Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 755-763

  Andrighetti Fröhner, Carla R ^a   de Oliveira, Kely N ^a   Gaspar Silva, Daniela ^a   Pacheco, Letícia K ^a   Joussef, Antônio C ^a   Steindel, Mário ^a   Simões, Cláudia M O ^a   de Souza, Alessandra M T ^b,c   Magalhaes, Uiaran O ^b   Afonso, Ilídio F ^b   Rodrigues, Carlos R ^b   Nunes, Ricardo J ^a   Castro, Helena C ^c  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Departamento de Biologia Celular e Molecular   (Brazil)

Author keywords

Amastigote; Antiparasite; Leishmaniasis; Promastigote; SAR; Sulfonamide 4 methoxychalcones

Indexed keywords

CHALCONE; PENTAMIDINE; SULFONAMIDE; SULFONAMIDE 4 METHOXYCHALCONE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; DRUG SYNTHESIS; EPIMASTIGOTE; LEISHMANIA BRAZILIENSIS; NONHUMAN; PROMASTIGOTE; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPROTOZOAL AGENTS; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; LEISHMANIA BRAZILIENSIS; MODELS, MOLECULAR; PARASITIC SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 60149095715     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.04.016     Document Type: Article

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