Prolactin receptor-associated protein/17β-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival

Molecular Endocrinology

Volumn 22, Issue 10, 2008, Pages 2268-2277

  Shehu, Aurora ^a   Mao, Jifang ^a   Gibori, Gil B ^a   Halperin, Julia ^a   Le, Jamie ^a   Devi, Y Sangeeta ^a   Merrill, Bradley ^a   Kiyokawa, Hiroaki ^b   Gibori, Geula ^a,c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c M/C 901 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ESTROGEN; PROLACTIN RECEPTOR; PROLACTIN RECEPTOR ASSOCIATED PROTEIN; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ANATOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MALFORMATION; BREEDING; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME SYNTHESIS; EXON; FEMALE; FETUS; FETUS DEATH; FETUS DEVELOPMENT; GENE; GENE DELETION; HEART DISEASE; HETEROZYGOTE; IN VIVO STUDY; INFERTILITY; KNOCKOUT MOUSE; LITTER SIZE; MALE; MOUSE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PREGNANCY; PRIORITY JOURNAL; REGULATORY MECHANISM; SURVIVAL; UTERUS;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; EMBRYO, MAMMALIAN; FEMALE; GENE TARGETING; IN SITU HYBRIDIZATION; MALE; MICE; MICE, KNOCKOUT; PHOSPHOPROTEINS; PREGNANCY; TISSUE DISTRIBUTION;

MUS; RODENTIA;

EID: 52949106142     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2008-0165     Document Type: Article

References (44)

