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Volumn 23, Issue 1, 2008, Pages 57-65

Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN CELL; CELL DIVISION; CHEEK; CHROMOSOME 17; CHROMOSOME 21; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HEREDITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MONOSOMY; PRIORITY JOURNAL; TRISOMY;

EID: 38549181768     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gem044     Document Type: Article
Times cited : (90)

References (63)
  • 1
    • 0037072064 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Burns, A., Byrne, E. J. and Maurer, K. (2002) Alzheimer's disease. Lancet, 360, 163-165.
    • (2002) Lancet , vol.360 , pp. 163-165
    • Burns, A.1    Byrne, E.J.2    Maurer, K.3
  • 2
    • 0034801730 scopus 로고    scopus 로고
    • Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
    • Du, A. T., Schuff, N., Amend, D. et al. (2001) Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J. Neurol. Neurosurg. Psychiatr., 71, 441-447.
    • (2001) J. Neurol. Neurosurg. Psychiatr , vol.71 , pp. 441-447
    • Du, A.T.1    Schuff, N.2    Amend, D.3
  • 3
    • 0031781988 scopus 로고    scopus 로고
    • Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    • Haroutunian, V., Perl, D. P., Purohit, D. P., Marin, D., Khan, K., Lantz, M., Davis, K. L. and Mohs, R. C. (1998) Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch. Neurol., 55, 1185-1191.
    • (1998) Arch. Neurol , vol.55 , pp. 1185-1191
    • Haroutunian, V.1    Perl, D.P.2    Purohit, D.P.3    Marin, D.4    Khan, K.5    Lantz, M.6    Davis, K.L.7    Mohs, R.C.8
  • 4
    • 0042888669 scopus 로고    scopus 로고
    • Clinical practice. Early Alzheimer's disease
    • Kawas, C. H. (2003) Clinical practice. Early Alzheimer's disease. N. Engl. J. Med., 349, 1056-1063.
    • (2003) N. Engl. J. Med , vol.349 , pp. 1056-1063
    • Kawas, C.H.1
  • 5
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson, M. P. (2004) Pathways towards and away from Alzheimer's disease. Nature, 430, 631-639.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 6
    • 0034573291 scopus 로고    scopus 로고
    • Piecing together Alzheimer's
    • St George-Hyslop, P. H. (2000) Piecing together Alzheimer's. Sci. Am., 283, 76-83.
    • (2000) Sci. Am , vol.283 , pp. 76-83
    • St George-Hyslop, P.H.1
  • 7
    • 0024312664 scopus 로고
    • Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease
    • Iqbal, K., Grundke-Iqbal, I., Smith, A. J., George, L., Tung, Y. C. and Zaidi, T. (1989) Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc. Natl Acad. Sci. USA, 86, 5646-5650.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 5646-5650
    • Iqbal, K.1    Grundke-Iqbal, I.2    Smith, A.J.3    George, L.4    Tung, Y.C.5    Zaidi, T.6
  • 9
    • 0031694617 scopus 로고    scopus 로고
    • The dynamic behavior of individual microtubules associated with chromosomes in vitro
    • Hunt, A. J. and McIntosh, J. R. (1998) The dynamic behavior of individual microtubules associated with chromosomes in vitro. Mol. Biol. Cell, 9, 2857-2871.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 2857-2871
    • Hunt, A.J.1    McIntosh, J.R.2
  • 10
    • 0036843631 scopus 로고    scopus 로고
    • The beta-amyloid precursor protein (APP) and Alzheimer's disease: Does the tail wag the dog?
    • Koo, E. H. (2002) The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? Traffic, 3, 763-770.
    • (2002) Traffic , vol.3 , pp. 763-770
    • Koo, E.H.1
  • 12
    • 0035140477 scopus 로고    scopus 로고
    • Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis
    • Maluf, S. W. and Erdtmann, B. (2001) Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis. Cancer Genet. Cytogenet., 124, 71-75.
