메뉴 건너뛰기




Volumn 7, Issue 7, 2011, Pages

Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; INTEGRASE; LENTIVIRUS VECTOR; RETROVIRUS VECTOR; SHORT HAIRPIN RNA; MUTAGENIC AGENT;

EID: 79960945044     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002110     Document Type: Review
Times cited : (6)

References (97)
  • 1
    • 77956873809 scopus 로고    scopus 로고
    • Ten years of genetics and genomics: what have we achieved and where are we heading?
    • Heard E, Tishkoff S, Todd JA, Vidal M, Wagner GP, et al. Ten years of genetics and genomics: what have we achieved and where are we heading? Nat Rev Genet 11: 723-733.
    • Nat Rev Genet , vol.11 , pp. 723-733
    • Heard, E.1    Tishkoff, S.2    Todd, J.A.3    Vidal, M.4    Wagner, G.P.5
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA, Hallmarks of cancer: the next generation. Cell 144: 646-674.
    • Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW, (2004) Cancer genes and the pathways they control. Nat Med 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 4
    • 77957371828 scopus 로고    scopus 로고
    • Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10
    • Choate KA, Lu Y, Zhou J, Choi M, Elias PM, et al. Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10. Science.
    • Science
    • Choate, K.A.1    Lu, Y.2    Zhou, J.3    Choi, M.4    Elias, P.M.5
  • 5
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K, (1996) Clonal selection and learning in the antibody system. Nature 381: 751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 6
    • 20544466648 scopus 로고    scopus 로고
    • Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
    • Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, et al. (2005) Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435: 903-910.
    • (2005) Nature , vol.435 , pp. 903-910
    • Muotri, A.R.1    Chu, V.T.2    Marchetto, M.C.3    Deng, W.4    Moran, J.V.5
  • 7
    • 69349096044 scopus 로고    scopus 로고
    • L1 retrotransposition in human neural progenitor cells
    • Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, et al. (2009) L1 retrotransposition in human neural progenitor cells. Nature 460: 1127-1131.
    • (2009) Nature , vol.460 , pp. 1127-1131
    • Coufal, N.G.1    Garcia-Perez, J.L.2    Peng, G.E.3    Yeo, G.W.4    Mu, Y.5
  • 9
    • 0029993858 scopus 로고    scopus 로고
    • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
    • Naldini L, Blomer U, Gage FH, Trono D, Verma IM, (1996) Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A 93: 11382-11388.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11382-11388
    • Naldini, L.1    Blomer, U.2    Gage, F.H.3    Trono, D.4    Verma, I.M.5
  • 10
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, et al. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3    Ory, D.4    Mulligan, R.5
  • 12
    • 0037452812 scopus 로고    scopus 로고
    • A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
    • Tiscornia G, Singer O, Ikawa M, Verma IM, (2003) A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A 100: 1844-1848.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1844-1848
    • Tiscornia, G.1    Singer, O.2    Ikawa, M.3    Verma, I.M.4
  • 13
    • 0028117777 scopus 로고
    • A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors
    • Federspiel MJ, Bates P, Young JA, Varmus HE, Hughes SH, (1994) A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. Proc Natl Acad Sci U S A 91: 11241-11245.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11241-11245
    • Federspiel, M.J.1    Bates, P.2    Young, J.A.3    Varmus, H.E.4    Hughes, S.H.5
  • 14
    • 0033040497 scopus 로고    scopus 로고
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
    • Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A, (1999) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97: 703-716.
    • (1999) Cell , vol.97 , pp. 703-716
    • Doetsch, F.1    Caille, I.2    Lim, D.A.3    Garcia-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 15
    • 0033046971 scopus 로고    scopus 로고
    • A model for studying megakaryocyte development and biology
    • Murphy GJ, Leavitt AD, (1999) A model for studying megakaryocyte development and biology. Proc Natl Acad Sci U S A 96: 3065-3070.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3065-3070
    • Murphy, G.J.1    Leavitt, A.D.2
  • 16
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, et al. (2000) Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25: 55-57.
    • (2000) Nat Genet , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5
  • 17
    • 0032418416 scopus 로고    scopus 로고
    • A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    • Holland EC, Hively WP, DePinho RA, Varmus HE, (1998) A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12: 3675-3685.
