Trypanocidal agents with low cytotoxicity to mammalian cell line: A comparison of the theoretical and biological features of lapachone derivatives

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5459-5466

  Ferreira, Vitor F ^a   Jorqueira, Alessandra ^a   Souza, Alessandra M T ^a   da Silva, Milton N ^a   de Souza, Maria C B V ^a   Gouvêa, Robson M ^a   Rodrigues, Carlos R ^b   Pinto, Antonio V ^b   Castro, Helena C ^a   Santos, Dilvani O ^a   Araújo, Humberto P ^a   Bourguignon, Saulo C ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Lapachone; Lapachone; Computational; Cytotoxicity; Trypanocidal agent

Indexed keywords

12 METHYLSULFONATE 3 DIHYDRO 2,2 DIMETHIOSPIRO[4H 1 OXAFENANTHREN 6,2 OXYRAN] 5(6H) ONE; 4 METHOXY 1,2 NAPHTHOQUINONE; ALPHA LAPACHONE; ANTITRYPANOSOMAL AGENT; BETA LAPACHONE; FUNCTIONAL GROUP; NAPHTHOQUINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; BIOLOGY; CALCULATION; CHAGAS DISEASE; COMPARATIVE STUDY; CONSTANTS AND COEFFICIENTS; CONTROLLED STUDY; DENSITY; DIPOLE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRICITY; ENERGY; MAMMAL CELL; MATHEMATICAL PARAMETERS; MOLECULAR MODEL; NONHUMAN; THEORY; TRYPANOSOMA CRUZI; VERO CELL;

ANIMALS; CELL LINE; ELECTROSTATICS; NAPHTHOQUINONES; OXIDATION-REDUCTION; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

MAMMALIA; TRYPANOSOMA CRUZI;

EID: 33745626156     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.046     Document Type: Article

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