Cell cycle reactivation in mature neurons: A link with brain plasticity, neuronal injury and neurodegenerative diseases?

Neuroscience Bulletin

Volumn 27, Issue 3, 2011, Pages 185-196

  Hernández Ortega, Karina ^a   Quiroz Baez, Ricardo ^a,b   Arias, Clorinda ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Alzheimer's disease; brain plasticity; cell cycle; neurodegeneration

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CELL CYCLE PROTEIN 20; CELL CYCLE PROTEIN 6; CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; DNA POLYMERASE; FLAVOPIRIDOL; MINICHROMOSOME MAINTENANCE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; NERVE GROWTH FACTOR; ORIGIN RECOGNITION COMPLEX; POLO LIKE KINASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR FKHR; UNINDEXED DRUG; UVOMORULIN;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; DNA DAMAGE; DNA REPAIR; DRUG EFFECT; EPILEPSY; HUMAN; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STROKE; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; CELL CYCLE PROTEINS; G1 PHASE; HUMANS; NERVE DEGENERATION; NEURODEGENERATIVE DISEASES; NEURONAL PLASTICITY; NEURONS;

EID: 79960664047     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-011-1002-z     Document Type: Article

References (88)

1. X. Graña E.P. Reddy 1995 Cell cycle control in mammalian cells: role of cyclins, cyclins dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CDKIs) Oncogene 11 211 219 7624138
2. E. Lees 1995 Cyclin dependent kinase regulation Curr Opin Cell Biol 7 773 780 8608007 10.1016/0955-0674(95)80060-3 1:CAS:528:DyaK2MXpslymsbk%3D
3. C.L. Frank L.H. Tsai 2009 Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity Neuron 62 312 326 19447088 10.1016/j.neuron.2009.03.029 1:CAS:528: DC%2BD1MXmsFWjt7k%3D
4. D. Santamaría C. Barrière A. Cerqueira S. Hunt C. Tardy K. Newton, et al. 2007 Cdk1 is sufficient to drive the mammalian cell cycle Nature 448 811 816 17700700 10.1038/nature06046 (Pubitemid 47266342)
5. V. Sudakin D. Ganoth A. Dahan H. Heller J. Hershko F.C. Luca, et al. 1995 The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis Mol Biol Cell 6 185 197 7787245 1:CAS:528:DyaK2MXksFGhsbg%3D
6. H.C. Vodermaier 2004 APC/C and SCF: controlling each other and the cell cycle Curr Biol 14 R787 796 15380093 10.1016/j.cub.2004.09.020 1:CAS:528:DC%2BD2cXnvFansL0%3D (Pubitemid 39239354)
7. Y. Dai S. Grant 2003 Cyclin-dependent kinase inhibitors Curr Opin Pharmacol 3 362 370 12901944 10.1016/S1471-4892(03)00079-1 1:CAS:528: DC%2BD3sXlvFGju74%3D (Pubitemid 36908939)
8. L. Meijer E. Raymond 2003 Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials Acc Chem Res 36 417 425 12809528 10.1021/ar0201198 1:CAS:528:DC%2BD3sXhs1Oksro%3D
9. S. Bach M. Knockaert J. Reinhardt O. Lozach S. Schmitt B. Baratte, et al. 2005 Roscovitine targets, protein kinases and pyridoxal kinase J Biol Chem 280 31208 31219 15975926 10.1074/jbc.M500806200 1:CAS:528:DC%2BD2MXpsVCmurY%3D (Pubitemid 41291858)
10. K. Herrup J.C. Busser 1995 The induction of multiple cell cycle events precedes target-related neuronal death Development 121 2385 2395 7671804 1:CAS:528:DyaK2MXnsFSgsr8%3D
11. K. Hernández-Ortega P. Ferrera C. Arias 2007 Sequential expression of cell-cycle regulators and Alzheimer's disease-related proteins in entorhinal cortex after hippocampal excitotoxic damage J Neurosci Res 85 1744 1751 17455309 10.1002/jnr.21301 (Pubitemid 46849622)