    • (1998) Genes Dev , vol.12 , pp. 3675-3685
    • Holland, E.C.1    Hively, W.P.2    DePinho, R.A.3    Varmus, H.E.4
  • 19
    • 0036802652 scopus 로고    scopus 로고
    • An RCAS-TVA-based approach to designer mouse models
    • Orsulic S, (2002) An RCAS-TVA-based approach to designer mouse models. Mamm Genome 13: 543-547.
    • (2002) Mamm Genome , vol.13 , pp. 543-547
    • Orsulic, S.1
  • 20
    • 0034783643 scopus 로고    scopus 로고
    • Systematic determination of the packaging limit of lentiviral vectors
    • Kumar M, Keller B, Makalou N, Sutton RE, (2001) Systematic determination of the packaging limit of lentiviral vectors. Hum Gene Ther 12: 1893-1905.
    • (2001) Hum Gene Ther , vol.12 , pp. 1893-1905
    • Kumar, M.1    Keller, B.2    Makalou, N.3    Sutton, R.E.4
  • 21
    • 25144469504 scopus 로고    scopus 로고
    • Electric pulse-mediated gene delivery to various animal tissues
    • Mir LM, Moller PH, Andre F, Gehl J, (2005) Electric pulse-mediated gene delivery to various animal tissues. Adv Genet 54: 83-114.
    • (2005) Adv Genet , vol.54 , pp. 83-114
    • Mir, L.M.1    Moller, P.H.2    Andre, F.3    Gehl, J.4
  • 22
    • 38749112180 scopus 로고    scopus 로고
    • Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation
    • Barnabe-Heider F, Meletis K, Eriksson M, Bergmann O, Sabelstrom H, et al. (2008) Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation. Nat Methods 5: 189-196.
    • (2008) Nat Methods , vol.5 , pp. 189-196
    • Barnabe-Heider, F.1    Meletis, K.2    Eriksson, M.3    Bergmann, O.4    Sabelstrom, H.5
  • 24
    • 84934436744 scopus 로고    scopus 로고
    • Site-specific chromosomal integration mediated by phiC31 integrase
    • Keravala A, Calos MP, (2008) Site-specific chromosomal integration mediated by phiC31 integrase. Methods Mol Biol 435: 165-173.
    • (2008) Methods Mol Biol , vol.435 , pp. 165-173
    • Keravala, A.1    Calos, M.P.2
  • 25
    • 77956210439 scopus 로고    scopus 로고
    • Impact of hydrodynamic injection and phiC31 integrase on tumor latency in a mouse model of MYC-induced hepatocellular carcinoma
    • doi:10.1371/journal.pone.0011367
    • Woodard LE, Keravala A, Jung WE, Wapinski OL, Yang Q, et al. Impact of hydrodynamic injection and phiC31 integrase on tumor latency in a mouse model of MYC-induced hepatocellular carcinoma. PLoS ONE 5: e11367 doi:10.1371/journal.pone.0011367.
    • PLoS ONE , vol.5
    • Woodard, L.E.1    Keravala, A.2    Jung, W.E.3    Wapinski, O.L.4    Yang, Q.5
  • 26
    • 23744479962 scopus 로고    scopus 로고
    • Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
    • Ding S, Wu X, Li G, Han M, Zhuang Y, et al. (2005) Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell 122: 473-483.
    • (2005) Cell , vol.122 , pp. 473-483
    • Ding, S.1    Wu, X.2    Li, G.3    Han, M.4    Zhuang, Y.5
  • 27
    • 0030662074 scopus 로고    scopus 로고
    • Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
    • Ivics Z, Hackett PB, Plasterk RH, Izsvak Z, (1997) Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91: 501-510.
    • (1997) Cell , vol.91 , pp. 501-510
    • Ivics, Z.1    Hackett, P.B.2    Plasterk, R.H.3    Izsvak, Z.4
  • 28
    • 0034103009 scopus 로고    scopus 로고
    • Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system
    • Yant SR, Meuse L, Chiu W, Ivics Z, Izsvak Z, et al. (2000) Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. Nat Genet 25: 35-41.
