MicroRNA function in the nervous system

Progress in Molecular Biology and Translational Science

Volumn 102, Issue , 2011, Pages 47-100

  Fiore, Roberto ^a   Khudayberdiev, Sharof ^a   Saba, Reuben ^a   Schratt, Gerhard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

MicroRNA; Neurological disease; Neuronal activity; Neuronal differentiation; Synaptic plasticity; Synaptogenesis

Indexed keywords

EID: 80051862685     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-415795-8.00004-0     Document Type: Chapter

References (163)

1. A. Kriegstein, and A. Alvarez-Buylla The glial nature of embryonic and adult neural stem cells Annu Rev Neurosci 32 2009 149 184 10.1146/annurev.neuro. 051508.135600
2. R.C. Lee, R.L. Feinbaum, and V. Ambros The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 75 1993 843 854 (Pubitemid 24014542)
3. A.J. Giraldez, R.M. Cinalli, M.E. Glasner, A.J. Enright, J.M. Thomson, and S. Baskerville MicroRNAs regulate brain morphogenesis in zebrafish Science 308 2005 833 838 10.1126/science.1109020 (Pubitemid 40629259)
4. E. Bernstein, S.Y. Kim, M.A. Carmell, E.P. Murchison, H. Alcorn, and M.Z. Li Dicer is essential for mouse development Nat Genet 35 2003 215 217 10.1038/ng1253 (Pubitemid 37363172)
5. D. De Pietri Tonelli, J.N. Pulvers, C. Haffner, E.P. Murchison, G.J. Hannon, and W.B. Huttner miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex Development 135 2008 3911 3921 10.1242/dev.025080
6. Y. Kawase-Koga, R. Low, G. Otaegi, A. Pollock, H. Deng, and F. Eisenhaber RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells J Cell Sci 123 2010 586 594 10.1242/jcs.059659
7. P.S. Choi, L. Zakhary, W.Y. Choi, S. Caron, E. Alvarez-Saavedra, and E.A. Miska Members of the miRNA-200 family regulate olfactory neurogenesis Neuron 57 2008 41 55 10.1016/j.neuron.2007.11.018
8. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
9. T.H. Davis, T.L. Cuellar, S.M. Koch, A.J. Barker, B.D. Harfe, and M.T. McManus Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus J Neurosci 28 2008 4322 4330 10.1523/JNEUROSCI.4815- 07.2008
10. J. Kim, K. Inoue, J. Ishii, W.B. Vanti, S.V. Voronov, and E. Murchison A microRNA feedback circuit in midbrain dopamine neurons Science 317 2007 1220 1224 10.1126/science.1140481
11. A. Schaefer, D. O'Carroll, C.L. Tan, D. Hillman, M. Sugimori, and R. Llinas Cerebellar neurodegeneration in the absence of microRNAs J Exp Med 204 2007 1553 1558 10.1084/jem.20070823 (Pubitemid 47048023)
12. T.L. Cuellar, T.H. Davis, P.T. Nelson, G.B. Loeb, B.D. Harfe, and E. Ullian Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration Proc Natl Acad Sci USA 105 2008 5614 5619 10.1073/pnas.0801689105 (Pubitemid 351753911)
13. R.J. Taft, E.A. Glazov, T. Lassmann, Y. Hayashizaki, P. Carninci, and J.S. Mattick Small RNAs derived from snoRNAs RNA 15 2009 1233 1240 10.1261/rna.1528909
14. K. Okamura, and E.C. Lai Endogenous small interfering RNAs in animals Nat Rev Mol Cell Biol 9 2008 673 678 10.1038/nrm2479
15. J.E. Babiarz, J.G. Ruby, Y. Wang, D.P. Bartel, and R. Blelloch Mouse ES cells express endogenous shRNAs, siRNAs, and other microprocessor-independent, Dicer-dependent small RNAs Genes Dev 22 2008 2773 2785 10.1101/gad.1705308
16. Y. Wang, R. Medvid, C. Melton, R. Jaenisch, and R. Blelloch DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal Nat Genet 39 2007 380 385 10.1038/ng1969 (Pubitemid 46328490)
17. N. Suh, L. Baehner, F. Moltzahn, C. Melton, A. Shenoy, and J. Chen MicroRNA function is globally suppressed in mouse oocytes and early embryos Curr Biol 20 2010 271 277 10.1016/j.cub.2009.12.044
18. R. Yi, H.A. Pasolli, M. Landthaler, M. Hafner, T. Ojo, and R. Sheridan DGCR8-dependent microRNA biogenesis is essential for skin development Proc Natl Acad Sci USA 106 2009 498 502 10.1073/pnas.0810766105
