Molecular modeling of drug-DNA interactions: Virtual screening to structure-based design

Biochimie

Volumn 93, Issue 8, 2011, Pages 1252-1266

  Ma, Dik Lung ^a   Chan, Daniel Shiu Hin ^a   Lee, Paul ^a   Kwan, Maria Hiu Tung ^a   Leung, Chung Hang ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Drug DNA interactions; G quadruplex DNA; Structure based design; Virtual screening

Indexed keywords

ACRIDINE DERIVATIVE; DAUNORUBICIN; DISTAMYCIN A; ELLIPTICINE; GUANINE QUADRUPLEX; TELOMESTATIN;

DNA STRUCTURE; DRUG DESIGN; DRUG DNA INTERACTION; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; LIGAND BINDING; MOLECULAR MODEL; REVIEW;

EID: 79960697801     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.04.002     Document Type: Short Survey

References (106)

1. J.D. Watson, and F.H.C. Crick Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid Nature 171 1953 737 738
2. M.F. Gellert, M.N. Lipsett, and D.H. Davies Helix formation by guanylic acid Proc. Natl. Acad. Sci. U S A 48 1962 2013 2018
3. R. Langridge, and A. Rich Molecular structure of helical polycytidylic acid Nature 198 1963 725 728
4. K. Gehring, J.L. Leroy, and M. Gueron A tetrameric DNA structure with protonated cytosine-cytosine base pairs Nature 363 1993 561 565 (Pubitemid 23186646)
5. G. Felsenfeld, D.R. Davies, and A. Rich Formation of a three-stranded polynucleotide molecule J. Am. Chem. Soc. 79 1957 2023 2024
6. K.R. Fox Targeting DNA with triplexes Curr. Med. Chem. 7 2000 17 37 (Pubitemid 30395447)
7. K.M. Vasquez, and J.H. Wilson Triplex-directed modification of genes and gene activity Trends Biochem. Sci. 23 1998 4 9 (Pubitemid 28093985)
8. D. Praseuth, A.L. Guieysse, and C. Helene Triple helix formation and the antigene strategy for sequence-specific control of gene expression Biochim. Biophys. Acta Gene Struct. Expr. 1489 1999 181 206
9. J.L. Huppert, and S. Balasubramanian G-quadruplexes in promoters throughout the human genome Nucleic Acids Res. 35 2007 406 413 (Pubitemid 46232058)
10. A. Siddiqui-Jain, C.L. Grand, D.J. Bearss, and L.H. Hurley Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription Proc. Natl. Acad. Sci. U S A 99 2002 11593 11598 (Pubitemid 34994444)
11. T.-m. Ou, Y.-j. Lu, J.-h. Tan, Z.-s. Huang, K.-Y. Wong, and L.-q. Gu G-quadruplexes: targets in anticancer drug design ChemMedChem 3 2008 690 713
12. S. Balasubramanian, and S. Neidle G-quadruplex nucleic acids as therapeutic targets Curr. Opin. Chem. Biol. 13 2009 345 353
13. S. Neidle DNA minor-groove recognition by small molecules Nat. Prod. Rep. 18 2001 291 309 (Pubitemid 32589165)
14. X. Cai, P.J. Gray Jr.; and H.D.D. Von DNA minor groove binders: Back in the groove Cancer Treat. Rev. 35 2009 437 450
15. E.T. Kool Hydrogen bonding, base stacking, and steric effects in DNA replication Annu. Rev. Biophys. Biomol. Struct. 30 2001 1 22 (Pubitemid 32566154)
16. B.A.D. Neto, and A.A.M. Lapis Recent developments in the chemistry of deoxyribonucleic acid (DNA) intercalators: principles, design, synthesis, applications and trends Molecules 14 2009 1725 1746
17. N.J. Wheate, C.R. Brodie, J.G. Collins, S. Kemp, and J.R. Aldrich-Wright DNA intercalators in cancer therapy: organic and inorganic drugs and their spectroscopic tools of analysis Mini-Rev. Med. Chem. 7 2007 627 648 (Pubitemid 47099183)