    • (2000) Nat Genet , vol.25 , pp. 35-41
    • Yant, S.R.1    Meuse, L.2    Chiu, W.3    Ivics, Z.4    Izsvak, Z.5
  • 29
    • 34547638572 scopus 로고    scopus 로고
    • Generation of an inducible and optimized piggyBac transposon system
    • Cadinanos J, Bradley A, (2007) Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res 35: e87.
    • (2007) Nucleic Acids Res , vol.35
    • Cadinanos, J.1    Bradley, A.2
  • 30
    • 13144261694 scopus 로고    scopus 로고
    • Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells
    • Luo G, Ivics Z, Izsvak Z, Bradley A, (1998) Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc Natl Acad Sci U S A 95: 10769-10773.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 10769-10773
    • Luo, G.1    Ivics, Z.2    Izsvak, Z.3    Bradley, A.4
  • 31
    • 48249130858 scopus 로고    scopus 로고
    • Chromosomal transposition of PiggyBac in mouse embryonic stem cells
    • Wang W, Lin C, Lu D, Ning Z, Cox T, et al. (2008) Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci U S A 105: 9290-9295.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9290-9295
    • Wang, W.1    Lin, C.2    Lu, D.3    Ning, Z.4    Cox, T.5
  • 33
    • 58349109081 scopus 로고    scopus 로고
    • De novo induction of genetically engineered brain tumors in mice using plasmid DNA
    • Wiesner SM, Decker SA, Larson JD, Ericson K, Forster C, et al. (2009) De novo induction of genetically engineered brain tumors in mice using plasmid DNA. Cancer Res 69: 431-439.
    • (2009) Cancer Res , vol.69 , pp. 431-439
    • Wiesner, S.M.1    Decker, S.A.2    Larson, J.D.3    Ericson, K.4    Forster, C.5
  • 34
    • 39149118329 scopus 로고    scopus 로고
    • Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection
    • Bell JB, Podetz-Pedersen KM, Aronovich EL, Belur LR, McIvor RS, et al. (2007) Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc 2: 3153-3165.
    • (2007) Nat Protoc , vol.2 , pp. 3153-3165
    • Bell, J.B.1    Podetz-Pedersen, K.M.2    Aronovich, E.L.3    Belur, L.R.4    McIvor, R.S.5
  • 35
    • 73849086119 scopus 로고    scopus 로고
    • PiggyBac transposon-based inducible gene expression in vivo after somatic cell gene transfer
    • Saridey SK, Liu L, Doherty JE, Kaja A, Galvan DL, et al. (2009) PiggyBac transposon-based inducible gene expression in vivo after somatic cell gene transfer. Mol Ther 17: 2115-2120.
    • (2009) Mol Ther , vol.17 , pp. 2115-2120
    • Saridey, S.K.1    Liu, L.2    Doherty, J.E.3    Kaja, A.4    Galvan, D.L.5
  • 37
    • 65449154892 scopus 로고    scopus 로고
    • Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
    • Yusa K, Rad R, Takeda J, Bradley A, (2009) Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 6: 363-369.
    • (2009) Nat Methods , vol.6 , pp. 363-369
    • Yusa, K.1    Rad, R.2    Takeda, J.3    Bradley, A.4
  • 39
    • 70349696650 scopus 로고    scopus 로고
    • Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes
    • Nakazawa Y, Huye LE, Dotti G, Foster AE, Vera JF, et al. (2009) Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes. J Immunother 32: 826-836.
    • (2009) J Immunother , vol.32 , pp. 826-836
    • Nakazawa, Y.1    Huye, L.E.2    Dotti, G.3    Foster, A.E.4    Vera, J.F.5
  • 40
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, et al. The landscape of somatic copy-number alteration across human cancers. Nature 463: 899-905.
    • Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3    Wei, G.4    Raychaudhuri, S.5
  • 42
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5
  • 43
    • 55849099654 scopus 로고    scopus 로고
    • Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
    • Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, et al. (2008) Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A 105: 16224-16229.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16224-16229
    • Leary, R.J.1    Lin, J.C.2    Cummins, J.3    Boca, S.4    Wood, L.D.5
  • 44
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, et al. (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321: 1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5
  • 45
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3    Parsons, D.W.4    Lin, J.5
  • 46
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjoblom, T.5
  • 47
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • Meyerson M, Gabriel S, Getz G, Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet 11: 685-696.