19. P.K. Rao, Y. Toyama, H.R. Chiang, S. Gupta, M. Bauer, and R. Medvid Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure Circ Res 105 2009 585 594 10.1161/CIRCRESAHA.109.200451
20. M.M. Chong, J.P. Rasmussen, A.Y. Rudensky, and D.R. Littman The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease J Exp Med 205 2008 2005 2017 10.1084/jem.20081219
21. M. Kapsimali, W.P. Kloosterman, E. de Bruijn, F. Rosa, R.H. Plasterk, and S.W. Wilson MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system Genome Biol 8 2007 R173 10.1186/gb-2007-8-8-r173 (Pubitemid 351891464)
22. J.A. Nielsen, P. Lau, D. Maric, J.L. Barker, and L.D. Hudson Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis BMC Neurosci 10 2009 98 10.1186/1471-2202-10-98
23. L.A. Goff, J. Davila, M.R. Swerdel, J.C. Moore, R.I. Cohen, and H. Wu Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors PLoS ONE 4 2009 e7192 10.1371/journal.pone.0007192
24. A.M. Krichevsky, K.S. King, C.P. Donahue, K. Khrapko, and K.S. Kosik A microRNA array reveals extensive regulation of microRNAs during brain development RNA 9 2003 1274 1281 (Pubitemid 37151681)
25. L.F. Sempere, S. Freemantle, I. Pitha-Rowe, E. Moss, E. Dmitrovsky, and V. Ambros Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation Genome Biol 5 2004 R13 10.1186/gb-2004-5-3-r13
26. A. Rybak, H. Fuchs, L. Smirnova, C. Brandt, E.E. Pohl, and R. Nitsch A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment Nat Cell Biol 10 2008 987 993 10.1038/ncb1759
27. L. Smirnova, A. Grafe, A. Seiler, S. Schumacher, R. Nitsch, and F.G. Wulczyn Regulation of miRNA expression during neural cell specification Eur J Neurosci 21 2005 1469 1477 10.1111/j.1460-9568.2005.03978.x (Pubitemid 40646593)
28. R.J. Johnston, and O. Hobert A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans Nature 426 2003 845 849 10.1038/nature02255 (Pubitemid 38056870)
29. J. Nishino, I. Kim, K. Chada, and S.J. Morrison Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression Cell 135 2008 227 239 10.1016/j.cell.2008.09.017
30. C. Zhao, G. Sun, S. Li, M.F. Lang, S. Yang, and W. Li MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling Proc Natl Acad Sci USA 107 2010 1876 1881 10.1073/pnas.0908750107
31. X. Liang, C. Stahlhut, C. DelConte, G. Stefani, and F.J. Slack The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure Cell Cycle 7 2008 3935 3942
32. X. Li, and R.W. Carthew A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye Cell 123 2005 1267 1277 10.1016/j.cell.2005.10.040 (Pubitemid 41821784)
33. Y. Li, F. Wang, J.A. Lee, and F.B. Gao MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila Genes Dev 20 2006 2793 2805 10.1101/gad.1466306 (Pubitemid 44771742)
34. C. Leucht, C. Stigloher, A. Wizenmann, R. Klafke, A. Folchert, and L. Bally-Cuif MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary Nat Neurosci 11 2008 641 648 10.1038/nn.2115 (Pubitemid 351748112)
35. M. Shibata, D. Kurokawa, H. Nakao, T. Ohmura, and S. Aizawa MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium J Neurosci 28 2008 10415 10421 10.1523/JNEUROSCI.3219-08. 2008
36. C. Zhao, G. Sun, S. Li, and Y. Shi A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination Nat Struct Mol Biol 16 2009 365 371 10.1038/nsmb.1576
37. A.N. Packer, Y. Xing, S.Q. Harper, L. Jones, and B.L. Davidson The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease J Neurosci 28 2008 14341 14346 10.1523/JNEUROSCI.2390-08.2008
38. C. Delaloy, L. Liu, J.A. Lee, H. Su, F. Shen, and G.Y. Yang MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors Cell Stem Cell 6 2010 323 335 10.1016/j.stem.2010.02.015
39. A.S. Yoo, B.T. Staahl, L. Chen, and G.R. Crabtree MicroRNA-mediated switching of chromatin-remodelling complexes in neural development Nature 460 2009 642 646 10.1038/nature08139