18. A. Ambrus, D. Chen, J. Dai, R.A. Jones, and D. Yang Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization Biochemistry 44 2005 2048 2058 (Pubitemid 40227475)
19. D. Yang, and L.H. Hurley Structure of the biologically relevant G-quadruplex in the c-MYC promoter Nucleosides Nucleotides Nucleic Acids 25 2006 951 968 (Pubitemid 44180039)
20. A.K. Todd, S.M. Haider, G.N. Parkinson, and S. Neidle Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter Nucleic Acids Res. 35 2007 5799 5808 (Pubitemid 47506295)
21. S.-T.D. Hsu, P. Varnai, A. Bugaut, A.P. Reszka, S. Neidle, and S. Balasubramanian A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics J. Am. Chem. Soc. 131 2009 13399 13409
22. J. Dai, T.S. Dexheimer, D. Chen, M. Carver, A. Ambrus, R.A. Jones, and D. Yang An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution J. Am. Chem. Soc. 128 2006 1096 1098 (Pubitemid 43190620)
23. T.S. Dexheimer, D. Sun, and L.H. Hurley Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 p.omoter J. Am. Chem. Soc. 128 2006 5404 5415
24. A.R. De, S. Wood, D. Sun, L.H. Hurley, and S.W. Ebbinghaus Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1α promoter Biochemistry 44 2005 16341 16350 (Pubitemid 41785833)
25. K. Guo, V. Gokhale, L.H. Hurley, and D. Sun Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene Nucleic Acids Res. 36 2008 4598 4608
26. D. Sun, W.-J. Liu, K. Guo, J.J. Rusche, S. Ebbinghaus, V. Gokhale, and L.H. Hurley The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents Mol. Cancer Ther. 7 2008 880 889 (Pubitemid 351551041)
27. R.A. Alderden, M.D. Hall, and T.W. Hambley The discovery and development of cisplatin J. Chem. Educ. 83 2006 728 734
28. J. Liu, C.-H. Leung, A.L.-F. Chow, R.W.-Y. Sun, S.-C. Yan, and C.-M. Che Cyclometalated platinum(II) complexes as topoisomerase IIα poisons Chem. Commun. (Cambridge, U. K.) 47 2010 719 721
29. P. Wang, C.-H. Leung, D.-L. Ma, W. Lu, and C.-M. Che Organoplatinum(II) complexes with nucleobase motifs as inhibitors of human topoisomerase II catalytic activity Chem.-Asian J. 5 2010 2271 2280
30. H.M. Berman The protein data bank and the challenge of structural genomics Nat. Struct. Biol. 7 2000 957 959
31. J. Westbrook, Z. Feng, L. Chen, H. Yang, and H.M. Berman The protein data bank and structural genomics Nucleic Acids Res. 31 2003 489 491 (Pubitemid 36150437)
32. T.L. Blundell, H. Jhoti, and C. Abell High-throughput crystallography for lead discovery in drug design Nat. Rev. Drug Discov. 1 2002 45 54 (Pubitemid 37361403)
33. A. Sharff, and H. Jhoti High-throughput crystallography to enhance drug discovery Curr. Opin. Chem. Biol. 7 2003 340 345 (Pubitemid 36782360)
34. L.W. Tari, D.E. McRee, and A.J. Jennings Use of high-throughput crystallography and in silico methods for structure-based drug design Methods Biochem. Anal. 45 2005 107 129
35. R. Powers Advances in nuclear magnetic resonance for drug discovery Expert Opin. Drug Discov. 4 2009 1077 1098
36. G. Liu, Y. Shen, H.S. Atreya, D. Parish, Y. Shao, D.K. Sukumaran, R. Xiao, A. Yee, A. Lemak, and A. Bhattacharya NMR data collection and analysis protocol for high-throughput protein structure determination Proc. Natl. Acad. Sci. U S A 102 2005 10487 10492 (Pubitemid 41061581)