    • Nat Rev Genet , vol.11 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 48
    • 33748331308 scopus 로고    scopus 로고
    • The mighty mouse: genetically engineered mouse models in cancer drug development
    • Sharpless NE, Depinho RA, (2006) The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 5: 741-754.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 741-754
    • Sharpless, N.E.1    Depinho, R.A.2
  • 49
    • 0025633816 scopus 로고
    • In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts
    • Fiebig HH, Berger DP, Winterhalter BR, Plowman J, (1990) In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts. Cancer Treat Rev 17: 109-117.
    • (1990) Cancer Treat Rev , vol.17 , pp. 109-117
    • Fiebig, H.H.1    Berger, D.P.2    Winterhalter, B.R.3    Plowman, J.4
  • 50
    • 2042458747 scopus 로고    scopus 로고
    • Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
    • Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti JM, et al. (2001) Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 84: 1424-1431.
    • (2001) Br J Cancer , vol.84 , pp. 1424-1431
    • Johnson, J.I.1    Decker, S.2    Zaharevitz, D.3    Rubinstein, L.V.4    Venditti, J.M.5
  • 52
    • 67651102866 scopus 로고    scopus 로고
    • Humanized mice for modeling human infectious disease: challenges, progress, and outlook
    • Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, et al. (2009) Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe 6: 5-9.
    • (2009) Cell Host Microbe , vol.6 , pp. 5-9
    • Legrand, N.1    Ploss, A.2    Balling, R.3    Becker, P.D.4    Borsotti, C.5
  • 53
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • Shultz LD, Ishikawa F, Greiner DL, (2007) Humanized mice in translational biomedical research. Nat Rev Immunol 7: 118-130.
    • (2007) Nat Rev Immunol , vol.7 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 54
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S, (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 55
    • 37549030199 scopus 로고    scopus 로고
    • Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
    • Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, et al. (2007) Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318: 1920-1923.
    • (2007) Science , vol.318 , pp. 1920-1923
    • Hanna, J.1    Wernig, M.2    Markoulaki, S.3    Sun, C.W.4    Meissner, A.5
  • 56
    • 77955454021 scopus 로고    scopus 로고
    • Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
    • Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, et al. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci U S A 107: 12704-12709.
    • Proc Natl Acad Sci U S A , vol.107 , pp. 12704-12709
    • Tsuji, O.1    Miura, K.2    Okada, Y.3    Fujiyoshi, K.4    Mukaino, M.5
  • 57
    • 58849113643 scopus 로고    scopus 로고
    • Phenotypic correction of murine hemophilia A using an iPS cell-based therapy
    • Xu D, Alipio Z, Fink LM, Adcock DM, Yang J, et al. (2009) Phenotypic correction of murine hemophilia A using an iPS cell-based therapy. Proc Natl Acad Sci U S A 106: 808-813.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 808-813
    • Xu, D.1    Alipio, Z.2    Fink, L.M.3    Adcock, D.M.4    Yang, J.5
  • 58
    • 77955814966 scopus 로고    scopus 로고
    • Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells
    • Alipio Z, Liao W, Roemer EJ, Waner M, Fink LM, et al. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci U S A 107: 13426-13431.
    • Proc Natl Acad Sci U S A , vol.107 , pp. 13426-13431
    • Alipio, Z.1    Liao, W.2    Roemer, E.J.3    Waner, M.4    Fink, L.M.5
  • 59
    • 42649130264 scopus 로고    scopus 로고
    • Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    • Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, et al. (2008) Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A 105: 5856-5861.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5856-5861
    • Wernig, M.1    Zhao, J.P.2    Pruszak, J.3    Hedlund, E.4    Fu, D.5
  • 61
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5
  • 62
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells
    • Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, et al. (2008) Disease-specific induced pluripotent stem cells. Cell 134: 877-886.
    • (2008) Cell , vol.134 , pp. 877-886
    • Park, I.H.1    Arora, N.2    Huo, H.3    Maherali, N.4    Ahfeldt, T.5
  • 63
    • 70349454058 scopus 로고    scopus 로고
    • Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
    • Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, et al. (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell 16: 324-335.
