Allele variants in functional microRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders

Human Mutation

Volumn 30, Issue 7, 2009, Pages 1062-1071

  Muiños Gimeno, Margarita ^a,b   Guidi, Monica ^a,b   Kagerbauer, Birgit ^a,b   Martín Santos, Roćo ^c,d   Navinés, Ricard ^c   Alonso, Pino ^e   Menchón, José M ^e   Gratacòs, Mònica ^a,b   Estivill, Xavier ^a,b,f   Espinosa Parrilla, Yolanda ^a,b  

^a CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^f UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Anxiety disorder; Hoarding; microRNA; NTRK3; Obsessive compulsive; Panic; SNP

Indexed keywords

MICRORNA; NEUROTROPHIN 3 RECEPTOR;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DISORDER; PANIC; PHENOTYPIC VARIATION; PRIORITY JOURNAL;

3' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; ALLELES; ANXIETY DISORDERS; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PANIC DISORDER; PROTEIN ISOFORMS; RECEPTOR, TRKC; YOUNG ADULT;

EID: 67649672149     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.21005     Document Type: Article

References (53)

1. Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure 4th LS, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. 2005. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310:317-320.
2. Alonso P, Gratacos M, Menchon JM, Segalas C, Gonzalez JR, Labad J, Bayes M, Real E, de Cid R, Pertusa A, Escaramís G, Vallejo J, Estivill X. 2008. Genetic susceptibility to obsessive-compulsive hoarding: the contribution of neurotrophic tyrosine kinase receptor type 3 gene. Genes Brain Behav 7:778-785.
3. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders (DSM IV). Washington, DC: American Psychiatric Press. 944p.
4. Arrindell WA, Eisemann M, Richter J, Oei TP, Caballo VE, van der Ende J, Sanavio E, Bages N, Feldman L, Torres B, Sica C, Iwawaki S, Edelmann RJ, Crozier WR, Furnham A, Hudson BL, Aguilar G, Arrindell WA, Bagés N, Bentall R, Bridges KR, Buchanan A, Caballo VE, Calvo MG, Canalda G, Castro J, Crozier WR, Davis M, Edelmann RJ, Eisemann M, Farrer RJ, Felman L, Frindte W, Furnham A, Gärling T, Gaszner P, Gillholm R, Gustafsson M, Hansson SB, Harris P, Hatzichristou C, Hudson BL, Iwawaki S, Johnston M, Kállai J, Kasielke E, Kenardy J, Leong CC, Liddell A, Montgomery I, Oei TP, Palenzuela DL, Pennington D, Peter M, Pickersgill MJ, Recinos LA, Richards JC, Richter J, Rydén O, Sanavio E, Sica C, Simón MA, Surman M, Torres B, van der Ende J, Zaldívar F. Cultural Clinical Psychology Study Group. 2003. Phobic anxiety in 11 nations. Part I: Dimensional constancy of the five-factor model. Behav Res Ther 41:461-479.
5. Bandelow B. 1995. Assessing the efficacy of treatments for panic disorder and agoraphobia. II. The Panic and Agoraphobia Scale. Int Clin Psychopharmacol 10:73-81.
6. Betel D, Wilson M, Gabow A, Marks DS, Sander C. 2008. The microRNA.org resource: targets and expression. Nucleic Acids Res 36(Database issue):D149-D153. (Pubitemid 351149712)
7. Brennecke J, Stark A, Russell RB, Cohen SM. 2005. Principles of microRNA-target recognition. PLoS Biol 3:e85. (Pubitemid 40605291)
8. Burmeister M, McInnis MG, Zollner S. 2008. Psychiatric genetics: progress amid controversy. Nat Rev Genet 9:527-540. (Pubitemid 351972757)
9. Camp NJ, Lowry MR, Richards RL, Plenk AM, Carter C, Hensel CH, Abkevich V, Skolnick MH, Shattuck D, Rowe KG, Hughes DC, Cannon-Albright LA. 2005. Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. Am J Med Genet B Neuropsychiatr Genet 135:85-93.
10. Chen K, Rajewsky N. 2006. Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet 38:1452-1456. (Pubitemid 44837570)
11. Dierssen M, Gratacos M, Sahun I, Martin M, Gallego X, Amador-Arjona A, Martinez de Lagran M, Murtra P, Marti E, Pujana MA, Pujana MA, Ferrer I, Dalfó E, Martínez-Cué C, Flórez J, Torres-Peraza JF, Alberch J, Maldonado R, Fillat C, Estivill X. 2006. Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction. Neurobiol Dis 24:403-418. (Pubitemid 44592571)
