Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 22, 2009, Pages 2081-2086

  Acimovic, Jure ^a   Lövgren Sandblom, Anita ^b   Monostory, Katalin ^c   Rozman, Damjana ^a   Golicnik, Marko ^a   Lutjohann, Dieter ^d   Björkhem, Ingemar ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b KAROLINSKA INSTITUTE   (Sweden)

^c CHEMICAL RESEARCH CENTER   (Hungary)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

Cholesterol biosynthesis intermediates; Gas chromatography mass spectrometry; Human hepatocytes

Indexed keywords

A-COEFFICIENT; CAMPESTEROL; CHOLESTEROL SYNTHESIS; CLINICAL APPLICATION; CULTURED CELL; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; HUMAN HEPATOCYTES; INHERITED DISORDERS; INTERNAL STANDARDS; LANOSTEROL; PLANT STEROLS; QUANTITATIVE ANALYSIS; SPECTROMETRIC ANALYSIS; SPECTROMETRIC METHODS; ZYMOSTEROL;

ALCOHOLS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; BODY FLUIDS; DEUTERIUM; GAS CHROMATOGRAPHY; GASES; LIPIDS; SPECTROMETERS; SPECTROMETRY;

CHOLESTEROL;

7 DEHYDROCHOLESTEROL; CAMPESTEROL; CHOLESTEROL; DESMOSTEROL; DIHYDROLANOSTEROL; FOLLICULAR FLUID MEIOSIS ACTIVATING STEROL; LANOSTEROL; LATHOSTEROL; PHYTOSTEROL; SITOSTEROL; SQUALENE; STEROL DERIVATIVE; TESTIS MEIOSIS ACTIVATING STEROL; UNCLASSIFIED DRUG; ZYMOSTEROL;

ACCURACY; ARTICLE; CHEMICAL STRUCTURE; CHOLESTEROL SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL CULTURE; MASS FRAGMENTOGRAPHY; PRECURSOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STANDARD;

ADULT; CELLS, CULTURED; CHOLESTEROL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEPATOCYTES; HUMANS; MALE; PHYTOSTEROLS;

EID: 67649197416     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.05.050     Document Type: Article

References (18)

1. Buhaescu I., and Izzedine H. Clin. Biochem. 40 (2007) 575
2. Waterham H.R. FEBS Lett. 580 (2006) 5442
3. Friesen J.A., and Rodwell V.W. Genome Biol. 5 (2004) 248
4. Bjorkhem I., Miettinen T., Reihner E., Ewerth S., Angelin B., and Einarsson K. J. Lipid Res. 28 (1987) 1137
5. Menys V.C., and Durrington P.N. Br. J. Pharmacol. 139 (2003) 881
6. Korosec T., Acimovic J., Seliskar M., Kocjan D., Tacer K.F., Rozman D., and Urleb U. Bioorg. Med. Chem. 16 (2008) 209
7. Paik M.J., Yu J., Hu M.B., Kim S.J., Kim K.R., Ahn Y.H., Choi S., and Lee G. Clin. Chim. Acta 396 (2008) 62
8. Luzon-Toro B., Zafra-Gomez A., and Ballesteros O. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 850 (2007) 177
9. Ahmida H.S., Bertucci P., Franzo L., Massoud R., Cortese C., Lala A., and Federici G. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 842 (2006) 43
10. Tamboli I.Y., Prager K., Thal D.R., Thelen K.M., Dewachter I., Pietrzik C.U., St George-Hyslop P., Sisodia S.S., De Strooper B., Heneka M.T., Filippov M.A., Muller U., van Leuven F., Lutjohann D., and Walter J. J. Neurosci. 28 (2008) 12097
11. Lindenthal B., Holleran A.L., Aldaghlas T.A., Ruan B., Schroepfer Jr. G.J., Wilson W.K., and Kelleher J.K. FASEB J. 15 (2001) 775
12. Bayliss K.M., and Skett P. In: Jones G.E. (Ed). Human Cell Culture Protocols (1996), Human Press, Totowa 369
13. Ferrini J.B., Ourlin J.C., Pichard L., Fabre G., and Maurel P. Methods Mol. Biol. 107 (1998) 341
14. Sanchez-Muniz F.J., Garcia-Linares M.C., Garcia-Arias M.T., Bastida S., and Viejo J. J. Nutr. 133 (2003) 2302
15. Heverin M., Meaney S., Brafman A., Shafir M., Olin M., Shafaati M., von Bahr S., Larsson L., Lovgren-Sandblom A., Diczfalusy U., Parini P., Feinstein E., and Bjorkhem I. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 2191
16. Hewitt K.N., Boon W.C., Murata Y., Jones M.E., and Simpson E.R. Endocrinology 144 (2003) 3895
17. Rozman D., Seliskar M., Cotman M., and Fink M. Mol. Cell. Endocrinol. 234 (2005) 47
18. M.G. de Sain-van der Velden, A. Verrips, B.H. Prinsen, M. de Barse, R. Berger, G. Visser, J. Inherit. Metab. Dis. (2009), in press.