40. N.J. Beveridge, P.A. Tooney, A.P. Carroll, N. Tran, and M.J. Cairns Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation Cell Signal 21 2009 1837 1845 10.1016/j.cellsig.2009. 07.019
41. J. Visvanathan, S. Lee, B. Lee, J.W. Lee, and S.K. Lee The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development Genes Dev 21 2007 744 749 10.1101/gad.1519107 (Pubitemid 46572354)
42. E.V. Makeyev, J. Zhang, M.A. Carrasco, and T. Maniatis The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing Mol Cell 27 2007 435 448 10.1016/j.molcel.2007.07. 015 (Pubitemid 47126944)
43. L.C. Cheng, E. Pastrana, M. Tavazoie, and F. Doetsch miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche Nat Neurosci 12 2009 399 408 10.1038/nn.2294
44. E. Ferretti, E. De Smaele, E. Miele, P. Laneve, A. Po, and M. Pelloni Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells EMBO J 27 2008 2616 2627 10.1038/emboj.2008.172
45. J. Godlewski, M.O. Nowicki, A. Bronisz, S. Williams, A. Otsuki, and G. Nuovo Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal Cancer Res 68 2008 9125 9130 10.1158/0008-5472.CAN-08-2629
46. A. Lehotzky, P. Lau, N. Tokesi, N. Muja, L.D. Hudson, and J. Ovadi Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation Glia 58 2010 157 168 10.1002/glia.20909
47. X. Zhao, X. He, X. Han, Y. Yu, F. Ye, and Y. Chen MicroRNA-mediated control of oligodendrocyte differentiation Neuron 65 2010 612 626 10.1016/j.neuron.2010.02.018
48. J.C. Dugas, T.L. Cuellar, A. Scholze, B. Ason, A. Ibrahim, and B. Emery Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination Neuron 65 2010 597 611 10.1016/j.neuron.2010.01.027
49. P. Cayirlioglu, I.G. Kadow, X. Zhan, K. Okamura, G.S. Suh, and D. Gunning Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems Science 319 2008 1256 1260 10.1126/science.1149483 (Pubitemid 351323024)
50. S. Roush, and F.J. Slack The let-7 family of microRNAs Trends Cell Biol 18 2008 505 516 10.1016/j.tcb.2008.07.007
51. F.G. Wulczyn, L. Smirnova, A. Rybak, C. Brandt, E. Kwidzinski, and O. Ninnemann Post-transcriptional regulation of the let-7 microRNA during neural cell specification FASEB J 21 2007 415 426 10.1096/fj.06-6130com (Pubitemid 46213489)
52. J.C. Schwamborn, E. Berezikov, and J.A. Knoblich The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors Cell 136 2009 913 925 10.1016/j.cell.2008.12.024
53. M.A. Newman, J.M. Thomson, and S.M. Hammond Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing RNA 14 2008 1539 1549 10.1261/rna.1155108
54. S.R. Viswanathan, G.Q. Daley, and R.I. Gregory Selective blockade of microRNA processing by Lin28 Science 320 2008 97 100 10.1126/science.1154040 (Pubitemid 351490762)
55. I. Heo, C. Joo, J. Cho, M. Ha, J. Han, and V.N. Kim Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA Mol Cell 32 2008 276 284 10.1016/j.molcel.2008.09.014
56. L.P. Lim, N.C. Lau, P. Garrett-Engele, A. Grimson, J.M. Schelter, and J. Castle Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs Nature 433 2005 769 773 10.1038/nature03315 (Pubitemid 40292988)
57. C. Conaco, S. Otto, J.J. Han, and G. Mandel Reciprocal actions of REST and a microRNA promote neuronal identity Proc Natl Acad Sci USA 103 2006 2422 2427 10.1073/pnas.0511041103 (Pubitemid 43271685)
58. N.A. Maiorano, and A. Mallamaci Promotion of embryonic cortico-cerebral neuronogenesis by miR-124 Neural Dev 4 2009 40 10.1186/1749-8104-4-40
59. S. Chang, R.J. Johnston Jr., C. Frokjaer-Jensen, S. Lockery, and O. Hobert MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode Nature 430 2004 785 789 10.1038/nature02752 (Pubitemid 39071349)
60. P. Lau, J.D. Verrier, J.A. Nielsen, K.R. Johnson, L. Notterpek, and L.D. Hudson Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes J Neurosci 28 2008 11720 11730 10.1523/JNEUROSCI. 1932-08.2008
61. Y. Kawase-Koga, G. Otaegi, and T. Sun Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system Dev Dyn 238 2009 2800 2812 10.1002/dvdy.22109
