Phosphorylation of FMRP inhibits association with Dicer

RNA

Volumn 15, Issue 3, 2009, Pages 362-366

  Cheever, Anne ^a   Ceman, Stephanie ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Dicer; FMRP; Mirna; Phosphorylation

Indexed keywords

DICER; FRAGILE X MENTAL RETARDATION PROTEIN; MESSENGER RNA; MESSENGER RNA PRECURSOR; MICRORNA; PROTEIN ANTIBODY; SERINE;

ANTIBODY SPECIFICITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; INHIBITION KINETICS; POLYSOME; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA SEQUENCE; TRANSLATION REGULATION;

ANIMALS; CELL LINE; FRAGILE X MENTAL RETARDATION PROTEIN; HELA CELLS; HUMANS; MICE; MICRORNAS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RIBONUCLEASE III; RNA, MESSENGER;

EID: 60849094795     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1500809     Document Type: Article

References (27)

1. Ambros, V. and Lee, R. 2001. An extensive class of small RNAs in Caenorhabditis elegans. Science 294: 862-864.
2. Bartel, D. 2004. MircroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
3. Brown, V., Jin, P., Ceman, S., Darnell, J.C., O'Donnell, W.T., Tenenbaum, S.A., Jin, X., Feng, Y., Wilkinson, K.D., Keene, J.D., et al. 2001. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107: 477-487.
4. Caudy, A., Myers, M., Hannon, G., and Hammond, S. 2002. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes & Dev. 16: 2491-2496.
5. Ceman, S., Brown, V., and Warren, S.T. 1999. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. Mol. Cell. Biol. 12: 7925-7932.
6. Ceman, S., O'Donnell, W., Reed, M., Patton, S., Pohl, J., and Warren, S. 2003. Phosphorylation influences the translation state of FMRP-associated polyribosomes. Hum. Mol. Genet. 12: 3295-3305.
7. Denli, A., Tops, B., Plasterk, R., Ketting, R., and Hannon, G. 2004. Processing of primary microRNAs by the microprocessor complex. Nature 432: 231-235.
8. Devys, D., Lutz, Y., Rouyer, N., Bellocq, J., and Mandel, J. 1993. The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of fragile X premutation. Nat. Genet. 4: 335-340.
9. Duan, R. and Jin, P. 2006. Identification of messenger RNAs and microRNAs associated with fragile X mental retardation protein. Methods Mol. Biol. 342: 267-276.
10. Gregory, R., Yan, K., Amuthan, G., Chendrimada, T., Doratoaj, B., Cooch, N., and Shiekhattar, R. 2004. The microprocessor complex mediates the genesis of microRNAs. Nature 432: 235-240.
11. Hammond, S.M., Caudy, A.A., and Hannon, G.J. 2001. Post-transcriptional gene silencing by double-stranded RNA. Nat. Rev. Genet. 2: 110-119.
12. Han, J., Lee, Y., Yeom, K., Kim, Y., Jin, H., and Kim, V.N. 2004. The Drosha-DGCR8 complex in primary microRNA processing. Genes & Dev. 18: 3016-3027.
13. Hutvagner, G. and Simard, M. 2008. Argonaute proteins: Key players in RNA silencing. Nat. Rev. Mol. Cell Biol. 9: 22-32.
14. Ishizuka, A., Siomi, M., and Siomi, H. 2002. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes & Dev. 16: 2497-2508.
15. Jin, P., Alisch, R., and Warren, S. 2004a. RNA and microRNAs in fragile X mental retardation. Nat. Cell Biol. 6: 1048-1053.
16. Jin, P., Zarnescu, D., Ceman, S., Nakamoto, M., Mowrey, J., Jongens, T., Nelson, D., Moses, K., and Warren, S. 2004b. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat. Neurosci. 7: 113-117.
17. Lee, R., Feinbaum, R., and Ambros, V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complimentarity to lin-14. Cell 75: 843-854.
18. Lee, Y., Ahn, C., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Radmark, O., Kim, S., and Kim, V.N. 2003. The nuclear RNase III Drosha initiates microRNA processing. Nature 425: 415-419.
19. Maroney, P., Yu, Y., Fisher, J., and Nilsen, T.W. 2006. Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat. Struct. Mol. Biol. 12: 1102-1107.
20. Narayanan, U., Nalavadi, V., Nakamoto, M., Pallas, D., Ceman, S., Bassell, G., and Warren, S. 2007. FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. J. Neurosci. 27: 14349-14357.
21. Nottrott, S., Simard, M., and Richter, J. 2006. Human let-7a miRNA blocks protein production on actively translating polyribosomes. Nat. Struct. Mol. Biol. 12: 1108-1114.
22. Perron, P. and Provost, P. 2008. Protein interactions and complexes in human microRNA biogenesis and function. Front. Biosci. 13: 2537-2547.
23. Plante, I., Davidovic, L., Ouellet, D., Gobeil, L., Tremblay, S., Khandjian, E., and Provost, P. 2006. Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs. J. Biomed. Biotechnol. 2006: 1-12.
24. Terracciano, A., Chiurazzi, P., and Neri, G. 2005. Fragile X syndrome. Am. J. Med. C Semin. Med. Genet. 137C: 32-37.
25. Vasudevan, S. and Steitz, J. 2007. AU-Rich-element-mediated upre-gulation of translation by FXR1 and argonaute 2. Cell 128: 1105-1118.
26. Vasudevan, S., Tong, Y., and Steitz, J. 2007. Switching from repression to activation: MicroRNAs can up-regulate translation. Science 318: 1931-1934.
27. Yi, R., Qin, Y., Macara, I., and Cullen, B. 2003. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes & Dev. 17: 3011-3016.