    • (2009) Cancer Cell , vol.16 , pp. 324-335
    • Bric, A.1    Miething, C.2    Bialucha, C.U.3    Scuoppo, C.4    Zender, L.5
  • 64
    • 70349536006 scopus 로고    scopus 로고
    • In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression
    • Meacham CE, Ho EE, Dubrovsky E, Gertler FB, Hemann MT, (2009) In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat Genet 41: 1133-1137.
    • (2009) Nat Genet , vol.41 , pp. 1133-1137
    • Meacham, C.E.1    Ho, E.E.2    Dubrovsky, E.3    Gertler, F.B.4    Hemann, M.T.5
  • 65
    • 56349121125 scopus 로고    scopus 로고
    • An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
    • Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, et al. (2008) An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135: 852-864.
    • (2008) Cell , vol.135 , pp. 852-864
    • Zender, L.1    Xue, W.2    Zuber, J.3    Semighini, C.P.4    Krasnitz, A.5
  • 66
    • 0029892554 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis as a strategy to identify cancer genes
    • Jonkers J, Berns A, (1996) Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim Biophys Acta 1287: 29-57.
    • (1996) Biochim Biophys Acta , vol.1287 , pp. 29-57
    • Jonkers, J.1    Berns, A.2
  • 67
    • 27944496521 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis: past, present and future
    • Uren AG, Kool J, Berns A, van Lohuizen M, (2005) Retroviral insertional mutagenesis: past, present and future. Oncogene 24: 7656-7672.
    • (2005) Oncogene , vol.24 , pp. 7656-7672
    • Uren, A.G.1    Kool, J.2    Berns, A.3    van Lohuizen, M.4
  • 68
    • 67649450275 scopus 로고    scopus 로고
    • High-throughput insertional mutagenesis screens in mice to identify oncogenic networks
    • Kool J, Berns A, (2009) High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nat Rev Cancer 9: 389-399.
    • (2009) Nat Rev Cancer , vol.9 , pp. 389-399
    • Kool, J.1    Berns, A.2
  • 69
    • 0037235453 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis: tagging cancer pathways
    • Mikkers H, Berns A, (2003) Retroviral insertional mutagenesis: tagging cancer pathways. Adv Cancer Res 88: 53-99.
    • (2003) Adv Cancer Res , vol.88 , pp. 53-99
    • Mikkers, H.1    Berns, A.2
  • 70
    • 0023848501 scopus 로고
    • Insertional mutagenesis of the Drosophila genome with single P elements
    • Cooley L, Kelley R, Spradling A, (1988) Insertional mutagenesis of the Drosophila genome with single P elements. Science 239: 1121-1128.
    • (1988) Science , vol.239 , pp. 1121-1128
    • Cooley, L.1    Kelley, R.2    Spradling, A.3
  • 71
    • 0017742999 scopus 로고
    • Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics
    • Kleckner N, Roth J, Botstein D, (1977) Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol 116: 125-159.
    • (1977) J Mol Biol , vol.116 , pp. 125-159
    • Kleckner, N.1    Roth, J.2    Botstein, D.3
  • 72
    • 34347337601 scopus 로고    scopus 로고
    • Toward simpler and faster genome-wide mutagenesis in mice
    • Wu S, Ying G, Wu Q, Capecchi MR, (2007) Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet 39: 922-930.
    • (2007) Nat Genet , vol.39 , pp. 922-930
    • Wu, S.1    Ying, G.2    Wu, Q.3    Capecchi, M.R.4
  • 73
    • 0034964286 scopus 로고    scopus 로고
    • Transposition and gene disruption in the male germline of the mouse
    • Dupuy AJ, Fritz S, Largaespada DA, (2001) Transposition and gene disruption in the male germline of the mouse. Genesis 30: 82-88.