37. B.O. Villoutreix, R. Eudes, and M.A. Miteva Structure-based virtual ligand screening: recent success stories Comb. Chem. High Throughput Screen. 12 2009 1000 1016
38. M. Pellecchia Fragment-based drug discovery takes a virtual turn Nat. Chem. Biol. 5 2009 274 275
39. C.N. Cavasotto, and A.J.W. Orry Ligand docking and structure-based virtual screening in drug discovery Curr. Top. Med. Chem. 7 2007 1006 1014 (Pubitemid 47040528)
40. D.S.-H. Chan, H.-M. Lee, F. Yang, C.-M. Che, C.C.L. Wong, R. Abagyan, C.-H. Leung, and D.-L. Ma Structure-based discovery of natural-product-like TNF-α inhibitors Angew. Chem. Int. Ed. 49 2010 2860 2864
41. C.-H. Leung, D.S.-H. Chan, R. Abagyan, S.M.-Y. Lee, G.-Y. Zhu, W.-F. Fong, and D.-L. Ma A Natural Product-Like Inhibitor of NEDD8-Activating Enzyme, Chem Comm 47 2011 2511 2513
42. E.M. Bowers, G. Yan, C. Mukherjee, A. Orry, L. Wang, M.A. Holbert, N.T. Crump, C.A. Hazzalin, G. Liszczak, and H. Yuan Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor Chem. Biol. (Cambridge, MA, U. S.) 17 2010 471 482
43. M. Montes, E. Braud, M.A. Miteva, M.-L. Goddard, O. Mondesert, S. Kolb, M.-P. Brun, B. Ducommun, C. Garbay, and B.O. Villoutreix Receptor-based virtual ligand screening for the identification of novel CDC25 p.osphatase inhibitors J. Chem. Inf. Model. 48 2008 157 165 (Pubitemid 351271061)
44. M.M. Dailey, C. Hait, P.A. Holt, J.M. Maguire, J.B. Meier, M.C. Miller, L. Petraccone, and J.O. Trent Structure-based drug design: from nucleic acid to membrane protein targets Exp. Mol. Pathol. 86 2009 141 150
45. M.D. Frank-Kamenetskii, and S.M. Mirkin Triplex DNA structures Annu. Rev. Biochem. 64 1995 65 95
46. A. Kalota, S.E. Shetzline, and A.M. Gewirtz Progress in the development of nucleic acid therapeutics for cancer Cancer Biol. Ther. 3 2004 4 12 (Pubitemid 41348538)
47. J.Y. Chin, E.B. Schleifman, and P.M. Glazer Repair and recombination induced by triple helix DNA Front. Biosci. 12 2007 4288 4297
48. M.M. Seidman, N. Puri, A. Majumdar, B. Cuenoud, P.S. Miller, and R. Alam The development of bioactive triple helix-forming oligonucleotides Ann. N. Y. Acad. Sci. 1058 2005 119 127
49. H.-G. Kim, J.F. Reddoch, C. Mayfield, S. Ebbinghaus, N. Vigneswaran, S. Thomas, and D.M. Miller Inhibition of transcription of the human c-myc protooncogene by intermolecular triplex Biochemistry 37 1998 2299 2304 (Pubitemid 28119303)
50. M.M. Seidman, and P.M. Glazer The potential for gene repair via triple helix formation J. Clin. Invest. 112 2003 487 494 (Pubitemid 38056331)
51. G.M. Carbone, E. McGuffie, S. Napoli, C.E. Flanagan, C. Dembech, U. Negri, F. Arcamone, M.L. Capobianco, and C.V. Catapano DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 p.omoter of the human c-myc gene Nucleic Acids Res. 32 2004 2396 2410 (Pubitemid 38854794)
52. J. Lacoste, J.-C. Francois, and C. Helene Triple helix formation with purine-rich phosphorothioate-containing oligonucleotides covalently linked to an acridine derivative Nucleic Acids Res. 25 1997 1991 1998 (Pubitemid 27303395)
53. C. Marchand, C. Bailly, C.H. Nguyen, E. Bisagni, T. Garestier, C. Helene, and M.J. Waring Stabilization of triple helical DNA by a benzopyridoquinoxaline intercalator Biochemistry 35 1996 5022 5032 (Pubitemid 26126719)