12. D.S. Park E.J. Morris J. Padmanabban M.L. Shelanski H.M. Geller L.A. Greene 1998 Cyclin dependent kinases participate in death of neurons evoked by DNA-damaging agents J Cell Biol 143 457 467 9786955 10.1083/jcb.143.2.457 1:CAS:528:DyaK1cXmsl2gtbk%3D (Pubitemid 28487863)
13. E. Verdaguer E. García-Jordà A.M. Canudas E. Domínguez A. Jiménez D. Pubill, et al. 2002 Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry Neuroreport 13 413 416 11930151 10.1097/00001756-200203250-00010 1:CAS:528:DC%2BD38XnsFKkurk%3D (Pubitemid 34293180)
14. A. Copani F. Condorelli A. Caruso C. Vancheri A. Sala A.M. Giuffrida Stella, et al. 1999 Mitotic signaling by β-amyloid causes neuronal death FASEB J 13 2225 2234 10593870 1:CAS:528:DyaK1MXotVKitb4%3D
15. A. Giovanni F. Wirtz-Brugger E. Keramaris R. Slack D.S. Park 1999 Involment of cell cycle elements, cyclin dependent kinases, pRb, and E2FxDP, in β-amyloid induced neuronal death J Biol Chem 274 19011 19016 10383401 10.1074/jbc.274.27.19011 1:CAS:528:DyaK1MXksVWls7g%3D (Pubitemid 29314095)
16. K. Bhaskar M. Miller A. Chludzinski K. Herrup M. Zagorski B.T. Lamb 2009 The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events Mol Neurodegener 4 14 31 19291319 10.1186/1750-1326-4-14
17. T. Hayashi K. Sakai C. Sasaki W.R. Zhang K. Abe 2000 Phosphorylation of retinoblastoma protein in rat brain after transient middle cerebral artery occlusion Neuropathol Appl Neurobiol 26 390 397 10931373 10.1046/j.1365-2990. 2000.00264.x 1:CAS:528:DC%2BD3cXmsFalurg%3D (Pubitemid 30609435)
18. K.R. Byrnes A.I. Faden 2007 Role of cell cycle proteins in CNS injury Neurochem Res 32 1799 1807 17404835 10.1007/s11064-007-9312-2 1:CAS:528:DC%2BD2sXhtVGmsLzI (Pubitemid 47428847)
19. Z. Nagy M.M. Esiri 1998 Neuronal cyclin expression in the hippocampus in temporal lobe epilepsy Exp Neurol 150 240 247 9527893 10.1006/exnr.1997.6753 1:STN:280:DyaK1c7pslWgug%3D%3D (Pubitemid 28231955)
20. S. Rangathan S. Bowser 2003 Alterations in G1 to S phase cell cycle regulators during amyotrophic lateral sclerosis Am J Pathol 162 823 835 10.1016/S0002-9440(10)63879-5
21. K.L. Jordan-Sciutto R. Dorsey E.M. Chalovich R.R. Hammond C.L. Achim 2003 Expression patterns of retinoblastoma protein in Parkinson disease J Neuropathol Exp Neurol 62 68 74 12528819 1:CAS:528:DC%2BD3sXpsVKntg%3D%3D (Pubitemid 36068894)
22. T. Arendt L. Rödel U. Gärtner M. Holzer 1996 Expression of the cyclindependent kinase inhibitor p16 in Alzheimer's disease Neuroreport 7 3047 3049 9116237 10.1097/00001756-199611250-00050 1:STN:280:DyaK2s7ms1ertA%3D%3D (Pubitemid 26426387)
23. Z. Nagy M.M. Esiri A.M. Cato A.D. Smith 1997 Cell cycle markers in the hippocampus in Alzheimer's disease Acta Neuropathol (Berl) 94 6 15 10.1007/s004010050665 1:STN:280:DyaK2szmslyhsw%3D%3D (Pubitemid 27289096)
24. I. Vincent G. Jicha M. Rosado D. Dickson 1997 Aberrant expression of mitotic Cdc2/Cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain J Neurosci 17 3588 3598 9133382 1:CAS:528:DyaK2sXjt1WktL8%3D (Pubitemid 27200586)
25. J. Busser D.S. Geldmacher K. Herrup 1998 Ectopic cell cycle proteins predict the sites of neuronal death in Alzheimer's disease brain J Neurosci 18 2801 2807 9525997 1:CAS:528:DyaK1cXis1ejt70%3D (Pubitemid 28163210)
26. A.K. Raina X. Zhu M.A. Smith 2004 Alzheimer's disease and the cell cycle Acta Neurobiol Exp (Wars) 64 107 112 (Pubitemid 38453811)