    • (2001) Genesis , vol.30 , pp. 82-88
    • Dupuy, A.J.1    Fritz, S.2    Largaespada, D.A.3
  • 74
    • 0035810931 scopus 로고    scopus 로고
    • Regulated transposition of a fish transposon in the mouse germ line
    • Fischer SE, Wienholds E, Plasterk RH, (2001) Regulated transposition of a fish transposon in the mouse germ line. Proc Natl Acad Sci U S A 98: 6759-6764.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6759-6764
    • Fischer, S.E.1    Wienholds, E.2    Plasterk, R.H.3
  • 75
    • 0035979255 scopus 로고    scopus 로고
    • Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice
    • Horie K, Kuroiwa A, Ikawa M, Okabe M, Kondoh G, et al. (2001) Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A 98: 9191-9196.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9191-9196
    • Horie, K.1    Kuroiwa, A.2    Ikawa, M.3    Okabe, M.4    Kondoh, G.5
  • 76
    • 58749102564 scopus 로고    scopus 로고
    • The expanding role of mouse genetics for understanding human biology and disease
    • Nguyen D, Xu T, (2008) The expanding role of mouse genetics for understanding human biology and disease. Dis Model Mech 1: 56-66.
    • (2008) Dis Model Mech , vol.1 , pp. 56-66
    • Nguyen, D.1    Xu, T.2
  • 77
    • 62949113127 scopus 로고    scopus 로고
    • A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells
    • Wang W, Bradley A, Huang Y, (2009) A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells. Genome Res 19: 667-673.
    • (2009) Genome Res , vol.19 , pp. 667-673
    • Wang, W.1    Bradley, A.2    Huang, Y.3
  • 78
    • 77951702702 scopus 로고    scopus 로고
    • Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas
    • Bender AM, Collier LS, Rodriguez FJ, Tieu C, Larson JD, et al. Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas. Cancer Res 70: 3557-3565.
    • Cancer Res , vol.70 , pp. 3557-3565
    • Bender, A.M.1    Collier, L.S.2    Rodriguez, F.J.3    Tieu, C.4    Larson, J.D.5
  • 79
    • 70350537021 scopus 로고    scopus 로고
    • Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality
    • Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, et al. (2009) Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res 69: 8429-8437.
    • (2009) Cancer Res , vol.69 , pp. 8429-8437
    • Collier, L.S.1    Adams, D.J.2    Hackett, C.S.3    Bendzick, L.E.4    Akagi, K.5
  • 80
    • 22444444402 scopus 로고    scopus 로고
    • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
    • Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA, (2005) Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436: 272-276.
    • (2005) Nature , vol.436 , pp. 272-276
    • Collier, L.S.1    Carlson, C.M.2    Ravimohan, S.3    Dupuy, A.J.4    Largaespada, D.A.5
  • 81
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA, (2005) Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436: 221-226.
    • (2005) Nature , vol.436 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3    Copeland, N.G.4    Jenkins, N.A.5
  • 82
    • 70350227239 scopus 로고    scopus 로고
    • A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice
    • Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, et al. (2009) A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res 69: 8150-8156.
    • (2009) Cancer Res , vol.69 , pp. 8150-8156
    • Dupuy, A.J.1    Rogers, L.M.2    Kim, J.3    Nannapaneni, K.4    Starr, T.K.5
  • 83
    • 78449294626 scopus 로고    scopus 로고
    • PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice
    • Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, et al. PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice. Science.
    • Science
    • Rad, R.1    Rad, L.2    Wang, W.3    Cadinanos, J.4    Vassiliou, G.5
  • 84
    • 62149116794 scopus 로고    scopus 로고
    • A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
    • Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, et al. (2009) A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol 27: 264-274.
    • (2009) Nat Biotechnol , vol.27 , pp. 264-274
    • Keng, V.W.1    Villanueva, A.2    Chiang, D.Y.3    Dupuy, A.J.4    Ryan, B.J.5
  • 85
    • 63049105067 scopus 로고    scopus 로고
    • A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
    • Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, et al. (2009) A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 323: 1747-1750.
    • (2009) Science , vol.323 , pp. 1747-1750
    • Starr, T.K.1    Allaei, R.2    Silverstein, K.A.3    Staggs, R.A.4    Sarver, A.L.5
  • 86
    • 79955469651 scopus 로고    scopus 로고
    • Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
    • Vassiliou GS, Cooper JL, Rad R, Li J, Rice S, et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet.
    • Nat Genet
    • Vassiliou, G.S.1    Cooper, J.L.2    Rad, R.3    Li, J.4    Rice, S.5
  • 87
    • 70349176337 scopus 로고    scopus 로고
    • Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons
    • Liang Q, Kong J, Stalker J, Bradley A, (2009) Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons. Genesis 47: 404-408.