54. A.A. Moraru-Allen, S. Cassidy, J.-L.A. Alvarez, K.R. Fox, T. Brown, and A.N. Lane Coralyne has a preference for intercalation between TA-T triples in intramolecular DNA triple helixes Nucleic Acids Res. 25 1997 1890 1896 (Pubitemid 27303382)
55. B.A. Janowski, J. Hu, and D.R. Corey Silencing gene expression by targeting chromosomal DNA with antigene peptide nucleic acids and duplex RNAs Nat. Protoc. 1 2006 436 443
56. R.L. Beane, R. Ram, S. Gabillet, K. Arar, B.P. Monia, and D.R. Corey Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA Biochemistry 46 2007 7572 7580 (Pubitemid 46986381)
57. M. Keppler, O. Zegrocka, L. Strekowski, and K.R. Fox DNA triple helix stabilization by a naphthylquinoline dimer FEBS Lett. 447 1999 223 226 (Pubitemid 29146090)
58. O. Baudoin, C. Marchand, M.-P. Teulade-Fichou, J.-P. Vigneron, J.-S. Sun, T. Garestier, C. Helene, and J.-M. Lehn Stabilization of DNA triple helixes by crescent-shaped dibenzophenanthrolines Chem.-Eur. J. 4 1998 1504 1508 (Pubitemid 28382531)
59. J.B. Chaires, J. Ren, M. Henary, O. Zegrocka, G.R. Bishop, and L. Strekowski Triplex selective 2-(2-naphthyl)quinoline compounds: origins of affinity and new design principles J. Am. Chem. Soc. 125 2003 7272 7283 (Pubitemid 36798973)
60. P.A. Holt, P. Ragazzon, L. Strekowski, J.B. Chaires, and J.O. Trent Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform Nucleic Acids Res. 37 2009 1280 1287
61. A.H. Fairlamb Chemotherapy of human African trypanosomiasis: current and future prospects Trends Parasitol. 19 2003 488 494 (Pubitemid 37329657)
62. J. Mann, A. Baron, Y. Opoku-Boahen, E. Johansson, G. Parkinson, L.R. Kelland, and S. Neidle A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity J. Med. Chem. 44 2001 138 144 (Pubitemid 32096658)
63. R.K. Arafa, R. Brun, T. Wenzler, F.A. Tanious, W.D. Wilson, C.E. Stephens, and D.W. Boykin Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs J. Med. Chem. 48 2005 5480 5488 (Pubitemid 41209245)
64. D.A. Evans, and S. Neidle Virtual screening of DNA minor groove binders J. Med. Chem. 49 2006 4232 4238 (Pubitemid 44036666)
65. S. Mallena, M.P.H. Lee, C. Bailly, S. Neidle, A. Kumar, D.W. Boykin, and W.D. Wilson Thiophene-based diamidine forms a "super" at binding minor groove agent J. Am. Chem. Soc. 126 2004 13659 13669 (Pubitemid 39407245)
66. P.A. Holt, J.B. Chaires, and J.O. Trent Molecular docking of intercalators and groove-binders to nucleic acids using autodock and surflex J. Chem. Inf. Model. 48 2008 1602 1615
67. S. Cosconati, L. Marinelli, R. Trotta, A. Virno, L. Mayol, E. Novellino, A.J. Olson, and A. Randazzo Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders J. Am. Chem. Soc. 131 2009 16336 16337
68. J. Dash, P.S. Shirude, S.-T.D. Hsu, and S. Balasubramanian Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes J. Am. Chem. Soc. 130 2008 15950 15956
69. Q. Li, J. Xiang, X. Li, L. Chen, X. Xu, Y. Tang, Q. Zhou, L. Li, H. Zhang, and H. Sun Stabilizing parallel G-quadruplex DNA by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves Biochimie 91 2009 811 819
70. + ions Nucleic Acids Res. 32 2004 1097 1102 (Pubitemid 38854711)
