-
1
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
Lindahl T. Instability and decay of the primary structure of DNA. Nature, 1993, 362(6422): 7091-7095.
-
(1993)
Nature
, vol.362
, Issue.6422
, pp. 7091-7095
-
-
Lindahl, T.1
-
3
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou B B, Elledge S J. The DNA damage response: putting checkpoints in perspective. Nature, 2000, 408(6811): 433-439.
-
(2000)
Nature
, vol.408
, Issue.6811
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
4
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham R T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev, 2001, 15(17): 2177-2196.
-
(2001)
Genes Dev
, vol.15
, Issue.17
, pp. 2177-2196
-
-
Abraham, R.T.1
-
5
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C J, Kastan M B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature, 2003, 421(6922): 499-506.
-
(2003)
Nature
, vol.421
, Issue.6922
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
6
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee J H, Paull T T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science, 2005, 308(5721): 551-554.
-
(2005)
Science
, vol.308
, Issue.5721
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
7
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J, Coates J, Jackson S P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature, 2005, 434(7033): 605-611.
-
(2005)
Nature
, vol.434
, Issue.7033
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
8
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown E J, Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev, 2003, 17(5): 615-628.
-
(2003)
Genes Dev
, vol.17
, Issue.5
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
9
-
-
3242670803
-
ATR and ATM regulate the timing of DNA replication origin firing
-
Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nature Cell Biol, 2004, 6(7): 648-655.
-
(2004)
Nature Cell Biol
, vol.6
, Issue.7
, pp. 648-655
-
-
Shechter, D.1
Costanzo, V.2
Gautier, J.3
-
10
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L, Elledge S J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 2003, 300(5625): 1542-1548.
-
(2003)
Science
, vol.300
, Issue.5625
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
11
-
-
0035929237
-
Opening of the clamp: An intimate view of an ATP-driven biological machine
-
Ellison V, Stillman B. Opening of the clamp: an intimate view of an ATP-driven biological machine. Cell, 2001, 106(6): 655-660.
-
(2001)
Cell
, vol.106
, Issue.6
, pp. 655-660
-
-
Ellison, V.1
Stillman, B.2
-
12
-
-
3342915628
-
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
-
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson S P, Bartek J, Lukas J. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J, 2004, 23(13): 2674-2683.
-
(2004)
EMBO J
, vol.23
, Issue.13
, pp. 2674-2683
-
-
Lukas, C.1
Melander, F.2
Stucki, M.3
Falck, J.4
Bekker-Jensen, S.5
Goldberg, M.6
Lerenthal, Y.7
Jackson, S.P.8
Bartek, J.9
Lukas, J.10
-
13
-
-
0038613469
-
Checkpoint mediators: Relaying signals from DNA strand breaks
-
Canman C E. Checkpoint mediators: relaying signals from DNA strand breaks. Curr Biol, 2003, 13(12): R488-R490.
-
(2003)
Curr Biol
, vol.13
, Issue.12
-
-
Canman, C.E.1
-
14
-
-
0037291130
-
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17
-
Lee J, Kumagai A, Dunphy W G. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell, 2003, 11(2): 329-340.
-
(2003)
Mol Cell
, vol.11
, Issue.2
, pp. 329-340
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
15
-
-
10944262393
-
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
-
Unal E, Arbel-Eden A, Sattler U, Shroff R, Lichten M, Haber J E, Koshland D. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell, 2004, 16(6): 991-1002.
-
(2004)
Mol Cell
, vol.16
, Issue.6
, pp. 991-1002
-
-
Unal, E.1
Arbel-Eden, A.2
Sattler, U.3
Shroff, R.4
Lichten, M.5
Haber, J.E.6
Koshland, D.7
-
16
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
Celeste A, Fernandez-Capetillo O, Kruhlak M J, Pilch D R, Staudt D W, Lee A, Bonner R F, Bonner W M, Nussenzweig A. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol, 2003, 5(7): 675-679.