27. A. Copani F. Caraci J.J. Hoozemans M. Calafiore M.A. Sortino F. Nicoletti 2007 The nature of the cell cycle in neurons: focus on a " noncanonical" pathway of DNA replication causally related to death Biochim Biophys Acta 1772 409 412 17196375 1:CAS:528:DC%2BD2sXjtVahur0%3D (Pubitemid 46400384)
28. A. McShea H.G. Lee R.B. Petersen G. Casadesus I. Vincent N.J. Linford, et al. 2007 Neuronal cell cycle re-entry mediates Alzheimer disease-type changes Biochim Biophys Acta 1772 467 472 17095196 1:CAS:528:DC%2BD2sXjtVahu74%3D (Pubitemid 46400380)
29. Z. Nagy 2007 The dysregulation of the cell cycle and the diagnosis of Alzheimer's disease Biochim Biophys Acta 1772 402 408 17182224 1:CAS:528:DC%2BD2sXjtVahurw%3D (Pubitemid 46400385)
30. C. Zekanowski U. Wojda 2009 Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease Acta Neurobiol Exp (Wars) 69 232 253
31. E.Y. Lee C.Y. Chang N. Hu Y.C. Wang C.C. Lai K. Herrup, et al. 1992 Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis Nature 359 288 294 1406932 10.1038/359288a0 1:CAS:528: DyaK38XmtV2mtbo%3D
32. A.R. Clarke E.R. Maandag M. van Roon N.M. van der Lugt M. van der Valk M.L. Hooper, et al. 1992 Requirement for a functional Rb-1 gene in murine development Nature 359 328 330 1406937 10.1038/359328a0 1:CAS:528: DyaK38XmtV2mtbs%3D
33. T. Jacks A. Fazeli E.M. Schmitt R.T. Bronson M.A. Goodell R.A. Weinberg 1992 Effects of an Rb mutation in the mouse Nature 359 295 300 1406933 10.1038/359295a0 1:CAS:528:DyaK38XlvV2hu7s%3D
34. D.X. Liu L.A. Greene 2001 Neuronal apoptosis at the G1/S cell cycle checkpoint Cell Tissue Res 305 217 228 11545259 10.1007/s004410100396 1:CAS:528:DC%2BD3MXltVGitLg%3D (Pubitemid 32681898)
35. E.B.E. Becker A. Bonni 2004 Cell cycle regulation of neuronal apoptosis in development and disease Prog Neurobiol 72 1 25 15019174 10.1016/j.pneurobio. 2003.12.005 1:CAS:528:DC%2BD2cXhs12js7k%3D (Pubitemid 38294359)
36. A. Tomashevski D.R. Webster P. Grammas M. Gorospe I.I. Kruman 2010 Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons Cell Death Differ 17 1189 1198 20111042 10.1038/cdd.2009.221 1:CAS:528:DC%2BC3cXnsVOgu74%3D
37. I. Ajioka R.A.P. Martins I.T. Bayazitov S. Donovan D.A. Johnson S. Frase, et al. 2007 Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice Cell 131 378 390 17956737 10.1016/j.cell.2007. 09.036 1:CAS:528:DC%2BD2sXht1KqsbfM (Pubitemid 47576143)
38. S. Schmetsdorf E. Arnold M. Holzer T. Arendt U. Gärtner 2009 A putative role for cell cycle-related proteins in microtubule-based neuroplasticity Eur J Neurosci 29 1096 1107 19302146 10.1111/j.1460-9568.2009. 06661.x
39. S. Schmetsdorf U. Gärtner T. Arendt 2007 Constitutive expression of functionally active cyclin-dependent kinases and their binding partners suggests noncanonical functions of cell cycle regulators in differentiated neurons Cereb Cortex 17 1821 1829 17050646 10.1093/cercor/bhl091 (Pubitemid 47216499)
40. T. Arendt 2009 Synaptic degeneration in Alzheimer's disease Acta Neuropathol 118 167 179 19390859 10.1007/s00401-009-0536-x
41. F. Chang L.S. Steelman J.A. McCubrey 2002 Raf-induced cell cycle progression in human TF-1 hematopoietic cells Cell Cycle 1 220 226 12429936 10.4161/cc.1.3.128 1:CAS:528:DC%2BD38Xnt1yitbo%3D
42. R.C. Sears J.R. Nevins 2002 Signaling networks that link cell proliferation and cell fate J Biol Chem 277 11617 11620 11805123 10.1074/jbc.R100063200 1:CAS:528:DC%2BD38XivVelu7o%3D (Pubitemid 34952710)