62. D. Shin, J.Y. Shin, M.T. McManus, L.J. Ptacek, and Y.H. Fu Dicer ablation in oligodendrocytes provokes neuronal impairment in mice Ann Neurol 66 2009 843 857 10.1002/ana.21927
63. K. Zheng, H. Li, Y. Zhu, Q. Zhu, and M. Qiu MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord J Neurosci 30 2010 8245 8250 10.1523/JNEUROSCI.1169-10.2010
64. N. Vo, M.E. Klein, O. Varlamova, D.M. Keller, T. Yamamoto, and R.H. Goodman A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis Proc Natl Acad Sci USA 102 2005 16426 16431 (Pubitemid 41688930)
65. G.A. Wayman, M. Davare, H. Ando, D. Fortin, O. Varlamova, and H.Y. Cheng An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP Proc Natl Acad Sci USA 105 2008 9093 9098 10.1073/pnas.0803072105
66. J.Y. Yu, K.H. Chung, M. Deo, R.C. Thompson, and D.L. Turner MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation Exp Cell Res 314 2008 2618 2633 10.1016/j.yexcr.2008.06.002
67. D. Edbauer, J.R. Neilson, K.A. Foster, C.F. Wang, D.P. Seeburg, and M.N. Batterton Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132 Neuron 65 2010 373 384 10.1016/j.neuron.2010.01. 005
68. R. Fiore, S. Khudayberdiev, M. Christensen, G. Siegel, S.W. Flavell, and T.K. Kim Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels EMBO J 28 2009 697 710 10.1038/emboj.2009.10
69. R.D. Smrt, K.E. Szulwach, R.L. Pfeiffer, X. Li, W. Guo, and M. Pathania MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1 Stem Cells 28 2010 1060 1070 10.1002/stem.431
70. J.Z. Parrish, P. Xu, C.C. Kim, L.Y. Jan, and Y.N. Jan The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons Neuron 63 2009 788 802 10.1016/j.neuron.2009.08.006
71. E.E. Caygill, and L.A. Johnston Temporal regulation of metamorphic processes in Drosophila by the let-7 and miR-125 heterochronic microRNAs Curr Biol 18 2008 943 950 10.1016/j.cub.2008.06.020
72. G.M. Schratt, F. Tuebing, E.A. Nigh, C.G. Kane, M.E. Sabatini, and M. Kiebler A brain-specific microRNA regulates dendritic spine development Nature 439 2006 283 289 10.1038/nature04367 (Pubitemid 43128846)
73. G. Siegel, G. Obernosterer, R. Fiore, M. Oehmen, S. Bicker, and M. Christensen A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis Nat Cell Biol 11 2009 705 716 10.1038/ncb1876
74. S. Impey, M. Davare, A. Lasiek, D. Fortin, H. Ando, and O. Varlamova An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling Mol Cell Neurosci 43 2010 146 156 10.1016/j.mcn.2009.10.005
75. J. Gao, W.Y. Wang, Y.W. Mao, J. Graff, J.S. Guan, and L. Pan A novel pathway regulates memory and plasticity via SIRT1 and miR-134 Nature 466 2010 1105 1109 10.1038/nature09271
76. H.Y. Cheng, J.W. Papp, O. Varlamova, H. Dziema, B. Russell, and J.P. Curfman microRNA modulation of circadian-clock period and entrainment Neuron 54 2007 813 829 10.1016/j.neuron.2007.05.017 (Pubitemid 46843524)
77. J. Karr, V. Vagin, K. Chen, S. Ganesan, O. Olenkina, and V. Gvozdev Regulation of glutamate receptor subunit availability by microRNAs J Cell Biol 185 2009 685 697 10.1083/jcb.200902062
78. D.J. Simon, J.M. Madison, A.L. Conery, K.L. Thompson-Peer, M. Soskis, and G.B. Ruvkun The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions Cell 133 2008 903 915 10.1016/j.cell.2008.04.035 (Pubitemid 351707687)
79. M.A. Sutton, and E.M. Schuman Dendritic protein synthesis, synaptic plasticity, and memory Cell 127 2006 49 58 10.1016/j.cell.2006.09.014 (Pubitemid 44466643)
80. J. Kim, A. Krichevsky, Y. Grad, G.D. Hayes, K.S. Kosik, and G.M. Church Identification of many microRNAs that copurify with polyribosomes in mammalian neurons Proc Natl Acad Sci USA 101 2004 360 365 10.1073/pnas.2333854100 (Pubitemid 38084255)
81. G. Lugli, J. Larson, M.E. Martone, Y. Jones, and N.R. Smalheiser Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner J Neurochem 94 2005 896 905 10.1111/j.1471-4159.2005.03224.x (Pubitemid 41170578)