71. S. Cosconati, L. Marinelli, R. Trotta, A. Virno, T.S. De, R. Romagnoli, B. Pagano, V. Limongelli, C. Giancola, and P.G. Baraldi Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle J. Am. Chem. Soc. 132 2010 6425 6433
72. L. Martino, A. Virno, B. Pagano, A. Virgilio, M.S. Di, A. Galeone, C. Giancola, G. Bifulco, L. Mayol, and A. Randazzo Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4 J. Am. Chem. Soc. 129 2007 16048 16056
73. F.X. Han, R.T. Wheelhouse, and L.H. Hurley Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition J. Am. Chem. Soc. 121 1999 3561 3570 (Pubitemid 29200264)
74. C.L. Grand, H. Han, R.M. Munoz, S. Weitman, H.D.D. Von, L.H. Hurley, and D.J. Bearss The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo Mol. Cancer Ther. 1 2002 565 573
75. T.M. del, P. Bucek, A. Avino, J. Jaumot, C. Gonzalez, R. Eritja, and R. Gargallo Targeting the G-quadruplex-forming region near the P1 p.omoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and with the complementary C-rich strand Biochimie 91 2009 894 902
76. Y.-J. Lu, T.-M. Ou, J.-H. Tan, J.-Q. Hou, W.-Y. Shao, D. Peng, N. Sun, X.-D. Wang, W.-B. Wu, and X.-Z. Bu 5-N-methylated quindoline derivatives as telomeric G-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation J. Med. Chem. 51 2008 6381 6392
77. X.-D. Wang, T.-M. Ou, Y.-J. Lu, Z. Li, Z. Xu, C. Xi, J.-H. Tan, S.-L. Huang, L.-K. An, and D. Li Turning off transcription of the bcl-2 gene by Stabilizing the bcl-2 promoter quadruplex with quindoline derivatives J. Med. Chem. 53 2010 4390 4398
78. Z.A.E. Waller, P.S. Shirude, R. Rodriguez, and S. Balasubramanian Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition Chem. Commun. 2008 2008 1467 1469 (Pubitemid 351367583)
79. M. Bejugam, S. Sewitz, P.S. Shirude, R. Rodriguez, R. Shahid, and S. Balasubramanian Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression J. Am. Chem. Soc. 129 2007 12926 12927 (Pubitemid 350058320)
80. D.-L. Ma, T.-S. Lai, F.-Y. Chan, W.-H. Chung, R. Abagyan, Y.-C. Leung, and K.-Y. Wong Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking ChemMedChem 3 2008 881 884
81. G.N. Parkinson, M.P.H. Lee, and S. Neidle Crystal structure of parallel quadruplexes from human telomeric DNA Nature (London, U. K.) 417 2002 876 880 (Pubitemid 34670337)
82. C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 23 1997 3 25 (Pubitemid 27046991)
83. M. Totrov, and R. Abagyan Flexible protein-ligand docking by global energy optimization in internal coordinates Proteins Suppl. 1 1997 215 220 (Pubitemid 28090502)
84. H.-M. Lee, D.S.-H. Chan, F. Yang, H.-Y. Lam, S.-C. Yan, C.-M. Che, D.-L. Ma, and C.-H. Leung Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening Chem. Commun. (Cambridge, U. K.) 46 2010 4680 4682
85. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 70 2007 461 477 (Pubitemid 46595760)
86. F.E. Koehn, and G.T. Carter The evolving role of natural products in drug discovery Nat. Rev. Drug Discov. 4 2005 206 220 (Pubitemid 40372555)
87. J.W.H. Li, and J.C. Vederas Drug discovery and natural products end of an era or an endless frontier? Science 325 2009 161 165
88. M.S. Butler Natural products to drugs: natural product-derived compounds in clinical trials Nat. Prod. Rep. 25 2008 475 516 (Pubitemid 351725315)