    • (2009) Genesis , vol.47 , pp. 404-408
    • Liang, Q.1    Kong, J.2    Stalker, J.3    Bradley, A.4
  • 88
    • 85049057026 scopus 로고    scopus 로고
    • Gene Transfer Efficiency and Genome-Wide Integration Profiling of Sleeping Beauty, Tol2, and PiggyBac Transposons in Human Primary T Cells
    • Huang X, Guo H, Tammana S, Jung YC, Mellgren E, et al. Gene Transfer Efficiency and Genome-Wide Integration Profiling of Sleeping Beauty, Tol2, and PiggyBac Transposons in Human Primary T Cells. Mol Ther.
    • Mol Ther
    • Huang, X.1    Guo, H.2    Tammana, S.3    Jung, Y.C.4    Mellgren, E.5
  • 89
    • 0030199150 scopus 로고    scopus 로고
    • Excision of the piggyBac transposable element in vitro is a precise event that is enhanced by the expression of its encoded transposase
    • Elick TA, Bauser CA, Fraser MJ, (1996) Excision of the piggyBac transposable element in vitro is a precise event that is enhanced by the expression of its encoded transposase. Genetica 98: 33-41.
    • (1996) Genetica , vol.98 , pp. 33-41
    • Elick, T.A.1    Bauser, C.A.2    Fraser, M.J.3
  • 90
    • 9144274389 scopus 로고    scopus 로고
    • Excision of Sleeping Beauty transposons: parameters and applications to gene therapy
    • Liu G, Aronovich EL, Cui Z, Whitley CB, Hackett PB, (2004) Excision of Sleeping Beauty transposons: parameters and applications to gene therapy. J Gene Med 6: 574-583.
    • (2004) J Gene Med , vol.6 , pp. 574-583
    • Liu, G.1    Aronovich, E.L.2    Cui, Z.3    Whitley, C.B.4    Hackett, P.B.5
  • 91
    • 27144450204 scopus 로고    scopus 로고
    • Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system
    • Keng VW, Yae K, Hayakawa T, Mizuno S, Uno Y, et al. (2005) Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nat Methods 2: 763-769.
    • (2005) Nat Methods , vol.2 , pp. 763-769
    • Keng, V.W.1    Yae, K.2    Hayakawa, T.3    Mizuno, S.4    Uno, Y.5
  • 92
    • 33749416026 scopus 로고    scopus 로고
    • Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers
    • doi:10.1371/journal.pgen.0020156
    • Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, et al. (2006) Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet 2: e156 doi:10.1371/journal.pgen.0020156.
    • (2006) PLoS Genet , vol.2
    • Geurts, A.M.1    Collier, L.S.2    Geurts, J.L.3    Oseth, L.L.4    Bell, M.L.5
  • 93
    • 0035341376 scopus 로고    scopus 로고
    • Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development
    • Lee T, Luo L, (2001) Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci 24: 251-254.
    • (2001) Trends Neurosci , vol.24 , pp. 251-254
    • Lee, T.1    Luo, L.2
  • 94
    • 0242666126 scopus 로고    scopus 로고
    • A genetic screen in Drosophila for metastatic behavior
    • Pagliarini RA, Xu T, (2003) A genetic screen in Drosophila for metastatic behavior. Science 302: 1227-1231.
    • (2003) Science , vol.302 , pp. 1227-1231
    • Pagliarini, R.A.1    Xu, T.2
  • 95
    • 0027267041 scopus 로고
    • Analysis of genetic mosaics in developing and adult Drosophila tissues
    • Xu T, Rubin GM, (1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
    • (1993) Development , vol.117 , pp. 1223-1237
    • Xu, T.1    Rubin, G.M.2
  • 96
    • 38649140712 scopus 로고    scopus 로고
    • Transparent adult zebrafish as a tool for in vivo transplantation analysis
    • White RM, Sessa A, Burke C, Bowman T, LeBlanc J, et al. (2008) Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell 2: 183-189.
    • (2008) Cell Stem Cell , vol.2 , pp. 183-189
    • White, R.M.1    Sessa, A.2    Burke, C.3    Bowman, T.4    LeBlanc, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.