43. T. Arendt U. Gärtner G. Seeger G. Barmashenko K. Palm T. Mittmann, et al. 2004 Neuronal activation of Ras regulates synaptic connectivity Eur J Neurosci 19 2953 2966 15182302 10.1111/j.0953-816X.2004.03409.x (Pubitemid 38822585)
44. K.I. Nakayama K. Nakayama 2006 Ubiquitin system regulating G1 and S phases of cell cycle Tanpakushitsu Kakusan Koso 51 1362 1369 16922401 1:CAS:528:DC%2BD28XovVSgur8%3D
45. T. Kuczera R.M. Stilling H.E. Hsia S. Bahari-Javan S. Irniger K. Nasmyth, et al. 2010 The anaphase promoting complex is required for memory function in mice Learn Mem 18 49 57 21191042 10.1101/lm.1998411
46. Y. Konishi J. Stegmüller T. Matsuda S. Bonni A. Bonni 2004 Cdh1-APC controls axonal growth and patterning in the mammalian brain Science 303 1026 1030 14716021 10.1126/science.1093712 1:CAS:528:DC%2BD2cXhtlWnu7c%3D (Pubitemid 38209709)
47. J. Zhang H. Li O. Yabut H. Fitzpatrick G. D'Arcangelo K. Herrup 2010 Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex J Neurosci 30 5219 5228 20392944 10.1523/JNEUROSCI.5628-09.2010 1:CAS:528:DC%2BC3cXlvVagtrc%3D
48. D.P. Seeburg M. Feliu-Mojer J. Gaiottino D.T. Pak M. Sheng 2008 Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity Neuron 58 571 583 18498738 10.1016/j.neuron.2008.03.021 1:CAS:528:DC%2BD1cXmsVOqtLs%3D (Pubitemid 351681992)
49. L.A. Greene D.X. Liu C.M. Troy S.C. Biswas 2007 Cell cycle molecules define a pathway required for neuron death in development and disease Biochim Biophys Acta 1772 392 401 17229557 1:CAS:528:DC%2BD2sXjtVahur8%3D (Pubitemid 46400389)
50. S.C. Biswas Y. Zhang G. Iyirhiaro R.T. Willett Y. Rodriguez Gonzalez S.P. Cregan, et al. 2010 Sertad1 plays an essential role in developmental and pathological neuron death J Neurosci 30 3973 3982 20237268 10.1523/JNEUROSCI. 6421-09.2010 1:CAS:528:DC%2BC3cXlvVantLw%3D
51. J. Zhang H. Li K. Herrup 2010 Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation J Biol Chem 285 14052 14061 20189989 10.1074/jbc.M109.068262 1:CAS:528:DC%2BC3cXltFOgtb0%3D
52. D.S. Park E.J. Morris L.A. Greene H.M. Geller 1997 G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis J Neurosci 17 1256 1270 9006970 1:CAS:528:DyaK2sXhtVGlurg%3D (Pubitemid 27073728)
53. H. Osuga S. Osuga F. Wang R. Fetni M.J. Hogan R.S. Slack, et al. 2000 Cyclin-dependent kinases as a therapeutic target for stroke Proc Natl Acad Sci U S A 97 10254 10259 10944192 10.1073/pnas.170144197 1:CAS:528: DC%2BD3cXmtlehtL8%3D
54. ARF links the tumour suppressors RB and p53 Nature 395 124 125 9744267 10.1038/25867 1:CAS:528:DyaK1cXmtVemsrY%3D (Pubitemid 28425642)
55. M.C. Moroni E.S. Hickman E. Lazzerini Denchi G. Caprara E. Colli, et al. 2001 Apaf-1 is a transcriptional target for E2F and p53 Nat Cell Biol 3 552 558 11389439 10.1038/35078527 1:CAS:528:DC%2BD3MXksFelurw%3D (Pubitemid 32536851)
56. Z. Nahle J. Polakoff R.V. Davuluri M.E. McCurrach M.D. Jacobson M. Narita, et al. 2002 Direct coupling of the cell cycle and cell death machinery by E2F Nat Cell Biol 4 859 864 12389032 10.1038/ncb868 1:CAS:528: DC%2BD3sXhtVKmsA%3D%3D (Pubitemid 35331360)
57. Y. Konishi A. Bonni 2003 The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons J Neurosci 23 1649 1658 12629169 1:CAS:528:DC%2BD3sXjtFyltLo%3D (Pubitemid 36314720)
