Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure-activity relationship (SAR)

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 5046-5052

  Bello, Murilo Lamim ^a,b   Chiaradia, Louise Domeneghini ^c   Dias, Luiza Rosaria Sousa ^b   Pacheco, Letícia Kramer ^c   Stumpf, Taisa Regina ^c   Mascarello, Alessandra ^c   Steindel, Mário ^c   Yunes, Rosendo Augusto ^c   Castro, Helena Carla ^b   Nunes, Ricardo José ^c   Rodrigues, Carlos Rangel ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Antileishmanial activity; Chalcones; Leishmania braziliensis; Molecular modeling; SAR

Indexed keywords

1 (2',4',5' TRIMETHOXYPHENYL) 3 (2 CHLOROPHENYL) 2 PROPEN 1 ONE; 1 (2',4',5' TRIMETHOXYPHENYL) 3 (3 CHLOROPHENYL) 2 PROPEN 1 ONE; 1 (2',4',5' TRIMETHOXYPHENYL) 3 (3 METHOXYPHENYL) 2 PROPEN 1 ONE; 1 (2',4',5' TRIMETHOXYPHENYL) 3 (3,4 DICHLOROPHENYL) 2 PROPEN 1 ONE; 1 (2',4',5' TRIMETHOXYPHENYL) 3 (4 CHLOROPHENYL) 2 PROPEN 1 ONE; 1 (2',4',5' TRIMETHOXYPHENYL) 3 PHENYL 2 PROPEN 1 ONE; AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; ANTILEISHMANIAL AGENT; CHALCONE DERIVATIVE; MEGLUMINE ANTIMONATE; METHOXYCHALCONE DERIVATIVE; PENTAMIDINE; PENTAMIDINE ISETHIONATE; STIBOGLUCONATE SODIUM; TRIMETHOXY CHALCONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTILEISHMANIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; GROWTH INHIBITION; IC 50; LEISHMANIA BRAZILIENSIS; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ANTIPROTOZOAL AGENTS; CHALCONE; LEISHMANIA BRAZILIENSIS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

LEISHMANIA BRAZILIENSIS;

EID: 79961167431     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.023     Document Type: Article

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