-
(2003)
Nat Cell Biol
, vol.5
, Issue.7
, pp. 675-679
-
-
Celeste, A.1
Fernandez-Capetillo, O.2
Kruhlak, M.J.3
Pilch, D.R.4
Staudt, D.W.5
Lee, A.6
Bonner, R.F.7
Bonner, W.M.8
Nussenzweig, A.9
-
17
-
-
10944232673
-
Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair
-
Strom L, Lindroos H B, Shirahige K, Sjogren C. Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. Mol Cell, 2004, 16(6): 1003-1015.
-
(2004)
Mol Cell
, vol.16
, Issue.6
, pp. 1003-1015
-
-
Strom, L.1
Lindroos, H.B.2
Shirahige, K.3
Sjogren, C.4
-
18
-
-
9244252580
-
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
-
Huyen Y, Zgheib O, Ditullio R A Jr, Gorgoulis V G, Zacharatos P, Petty T J, Sheston E A, Mellert H S, Stavridi E S, Halazonetis T D. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature, 2004, 432(7015): 406-411.
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 406-411
-
-
Huyen, Y.1
Zgheib, O.2
Ditullio Jr., R.A.3
Gorgoulis, V.G.4
Zacharatos, P.5
Petty, T.J.6
Sheston, E.A.7
Mellert, H.S.8
Stavridi, E.S.9
Halazonetis, T.D.10
-
19
-
-
22444448143
-
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response
-
Masumoto H, Hawke D, Kobayashi R, Verreault A. A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature, 2005, 436(7048): 294-298.
-
(2005)
Nature
, vol.436
, Issue.7048
, pp. 294-298
-
-
Masumoto, H.1
Hawke, D.2
Kobayashi, R.3
Verreault, A.4
-
20
-
-
21244456772
-
Complicated tails: Histone modifications and the DNA damage response
-
Vidanes G M, Bonilla C Y, Toczyski D P. Complicated tails: Histone modifications and the DNA damage response. Cell, 2005, 121(7): 973-976.
-
(2005)
Cell
, vol.121
, Issue.7
, pp. 973-976
-
-
Vidanes, G.M.1
Bonilla, C.Y.2
Toczyski, D.P.3
-
21
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nature Rev Cancer, 2003, 3(3): 155-168.
-
(2003)
Nature Rev Cancer
, vol.3
, Issue.3
, pp. 155-168
-
-
Shiloh, Y.1
-
22
-
-
0035545996
-
Mammalian G1-and S-phase checkpoints in response to DNA damage
-
Bartek J, Lukas J. Mammalian G1-and S-phase checkpoints in response to DNA damage. Cur Opin Cell Biol, 2001, 13(6): 738-747.
-
(2001)
Cur Opin Cell Biol
, vol.13
, Issue.6
, pp. 738-747
-
-
Bartek, J.1
Lukas, J.2
-
23
-
-
5044220936
-
Checking on DNA damage in S phase
-
Bartek J, Lukas C, Lukas J. Checking on DNA damage in S phase. Nature Rev Mol Cell Biol, 2004, 5(10): 792-804.
-
(2004)
Nature Rev Mol Cell Biol
, vol.5
, Issue.10
, pp. 792-804
-
-
Bartek, J.1
Lukas, C.2
Lukas, J.3
-
24
-
-
0036510055
-
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
-
Falck J, Petrini J H, Williams B R, Lukas J, Bartek J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nature Genet, 2002, 30(3): 290-294.
-
(2002)
Nature Genet
, vol.30
, Issue.3
, pp. 290-294
-
-
Falck, J.1
Petrini, J.H.2
Williams, B.R.3
Lukas, J.4
Bartek, J.5
-
25
-
-
0012966157
-
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of CDC25A
-
Sorensen C S, Syljuasen R G, Falck J, Schroeder T, Ronnstrand L, Khanna K K, Zhou B B, Bartek J, Lukas J. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of CDC25A. Cancer Cell, 2003, 3(3): 247-258.
