메뉴 건너뛰기




Volumn 107, Issue 1, 2008, Pages 127-140

Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine

Author keywords

6 OHDA; Akt; Antioxidants; Cell cycle proteins; JNK; Post mitotic PC12 cells

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTOXIN; OXIDOPAMINE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

EID: 52049104485     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05588.x     Document Type: Article
Times cited : (57)

References (79)
  • 1
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
    • Alessi D. R., Cuenda A., Cohen P., Dudley D. T. Saltiel A. R. (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270, 27489 27494.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 2
    • 1542381057 scopus 로고    scopus 로고
    • Cell cycle regulation of neuronal apoptosis in development and disease
    • Becker E. B. E. Bonni A. (2004) Cell cycle regulation of neuronal apoptosis in development and disease. Prog. Neurobiol. 72, 1 25.
    • (2004) Prog. Neurobiol. , vol.72 , pp. 1-25
    • Becker, E.B.E.1    Bonni, A.2
  • 3
    • 0035923665 scopus 로고    scopus 로고
    • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    • Bennett B. L., Sasaki D. T., Murray B. W. et al. (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl Acad. Sci. USA 98, 13681 13686.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 13681-13686
    • Bennett, B.L.1    Sasaki, D.T.2    Murray, B.W.3
  • 4
    • 0037147122 scopus 로고    scopus 로고
    • Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation
    • Biswas S. C. Greene L. A. (2002) Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. J. Biol. Chem. 277, 49511 49516.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49511-49516
    • Biswas, S.C.1    Greene, L.A.2
  • 5
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D., Torch S., Lambeng N., Nissou M., Benabid A. L., Sadoul R. Verna J. M. (2001) Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog. Neurobiol. 65, 135 172.
    • (2001) Prog. Neurobiol. , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.L.5    Sadoul, R.6    Verna, J.M.7
  • 7
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and -independent control of neuronal survival by the PI3K/Akt signalling pathway
    • Brunet A., Datta S. R. Greenberg M. E. (2001) Transcription-dependent and -independent control of neuronal survival by the PI3K/Akt signalling pathway. Curr. Opin. Neurobiol. 11, 297 305.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 8
    • 11844268081 scopus 로고    scopus 로고
    • Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress
    • Chen X. C., Zhou Y. C., Chen Y., Zhu Y. G., Fang F. Chen L. M. (2005) Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress. Acta Pharmacol. Sin. 26, 56 62.
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 56-62
    • Chen, X.C.1    Zhou, Y.C.2    Chen, Y.3    Zhu, Y.G.4    Fang, F.5    Chen, L.M.6
  • 9
    • 18844434370 scopus 로고    scopus 로고
    • Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
    • Chong Z. Z., Li F. Maiese K. (2005) Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog. Neurobiol. 75, 207 246.
    • (2005) Prog. Neurobiol. , vol.75 , pp. 207-246
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 10
    • 18344383345 scopus 로고    scopus 로고
    • Pocket proteins and cell cycle control
    • Cobrinik D. (2005) Pocket proteins and cell cycle control. Oncogene 24, 2796 2809.
    • (2005) Oncogene , vol.24 , pp. 2796-2809
    • Cobrinik, D.1
  • 11
    • 0016378870 scopus 로고
    • The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
    • Cohen G. Heikkila R. E. (1974) The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem. 249, 2447 2452.
    • (1974) J. Biol. Chem. , vol.249 , pp. 2447-2452
    • Cohen, G.1    Heikkila, R.E.2
  • 12
    • 0036270446 scopus 로고    scopus 로고
    • Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: Dependence on Ca (2+) and PI3-kinase
    • Crossthwaite A. J., Hasan S. Williams R. J. (2002) Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca (2+) and PI3-kinase. J. Neurochem. 80, 24 35.
    • (2002) J. Neurochem. , vol.80 , pp. 24-35
    • Crossthwaite, A.J.1    Hasan, S.2    Williams, R.J.3