82. S.I. Ashraf, A.L. McLoon, S.M. Sclarsic, and S. Kunes Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila Cell 124 2006 191 205 10.1016/j.cell.2005.12.017 (Pubitemid 43069319)
83. S. Banerjee, P. Neveu, and K.S. Kosik A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation Neuron 64 2009 871 884 10.1016/j.neuron.2009.11.023
84. S.A. Barbee, P.S. Estes, A.M. Cziko, J. Hillebrand, R.A. Luedeman, and J.M. Coller Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies Neuron 52 2006 997 1009 10.1016/j.neuron.2006.10.028 (Pubitemid 44909400)
85. M.J. Kye, T. Liu, S.F. Levy, N.L. Xu, B.B. Groves, and R. Bonneau Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR RNA 13 2007 1224 1234 10.1261/rna.480407 (Pubitemid 47080468)
86. G. Lugli, V.I. Torvik, J. Larson, and N.R. Smalheiser Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain J Neurochem 106 2008 650 661 10.1111/j.1471-4159.2008.05413.x
87. S. Bicker, and G. Schratt microRNAs: tiny regulators of synapse function in development and disease J Cell Mol Med 12 2008 1466 1476 10.1111/j.1582-4934. 2008.00400.x
88. K.S. Kosik The neuronal microRNA system Nat Rev Neurosci 7 2006 911 920 10.1038/nrn2037 (Pubitemid 44780721)
89. N. Cougot, S.N. Bhattacharyya, L. Tapia-Arancibia, R. Bordonne, W. Filipowicz, and E. Bertrand Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation J Neurosci 28 2008 13793 13804 10.1523/JNEUROSCI.4155-08.2008
90. D. Berdnik, A.P. Fan, C.J. Potter, and L. Luo MicroRNA processing pathway regulates olfactory neuron morphogenesis Curr Biol 18 2008 1754 1759 10.1016/j.cub.2008.09.045
91. R. Pinter, and R. Hindges Perturbations of microRNA function in mouse dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm PLoS ONE 5 2010 e10021 10.1371/journal.pone.0010021
92. P. Rajasethupathy, F. Fiumara, R. Sheridan, D. Betel, S.V. Puthanveettil, and J.J. Russo Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB Neuron 63 2009 803 817 10.1016/j.neuron.2009.05.029
93. O. Natera-Naranjo, A. Aschrafi, A.E. Gioio, and B.B. Kaplan Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons RNA 16 2010 1516 1529 10.1261/rna.1833310
94. A. Aschrafi, A.D. Schwechter, M.G. Mameza, O. Natera-Naranjo, A.E. Gioio, and B.B. Kaplan MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons J Neurosci 28 2008 12581 12590 10.1523/JNEUROSCI.3338-08.2008
95. S.W. Flavell, and M.E. Greenberg Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system Annu Rev Neurosci 31 2008 563 590 10.1146/annurev.neuro.31.060407.125631
96. H. Siomi, and M.C. Siomi Posttranscriptional regulation of microRNA biogenesis in animals Mol Cell 38 2010 323 332 10.1016/j.molcel.2010.03.013
97. Y. Kawahara, B. Zinshteyn, P. Sethupathy, H. Iizasa, A.G. Hatzigeorgiou, and K. Nishikura Redirection of silencing targets by adenosine-to-inosine editing of miRNAs Science 315 2007 1137 1140 10.1126/science.1138050 (Pubitemid 46328026)
98. G. Obernosterer, P.J. Leuschner, M. Alenius, and J. Martinez Post-transcriptional regulation of microRNA expression RNA 12 2006 1161 1167 10.1261/rna.2322506 (Pubitemid 43990541)
99. J. Krol, V. Busskamp, I. Markiewicz, M.B. Stadler, S. Ribi, and J. Richter Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs Cell 141 2010 618 631 10.1016/j.cell.2010.03.039
100. X.L. Xu, Y. Li, F. Wang, and F.B. Gao The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in Drosophila J Neurosci 28 2008 11883 11889 10.1523/JNEUROSCI.4114-08.2008
101. K.L. Stark, B. Xu, A. Bagchi, W.S. Lai, H. Liu, and R. Hsu Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model Nat Genet 40 2008 751 760 10.1038/ng.138 (Pubitemid 351748862)
102. P. Jin, D.C. Zarnescu, S. Ceman, M. Nakamoto, J. Mowrey, and T.A. Jongens Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway Nat Neurosci 7 2004 113 117 10.1038/nn1174 (Pubitemid 38129786)
