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Volumn 62, Issue , 1997, Pages 191-204

Multiple roles of cholesterol in hedgehog protein biogenesis and signaling

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; SONIC HEDGEHOG PROTEIN; TERATOGENIC AGENT; THIOESTER;

EID: 0031433171     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1997.062.01.025     Document Type: Conference Paper
Times cited : (109)

References (79)
  • 1
    • 0001728429 scopus 로고
    • The problem of cyclopia (part I)
    • Adelmann H.B. 1936a. The problem of cyclopia (part I). Q. Rev. Biol. 11: 116.
    • (1936) Q. Rev. Biol. , vol.11 , pp. 116
    • Adelmann, H.B.1
  • 2
    • 0001728431 scopus 로고
    • The problem of cyclopia (part II)
    • _. 1936b. The problem of cyclopia (part II). Q. Rev. Biol. 11: 284.
    • (1936) Q. Rev. Biol. , vol.11 , pp. 284
  • 4
    • 0000040356 scopus 로고
    • A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum
    • Binns W., James L.F., Shupe J.L., and Everett G. 1963. A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum. Am. J. Vet. Res. 24: 1164.
    • (1963) Am. J. Vet. Res. , vol.24 , pp. 1164
    • Binns, W.1    James, L.F.2    Shupe, J.L.3    Everett, G.4
  • 6
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown M.S. and Goldstein J.L. 1997. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331.
    • (1997) Cell , vol.89 , pp. 331
    • Brown, M.S.1    Goldstein, J.L.2
  • 7
    • 0028966517 scopus 로고
    • Proteolytic processing yields two secreted forms of Sonic hedgehog
    • Bumcrot D.A., Takada R., and McMahon A.P. 1995. Proteolytic processing yields two secreted forms of Sonic hedgehog. Mol. Cell. Biol. 15: 2294.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2294
    • Bumcrot, D.A.1    Takada, R.2    McMahon, A.P.3
  • 8
    • 0030250401 scopus 로고    scopus 로고
    • Warthog and Groundhog, novel families related to Hedgehog
    • Burglin T.R. 1996. Warthog and Groundhog, novel families related to Hedgehog. Curr. Biol. 6: 1047.
    • (1996) Curr. Biol. , vol.6 , pp. 1047
    • Burglin, T.R.1
  • 11
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing hedgehog
    • Chen Y. and Struhl G. 1996. Dual roles for patched in sequestering and transducing hedgehog. Cell 87: 553.
    • (1996) Cell , vol.87 , pp. 553
    • Chen, Y.1    Struhl, G.2
  • 12
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • Chiang C., Litingtung Y., Lee E., Young K., Corden J.L., Westphal H., and Beachy P. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407.
    • (1996) Nature , vol.383 , pp. 407
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.4    Corden, J.L.5    Westphal, H.6    Beachy, P.7
  • 13
    • 0028670452 scopus 로고
    • α-2 macroglobulin, complement, and biological defense: Antigens, growth factors, microbial proteases, and receptor ligation
    • Chu C.T. and Pizzo S.V. 1994. α-2 macroglobulin, complement, and biological defense: Antigens, growth factors, microbial proteases, and receptor ligation. Lab. Invest. 71: 792.
    • (1994) Lab. Invest. , vol.71 , pp. 792
    • Chu, C.T.1    Pizzo, S.V.2
  • 14
    • 0026489538 scopus 로고
    • Perspectives on holoprosencephaly. II. Central nervous system, craniofacial anatomy, syndrome commentary, diagnostic approach, and experimental studies
    • Cohen M.M. and Sulik K.K. 1992. Perspectives on holoprosencephaly. II. Central nervous system, craniofacial anatomy, syndrome commentary, diagnostic approach, and experimental studies. J. Craniofacial Genet. Dev. Biol. 12: 196.
    • (1992) J. Craniofacial Genet. Dev. Biol. , vol.12 , pp. 196
    • Cohen, M.M.1    Sulik, K.K.2
  • 15
    • 0030789206 scopus 로고    scopus 로고
    • Statistical modeling, phylogenetic analysis and structure prediction of a protein splicing domain common to inteins and Hedgehog proteins
    • Dalgaard J.Z., Moser M.J., Hughey R., and Mian I.S. 1997. Statistical modeling, phylogenetic analysis and structure prediction of a protein splicing domain common to inteins and Hedgehog proteins. J. Comput. Biol. 4: 193.