    • (2001) Cancer Genet. Cytogenet , vol.124 , pp. 71-75
    • Maluf, S.W.1    Erdtmann, B.2
  • 16
  • 17
    • 0031447765 scopus 로고    scopus 로고
    • Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease
    • Migliore, L., Testa,A., Scarpato, R., Pavese,N., Petrozzi, L. andBonuccelli,U. (1997) Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease. Hum. Genet., 101, 299-305.
    • (1997) Hum. Genet , vol.101 , pp. 299-305
    • Migliore, L.1    Testa, A.2    Scarpato, R.3    Pavese, N.4    Petrozzi, L.5    andBonuccelli, U.6
  • 18
    • 0033399922 scopus 로고    scopus 로고
    • Preferencial occurence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients
    • Migliore, L., Botto, N., Scarpato, R., Petrozzi, L., Cipriani, G. and Bonuccelli, U. (1999) Preferencial occurence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients. Cytogenet. Cell Genet., 87, 41-46.
    • (1999) Cytogenet. Cell Genet , vol.87 , pp. 41-46
    • Migliore, L.1    Botto, N.2    Scarpato, R.3    Petrozzi, L.4    Cipriani, G.5    Bonuccelli, U.6
  • 19
    • 0033033062 scopus 로고    scopus 로고
    • Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease
    • Geller, L. N. and Potter, H. (1999) Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease. Neurobiol. Dis., 6, 167-179.
    • (1999) Neurobiol. Dis , vol.6 , pp. 167-179
    • Geller, L.N.1    Potter, H.2
  • 21
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 22
    • 0028783689 scopus 로고
    • Standardization of counting micronuclei: Definition of a protocol to measure genotoxic damage in human exfoliated cells
    • Belien, J. A., Copper, M. P., Braakhuis, B. J., Snow, G. B. and Baak, J. P. (1995) Standardization of counting micronuclei: definition of a protocol to measure genotoxic damage in human exfoliated cells. Carcinogenesis, 16, 2395-2400.
    • (1995) Carcinogenesis , vol.16 , pp. 2395-2400
    • Belien, J.A.1    Copper, M.P.2    Braakhuis, B.J.3    Snow, G.B.4    Baak, J.P.5
  • 23
    • 0026551790 scopus 로고
    • Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction
    • Dunham, I., Lengauer, C., Cremer, T. and Featherstone, T. (1992) Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction. Hum. Genet., 88, 457-462.
    • (1992) Hum. Genet , vol.88 , pp. 457-462
    • Dunham, I.1    Lengauer, C.2    Cremer, T.3    Featherstone, T.4
  • 24
    • 0022780916 scopus 로고
    • Structure, organization, and sequence of alpha satellite DNA from human chromosome 17: Evidence for evolution by unequal crossing-over and an ancestral pentamer repeat shared with the human X chromosome
    • Waye, J. S. and Willard, H. F. (1986) Structure, organization, and sequence of alpha satellite DNA from human chromosome 17: evidence for evolution by unequal crossing-over and an ancestral pentamer repeat shared with the human X chromosome. Mol. Cell. Biol., 6, 3156-3165.
    • (1986) Mol. Cell. Biol , vol.6 , pp. 3156-3165
    • Waye, J.S.1    Willard, H.F.2
  • 25
    • 0343319476 scopus 로고
    • Fluorescence in situ hybridization with human chromosome-specific libraries: Detection of trisomy 21 and translocations of chromosome 4
    • Pinkel, D., Landegent, J., Collins, C., Fuscoe, J., Segraves, R., Lucas, J. and Gray, J. (1988) Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proc. Natl Acad. Sci. USA, 85, 9138-9142.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 9138-9142
    • Pinkel, D.1    Landegent, J.2    Collins, C.3    Fuscoe, J.4    Segraves, R.5    Lucas, J.6    Gray, J.7
  • 26
    • 0025005697 scopus 로고
    • Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome-specific DNA probes
    • Eastmond, D. A. and Pinkel, D. (1990) Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome-specific DNA probes. Mutat. Res., 234, 303-318.
    • (1990) Mutat. Res , vol.234 , pp. 303-318
    • Eastmond, D.A.1    Pinkel, D.2
  • 27
    • 0034019909 scopus 로고    scopus 로고
    • Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: Detection by fluorescence in situ hybridization on binucleated lymphocytes
    • Shi, Q., Adler, I. D., Zhang, J., Zhang, X., Shan, X. and Martin, R. (2000) Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes. Hum. Genet., 106, 29-35.
