Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA

Biochemistry

Volumn 46, Issue 25, 2007, Pages 7572-7580

  Beane, Randall L ^a   Ram, Rosalyn ^a   Gabillet, Sylvie ^b   Arar, Khalil ^b   Monia, Brett P ^c   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SIGMA Proligo Genopole Campus 1 ^*  (France)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; NUCLEIC ACIDS; OLIGOMERS; SYNTHESIS (CHEMICAL);

ANDROGEN RECEPTORS (AR); CHROMOSOMAL TARGET SEQUENCES; CHROMOSOME STRUCTURE; THERAPEUTIC APPLICATIONS;

GENE EXPRESSION;

ANDROGEN RECEPTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENTARY DNA; DNA; LOCKED NUCLEIC ACID; NUCLEIC ACID BASE; OLIGOMER; OLIGONUCLEOTIDE; PROGESTERONE RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; CHROMOSOME; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION;

BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMOSOMES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TARGETING; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); RECEPTORS, ANDROGEN; RECEPTORS, PROGESTERONE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

EID: 34250886279     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700227g     Document Type: Article

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