A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity

Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2001, Pages 138-144

  Mann, J ^a,c   Baron, A ^a,c   Opoku Boahen, Y ^a   Johansson, E ^b   Parkinson, G ^b   Kelland, L R ^b   Neidle, S ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 BIS [4' (3'' DIMETHYLAMINO 1'' PROPYLOXY)PHENYL] 5,5 BI 1H BENZIMIDAZOLE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BENZIMIDAZOLE DERIVATIVE; BROSTALLICIN; CISPLATIN; DISTAMYCIN A DERIVATIVE; DNA; DOXORUBICIN; PIBENZIMOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BASE PAIRING; CANCER GROWTH; CELL LINE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG ACTIVITY; DRUG BINDING; DRUG DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; NUCLEOTIDE SEQUENCE; OVARY CARCINOMA; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ZONE ELECTROPHORESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DNA; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICE, NUDE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0035905830     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000297b     Document Type: Article

References (41)

1. Dicationic diaryl furans as anti-pneumocystis carinii agents
2. 2
3. 2,5-bis[4-(nalkylamidino)phenyl]furans as anti-pneumocystis carinii agents
4. 2,4-diphenyl furan diamidines as novel anti-pneumocystis carinii pneumonia agents
5. Cytotoxicity of bis(phenylamidinium) furan alkyl derivatives in human tumour cell lines: Relation to DNA minor groove binding
6. Alpha-bromoacryloyl derivative of distamycin A (PNU 151807): A new noncovalent minor groove DNA binder with antineoplastic activity
7. Synthetic DNA minor groove-binding drugs
8. Chemotherapeutic studies on litomosodoides carini infection of mastomys nataleusis 1. The filaricidal action of 2,6-bis-benzimidazoles
9. Evaluation of pibenzimol (NSC322921) in refractory solid malignancies
10. Phase II study of pibenzimol in pancreatic cancer - A Southwest Oncology Group Study
11. Microbial mutagenic effects of the DNA minor groove binder pibenzimol (Hoechst 33258) and a series of mustard analogues
12. The mutagenic properties of DNA minor-groove binding ligands
13. Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA
14. DNA minor groove-binding ligands: A different class of mammalian DNA topoisomerase I inhibitors
15. Molecular recognition of B-DNA by Hoechst 33258
16. 2 duplex
17. Intrinsic conformational preferences of the Hoechst dye family and their influence on DNA binding
18. 2 by Hoechst 33258: A highfield NMR study
19. 2 studied in solution by NMR spectroscopy
20. Analysis of van der Waals and electrostatic contributions in the interactions of minor-groove binding benzimidazoles with DNA
21. 2
22. 2
23. 2: The role of hydrogen bonding in minor groove drug-DNA recognition
24. Isohelicity and phasing in drug-DNA sequence recognition: Crystal structure of a tris (benzimidazole)-oligonucleotide complex
25. A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: A potential mechanism for topoisomerase I poisoning
26. Quantitative structure - Activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents
27. DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles
28. Symmetric bis-benzimidazoles, a new class of sequence-selective DNA-binding molecules
29. Defining the structure of irregular nucleic acids - Conventions and principles
30. The NCI anti-cancer drug screen: A smart screen to identify effectors of novel targets
31. In vivo cultivation of tumor cells in hollow fibres
32. A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity
33. Modulation of transcription factor-DNA interactions by anticancer drugs
34. Bis-benzimidazole anticancer agents: Targeting human tumour helicases
35. Effects of a new antioestrogen idoxifene on cisplatin- and doxorubicinsensitive and resistant human ovarian carcinoma cell lines
36. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
37. Crystallographic R factor refinement by molecular dynamics
38. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
39. The nucleic acid database: A comprehensive relational database of three-dimensional structures of nucleic acids