103. W.J. Lukiw Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus Neuroreport 18 2007 297 300 10.1097/WNR.0b013e3280148e8b
104. W.X. Wang, B.W. Rajeev, A.J. Stromberg, N. Ren, G. Tang, and Q. Huang The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 J Neurosci 28 2008 1213 1223 10.1523/JNEUROSCI.5065- 07.2008 (Pubitemid 351186356)
105. S.S. Hebert, K. Horre, L. Nicolai, A.S. Papadopoulou, W. Mandemakers, and A.N. Silahtaroglu Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression Proc Natl Acad Sci USA 105 2008 6415 6420 10.1073/pnas.0710263105 (Pubitemid 351758360)
106. V. Boissonneault, I. Plante, S. Rivest, and P. Provost MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1 J Biol Chem 284 2009 1971 1981 10.1074/jbc. M807530200
107. E. Vilardo, C. Barbato, M. Ciotti, C. Cogoni, and F. Ruberti MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons J Biol Chem 285 2010 18344 18351 10.1074/jbc.M110.112664
108. S.S. Hebert, K. Horre, L. Nicolai, B. Bergmans, A.S. Papadopoulou, and A. Delacourte MicroRNA regulation of Alzheimer's Amyloid precursor protein expression Neurobiol Dis 33 2009 422 428 10.1016/j.nbd.2008.11.009
109. X. Wang, P. Liu, H. Zhu, Y. Xu, C. Ma, and X. Dai miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation Brain Res Bull 80 2009 268 273 10.1016/j.brainresbull.2009.08. 006
110. H. Wang, J. Liu, Y. Zong, Y. Xu, W. Deng, and H. Zhu miR-106b Aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-beta type II receptor Brain Res 2010 10.1016/j.brainres.2010.08.023
111. W.J. Lukiw, Y. Zhao, and J.G. Cui An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells J Biol Chem 283 2008 31315 31322 10.1074/jbc.M805371200
112. A.I. Pogue, Y.Y. Li, J.G. Cui, Y. Zhao, T.P. Kruck, and M.E. Percy Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells J Inorg Biochem 103 2009 1591 1595 10.1016/j.jinorgbio.2009.05.012
113. K.D. Taganov, M.P. Boldin, K.J. Chang, and D. Baltimore NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses Proc Natl Acad Sci USA 103 2006 12481 12486 10.1073/pnas.0605298103 (Pubitemid 44267285)
114. R. Saba, C.D. Goodman, R.L. Huzarewich, C. Robertson, and S.A. Booth A miRNA signature of prion induced neurodegeneration PLoS ONE 3 2008 e3652 10.1371/journal.pone.0003652
115. J. Montag, R. Hitt, L. Opitz, W.J. Schulz-Schaeffer, G. Hunsmann, and D. Motzkus Upregulation of miRNA hsa-miR-342-3p in experimental and idiopathic prion disease Mol. Neurodegener 4 2009 36 10.1186/1750-1326-4-36
116. J.M. van der Walt, M.A. Noureddine, R. Kittappa, M.A. Hauser, W.K. Scott, and R. McKay Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease Am J Hum Genet 74 2004 1121 1127 10.1086/421052 (Pubitemid 38669311)
117. G. Wang, J.M. van der Walt, G. Mayhew, Y.J. Li, S. Zuchner, and W.K. Scott Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein Am J Hum Genet 82 2008 283 289 10.1016/j.ajhg.2007.09.021
118. S. Gehrke, Y. Imai, N. Sokol, and B. Lu Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression Nature 466 2010 637 641 10.1038/nature09191
119. R. Johnson, C. Zuccato, N.D. Belyaev, D.J. Guest, E. Cattaneo, and N.J. Buckley A microRNA-based gene dysregulation pathway in Huntington's disease Neurobiol Dis 29 2008 438 445 10.1016/j.nbd.2007.11.001
120. J.N. Savas, A. Makusky, S. Ottosen, D. Baillat, F. Then, and D. Krainc Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies Proc Natl Acad Sci USA 105 2008 10820 10825 10.1073/pnas.0800658105
121. A.H. Williams, G. Valdez, V. Moresi, X. Qi, J. McAnally, and J.L. Elliott MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice Science 326 2009 1549 1554 10.1126/science.1181046
122. S. Haramati, E. Chapnik, Y. Sztainberg, R. Eilam, R. Zwang, and N. Gershoni miRNA malfunction causes spinal motor neuron disease Proc Natl Acad Sci USA 107 2010 13111 13116 10.1073/pnas.1006151107
