Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5765-5770

  Rolim Bernardino, Alice Maria ^a   da Silva Pinheiro, Luiz Carlos ^a   Rodrigues, Carlos Rangel ^b   Loureiro, Natália Izabel ^a   Castro, Helena Carla ^a   Lanfredi Rangel, Adriana ^c   Sabatini Lopes, Juliano ^c   Borges, Júlio César ^a   Carvalho, Jane Maria ^a   Romeiro, Gilberto Alves ^a   Ferreira, Vitor Francisco ^a   Frugulhetti, Izabel C P P ^a   Vannier Santos, Marcos André ^c  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antiparasite agent; Giardiasis; Structure activity relationship; Thieno 2,3 b pyridine

Indexed keywords

4 (3' BROMOPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (3' CHLOROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (3' FLUOROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (3' METHOXYPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (3' METHYLPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (3' NITROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (4' BROMOPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (4' CHLOROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (4' FLUOROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (4' METHOXYPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (4' METHYLPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (4' NITROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 (PHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ANTIPARASITIC AGENT; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DIPOLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; GIARDIA LAMBLIA; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

AMINOPYRIDINES; ANIMALS; ANTIPROTOZOAL AGENTS; GIARDIA LAMBLIA; HOMINIDAE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

GIARDIA INTESTINALIS;

EID: 33745585795     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.013     Document Type: Article

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