    • (1997) J. Comput. Biol. , vol.4 , pp. 193
    • Dalgaard, J.Z.1    Moser, M.J.2    Hughey, R.3    Mian, I.S.4
  • 17
    • 0031044526 scopus 로고    scopus 로고
    • Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome
    • Dehart D.B., Lanoue L., Tint G.S., and Sulik K.K. 1997. Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome. Am. J. Med. Genet. 68: 328.
    • (1997) Am. J. Med. Genet. , vol.68 , pp. 328
    • Dehart, D.B.1    Lanoue, L.2    Tint, G.S.3    Sulik, K.K.4
  • 19
    • 0030611387 scopus 로고    scopus 로고
    • Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity
    • Duan X., Gimble F.S., and Quiocho F.A. 1997. Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Cell 89: 555.
    • (1997) Cell , vol.89 , pp. 555
    • Duan, X.1    Gimble, F.S.2    Quiocho, F.A.3
  • 20
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y., Epstein D.J., St. Jacques B., Shen L., Mohler J., McMahon J.A., and McMahon A.P. 1993. Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity. Cell 75: 1417.
    • (1993) Cell , vol.75 , pp. 1417
    • Echelard, Y.1    Epstein, D.J.2    St. Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 23
    • 0028918775 scopus 로고
    • Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes
    • Farese R.V., Ruland S.L., Flynn L.M., Stokowski R.P., and Young S.G. 1995. Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc. Natl. Acad. Sci. 92: 1774.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 1774
    • Farese, R.V.1    Ruland, S.L.2    Flynn, L.M.3    Stokowski, R.P.4    Young, S.G.5
  • 24
    • 0029933263 scopus 로고    scopus 로고
    • A novel function for apolipoprotein B: Lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice
    • Farese R.V., Cases S., Ruland S.L., Kayden H.J., Wong J.S., Young S.G., and Hamilton R.L. 1996. A novel function for apolipoprotein B: Lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice. J. Lipid Res. 37: 347.
    • (1996) J. Lipid Res. , vol.37 , pp. 347
    • Farese, R.V.1    Cases, S.2    Ruland, S.L.3    Kayden, H.J.4    Wong, J.S.5    Young, S.G.6    Hamilton, R.L.7
  • 25
    • 0030469087 scopus 로고    scopus 로고
    • Steroidal alkaloid teratogens: Molecular probes for investigation of craniofacial malformations
    • Gaffield W. and Keeler R.F. 1996. Steroidal alkaloid teratogens: Molecular probes for investigation of craniofacial malformations. J. Toxicol. 15: 303.
    • (1996) J. Toxicol. , vol.15 , pp. 303
    • Gaffield, W.1    Keeler, R.F.2
  • 26
    • 0021856440 scopus 로고
    • Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme
    • Gil G., Faust J.R., Chin D.J., Goldstein J.L., and Brown M.S. 1985. Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell 41: 249.
    • (1985) Cell , vol.41 , pp. 249
    • Gil, G.1    Faust, J.R.2    Chin, D.J.3    Goldstein, J.L.4    Brown, M.S.5
  • 27
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
    • Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., and Scott M.P. 1996. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog. Genes Dev. 10: 301.
    • (1996) Genes Dev. , vol.10 , pp. 301
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 28
    • 0030051163 scopus 로고    scopus 로고
    • Activation of glycosylasparaginase: Formation of active N-terminal threonine by intramolecular autoproteolysis
    • Guan C., Cui T., Rao V., Liao W., Benner J., Lin C.-L., and Comb D. 1996. Activation of glycosylasparaginase: Formation of active N-terminal threonine by intramolecular autoproteolysis. J. Biol. Chem. 271: 1732.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1732
    • Guan, C.1    Cui, T.2    Rao, V.3    Liao, W.4    Benner, J.5    Lin, C.-L.6    Comb, D.7
  • 29
    • 0028841677 scopus 로고
    • A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog
    • Hall T.M.T., Porter J.A., Beachy P.A., and Leahy D.J. 1995. A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature 378: 212.
