HIV-1 protease inhibitors: Enthalpic versus entropic optimization of the binding affinity

Biochemistry

Volumn 39, Issue 9, 2000, Pages 2201-2207

  Velazquez Campoy, Adrian ^a   Todd, Matthew J ^a   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLPEPSTATIN; PROTEINASE INHIBITOR; TRIPEPTIDE;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SCREENING; ENTHALPY; ENTROPY; ENZYME INHIBITOR INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEINASE INHIBITION; SOLVATION; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG RESISTANCE; ENTROPY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034093758     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992399d     Document Type: Article

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