    • (2000) Hum. Genet , vol.106 , pp. 29-35
    • Shi, Q.1    Adler, I.D.2    Zhang, J.3    Zhang, X.4    Shan, X.5    Martin, R.6
  • 28
    • 33750968801 scopus 로고    scopus 로고
    • Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes in Alzheimer disease patients
    • Zivkovic, L., Spremo-Potparevic, B., Djelic, N. and Bajic, V. (2006) Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes in Alzheimer disease patients. Mech. Ageing Dev., 127, 892-896.
    • (2006) Mech. Ageing Dev , vol.127 , pp. 892-896
    • Zivkovic, L.1    Spremo-Potparevic, B.2    Djelic, N.3    Bajic, V.4
  • 29
    • 0031044285 scopus 로고    scopus 로고
    • Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome
    • Jenkins, E. C., Schupf, N., Genovese, M. et al. (1997) Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome. Am. J. Med. Genet., 68, 147-151.
    • (1997) Am. J. Med. Genet , vol.68 , pp. 147-151
    • Jenkins, E.C.1    Schupf, N.2    Genovese, M.3
  • 30
    • 16644378702 scopus 로고    scopus 로고
    • Telomeres on chromosome 21 and aging in lymphocytes and gingival fibroblasts from individuals with Down syndrome
    • de Arruda Cardoso Smith, M., Borsatto-Galera, B., Feller, R. I. et al. (2004) Telomeres on chromosome 21 and aging in lymphocytes and gingival fibroblasts from individuals with Down syndrome. J. Oral Sci., 46, 171-177.
    • (2004) J. Oral Sci , vol.46 , pp. 171-177
    • de Arruda Cardoso Smith, M.1    Borsatto-Galera, B.2    Feller, R.I.3
  • 31
    • 13344293701 scopus 로고    scopus 로고
    • Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome
    • Teller, J. K., Russo, C., DeBusk, L. M. et al. (1996) Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome. Nat. Med., 2, 93-95.
    • (1996) Nat. Med , vol.2 , pp. 93-95
    • Teller, J.K.1    Russo, C.2    DeBusk, L.M.3
  • 32
    • 33846089505 scopus 로고    scopus 로고
    • A review of genome mutation and Alzheimer's disease
    • Thomas, P. and Fenech, M. (2007) A review of genome mutation and Alzheimer's disease. Mutagenesis, 22, 15-33.
    • (2007) Mutagenesis , vol.22 , pp. 15-33
    • Thomas, P.1    Fenech, M.2
  • 33
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy, J. and Allsop, D. (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci., 12, 383-388.
    • (1991) Trends Pharmacol. Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 34
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J. and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science, 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 35
    • 0034672421 scopus 로고    scopus 로고
    • Alzheimer's disease: A dysfunction of the amyloid precursor protein(1)
    • Neve, R. L., McPhie, D. L. and Chen, Y. (2000) Alzheimer's disease: a dysfunction of the amyloid precursor protein(1). Brain Res., 886, 54-66.
    • (2000) Brain Res , vol.886 , pp. 54-66
    • Neve, R.L.1    McPhie, D.L.2    Chen, Y.3
  • 36
    • 0031967942 scopus 로고    scopus 로고
    • A new paradigm for neurotoxicity by FAD mutants of betaAPP: A signaling abnormality
    • Nishimoto, I. (1998) A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality. Neurobiol. Aging, 19, S33-S38.
    • (1998) Neurobiol. Aging , vol.19
    • Nishimoto, I.1
  • 37
    • 33748426487 scopus 로고    scopus 로고
    • Unraveling in vivo functions of amyloid precursor protein: Insights from knockout and knockdown studies
    • Senechal, Y., Larmet, Y. and Dev, K. K. (2006) Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies. Neurodegener. Dis., 3, 134-147.