12. Eletto D, Russo G, Passiatore G, Del Valle L, Giordano A, Khalili K, Gualco E, Peruzzi F. 2008. Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a. J Cell Physiol 216:764-770.
13. Esteban PF, Yoon HY, Becker J, Dorsey SG, Caprari P, Palko ME, Coppola V, Saragovi HU, Randazzo PA, Tessarollo L. 2006. A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol 173:291-299.
14. Feng Y, Vetro A, Kiss E, Kapornai K, Daroczi G, Mayer L, Tamas Z, Baji I, Gadoros J, King N, Kennedy JL, Wigg K, Kovacs M, Barr CL, International Consortium for Childhood-Onset Mood Disorders. 2008. Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders. Am J Psychiatry 165:610-616.
15. Filipowicz W, Bhattacharyya SN, Sonenberg N. 2008. Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9:102-114.
16. First MB, Spitzer RL, GibbonM, Williams JBW. 1997. Structured clinical interview for DSM-IV axis I disorders - clinician version (SCID-CV). Washington, DC: American Psychiatric Press, Inc.
17. Gong H, Liu CM, Liu DP, Liang CC. 2005. The role of small RNAs in human diseases: potential troublemaker and therapeutic tools. Med Res Rev 25:361-381. (Pubitemid 40489667)
18. Gonzalez JR, Armengol L, Sole X, Guino E, Mercader JM, Estivill X, Moreno V. 2007. SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23:644-645. (Pubitemid 46522604)
19. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS. 1989. The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability. Arch Gen Psychiatry 46:1006-1011.
20. Gratacos M, Sahun I, Gallego X, Amador-Arjona A, Estivill X, Dierssen M. 2007. Candidate genes for panic disorder: insight from human and mouse genetic studies. Genes Brain Behav 6(Suppl 1):2-23. (Pubitemid 46744107)
21. Hamilton M. 1960. A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-61.
22. Holmans P, Weissman MM, Zubenko GS, Scheftner WA, Crowe RR, Depaulo Jr JR, Knowles JA, Zubenko WN, Murphy-Eberenz K, Marta DH, Boutelle S, McInnis MG, Adams P, Gladis M, Steele J, Miller EB, Potash JB, Mackinnon DF, Levinson DF. 2007. Genetics of recurrent early-onset major depression (GenRED): final genome scan report. Am J Psychiatry 164:248-258. (Pubitemid 46318562)
23. Huang EJ, Reichardt LF. 2001. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736. (Pubitemid 32695243)
24. Ichinose T, Snider WD. 2000. Differential effects of TrkC isoforms on sensory axon outgrowth. J Neurosci Res 59:365-371. (Pubitemid 30107976)
25. Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. 2001. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature 410: 89-93. (Pubitemid 32225841)
26. Jensen KP, Covault J, Conner TS, Tennen H, Kranzler HR, Furneaux HM. 2009. A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. Mol Psychiatry 14:381-389.
27. Kaufman AS, Lichtenberger EO. 1999. Essentials of WAIS-III assessment. New York: Wiley.
28. Keen-Kim D, Mathews CA, Reus VI, Lowe TL, Herrera LD, Budman CL, Gross-Tsur V, Pulver AE, Bruun RD, Erenberg G, Naarden A, Sabatti C, Freimer NB. 2006. Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. Hum Mol Genet 15:3324-3328. (Pubitemid 44649118)
29. King VR, Michael GJ, Joshi RK, Priestley JV. 1999. trkA, trkB, and trkC messenger RNA expression by bulbospinal cells of the rat. Neuroscience 92:935-944. (Pubitemid 29287539)
30. Laneve P, Di Marcotullio L, Gioia U, Fiori ME, Ferretti E, Gulino A, Bozzoni I, Caffarelli E. 2007. The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc Natl Acad Sci USA 104:7957-7962. (Pubitemid 47185858)
31. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. 2003. Prediction of mammalian microRNA targets. Cell 115:787-798. (Pubitemid 38058492)
32. Martin MM, Buckenberger JA, Jiang J, Malana GE, Nuovo GJ, Chotani M, Feldman DS, Schmittgen TD, Elton TS. 2007. The human angiotensin II type 1 receptor 11166 A/C polymorphism attenuates microrna-155 binding. J Biol Chem 282:24262-24269. (Pubitemid 47328062)
33. Mathews CA, Nievergelt CM, Azzam A, Garrido H, Chavira DA, Wessel J, Bagnarello M, Reus VI, Schork NJ. 2007. Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding. Am J Med Genet B Neuropsychiatr Genet 144:174-182. (Pubitemid 46606642)
