In vitro affinity maturation of human GM-CSF antibodies by targeted CDR-diversification

Molecular Immunology

Volumn 46, Issue 1, 2008, Pages 135-144

  Steidl, Stefan ^a   Ratsch, Olaf ^a   Brocks, Bodo ^a   Dürr, Manuela ^a   Thomassen Wolf, Elisabeth ^a  

^a MORPHOSYS AG   (Germany)

Author keywords

Affinity maturation; GM CSF; Human antibodies; Phage display

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY MOR03682; MONOCLONAL ANTIBODY MOR03684; MONOCLONAL ANTIBODY MOR03929; MONOCLONAL ANTIBODY MOR04252; MONOCLONAL ANTIBODY MOR04287; MONOCLONAL ANTIBODY MOR04290; MONOCLONAL ANTIBODY MOR04302; MONOCLONAL ANTIBODY MOR04357; STAT5 PROTEIN; TRINUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIBODY LIBRARY; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CHO CELL; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; HEAVY CHAIN; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; INFLAMMATION; LIGHT CHAIN; MEASUREMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOMATIC HYPERMUTATION;

ANIMALS; ANTIBODY AFFINITY; CELL NUCLEUS; CELL PROLIFERATION; CHO CELLS; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; CRICETINAE; CRICETULUS; CROSS REACTIONS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MACACA MULATTA; NEUTRALIZATION TESTS; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN TRANSPORT; RATS; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; STAT5 TRANSCRIPTION FACTOR;

MAMMALIA; RATTUS;

EID: 52949093147     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.07.013     Document Type: Article

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