    • (2006) Neurodegener. Dis , vol.3 , pp. 134-147
    • Senechal, Y.1    Larmet, Y.2    Dev, K.K.3
  • 39
    • 0037186074 scopus 로고    scopus 로고
    • Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome
    • Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H. and Yankner, B. A. (2002) Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron, 33, 677-688.
    • (2002) Neuron , vol.33 , pp. 677-688
    • Busciglio, J.1    Pelsman, A.2    Wong, C.3    Pigino, G.4    Yuan, M.5    Mori, H.6    Yankner, B.A.7
  • 40
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • Busciglio, J. and Yankner, B. A. (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature, 378, 776-779.
    • (1995) Nature , vol.378 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 41
    • 33748744258 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome
    • Shukkur, E. A., Shimohata, A., Akagi, T. et al. (2006) Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. Hum. Mol. Genet., 15, 2752-2762.
    • (2006) Hum. Mol. Genet , vol.15 , pp. 2752-2762
    • Shukkur, E.A.1    Shimohata, A.2    Akagi, T.3
  • 43
    • 33846533244 scopus 로고    scopus 로고
    • The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between {beta}-amyloid production and tau phosphorylation in Alzheimer disease
    • Kimura, R., Kamino, K., Yamamoto, M. et al. (2007) The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between {beta}-amyloid production and tau phosphorylation in Alzheimer disease. Hum. Mol. Genet., 16, 15-23.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 15-23
    • Kimura, R.1    Kamino, K.2    Yamamoto, M.3
  • 44
    • 34347353311 scopus 로고    scopus 로고
    • Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
    • Lazarov, O., Morfini, G. A., Pigino, G., Gadadhar, A., Chen, X., Robinson, J., Ho, H., Brady, S. T. and Sisodia, S. S. (2007) Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J. Neurosci., 27, 7011-7020.
    • (2007) J. Neurosci , vol.27 , pp. 7011-7020
    • Lazarov, O.1    Morfini, G.A.2    Pigino, G.3    Gadadhar, A.4    Chen, X.5    Robinson, J.6    Ho, H.7    Brady, S.T.8    Sisodia, S.S.9
  • 45
    • 0025801967 scopus 로고
    • Review and hypothesis: Alzheimer disease and Down syndrome-chromosome 21 nondisjunction may underlie both disorders
    • Potter, H. (1991) Review and hypothesis: Alzheimer disease and Down syndrome-chromosome 21 nondisjunction may underlie both disorders. Am. J. Hum. Genet., 48, 1192-1200.
    • (1991) Am. J. Hum. Genet , vol.48 , pp. 1192-1200
    • Potter, H.1
  • 46
    • 3042591660 scopus 로고    scopus 로고
    • Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21
    • Wang, X., Thomas, P., Xue, J. and Fenech, M. (2004) Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21. Mutat. Res., 551, 167-180.
    • (2004) Mutat. Res , vol.551 , pp. 167-180
    • Wang, X.1    Thomas, P.2    Xue, J.3    Fenech, M.4
  • 47
    • 0028095222 scopus 로고
    • Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome
    • Schupf, N., Kapell, D., Lee, J. H., Ottman, R. and Mayeux, R. (1994) Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome. Lancet, 344, 353-356.
    • (1994) Lancet , vol.344 , pp. 353-356
    • Schupf, N.1    Kapell, D.2    Lee, J.H.3    Ottman, R.4    Mayeux, R.5
  • 48
    • 0021984177 scopus 로고
    • Limits of neurogenesis in primates
    • Rakic, P. (1985) Limits of neurogenesis in primates. Science, 227, 1054-1056.
    • (1985) Science , vol.227 , pp. 1054-1056
    • Rakic, P.1
  • 50
    • 0030761059 scopus 로고    scopus 로고
    • Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
    • Li, J., Xu, M., Zhou, H., Ma, J. and Potter, H. (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell, 90, 917-927.
    • (1997) Cell , vol.90 , pp. 917-927
    • Li, J.1    Xu, M.2    Zhou, H.3    Ma, J.4    Potter, H.5
  • 52
    • 0030028429 scopus 로고    scopus 로고
    • Wragg, M., Hutton, M. and Talbot, C. (1996) Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's disease Collaborative Group. Lancet, 347, 509-512.