    • (1995) Nature , vol.378 , pp. 212
    • Hall, T.M.T.1    Porter, J.A.2    Beachy, P.A.3    Leahy, D.J.4
  • 30
    • 0342813091 scopus 로고    scopus 로고
    • Crystal structure of a Hedgehog autoprocessing domain: Conservation of structure, sequence, and reaction mechanism between Hedgehog and self-splicing proteins
    • Hall T.M.T., Porter J.A., Young K.E., Koonin F.V., Beachy P.A., and Leahy D.J. 1997. Crystal structure of a Hedgehog autoprocessing domain: Conservation of structure, sequence, and reaction mechanism between Hedgehog and self-splicing proteins. Cell. 91: 85.
    • (1997) Cell. , vol.91 , pp. 85
    • Hall, T.M.T.1    Porter, J.A.2    Young, K.E.3    Koonin, F.V.4    Beachy, P.A.5    Leahy, D.J.6
  • 33
    • 0030457014 scopus 로고    scopus 로고
    • Ubiquitin-dependent protein degradation
    • Hochstrasser M. 1996. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30: 405.
    • (1996) Annu. Rev. Genet. , vol.30 , pp. 405
    • Hochstrasser, M.1
  • 34
    • 0027478167 scopus 로고
    • Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice
    • Homanics G.E., Smith T.J., Zhang S.H., Lee D., Young S.G., and Maeda N. 1993. Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc. Natl. Acad. Sci. 90: 2389.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 2389
    • Homanics, G.E.1    Smith, T.J.2    Zhang, S.H.3    Lee, D.4    Young, S.G.5    Maeda, N.6
  • 35
    • 0030298339 scopus 로고    scopus 로고
    • Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
    • Hua X., Nohturfft A., Goldstein J.L., and Brown M.S. 1996. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 87: 415.
    • (1996) Cell , vol.87 , pp. 415
    • Hua, X.1    Nohturfft, A.2    Goldstein, J.L.3    Brown, M.S.4
  • 36
    • 0028800863 scopus 로고
    • Apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-1 transport rates in heterozygotes
    • Huang L.-S., Voyiaziakis E., Markenson D.F., Sokol K.A., Hayek T., and Breslow J.L. 1995. apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-1 transport rates in heterozygotes. J. Clin. Invest. 96: 2152.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2152
    • Huang, L.-S.1    Voyiaziakis, E.2    Markenson, D.F.3    Sokol, K.A.4    Hayek, T.5    Breslow, J.L.6
  • 37
    • 0027761917 scopus 로고
    • Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo
    • Ingham P.W. 1993. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366: 560.
    • (1993) Nature , vol.366 , pp. 560
    • Ingham, P.W.1
  • 38
    • 0025815911 scopus 로고
    • Role of the Drosophila patched gene in positional signalling
    • Ingham P.W., Taylor A.M., and Nakano Y. 1991. Role of the Drosophila patched gene in positional signalling. Nature 353: 184.
    • (1991) Nature , vol.353 , pp. 184
    • Ingham, P.W.1    Taylor, A.M.2    Nakano, Y.3
  • 39
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi S., Brown M.S., Goldstein J.L., Gerard R.D., Hammer R.E., and Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92: 883.
    • (1993) J. Clin. Invest. , vol.92 , pp. 883
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 40
    • 0014245807 scopus 로고
    • Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources
    • Keeler R.F. and Binns W. 1968. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology 1: 5.
    • (1968) Teratology , vol.1 , pp. 5
    • Keeler, R.F.1    Binns, W.2
  • 42
    • 0029028990 scopus 로고
    • Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
    • Lai C.-J., Ekker S.C., Beachy P.A., and Moon R.T. 1995. Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage. Development 121: 2349.
    • (1995) Development , vol.121 , pp. 2349
    • Lai, C.-J.1    Ekker, S.C.2    Beachy, P.A.3    Moon, R.T.4
  • 43
    • 0030716476 scopus 로고    scopus 로고
    • Limb, genital. CNS and facial malformations result from gene/environment-induced cholesterol deficiency: Further evidence for a link to Sonic hedgehog
    • Lanoue L., Dehart D.B., Hinsdale M.E., Maeda N., Tint G.T., and Sulik K.K. 1997. Limb, genital. CNS and facial malformations result from gene/environment-induced cholesterol deficiency: Further evidence for a link to Sonic hedgehog. Am. J. Med. Genet. 73: 24.
