Antibacterial chalcones - Bioisosteric replacement of the 4′-hydroxy group

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 11, 2004, Pages 3047-3054

  Nielsen, Simon Feldbæk ^a,b   Boesen, Thomas ^a,c   Larsen, Mogens ^a,d   Schønning, Kristian ^a   Kromann, Hasse ^a,c  

^a Lica Pharmaceuticals A/S   (Denmark)

^b LEO PHARMA A S   (Denmark)

^c MedChem Aps   (Denmark)

^d H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2' FLUORO 4' HYDROXY 2,4 DICHLOROCHALCONE; 3' FLUORO 4' HYDROXY 2,4 DICHLOROCHALCONE; 3',5' DIFLUORO 4' HYDROXY 2,4 DICHLOROCHALCONE; 4 (3 PHENYLACRYLOYL)BENZOIC ACID; 4' CARBOXY 2 BROMOCHALCONE; 4' CARBOXY 2 BUTOXYCHALCONE; 4' CARBOXY 2 CHLOROCHALCONE; 4' CARBOXY 2 HYDROXYCHALCONE; 4' CARBOXY 2 TRIFLUOROMETHYLCHALCONE; 4' CARBOXY 2,4 DICHLOROCHALCONE; 4' CARBOXY 3 BROMOCHALCONE; 4' CARBOXY 3 CHLOROCHALCONE; 4' CARBOXY 3 HYDROXYCHALCONE; 4' CARBOXY 3 NITROCHALCONE; 4' CARBOXY 3 PHENOXYCHALCONE; 4' CARBOXY 3 TRIFLUOROMETHYLCHALCONE; 4' CARBOXY 3,5 BIS(TRIFLUOROMETHYLCHALCONE); 4' CARBOXY 3,5 DIBROMOCHALCONE; 4' CARBOXY 4 CHLOROCHALCONE; 4' CARBOXY 4 HYDROXYCHALCONE; 4' CARBOXY 4 METHOXYCHALCONE; 4' CARBOXY 4 METHYLCHALCONE; 4' CARBOXY 4 PHENOXYCHALCONE; 4' CARBOXY 4 TRIFLUOROMETHYLCHALCONE; 4' HYDROXY 2,4 DICHLOROCHALCONE; 4' TETRAZOYL 2,4 DICHLOROCHALCONE; ANTIINFECTIVE AGENT; CHALCONE DERIVATIVE; HYDROXYL GROUP; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACIDITY; ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; METHODOLOGY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; CARBOXYLIC ACIDS; CHALCONES; HYDROXIDES; MICROBIAL SENSITIVITY TESTS; SOLUBILITY; STAPHYLOCOCCUS AUREUS;

EID: 2442507656     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.071     Document Type: Article

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