    • Wragg, M., Hutton, M. and Talbot, C. (1996) Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's disease Collaborative Group. Lancet, 347, 509-512.
  • 53
    • 0030710512 scopus 로고    scopus 로고
    • Association of presenilin-1 polymorphism with cerebral amyloid angiopathy in the elderly
    • Yamada, M., Sodeyama, N., Itoh, Y., Suematsu, N., Otomo, E., Matsushita, M. and Mizusawa, H. (1997) Association of presenilin-1 polymorphism with cerebral amyloid angiopathy in the elderly. Stroke, 28, 2219-2221.
    • (1997) Stroke , vol.28 , pp. 2219-2221
    • Yamada, M.1    Sodeyama, N.2    Itoh, Y.3    Suematsu, N.4    Otomo, E.5    Matsushita, M.6    Mizusawa, H.7
  • 54
    • 0032521531 scopus 로고    scopus 로고
    • A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome
    • Tyrrel, J., Cosgrave, M., Hawi, Z., Mcpherson, J., Lawlor, B. and Gill, M. (1998) A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome. Biol. Psychiatr., 43, 397-400.
    • (1998) Biol. Psychiatr , vol.43 , pp. 397-400
    • Tyrrel, J.1    Cosgrave, M.2    Hawi, Z.3    Mcpherson, J.4    Lawlor, B.5    Gill, M.6
  • 55
    • 0343573410 scopus 로고    scopus 로고
    • Alzheimer disease and Down syndrome
    • Holtzman, D. M. (1997) Alzheimer disease and Down syndrome. Cytogenet. Cell Genet., 77 (Suppl 1), 17.
    • (1997) Cytogenet. Cell Genet , vol.77 , Issue.SUPPL. 1 , pp. 17
    • Holtzman, D.M.1
  • 57
    • 20244361897 scopus 로고    scopus 로고
    • A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease
    • Aisen, P. S., Egelko, S., Andrews, H. et al. (2003) A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease. Am. J. Geriatr. Psychiatry, 11, 246-249.
    • (2003) Am. J. Geriatr. Psychiatry , vol.11 , pp. 246-249
    • Aisen, P.S.1    Egelko, S.2    Andrews, H.3
  • 58
    • 0036669551 scopus 로고    scopus 로고
    • Homocysteine, folate deprivation and Alzheimer neuropathology
    • Shea, T. B., Lyons-Weiler, J. and Rogers, E. (2002) Homocysteine, folate deprivation and Alzheimer neuropathology. J. Alzheimers Dis., 4, 261-267.
    • (2002) J. Alzheimers Dis , vol.4 , pp. 261-267
    • Shea, T.B.1    Lyons-Weiler, J.2    Rogers, E.3
  • 59
    • 0037464488 scopus 로고    scopus 로고
    • Presenilin 1 gene silencing by S-adenosylmethionine: A treatment for Alzheimer disease?
    • Scarpa, S., Fuso, A., D'Anselmi, F. and Cavallaro, R. A. (2003) Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? FEBS Lett., 541, 145-148.
    • (2003) FEBS Lett , vol.541 , pp. 145-148
    • Scarpa, S.1    Fuso, A.2    D'Anselmi, F.3    Cavallaro, R.A.4
  • 60
    • 0036696954 scopus 로고    scopus 로고
    • Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts
    • Suzuki, T., Fujii, M. and Ayusawa, D. (2002) Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts. Exp. Gerontol., 37, 1005-1014.
    • (2002) Exp. Gerontol , vol.37 , pp. 1005-1014
    • Suzuki, T.1    Fujii, M.2    Ayusawa, D.3
  • 62
    • 0032845227 scopus 로고    scopus 로고
    • Abnormal folate metabolismandmutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
    • James, S. J., Pogribna, M., Pogribny, I. P. et al. (1999) Abnormal folate metabolismandmutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am. J. Clin. Nutr., 70, 495-501.
    • (1999) Am. J. Clin. Nutr , vol.70 , pp. 495-501
    • James, S.J.1    Pogribna, M.2    Pogribny, I.P.3


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