58. Z. Yuan E.B. Becker P. Merlo T. Yamada S. DiBacco Y. Konishi, et al. 2008 Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons Science 319 1665 1668 18356527 10.1126/science.1152337 1:CAS:528:DC%2BD1cXjsVamtb0%3D (Pubitemid 351432504)
59. Y. Konishi M. Lehtinen N. Donovan A. Bonni 2002 Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery Mol Cell 9 1005 1016 12049737 10.1016/S1097-2765(02)00524-5 1:CAS:528:DC%2BD38XksFKjtLk%3D (Pubitemid 34626670)
60. R.S. Freeman S. Estus E.M. Johnson Jr 1994 Analysis of cell cycle related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death Neuron 12 343 355 8110463 10.1016/0896-6273(94)90276-3 1:CAS:528:DyaK2cXis1Kltbs%3D (Pubitemid 24071299)
61. C.Y. Gao P.S. Zalenka 1995 Induction of cyclin B and H1 kinase activity in apoptotic PC12 cells Exp Cell Res 219 612 618 7641812 10.1006/excr.1995.1271 1:CAS:528:DyaK2MXnsFCqtr0%3D
62. S.A. Farinelli L.A. Greene 1996 Cell cycle blockers mimosine, ciclopirox, and derefoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support J Neurosci 16 1150 1162 8558244 1:CAS:528:DyaK28XmsVekug%3D%3D (Pubitemid 26140872)
63. B.A. Hamilton W.N. Frankel A.W. Kerrebrok T.L. Hawkins W. FitzHugh K. Kusumi, et al. 1996 Disruption of the nuclear hormone receptor RORα in staggerer mice Nature 379 736 739 8602221 10.1038/379736a0 1:CAS:528: DyaK28Xht1OisLk%3D (Pubitemid 26061737)
64. K. Herrup K. Sunter 1987 Numerical matching during cerebellar development: quantitative analysis of granule cell death in staggerer mouse chimeras J Neurosci 7 829 836 3559714 1:STN:280:DyaL2s7mvVKluw%3D%3D (Pubitemid 17032600)
65. T. Susuki M. Oishi D. Marshak A. Czernik A. Nairn P. Greengard 1994 Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein EMBO J 13 1114 1122 (Pubitemid 24074718)
66. Z. Nagy M.M. Esiri A.D. Smith 1997 Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions Acta Neuropathol 93 294 300 9083562 10.1007/s004010050617 1:STN:280: DyaK2s3jslSrtg%3D%3D (Pubitemid 27104426)
67. J.P. Lopes M. Blurton-Jones T.R. Yamasaki P. Agostinho F.M. LaFerla 2009 Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-β and tau pathology J Alzheimers Dis 16 541 549 19276549 1:CAS:528:DC%2BD1MXivVSiu7g%3D
68. J.P. Lopes C.R. Oliveira P. Agostinho 2010 Neurodegeneration in an Aβ-induced model of Alzheimer's disease: the role of Cdk5 Aging Cell 9 64 77 19895631 10.1111/j.1474-9726.2009.00536.x 1:CAS:528:DC%2BC3cXhtlKntrY%3D
69. Y. Yang D.S. Geldmacher K. Herrup 2001 DNA replication precedes neuronal cell death in Alzheimer's disease J Neurosci 21 26661 26668
70. P. Thomas M. Fenech 2008 Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease Mutagenesis 23 57 65 18048581 10.1093/mutage/gem044 1:CAS:528:DC%2BD1cXht1SgtbY%3D (Pubitemid 351161354)
71. D.J. Bonda T.A. Evans C. Santocanale J.C. Llosá J. Viña V.P. Bajic, et al. 2009 Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease Aging (Albany NY) 1 382 388 1:CAS:528:DC%2BD1MXht1GkurnK
72. A.K. Raina X. Zhu C.A. Rottkamp M. Monteiro A. Takeda M.A. Smith 2000 Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease J Neurosci Res 61 128 133 10878584 10.1002/1097-4547(20000715) 61:2<128::AID-JNR2>3.0.CO;2-H 1:CAS:528:DC%2BD3cXkslOgtr4%3D (Pubitemid 30451799)
73. X. Zhu S.L. Siedlak Y. Wang G. Perry R.J. Castellani M.L. Cohen, et al. 2008 Neuronal binucleation in Alzheimer disease hippocampus Neuropathol Appl Neurobiol 34 457 465 17995921 10.1111/j.1365-2990.2007.00908.x 1:STN:280:DC%2BD1cvnsFyiug%3D%3D