-
(2003)
Cancer Cell
, vol.3
, Issue.3
, pp. 247-258
-
-
Sorensen, C.S.1
Syljuasen, R.G.2
Falck, J.3
Schroeder, T.4
Ronnstrand, L.5
Khanna, K.K.6
Zhou, B.B.7
Bartek, J.8
Lukas, J.9
-
26
-
-
2942687831
-
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
-
Kitagawa R, Bakkenist C J, Mckinnon P J, Kastan M B. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev, 2004, 18(12): 1423-1438.
-
(2004)
Genes Dev
, vol.18
, Issue.12
, pp. 1423-1438
-
-
Kitagawa, R.1
Bakkenist, C.J.2
Mckinnon, P.J.3
Kastan, M.B.4
-
27
-
-
0037178722
-
Maintenance of Genome Stability in Saccharomyces cerevisiae
-
Kolodner R D, Putnam C D, Myung K. Maintenance of Genome Stability in Saccharomyces cerevisiae. Science, 2002, 297(5581): 552-557.
-
(2002)
Science
, vol.297
, Issue.5581
, pp. 552-557
-
-
Kolodner, R.D.1
Putnam, C.D.2
Myung, K.3
-
28
-
-
0036948433
-
Toward maintaining the genome: DNA damage and replication checkpoint
-
Nyberg K A, Michelson R J, Putnam C W, Weinert T A. Toward maintaining the genome: DNA damage and replication checkpoint. Annu Rev Genet, 2002, 36: 617-656.
-
(2002)
Annu Rev Genet
, vol.36
, pp. 617-656
-
-
Nyberg, K.A.1
Michelson, R.J.2
Putnam, C.W.3
Weinert, T.A.4
-
29
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan M B, Bartek J. Cell-cycle checkpoints and cancer. Nature, 2004, 432(7015): 316-323.
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
30
-
-
0037133566
-
The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1
-
Zhao X, Rothstein R. The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1. Proc Natl Acad Sci USA, 2002, 99(6): 3746-3751.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.6
, pp. 3746-3751
-
-
Zhao, X.1
Rothstein, R.2
-
31
-
-
0034119315
-
DNA repair protein Rad55 is terminal substrate of the DNA damage checkpoints
-
Bashkirov V I, King J S, Bashkirova E V, Schmuckli-Maurer J, Heyer W D. DNA repair protein Rad55 is terminal substrate of the DNA damage checkpoints. Mol Cell Biol, 2000(12), 20: 4393-4404.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.12
, pp. 4393-4404
-
-
Bashkirov, V.I.1
King, J.S.2
Bashkirova, E.V.3
Schmuckli-Maurer, J.4
Heyer, W.D.5
-
32
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
-
Syljuasen R G, Sorensen C S, Hansen L T, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol, 2005, 25(9): 3553-3562.
-
(2005)
Mol Cell Biol
, vol.25
, Issue.9
, pp. 3553-3562
-
-
Syljuasen, R.G.1
Sorensen, C.S.2
Hansen, L.T.3
Fugger, K.4
Lundin, C.5
Johansson, F.6
Helleday, T.7
Sehested, M.8
Lukas, J.9
Bartek, J.10
-
33
-
-
13944266820
-
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
-
Sorensen C S, Hansen L T, Dziegielewski J, Syljuasen R G, Lundin C, Bartek J, Helleday T. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol, 2005, 7(2): 195-201.
-
(2005)
Nat Cell Biol
, vol.7
, Issue.2
, pp. 195-201
-
-
Sorensen, C.S.1
Hansen, L.T.2
Dziegielewski, J.3
Syljuasen, R.G.4
Lundin, C.5
Bartek, J.6
Helleday, T.7
-
34
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
-
Riballo E, Kuhne M, Rief N, Doherty A, Smith G C, Recio M J, Reis C, Dahm K, Fricke A, Krempler A, Parker A R, Jackson S P, Gennery A, Jeggo P A, Loblich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell, 2004, 16(5): 715-724.