34. Menn B, Timsit S, Calothy G, Lamballe F. 1998. Differential expression of TrkC catalytic and noncatalytic isoforms suggests that they act independently or in association. J Comp Neurol 401:47-64. (Pubitemid 28485190)
35. Mercader JM, Saus E, Aguera Z, Bayes M, Boni C, Carreras A, Cellini E, de Cid R, Dierssen M, Escaramis G, Fernández-Aranda F, Forcano L, Gallego X, González JR, Gorwood P, Hebebrand J, Hinney A, Nacmias B, Puig A, Ribasés M, Ricca V, Romo L, Sorbi S, Versini A, Gratacòs M, Estivill X. 2008. Association of NTRK3 and its interaction with NGF suggest an altered crossregulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet 17:1234-1244. (Pubitemid 351566960)
36. Miguel EC, Leckman JF, Rauch S, do Rosario-Campos MC, Hounie AG, Mercadante MT, Chacon P, Pauls DL. 2005. Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry 10:258-275.
37. Pritchard JK, Stephens M, Donnelly P. 2000. Inference of population structure using multilocus genotype data. Genetics 155:945-959. (Pubitemid 30397141)
38. Pritchard JK. 2001. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 69:124-137.
39. Rajewsky N. 2006. microRNA target predictions in animals. Nat Genet 38(Suppl):S8-S13. (Pubitemid 43920937)
40. Sahun I, Gallego X, Gratacos M, Murtra P, Trullas R, Maldonado R, Estivill X, Dierssen M. 2007. Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry. Amino Acids 33:677-688. (Pubitemid 350165428)
41. Samuels JF, Bienvenu 3rd OJ, Pinto A, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Greenberg BD, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Riddle MA, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G. 2007. Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Behav Res Ther 45:673-686.
42. Sanchez JJ, Phillips C, Borsting C, Balogh K, Bogus M, Fondevila M, Harrison CD, Musgrave-Brown E, Salas A, Syndercombe-Court D, Schneider PM, Carracedo A, Morling N. 2006. A multiplex assay with 52 single nucleotide polymorphisms for human identification. Electrophoresis 27:1713-1724.
43. Sethupathy P, Corda B, Hatzigeorgiou AG. 2006. TarBase: a comprehensive database of experimentally supported animal microRNA targets. RNA 12:192-197. (Pubitemid 43121923)
44. Sethupathy P, Borel C, Gagnebin M, Grant GR, Deutsch S, Elton TS, Hatzigeorgiou AG, Antonarakis SE. 2007. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 30 untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am J Hum Genet 81:405-413. (Pubitemid 47236088)
45. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM. 2008. Whole-genome association study of bipolar disorder. Mol Psychiatry 13(6):558-569. (Pubitemid 351704939)
46. Smirnova L, Grafe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG. 2005. Regulation of miRNA expression during neural cell specification. Eur J Neurosci 21:1469-1477. (Pubitemid 40646593)
47. Smith MA, Makino S, Altemus M, Michelson D, Hong SK, Kvetnansky R, Post RM. 1995. Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus. Proc Natl Acad Sci USA 92:8788-8792.
48. Smoller JW, Tsuang MT. 1998. Panic and phobic anxiety: defining phenotypes for genetic studies. Am J Psychiatry 155:1152-1162. (Pubitemid 28402506)
49. Sullivan GM, Coplan JD, Kent JM, Gorman JM. 1999. The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias. Biol Psychiatry 46:1205-1218. (Pubitemid 30114438)
50. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C. 2007. Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet 81:829-834. (Pubitemid 47596550)
51. Teng KK, Hempstead BL. 2004. Neurotrophins and their receptors: signaling trios in complex biological systems. Cell Mol Life Sci 61:35-48. (Pubitemid 38121898)
52. Verma R, Holmans P, Knowles JA, Grover D, Evgrafov OV, Crowe RR, Scheftner WA, Weissman MM, DePaulo Jr JR, Potash JB, Levinson DF. 2008. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. Biol Psychiatry 63:1185-1189.
53. Wang G, van der Walt JM, Mayhew G, Li YJ, Zuchner S, Scott WK, Martin ER, Vance JM. 2008. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet 82:283-289.