1. Stocco C, Telleria C, Gibori G 2006 The molecular control of corpus luteum formation, function, and regression. Endocr Rev 28:117-149
2. Akinola LA, Poutanen M, Peltoketo H, Vihko R, Vihko P 1998 Characterization of rat 17β-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts. Gene 208:229-238
3. Ghersevich S, Nokelainen P, Poutanen M, Orava M, Autio-Harmainen H, Rajaniemi H, Vihko R 1994 Rat 17-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Endocrinology 135:1477-1487
4. Luu The V, Labrie C, Zhao HF, Couët J, Lachance Y, Simard J, Leblanc G, Côté J, Bérubé D, Gagne R 1989 Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5′-termini in human placenta. Mol Endocrinol 3:1301-1309
5. Peltoketo H, Isomaa V, Maentausta O, Vihko R 1988 Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA. FEBS Lett 239:73-77
6. Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX 1995 Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 A resolution. Structure 3:503-513
7. Alho-Richmond Si, Lilienkampf A, Wahala K 2006 Active site analysis of 17β-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT. Mol Cell Endocrinol 248:208-213
8. Hickey GJ, Oonk RB, Hall PF, Richards JS 1989 Aromatase cytochrome P450 and cholesterol side-chain cleavage cytochrome P450 in corpora lutea of pregnant rats: diverse regulation by peptide and steroid hormones. Endocrinology 125:1673-1682
9. McLean MP, Nelson S, Parmer T, Khan I, Steinschneider A, Puryear T, Gibori G 1990 Identification and characterization of an abundant phosphoprotein specific to the large luteal cell. Endocrinology 126:1796-1805
10. Nokelainen P, Peltoketo H, Vihko R, Vihko P 1998 Expression cloning of a novel estrogenic mouse 17β-hydroxysteroid dehydrogenase/17β- ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol 12:1048-1059
11. Risk M, Duan RW, Nelson S, Azhar S, Gibori G 1999 Characterization of PRAP as a novel 17β-hydroxysteroid dehydrogenase (17βHSD) enzyme. Biol Reprod Suppl 60:162
12. Duan WR, Linzer DI, Gibori G 1996 Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor. J Biol Chem 271:15602-15607
13. Parmer TG, McLean MP, Duan WR, Nelson SE, Albarracin CT, Khan I, Gibori G 1992 Hormonal and immunological characterization of the 32 kilodalton ovarian-specific protein. Endocrinology 131:2213-2221
14. Risk M, Shehu A, Mao J, Stocco CO, Goldsmith LT, Bowen-Shauver JM, Gibori G 2005 Cloning and characterization of a 5 regulatory region of the prolactin receptor-associated protein/17β-hydroxysteroid dehydrogenase 7 gene. Endocrinology 146:2807-2816
15. Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P 1999 Two 17β-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7. J Steroid Biochem Mol Biol 69:431-439
16. Risk M, Gibori G 2001 Mechanisms of luteal cell regulation by prolactin. In: Horseman ND, ed. Prolactin. Dordrecht: Kluwer Academic Publisher; 265-295
17. Bowen-Shauver J and Gibori G 2004 The corpus luteum of pregnancy. In: Adashi EY, Leung PCK, eds. The ovary. New York: Raven Press; 201-232
18. Breitling R, Krazeisen A, Moller G, Adamski J 2001 17β- hydroxysteroid dehydrogenase type 7 - an ancient 3-ketosteroid reductase of cholesterogenesis. Mol Cell Endocrinol 171:199-204
19. Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R 2003 Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Mol Endocrinol 17:1715-1725
20. Tozawa R, Ishibashi S, Osuga J, Yagyu H, Oka T, Chen Z, Ohashi K, Perrey S, Shionoiri F, Yahagi N, Harada K, Gotoda T, Yazaki Y, Yamada N 1999 Embryonic lethality and defective neural tube closure in mice lacking squalene synthase. J Biol Chem 274:30843-30848
21. Herman GE 2000 X-linked dominant disorders of cholesterol biosynthesis in man and mouse. Biochim Biophys Acta 1529:357-373
22. Porter FD 2002 Malformation syndromes due to inborn errors of cholesterol biosynthesis. J Clin Invest 110:715-724
23. Wilkinson DG, Nieto MA 1993 Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol 225:361-373
24. Nokelainen P, Peltoketo H, Mustonen M, Vihko P 2000 Expression of mouse 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 in the ovary, uterus, and placenta: localization from implantation to late pregnancy. Endocrinology 141:772-778
25. Bakker J, Honda S, Harada N, Balthazart J 2003 The aromatase knockout (ArKO) mouse provides new evidence that estrogens are required for the development of the female brain. Ann NY Acad Sci 1007:251-262
26. Bakker J, Baum MJ 2008 Role for estradiol in female-typical brain and behavioral sexual differentiation. Front Neuroendocrinol 29:1-16
27. Merlo S, Calafiore M, Vancheri C, Canonico PL, Copani A, Sortino MA 2007 Astrocyte-like cells as a main target for estrogen action during neuronal differentiation. Mol Cell Neurosci 34:562-570
28. Martínez-Cerdeño V, Noctor SC, Kriegstein AR 2006 Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex. Eur J Neurosci 24:3475-3488
29. Fisher CR, Graves KH, Parlow AF, Simpson ER 1998 Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 95:6965-6970
30. Michikawa M, Yanagisawa K 1999 Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. J Neurochem. 72:2278-2285
31. Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J 2006 Transcriptional regulation of human and murine 17β-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. J Mol Endocrinol 37:185-197
32. Seth G, McIvor RS, Hu W 2006 17-Hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells. J Biotechnol 121:241-252
33. Ohnesorg T, Adamski J 2006 Analysis of the 5-flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region. Mol Cell Endocrinol 248:164-167
34. Ferreri K, Talaverat F, Menon KM 1992 Increased cellular cholesterol upregulates high density lipoprotein binding to rat luteal cells. Endocrinology 131:2059-2064
35. Khan I, Belanger A, Chen Y-DI, Gibori G 1985 Influence of high density lipoprotein on estradiol stimulation of luteal steroidogenesis. Biol Reprod 32:96-104
36. Herrera E 2000 Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr 54(Suppl 1):S47-S51
37. Tint GS, Yu H, Shang Q, Xu G, Patel SB 2006 The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols. J Lipid Res 47:1535-1541
38. Fitzky BU, Witsch-Baumgartner M, Erdel M, Lee JN, Paik Y, Glossmann H, Utermann G, Moebius FF 1998 Mutations in the Δ7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome. Proc Natl Acad Sci USA 95:8181-8186
39. Salen G, Shefer S, Batta AK, Tint GS, Xu G, Honda A, Irons M, Elias ER 1996 Abnormal cholesterol biosynthesis in the Smith-Lemli-Opitz syndrome. J Lipid Res 37:1169-1180
40. Ohashi K, Osuga J, Tozawa R, Kitamine T, Yagyu H, Sekiya M, Tomita S, Okazaki H, Tamura Y, Yahagi N, Iizuka Y, Harada K, Gotoda T, Shimano H, Nobuhiro Yamada N, Ishibashi S 2003 Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. J Biol Chem 278:42936-42941
41. Saher G, Brugger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA 2005 High cholesterol level is essential for myelin membrane growth. Nat Neurosci 8:468-475
42. Fünfschilling U, Saher G, Xiao L, Möbius W, Nave KA 2007 Survival of adult neurons lacking cholesterol synthesis in vivo. BMC Neurosci 8:1
43. Gibori G, Khan I, Warshaw ML, McLean MP, Puryear TK, Nelson S, Durkee TJ, Azhar S, Steinschneider A, Rao MC 1988 Placental derived regulators and the complex control of luteal cell function. Recent Prog Horm Res 44:377-429
44. Warshaw ML, Johnson DC, Khan I, Eckstein B, Gibori G 1986 Placental secretion of androgens in the rat. Endocrinology 119:2642-2648