Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

Journal of Cell Biology

Volumn 188, Issue 5, 2010, Pages 629-638

  Beck, Halfdan ^a   Nähse, Viola ^b   Larsen, Marie Sofie Yoo ^a   Groth, Petra ^c   Clancy, Trevor ^b   Lees, Michael ^a   Jørgensen, Mette ^a   Helleday, Thomas ^c,d   Syljuåsen, Randi G ^b   Sørensen, Claus Storgaard ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CDC 25A; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; HELICASE; MINICHROMOSOME MAINTENANCE PROTEIN 2; REPLICATION LICENSING FACTOR CDT1; SINGLE STRANDED DNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE S PHASE; DNA DAMAGE; DNA REPLICATION; GENE; GENOME; GENOMICS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WEE1 GENE;

CDC25 PHOSPHATASES; CELL CYCLE PROTEINS; CELL LINE; CYCLIN-DEPENDENT KINASES; DNA DAMAGE; DNA REPLICATION; FLOW CYTOMETRY; GENOME, HUMAN; GENOMIC INSTABILITY; HUMANS; NUCLEAR PROTEINS; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; RNA, SMALL INTERFERING; S PHASE;

EID: 77949410508     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200905059     Document Type: Article

References (25)

1. Bader, G.D., D. Betel, and C.W. Hogue. 2003. BIND: the Biomolecular Interaction Network Database. Nucleic Acids Res. 31:248-250. doi:10.1093/nar/gkg056
2. Bartek, J., and J. Lukas. 2007. DNA damage checkpoints: from initiation to recovery or adaptation. Curr. Opin. Cell Biol. 19:238-245. doi:10.1016/j.ceb.2007.02.009
3. Bartkova, J., N. Rezaei, M. Liontos, P. Karakaidos, D. Kletsas, N. Issaeva, L.V. Vassiliou, E. Kolettas, K. Niforou, V.C. Zoumpourlis, et al. 2006. Oncogeneinduced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 444:633-637. doi:10.1038/nature05268
4. BenYehoyada, M., J. Gautier, and A. Dupré. 2007. The DNA damage response during an unperturbed Sphase. DNA Repair (Amst.). 6:914-922. doi:10.1016/j.dnarep.2007.02.005
5. Chen, Y., and R.Y. Poon. 2008. The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. Front. Biosci. 13:5016-5029.
6. Chow, J.P., W.Y. Siu, H.T. Ho, K.H. Ma, C.C. Ho, and R.Y. Poon. 2003. Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints. J. Biol. Chem. 278:40815-40828. doi:10.1074/jbc.M306683200
7. Coleman, T.R., and W.G. Dunphy. 1994. Cdc2 regulatory factors. Curr. Opin. Cell Biol. 6:877-882. doi:10.1016/09550674(94)90060-4
8. Di Micco, R., M. Fumagalli, A. Cicalese, S. Piccinin, P. Gasparini, C. Luise, C. Schurra, M. Garre', P.G. Nuciforo, A. Bensimon, et al. 2006. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature. 444:638-642. doi:10.1038/nature05327
9. Halazonetis, T.D., V.G. Gorgoulis, and J. Bartek. 2008. An oncogeneinduced DNA damage model for cancer development. Science. 319:1352-1355. doi:10.1126/science.1140735
10. Harvey, S.L., and D.R. Kellogg. 2003. Conservation of mechanisms controlling entry into mitosis: budding yeast wee1 delays entry into mitosis and is required for cell size control. Curr. Biol. 13:264-275. doi:10.1016/S09609822(03)00049-6
11. Jenssen, T.K., A. Laegreid, J. Komorowski, and E. Hovig. 2001. A literature network of human genes for high-throughput analysis of gene expression. Nat. Genet. 28:21-28. doi:10.1038/88213
12. Jørgensen, S., I. Elvers, M.B. Trelle, T. Menzel, M. Eskildsen, O.N. Jensen, T. Helleday, K. Helin, and C.S. Sørensen. 2007. The histone methyltransferase SET8 is required for Sphase progression. J. Cell Biol. 179:1337-1345. doi:10.1083/jcb.200706150
13. Kastan, M.B., and J. Bartek. 2004. Cell-cycle checkpoints and cancer. Nature. 432:316-323. doi:10.1038/nature03097
14. Kellogg, D.R. 2003. Wee1dependent mechanisms required for coordination of cell growth and cell division. J. Cell Sci. 116:4883-4890. doi:10.1242/jcs.00908
15. König, R., C.Y. Chiang, B.P. Tu, S.F. Yan, P.D. DeJesus, A. Romero, T. Bergauer, A. Orth, U. Krueger, Y. Zhou, and S.K. Chanda. 2007. A probability-based approach for the analysis of large-scale RNAi screens. Nat. Methods. 4:847-849. doi:10.1038/nmeth1089
16. Paulsen, R.D., D.V. Soni, R. Wollman, A.T. Hahn, M.C. Yee, A. Guan, J.A. Hesley, S.C. Miller, E.F. Cromwell, D.E. Solow-Cordero, et al. 2009. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol. Cell. 35:228-239. doi:10.1016/j.molcel. 2009.06.021
17. Russell, P., and P. Nurse. 1987. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell. 49:559-567. doi:10.1016/0092-8674(87)90458-2
18. Shannon, P., A. Markiel, O. Ozier, N.S. Baliga, J.T. Wang, D. Ramage, N. Amin, B. Schwikowski, and T. Ideker. 2003. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498-2504. doi:10.1101/gr.1239303
19. Sørensen, C.S., L.T. Hansen, J. Dziegielewski, R.G. Syljuåsen, C. Lundin, J. Bartek, and T. Helleday. 2005. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat. Cell Biol. 7:195-201. doi:10.1038/ncb1212
20. Stumpff, J., T. Duncan, E. Homola, S.D. Campbell, and T.T. Su. 2004. Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis. Curr. Biol. 14:2143-2148. doi:10.1016/j.cub.2004.11.050
21. Syljuåsen, R.G., C.S. Sørensen, L.T. Hansen, K. Fugger, C. Lundin, F. Johansson, T. Helleday, M. Sehested, J. Lukas, and J. Bartek. 2005. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol. Cell. Biol. 25:3553-3562. doi:10.1128/MCB.25.9.35533562.2005
22. Tada, S. 2007. Cdt1 and geminin: role during cell cycle progression and DNA damage in higher eukaryotes. Front. Biosci. 12:1629-1641. doi:10.2741/2175
23. Tominaga, Y., C. Li, R.H. Wang, and C.X. Deng. 2006. Murine Wee1 plays a critical role in cell cycle regulation and preimplantation stages of embryonic development. Int. J. Biol. Sci. 2:161-170.
24. Wang, X., R.D. Kennedy, K. Ray, P. Stuckert, T. Ellenberger, and A.D. D'Andrea. 2007. Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol. Cell. Biol. 27:3098-3108. doi:10.1128/MCB.0235706
25. Yuan, H., Y.M. Xie, and I.S. Chen. 2003. Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr-and gamma irradiation-induced apoptosis. J. Virol. 77:2063-2070. doi:10.1128/JVI.77.3.2063-2070.2003