-
(2004)
Mol Cell
, vol.16
, Issue.5
, pp. 715-724
-
-
Riballo, E.1
Kuhne, M.2
Rief, N.3
Doherty, A.4
Smith, G.C.5
Recio, M.J.6
Reis, C.7
Dahm, K.8
Fricke, A.9
Krempler, A.10
Parker, A.R.11
Jackson, S.P.12
Gennery, A.13
Jeggo, P.A.14
Loblich, M.15
-
35
-
-
0037226473
-
The mismatch repair system is required for S-phase checkpoint activation
-
Brown K D, Rathi A, Kamath R, Beardsley D I, Zhan Q, Mannino J L, Baskaran R. The mismatch repair system is required for S-phase checkpoint activation. Nat Genet, 2003, 33(1): 80-84.
-
(2003)
Nat Genet
, vol.33
, Issue.1
, pp. 80-84
-
-
Brown, K.D.1
Rathi, A.2
Kamath, R.3
Beardsley, D.I.4
Zhan, Q.5
Mannino, J.L.6
Baskaran, R.7
-
36
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgonlis V G, Vassiliou L V, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio R A Jr, Kastrinakis N G, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis T D. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature, 2005, 434(7035): 907-913.
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 907-913
-
-
Gorgonlis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
Kletsas, D.11
Yoneta, A.12
Herlyn, M.13
Kittas, C.14
Halazonetis, T.D.15
-
37
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J, Horejsi S, Koed K, Kramer K, Tort F, Zieger K, Guldberg P, Sehested M, Nesland J M, Lukas C, Orntoft T, Lukas J, Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 2005, 434(4075): 864-870.
-
(2005)
Nature
, vol.434
, Issue.4075
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, S.2
Koed, K.3
Kramer, K.4
Tort, F.5
Zieger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
Orntoft, T.11
Lukas, J.12
Bartek, J.13
-
38
-
-
0037148403
-
ATM function and telomere stability
-
Pandita T K. ATM function and telomere stability. Oncogene, 2002, 21(4): 611-618.
-
(2002)
Oncogene
, vol.21
, Issue.4
, pp. 611-618
-
-
Pandita, T.K.1
-
39
-
-
2942722673
-
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice
-
Treuner K, Helton R, Barlow C. Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice. Oncogene, 2004, 23(27): 4655-4661.
-
(2004)
Oncogene
, vol.23
, Issue.27
, pp. 4655-4661
-
-
Treuner, K.1
Helton, R.2
Barlow, C.3
-
40
-
-
0242678554
-
Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients
-
Bobailla-Morales L, Corona-Rivera A, Corona-Rivera J R, Buenrostro C, Garcia-Cobian T A, Corona-Rivera E, Cantu-Garza J M, Garcia-Cruz D. Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients. Am J Med Genet, 2003, 123(2): 148-152.
-
(2003)
Am J Med Genet
, vol.123
, Issue.2
, pp. 148-152
-
-
Bobailla-Morales, L.1
Corona-Rivera, A.2
Corona-Rivera, J.R.3
Buenrostro, C.4
Garcia-Cobian, T.A.5
Corona-Rivera, E.6
Cantu-Garza, J.M.7
Garcia-Cruz, D.8
-
41
-
-
0035830498
-
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae
-
Myung K, Datta A, Kolodner R D. Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell, 2001, 104(3): 397-408.
-
(2001)
Cell
, vol.104
, Issue.3
, pp. 397-408
-
-
Myung, K.1
Datta, A.2
Kolodner, R.D.3
-
42
-
-
0033957793
-
The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
-
Frei C, Gasser S M. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev, 2000, 14(1): 81-96.
-
(2000)
Genes Dev
, vol.14
, Issue.1
, pp. 81-96
-
-
Frei, C.1
Gasser, S.M.2
|