Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 1, 2007, Pages 211-219

  Dias, Luiza R S ^a   Santos, Marcelo B ^a   Albuquerque, Sérgio de ^b   Castro, Helena C ^a   de Souza, Alessandra M T ^a   Freitas, Antônio C C ^a   DiVaio, Maria A V ^a   Cabral, Lucio M ^c   Rodrigues, Carlos R ^c  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

1H pyrazolo 3,4 b pyridine; Antiparasite agent; Chagas; Structure activity relationship (SAR)

Indexed keywords

PYRIDINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; EVALUATION; MOLECULAR DYNAMICS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; CHAGAS DISEASE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PYRAZOLES; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

OSIRIS; TRYPANOSOMA CRUZI;

EID: 33751104210     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.067     Document Type: Article

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