    • (1997) Am. J. Med. Genet. , vol.73 , pp. 24
    • Lanoue, L.1    Dehart, D.B.2    Hinsdale, M.E.3    Maeda, N.4    Tint, G.T.5    Sulik, K.K.6
  • 44
    • 0026783674 scopus 로고
    • Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
    • Lee J.J., von Kessler D.P., Parks S., and Beachy P.A. 1992. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71: 33.
    • (1992) Cell , vol.71 , pp. 33
    • Lee, J.J.1    Von Kessler, D.P.2    Parks, S.3    Beachy, P.A.4
  • 47
    • 0000558386 scopus 로고
    • Das determinationsproblem.III. Das wirbeltierauge in der entwicklung und regeneration
    • Mangold O. 1931. Das determinationsproblem. III. Das wirbeltierauge in der entwicklung und regeneration. Ergeb. Biol. 7: 193.
    • (1931) Ergeb. Biol. , vol.7 , pp. 193
    • Mangold, O.1
  • 48
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that Patched is the Hedgehoc receptor
    • Marigo V., Davey R.A., Zuo Y., Cunningham J.M., and Tabin C.J. 1996. Biochemical evidence that Patched is the Hedgehoc receptor. Nature 384: 176.
    • (1996) Nature , vol.384 , pp. 176
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3    Cunningham, J.M.4    Tabin, C.J.5
  • 49
    • 0029019627 scopus 로고
    • Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
    • Marti E., Bumcrot D.A., Takada R., and McMahon A.P. 1995. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375: 322.
    • (1995) Nature , vol.375 , pp. 322
    • Marti, E.1    Bumcrot, D.A.2    Takada, R.3    McMahon, A.P.4
  • 50
    • 0024254534 scopus 로고
    • Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila
    • Mohler J. 1988. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 120: 1061.
    • (1988) Genetics , vol.120 , pp. 1061
    • Mohler, J.1
  • 51
    • 0026474841 scopus 로고
    • Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
    • Mohler J. and Vani K. 1992. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115: 957.
    • (1992) Development , vol.115 , pp. 957
    • Mohler, J.1    Vani, K.2
  • 52
    • 0029950031 scopus 로고    scopus 로고
    • Structural classification of proteins: New superfamilies
    • Murzin A.G. 1996. Structural classification of proteins: New superfamilies. Curr. Opin. Struct. Biol. 6: 386.
    • (1996) Curr. Opin. Struct. Biol. , vol.6 , pp. 386
    • Murzin, A.G.1
  • 53
    • 0026704101 scopus 로고
    • Combined influence of cholesterol and synthetic amphiphilic peptides upon bilayer thickness in model membranes
    • Nezil F.A. and Bloom M. 1992. Combined influence of cholesterol and synthetic amphiphilic peptides upon bilayer thickness in model membranes. Biophys. J. 61: 1176.
    • (1992) Biophys. J. , vol.61 , pp. 1176
    • Nezil, F.A.1    Bloom, M.2
  • 54
    • 0026673416 scopus 로고
    • The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase
    • Olender E.H. and Simoni R.D. 1992. The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase. J. Biol. Chem. 267: 4223.
    • (1992) J. Biol. Chem. , vol.267 , pp. 4223
    • Olender, E.H.1    Simoni, R.D.2
  • 55
    • 0028314608 scopus 로고
    • RSH/SLO ("Smith-Lemli-Opitz") syndrome: Historical, genetic, and developmental considerations
    • Opitz J.M. 1994. RSH/SLO ("Smith-Lemli-Opitz") syndrome: Historical, genetic, and developmental considerations. Am. J. Med. Genet. 50: 344.
    • (1994) Am. J. Med. Genet. , vol.50 , pp. 344
    • Opitz, J.M.1
  • 57
    • 0343624372 scopus 로고    scopus 로고
    • Modular organization of inteins and C-terminal autocatalytic domains
    • in press
    • Pietrokovski S. 1997. Modular organization of inteins and C-terminal autocatalytic domains. Protein Sci. (in press).
    • (1997) Protein Sci.
    • Pietrokovski, S.1
  • 58
    • 0027400583 scopus 로고
    • Induction of floor plate differentiation by contact-dependent, homeogenetic signals
    • Placzek M., Jessell T.M., and Dodd J. 1993. Induction of floor plate differentiation by contact-dependent, homeogenetic signals. Development 117: 205.
