Mouse knockout of the cholesterogenic cytochrome p450 lanosterol 14α-demethylase (Cyp51) resembles antley-bixler syndrome

Journal of Biological Chemistry

Volumn 286, Issue 33, 2011, Pages 29086-29097

  Keber, Rok ^a   Motaln, Helena ^a,b   Wagner, Kay D ^d,e   Debeljak, Nataša ^a   Rassoulzadegan, Minoo ^e,f   Ačimovič, Jure ^a   Rozman, Damjana ^a   Horvat, Simon ^a,c  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

^c NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^d INSERM   (France)

^e UNIVERSITÉ CÔTE D'AZUR   (France)

^f CENTRE DE BIOCHIMIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; CHOLESTEROL SYNTHESIS; CORONARY VESSEL; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; DEMETHYLASE; ENZYME SUBSTRATES; FIBROBLAST GROWTH FACTOR RECEPTOR 2; HEART DEVELOPMENT; HEART FAILURE; KNOCK OUTS; LANOSTEROL; MOLECULAR MECHANISM; ORTHOLOGS; RETINOIC ACIDS; SIGNALING PATHWAYS; SONIC HEDGEHOGS; UP-REGULATION; VASCULOGENESIS;

CELL CULTURE; CHOLESTEROL; GENES; GROWTH KINETICS; HEART;

MAMMALS;

7 DEHYDROCHOLESTEROL REDUCTASE; CHOLESTEROL; CYTOCHROME P450; DIHYDROLANOSTEROL; ENZYME; LANOSTEROL; MESSENGER RNA; RETINOIC ACID; SONIC HEDGEHOG PROTEIN; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTLEY BIXLER SYNDROME; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CORONARY BLOOD VESSEL; EMBRYO; EMBRYO DEVELOPMENT; ENZYME DEFICIENCY; ENZYME SUBSTRATE; FEMALE; GENE CONTROL; HEART DEVELOPMENT; HEART FAILURE; HEART VENTRICLE SEPTUM DEFECT; HYPOPLASIA; KNOCKOUT MOUSE; LETHALITY; MALE; MOUSE; NONHUMAN; ORTHOLOGY; PHENOTYPE; PRENATAL DISORDER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTLEY-BIXLER SYNDROME PHENOTYPE; CHOLESTEROL; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; HEART FAILURE; HEDGEHOG PROTEINS; HUMANS; LANOSTEROL; MICE; MICE, KNOCKOUT; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PERICARDIUM; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; SIGNAL TRANSDUCTION; STEROL 14-DEMETHYLASE; TRETINOIN;

ANIMALIA; ERINACEIDAE; MUS;

EID: 80051700976     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.253245     Document Type: Article

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