  • 13
    • 0032522924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
    • Crowder R. J. Freeman R. S. (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J. Neurosci. 18, 2933 2943.
    • (1998) J. Neurosci. , vol.18 , pp. 2933-2943
    • Crowder, R.J.1    Freeman, R.S.2
  • 14
    • 7244233043 scopus 로고    scopus 로고
    • Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutatione depletion in neuron/glia mesencephalic curltues
    • De Bernardo S., Canals S., Casarejos M. J., Solano R. M., Menendez J. Mena M. A. (2004) Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutatione depletion in neuron/glia mesencephalic curltues. J. Neurochem. 91, 667 682.
    • (2004) J. Neurochem. , vol.91 , pp. 667-682
    • De Bernardo, S.1    Canals, S.2    Casarejos, M.J.3    Solano, R.M.4    Menendez, J.5    Mena, M.A.6
  • 15
    • 0022445670 scopus 로고
    • Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
    • Denizot F. Lang R. (1986) Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 89, 271 277.
    • (1986) J. Immunol. Methods , vol.89 , pp. 271-277
    • Denizot, F.1    Lang, R.2
  • 16
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard B., Hibi M., Wu I. H., Barrett T., Su B., Deng T., Karin M. Davis R. J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025 1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 18
    • 11244280883 scopus 로고    scopus 로고
    • JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine
    • Eminel S., Klettner A., Roemer L., Herdegen T. Waetzig V. (2004) JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. J. Biol. Chem. 279, 55385 55392.
    • (2004) J. Biol. Chem. , vol.279 , pp. 55385-55392
    • Eminel, S.1    Klettner, A.2    Roemer, L.3    Herdegen, T.4    Waetzig, V.5
  • 19
    • 0029972440 scopus 로고    scopus 로고
    • Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support
    • Farinelli S. E. Greene L. A. (1996) Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J. Neurosci. 16, 1150 1162.
    • (1996) J. Neurosci. , vol.16 , pp. 1150-1162
    • Farinelli, S.E.1    Greene, L.A.2
  • 20
    • 0035668350 scopus 로고    scopus 로고
    • Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies
    • Ferrer I., Blanco R., Carmona M., Puig B., Barrachina M., Gomez C. Ambrosio S. (2001) Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies. J. Neural. Transm. 108, 1383 1396.
    • (2001) J. Neural. Transm. , vol.108 , pp. 1383-1396
    • Ferrer, I.1    Blanco, R.2    Carmona, M.3    Puig, B.4    Barrachina, M.5    Gomez, C.6    Ambrosio, S.7
  • 21
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of aging
    • Finkel T. Holbrook N. J. (2000) Oxidants, oxidative stress and the biology of aging. Nature 408, 239 247.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 22
    • 0035094532 scopus 로고    scopus 로고
    • Integrin signalling cia the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis
    • Gary D.S. Mattson M. P. (2001) Integrin signalling cia the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J. Neurochem. 76, 1485 1496.
    • (2001) J. Neurochem. , vol.76 , pp. 1485-1496
    • Gary, D.S.1    Mattson, M.P.2
  • 23
    • 33748047128 scopus 로고    scopus 로고
    • RB and cell cycle progression
    • Giacinti C. Giordano A. (2006) RB and cell cycle progression. Oncogene 25, 5220 5227.
    • (2006) Oncogene , vol.25 , pp. 5220-5227
    • Giacinti, C.1    Giordano, A.2
  • 24
    • 0028918841 scopus 로고
    • Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine
    • Glinka Y.Y. Youdim M. B. (1995) Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine. Eur. J. Pharmacol. 292, 329 332.
    • (1995) Eur. J. Pharmacol. , vol.292 , pp. 329-332
    • Glinka, Y.Y.1    Youdim, M.B.2
  • 25
    • 0035824526 scopus 로고    scopus 로고
    • 2. Regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase
    • 2. Regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase. J. Biol. Chem. 276, 46379 46385.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46379-46385
    • Goldshmit, Y.1    Erlich, S.2    Pinkas-Kramarski, R.3
  • 26
    • 0018095085 scopus 로고
    • Oxidative pathway for catecholamines in the genesis of neuromelanin and cytotoxic quineones