123. O.A. Burmistrova, A.Y. Goltsov, L.I. Abramova, V.G. Kaleda, V.A. Orlova, and E.I. Rogaev MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11) Biochemistry (Mosc) 72 2007 578 582 (Pubitemid 46835189)
124. Y. Zhu, T. Kalbfleisch, M.D. Brennan, and Y. Li A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene Schizophr Res 109 2009 86 89 10.1016/j.schres.2009.01.022
125. J. Feng, G. Sun, J. Yan, K. Noltner, W. Li, and C.H. Buzin Evidence for X-chromosomal schizophrenia associated with microRNA alterations PLoS ONE 4 2009 e6121 10.1371/journal.pone.0006121
126. T. Hansen, L. Olsen, M. Lindow, K.D. Jakobsen, H. Ullum, and E. Jonsson Brain expressed microRNAs implicated in schizophrenia etiology PLoS ONE 2 2007 e873 10.1371/journal.pone.0000873 (Pubitemid 351425674)
127. Y. Xu, F. Li, B. Zhang, K. Zhang, F. Zhang, and X. Huang MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia Schizophr Res 119 2010 219 227 10.1016/j.schres.2010.02.1070
128. Y. Xu, H. Liu, F. Li, N. Sun, Y. Ren, and Z. Liu A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform J Affect Disord 2010 10.1016/j.jad.2010.05.019
129. R. Tabares-Seisdedos, and J.L. Rubenstein Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer Mol Psychiatry 14 2009 563 589 10.1038/mp. 2009.2
130. D.O. Perkins, C.D. Jeffries, L.F. Jarskog, J.M. Thomson, K. Woods, and M.A. Newman microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder Genome Biol 8 2007 R27 10.1186/gb-2007-8-2-r27 (Pubitemid 351851029)
131. N.J. Beveridge, P.A. Tooney, A.P. Carroll, E. Gardiner, N. Bowden, and R.J. Scott Dysregulation of miRNA 181b in the temporal cortex in schizophrenia Hum Mol Genet 17 2008 1156 1168 10.1093/hmg/ddn005 (Pubitemid 351494187)
132. A.H. Kim, M. Reimers, B. Maher, V. Williamson, O. McMichael, and J.L. McClay MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders Schizophr Res 2010 10.1016/j.schres.2010.07.002
133. J.F. Abelson, K.Y. Kwan, B.J. O'Roak, D.Y. Baek, A.A. Stillman, and T.M. Morgan Sequence variants in SLITRK1 are associated with Tourette's syndrome Science 310 2005 317 320 10.1126/science.1116502 (Pubitemid 41457198)
134. K. Abu-Elneel, T. Liu, F.S. Gazzaniga, Y. Nishimura, D.P. Wall, and D.H. Geschwind Heterogeneous dysregulation of microRNAs across the autism spectrum Neurogenetics 9 2008 153 161 10.1007/s10048-008-0133-5
135. Z. Talebizadeh, M.G. Butler, and M.F. Theodoro Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism Autism Res 1 2008 240 250 10.1002/aur.33
136. T. Sarachana, R. Zhou, G. Chen, H.K. Manji, and V.W. Hu Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines Genome Med 2 2010 23 10.1186/gm144
137. H. Rong, T.B. Liu, K.J. Yang, H.C. Yang, D.H. Wu, and C.P. Liao MicroRNA-134 plasma levels before and after treatment for bipolar mania J Psychiatr Res 45 2010 10.1016/j.jpsychires.2010.04.028
138. M. Muinos-Gimeno, M. Guidi, B. Kagerbauer, R. Martin-Santos, R. Navines, and P. Alonso Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders Hum Mutat 30 2009 1062 1071 10.1002/humu.21005
139. K.P. Jensen, J. Covault, T.S. Conner, H. Tennen, H.R. Kranzler, and H.M. Furneaux A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors Mol Psychiatry 14 2009 381 389 10.1038/mp. 2008.15
140. R. Zhou, P. Yuan, Y. Wang, J.G. Hunsberger, A. Elkahloun, and Y. Wei Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers Neuropsychopharmacology 34 2009 1395 1405 10.1038/npp. 2008.131
141. J.F. Cryan, P.H. Kelly, H.C. Neijt, G. Sansig, P.J. Flor, and H. van Der Putten Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7 Eur J Neurosci 17 2003 2409 2417 (Pubitemid 36793749)
142. J. Kocerha, M.A. Faghihi, M.A. Lopez-Toledano, J. Huang, A.J. Ramsey, and M.G. Caron MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction Proc Natl Acad Sci USA 106 2009 3507 3512 10.1073/pnas.0805854106
