAL; BIOLOGICAL MODEL; EVOLUTION; GENETICS; IMMUNOLOGICAL TOLERANCE; REVIEW; RNA EDITING;

ALLELES; ANIMALS; EVOLUTION; GENE REARRANGEMENT, B-LYMPHOCYTE; HAPLOTYPES; HUMANS; IMMUNE TOLERANCE; MODELS, GENETIC; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, B-CELL; RNA EDITING;

EID: 0036614169     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-5323(02)00042-8     Document Type: Article

References (69)

1. The structure and organization of immunoglobulin genes in lower vertebrates
2. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
3. A hyperconversion mechanism generates the chicken light chain preimmune repertoire
4. Somatic diversification of immunoglobulin heavy chain VDJ genes: Evidence for somatic gene conversion in rabbits
5. The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: The protection
6. Naturally occurring antibodies devoid of light chains
7. Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies
8. A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG
9. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
10. Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins
11. Antigen receptor 'capacity' and the sensitivity of self-tolerance
12. Origin and evolution of the vertebrate immune system
13. Receptor selection in B and T lymphocytes
14. Immunoglobulin expression in diploid and polyploid interspecies hybrid of Xenopus: Evidence for allelic exclusion
15. Surrogate light chain in B cell development
16. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu
17. Transgenic mice with immunoglobulin genes
18. Ordered rearrangement of immunoglobulin heavy chain variable region segments
19. Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains
20. Polypeptide chains of human gamma-globulin cellular localization by flourescent antibody
21. Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: Human B cells can simultaneously express cell surface kappa and lambda light chains
22. Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans
23. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
24. Murine lambda gene rearrangements: The stochastic model prevails over the ordered model
25. Contribution of receptor editing to the antibody repertoire
26. The mouse immunoglobulin kappa locus contains about 140 variable gene segments
27. The 3′ part of the immunoglobulin kappa locus of the mouse
28. The central part of the mouse immunoglobulin κ locus
29. The 5′ part of the mouse immunoglobulin κ locus
30. Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene
31. A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation
32. The human immunoglobulin κ genes
33. Immunoglobulin λ genes
34. Lambda chains and genes in inbred mice
35. Ligand recognition by alpha beta T cell receptors
36. Non-random features of the repertoire expressed by the members of one V kappa gene family and of the V-J recombination
37. Light chain editing in kappa-deficient animals: A potential mechanism of B cell tolerance
38. Deficiency of kappa- or lambda-type immunoglobulins
39. Kappa-deficient mice are non-responders to dextran 3512: Is this unresponsiveness due to specialization of the kappa and lambda Ig repertoires?
40. Kappa-chain deficiency
41. Variant strain of rabbits lacking immunoglobulin kappa polypeptide chain
42. Molecular defects in a human immunoglobulin kappa chain deficiency
43. Deficiency of kappa- or lambda-type immunoglobulins
44. Light chain evolution
45. Deletion and editing of B cells that express antibodies to DNA
46. Editing disease-associated autoantibodies
47. Light chain replacement: A new model for antibody gene rearrangement
48. B lymphocytes may escape tolerance by revising their antigen receptors
49. V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling
50. B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection
51. Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest
52. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection
53. Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification
54. Receptor editing in self-reactive bone marrow B cells
55. Re-evaluation of the probabilities for productive arrangements on the kappa and lambda loci
56. B cells are programmed to activate kappa and lambda for rearrangement at consecutive developmental stages
57. Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies
58. Human cord blood kappa repertoire
59. Preferential rearrangement of V kappa 4 gene segments in pre-B cell lines
60. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development
61. Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells
62. Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes
63. The human kappa deleting element and the mouse recombining segment share DNA sequence homology
64. Receptor editing occurs frequently during normal B cell development
65. Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles
66. Theoretical limits to massive receptor editing in immature B cells
67. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice
68. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development
69. A critical role of lambda 5 protein in B cell development