74. J.J. Pei H. Braak C.X. Gong I. Grundke-Iqbal K. Iqbal B. Winblad, et al. 2002 Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration Acta Neuropathol 104 369 376 12200623 1:CAS:528:DC%2BD38XmsFGrtro%3D (Pubitemid 36075401)
75. A. Currais T. Hortobágyi S. Soriano 2009 The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease Aging (Albany NY) 1 363 371 1:CAS:528:DC%2BD1MXht1GkurnI
76. T. Arendt 2004 Neurodegeneration and plasticity Int J Dev Neurosci 22 507 514 15465280 10.1016/j.ijdevneu.2004.07.007 1:CAS:528:DC%2BD2cXotF2gsLs%3D (Pubitemid 39311439)
77. T. Arendt M.K. Brückner 2007 Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity Biochim Biophys Acta 1772 413 421 17236750 1:CAS:528:DC%2BD2sXjtVahuro%3D (Pubitemid 46400388)
78. J. Rashidian G. Iyirhiaro H. Aleyasin M. Rios I. Vincent S. Callaghan, et al. 2005 Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo Proc Natl Acad Sci U S A 102 14080 14085 16166266 10.1073/pnas.0500099102 1:CAS:528:DC%2BD2MXhtVOqsbbF (Pubitemid 41377706)
79. G.U. Höglinger J.J. Breunig C. Depboylu C. Rouaux P.P. Michel D. Alvarez-Fischer, et al. 2007 The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease Proc Natl Acad Sci U S A 104 3585 3590 17360686 10.1073/pnas.0611671104 (Pubitemid 46364202)
80. J.F. Staropoli C. McDermott C. Martinat B. Schulman E. Demireva A. Abeliovich 2003 Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity Neuron 37 735 749 12628165 10.1016/S0896-6273(03)00084-9 1:CAS:528:DC%2BD3sXitlSrsL8%3D (Pubitemid 36288547)
81. A.B. West V.L. Dawson T.M. Dawsona 2005 To die or grow: Parkinson's disease and cancer Trends Neurosci 28 348 352 15913799 10.1016/j.tins.2005.05. 002 1:CAS:528:DC%2BD2MXlsVequrc%3D (Pubitemid 40853857)
82. B.F. El-Khodor T.F. Oo N. Kholodilov R.E. Burke 2003 Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta Exp Neurol 179 17 27 12504864 10.1006/exnr.2002.8047 1:CAS:528:DC%2BD38Xps12ku78%3D (Pubitemid 36062615)
83. J. Rodriguez-Blanco V. Martín F. Herrera G. García-Santos I. Antolín C. Rodriguez 2008 Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine J Neurochem 107 127 140 18665912 10.1111/j.1471-4159.2008.05588.x 1:CAS:528:DC%2BD1cXht1KgtLbJ
84. P.D. Smith S.J. Crocker V. Jackson-Lewis K.L. Jordan-Sciutto S. Hayley M.P. Mount, et al. 2003 Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease Proc Natl Acad Sci U S A 100 13650 13655 14595022 10.1073/pnas.2232515100 1:CAS:528:DC%2BD3sXptFOitbo%3D (Pubitemid 37444794)
85. M.D. Nguyen M. Boudreau J. Kriz S. Couillard-Despres D.R. Kaplan J.P. Julien 2003 Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1 J Neurosci 23 2131 2140 12657672 1:CAS:528:DC%2BD3sXlsV2qsbg%3D (Pubitemid 36368901)
86. L. Ferraiuolo P.R. Heath H. Holden P. Kasher J. Kirby P.J. Shaw 2007 Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS J Neurosci 27 9201 9219 17715356 10.1523/JNEUROSCI.1470-07.2007 1:CAS:528:DC%2BD2sXhtVSnsLbF (Pubitemid 47312070)
87. C. Pelegrí J. Duran-Vilaregut J. del Valle N. Crespo-Biel I. Ferrer M. Pallàs, et al. 2008 Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid Int J Dev Neurosci 26 665 671 18768156 10.1016/j.ijdevneu.2008.07.016
88. H.G. Lee G. Casadesus A. Nunomura X. Zhu R.J. Castellani S.L. Richardson, et al. 2009 The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse Am J Pathol 174 891 897 19164506 10.2353/ajpath.2009.080583 1:CAS:528:DC%2BD1MXjs1Wgsr0%3D