143. D.E. Kuhn, G.J. Nuovo, M.M. Martin, G.E. Malana, A.P. Pleister, and J. Jiang Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts Biochem Biophys Res Commun 370 2008 473 477 10.1016/j.bbrc.2008.03.120
144. D.E. Kuhn, G.J. Nuovo, A.V. Terry Jr., M.M. Martin, G.E. Malana, and S.E. Sansom Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains J Biol Chem 285 2010 1529 1543 10.1074/jbc.M109.033407
145. K. Xu, B.A. Bogert, W. Li, K. Su, A. Lee, and F.B. Gao The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1 Curr Biol 14 2004 1025 1034 10.1016/j.cub.2004.05.055 (Pubitemid 38791564)
146. L. Yang, R. Duan, D. Chen, J. Wang, D. Chen, and P. Jin Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila Hum Mol Genet 16 2007 1814 1820 10.1093/hmg/ddm129 (Pubitemid 47244529)
147. A. Cheever, and S. Ceman Phosphorylation of FMRP inhibits association with Dicer RNA 15 2009 362 366 10.1261/rna.1500809
148. T. Fukuda, M. Itoh, T. Ichikawa, K. Washiyama, and Y. Goto Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice J Neuropathol Exp Neurol 64 2005 537 544 (Pubitemid 40781157)
149. D.G. Jugloff, B.P. Jung, D. Purushotham, R. Logan, and J.H. Eubanks Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2 Neurobiol Dis 19 2005 18 27 (Pubitemid 40544720)
150. Q. Chang, G. Khare, V. Dani, S. Nelson, and R. Jaenisch The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression Neuron 49 2006 341 348 (Pubitemid 43152236)
151. M.E. Klein, D.T. Lioy, L. Ma, S. Impey, G. Mandel, and R.H. Goodman Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA Nat Neurosci 10 2007 1513 1514 (Pubitemid 350175879)
152. V. Chandrasekar, and J.L. Dreyer microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity Mol Cell Neurosci 42 2009 350 362 10.1016/j.mcn.2009.08.009
153. A. Schaefer, H.I. Im, M.T. Veno, C.D. Fowler, A. Min, and A. Intrator Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction J Exp Med 207 2010 1843 1851 10.1084/jem.20100451
154. J.A. Hollander, H.I. Im, A.L. Amelio, J. Kocerha, P. Bali, and Q. Lu Striatal microRNA controls cocaine intake through CREB signalling Nature 466 2010 197 202 10.1038/nature09202
155. H.I. Im, J.A. Hollander, P. Bali, and P.J. Kenny MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212 Nat Neurosci 13 2010 1120 1127 10.1038/nn.2615
156. W. Huang, and M.D. Li Nicotine modulates expression of miR-140*, which targets the 3′-untranslated region of dynamin 1 gene (Dnm1) Int J Neuropsychopharmacol 12 2009 537 546 10.1017/S1461145708009528
157. K. Brebner, T.P. Wong, L. Liu, Y. Liu, P. Campsall, and S. Gray Nucleus accumbens long-term depression and the expression of behavioral sensitization Science 310 2005 1340 1343 10.1126/science.1116894 (Pubitemid 41698868)
158. A.Z. Pietrzykowski, R.M. Friesen, G.E. Martin, S.I. Puig, C.L. Nowak, and P.M. Wynne Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol Neuron 59 2008 274 287 10.1016/j.neuron.2008.05.032 (Pubitemid 352033687)
159. Q. Wu, P.Y. Law, L.N. Wei, and H.H. Loh Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3′ untranslated region: a role for microRNA23b FASEB J 22 2008 4085 4095 10.1096/fj.08-108175
160. Q. Wu, L. Zhang, P.Y. Law, L.N. Wei, and H.H. Loh Long-term morphine treatment decreases the association of mu-opioid receptor (MOR1) mRNA with polysomes through miRNA23b Mol Pharmacol 75 2009 744 750 10.1124/mol.108.053462
161. Y. He, C. Yang, C.M. Kirkmire, and Z.J. Wang Regulation of opioid tolerance by let-7 family microRNA targeting the mu opioid receptor J Neurosci 30 2010 10251 10258 10.1523/JNEUROSCI.2419-10.2010
162. H. Zheng, J. Chu, Y. Zeng, H.H. Loh, and P.Y. Law Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression J Biol Chem 285 2010 21994 22002 10.1074/jbc.M110.112607
163. H. Zheng, Y. Zeng, X. Zhang, J. Chu, H.H. Loh, and P.Y. Law mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD Mol Pharmacol 77 2010 102 109 10.1124/mol.109.060848