89. K. Shin-ya, K. Wierzba, K.-i. Matsuo, T. Ohtani, Y. Yamada, K. Furihata, Y. Hayakawa, and H. Seto Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus J. Am. Chem. Soc. 123 2001 1262 1263 (Pubitemid 32148203)
90. M.-Y. Kim, M. Gleason-Guzman, E. Izbicka, D. Nishioka, and L.H. Hurley The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures Cancer Res. 63 2003 3247 3256 (Pubitemid 36735879)
91. A.M. Burger, F. Dai, C.M. Schultes, A.P. Reszka, M.J. Moore, J.A. Double, and S. Neidle The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function Cancer Res. 65 2005 1489 1496 (Pubitemid 40270178)
92. M. Gunaratnam, O. Greciano, C. Martins, A.P. Reszka, C.M. Schultes, H. Morjani, J.-F. Riou, and S. Neidle Mechanism of acridine-based telomerase inhibition and telomere shortening Biochem. Pharmacol. 74 2007 679 689 (Pubitemid 47096640)
93. S. Sparapani, S.M. Haider, F. Doria, M. Gunaratnam, and S. Neidle Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes J. Am. Chem. Soc. 132 2010 12263 12272
94. M. Read, R.J. Harrison, B. Romagnoli, F.A. Tanious, S.H. Gowan, A.P. Reszka, W.D. Wilson, L.R. Kelland, and S. Neidle Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors Proc. Natl. Acad. Sci. U S A 98 2001 4844 4849 (Pubitemid 32397044)
95. + solution: insights into structure polymorphism of the human telomeric sequence Nucleic Acids Res. 35 2007 4927 4940 (Pubitemid 47394180)
96. H. Fernando, A.P. Reszka, J. Huppert, S. Ladame, S. Rankin, A.R. Venkitaraman, S. Neidle, and S. Balasubramanian A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene Biochemistry 45 2006 7854 7860 (Pubitemid 44185502)
97. S.N. Georgiades, K.N.H. Abd, K. Suntharalingam, and R. Vilar Interaction of metal complexes with G-quadruplex DNA Angew. Chem. Int. Ed. 49 2010 4020 4034
98. C.X. Zhang, and S.J. Lippard New metal complexes as potential therapeutics Curr. Opin. Chem. Biol. 7 2003 481 489 (Pubitemid 36980839)
99. P.C.A. Bruijnincx, and P.J. Sadler New trends for metal complexes with anticancer activity Curr. Opin. Chem. Biol. 12 2008 197 206
100. R.W.-Y. Sun, and C.-M. Che The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands Coord. Chem. Rev. 253 2009 1682 1691
101. D.-L. Ma, C.-M. Che, and S.-C. Yan Platinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA J. Am. Chem. Soc. 131 2009 1835 1846
102. P. Wu, D.-L. Ma, C.-H. Leung, S.-C. Yan, N. Zhu, R. Abagyan, and C.-M. Che Stabilization of G-quadruplex DNA with platinum(II) Schiff base complexes: luminescent probe and down-regulation of c-myc oncogene expression Chem.-Eur. J. 15 2009 13008 13021
103. P. Wang, C.-H. Leung, D.-L. Ma, S.-C. Yan, and C.-M. Che Structure-based design of platinum(II) complexes as c-myc oncogene down-regulators and luminescent probes for G-quadruplex DNA Chem.-Eur. J. 16 2010 6900 6911
104. S. Rhee, Z.-j. Han, K. Liu, H.T. Miles, and D.R. Davies Structure of a triple helical DNA with a triplex-duplex junction Biochemistry 38 1999 16810 16815
105. + solution: insights into the interconversion of human telomeric G-quadruplex structures Nucleic Acids Res. 38 2010 1009 1021
106. J. Weil, T. Min, C. Yang, S. Wang, C. Sutherland, N. Sinha, and C. Kang Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT) Acta Crystallogr. D Biol. Crystallogr. 55 1999 422 429 (Pubitemid 29083712)