    • (1993) Development , vol.117 , pp. 205
    • Placzek, M.1    Jessell, T.M.2    Dodd, J.3
  • 59
    • 0024512892 scopus 로고
    • Inhibition of cholesterol synthesis and cell growth by 24(R,S), 25-iminolanosterol and triparanol in cultured rat hepatoma cells
    • Popjak G., Meenan A., Parish E.J., and Nes W.D. 1989. Inhibition of cholesterol synthesis and cell growth by 24(R,S), 25-iminolanosterol and triparanol in cultured rat hepatoma cells. J. Biol. Chem. 264: 630.
    • (1989) J. Biol. Chem. , vol.264 , pp. 630
    • Popjak, G.1    Meenan, A.2    Parish, E.J.3    Nes, W.D.4
  • 60
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of Hedgehog signaling proteins in animal development
    • Porter J.A., Young K.E., and Beachy P.A. 1996a. Cholesterol modification of Hedgehog signaling proteins in animal development. Science 274: 255.
    • (1996) Science , vol.274 , pp. 255
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 63
  • 64
    • 0021891306 scopus 로고
    • High-performance liquid chromatography of sterols: Yeast sterols
    • Rodriguez R.J. and Parks L.W. 1985. High-performance liquid chromatography of sterols: Yeast sterols. Methods Enzymol. 111: 37.
    • (1985) Methods Enzymol. , vol.111 , pp. 37
    • Rodriguez, R.J.1    Parks, L.W.2
  • 65
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis
    • Roelink H., Porter J.A., Chiang C., Tanabe Y., Chang D.T., Beachy P.A., and Jessell T.M. 1995. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81: 445.
    • (1995) Cell , vol.81 , pp. 445
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessell, T.M.7
  • 67
    • 0026720521 scopus 로고
    • Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme a reductase: Implications for enzyme degradation in the endoplasmic reticulum
    • Roitelman J., Olender E.H., Bar-Nun S., Dunn W.A., Jr., and Simoni R.D. 1992. Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: Implications for enzyme degradation in the endoplasmic reticulum. J. Cell Biol. 117: 959.
    • (1992) J. Cell Biol. , vol.117 , pp. 959
    • Roitelman, J.1    Olender, E.H.2    Bar-Nun, S.3    Dunn Jr., W.A.4    Simoni, R.D.5
  • 68
    • 0001534522 scopus 로고
    • Action teratogene du triparanol chez l'animal
    • Roux, C. 1964. Action teratogene du triparanol chez l'animal. Arch. Franc. Pediatr. 21: 451.
    • (1964) Arch. Franc. Pediatr. , vol.21 , pp. 451
    • Roux, C.1
  • 69
    • 17444439499 scopus 로고
    • Action teratogene chez le rat d'un inhibiteur de la synthese du cholesterol, le AY9944
    • _. 1966. Action teratogene chez le rat d'un inhibiteur de la synthese du cholesterol, le AY9944. C.R. Soc. Biol. 160: 1353.
    • (1966) C.R. Soc. Biol. , vol.160 , pp. 1353
  • 70
    • 0018411725 scopus 로고
    • R: Prevention by a hypercholesterolemia-provoking diet
    • R: Prevention by a hypercholesterolemia-provoking diet. Teratology 19: 35.
    • (1979) Teratology , vol.19 , pp. 35
    • Roux, C.1    Horvath, C.2    Dupuis, R.3
  • 72
    • 0029144022 scopus 로고
    • Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100
    • Stefansson S., Chappell D.A., Argraves K.M., Strickland D.K., and Argraves W.S. 1995. Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100. J. Biol. Chem. 270: 19417.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19417
    • Stefansson, S.1    Chappell, D.A.2    Argraves, K.M.3    Strickland, D.K.4    Argraves, W.S.5
  • 74
    • 0027096741 scopus 로고
    • The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
    • Tabata T., Eaton S., and Kornberg T.B. 1992. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Der. 6: 2635.
    • (1992) Genes Der. , vol.6 , pp. 2635
    • Tabata, T.1    Eaton, S.2    Kornberg, T.B.3
  • 79
    • 0029838842 scopus 로고    scopus 로고
    • The mechanism of protein splicing and its modulation by mutation
    • Xu M.-Q. and Perler F.B. 1996. The mechanism of protein splicing and its modulation by mutation. EMBO J. 15: 5146.
    • (1996) EMBO J. , vol.15 , pp. 5146
    • Xu, M.-Q.1    Perler, F.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.