    • Graham D.G. (1978) Oxidative pathway for catecholamines in the genesis of neuromelanin and cytotoxic quineones. Mol. Pharmacol. 14, 633 643.
    • (1978) Mol. Pharmacol. , vol.14 , pp. 633-643
    • Graham, D.G.1
  • 27
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene L. A. Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl Acad. Sci. USA 73, 2424 2428.
    • (1976) Proc. Natl Acad. Sci. USA , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 28
    • 33947109561 scopus 로고    scopus 로고
    • Cell cycle molecules define a pathway required for neuron death in development and disease
    • Greene L. A., Liu D. X., Troy C. M. Biswas S. C. (2007) Cell cycle molecules define a pathway required for neuron death in development and disease. Biochim. Biophys. Acta 1772, 392 401.
    • (2007) Biochim. Biophys. Acta , vol.1772 , pp. 392-401
    • Greene, L.A.1    Liu, D.X.2    Troy, C.M.3    Biswas, S.C.4
  • 29
    • 33646849308 scopus 로고    scopus 로고
    • 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase C delta
    • Hanrott K., Gudmunsen L., O'Neill M. J. Wonnacott S. (2006) 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase C delta. J. Biol. Chem. 281, 5373 5382.
    • (2006) J. Biol. Chem. , vol.281 , pp. 5373-5382
    • Hanrott, K.1    Gudmunsen, L.2    O'Neill, M.J.3    Wonnacott, S.4
  • 30
    • 0035971563 scopus 로고    scopus 로고
    • AP-1 proteins in the adult brain: Facts and fiction about effectors of neuroprotection and neurodegeneration
    • Herdegen T. Waetzig V. (2001) AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. Oncogene 20, 2424 2437.
    • (2001) Oncogene , vol.20 , pp. 2424-2437
    • Herdegen, T.1    Waetzig, V.2
  • 31
    • 33644756798 scopus 로고    scopus 로고
    • Cumulative activation of akt and consequent inhibition of glycogen synthase kinase-3 by brain-derived neurotrophic factor and insulin-like growth factor-1 in cultured hippocampal neurons
    • Johnson-Farley N. N., Travkina T. Cowen D. S. (2006) Cumulative activation of akt and consequent inhibition of glycogen synthase kinase-3 by brain-derived neurotrophic factor and insulin-like growth factor-1 in cultured hippocampal neurons. J. Pharmacol. Exp. Ther. 316, 1062 1069.
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , pp. 1062-1069
    • Johnson-Farley, N.N.1    Travkina, T.2    Cowen, D.S.3
  • 33
    • 0034927814 scopus 로고    scopus 로고
    • Apoptotic signalling in dopamine-induced cell death: The role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases
    • Junn E. Mouradian M. M. (2001) Apoptotic signalling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases. J. Neurochem. 78, 374 383.
    • (2001) J. Neurochem. , vol.78 , pp. 374-383
    • Junn, E.1    Mouradian, M.M.2
  • 34
    • 33845242529 scopus 로고    scopus 로고
    • Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK 1/2 and Akt pathways
    • Kilic U., Kilic E., Jarve A., Guo Z., Spudich A., Bieber K., Barzena U., Bassetti C. L., Marti H. H. Hermann D. M. (2006) Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK 1/2 and Akt pathways. J. Neurosci. 29, 12439 12446.
    • (2006) J. Neurosci. , vol.29 , pp. 12439-12446
    • Kilic, U.1    Kilic, E.2    Jarve, A.3    Guo, Z.4    Spudich, A.5    Bieber, K.6    Barzena, U.7    Bassetti, C.L.8    Marti, H.H.9    Hermann, D.M.10
  • 35
    • 0037366104 scopus 로고    scopus 로고
    • Oxidative stress, cell cycle, and neurodegeneration
    • Klein J. A. Ackerman S. L. (2003) Oxidative stress, cell cycle, and neurodegeneration. J. Clin. Invest. 111, 785 793.
    • (2003) J. Clin. Invest. , vol.111 , pp. 785-793
    • Klein, J.A.1    Ackerman, S.L.2
  • 36
    • 0025231944 scopus 로고
    • A new compound which reversibly arrests T lymphocyte cell cycle near the G1/S boundary
    • Lalande M. Hanauske-Abel H. M. (1990) A new compound which reversibly arrests T lymphocyte cell cycle near the G1/S boundary. Exp. Cell Res. 188, 117 121.
    • (1990) Exp. Cell Res. , vol.188 , pp. 117-121
    • Lalande, M.1    Hanauske-Abel, H.M.2
  • 37
    • 33748306017 scopus 로고    scopus 로고
    • Differential involvement of mitochondrial permeability transition in cytotoxicity of 1-methyl-4-phenylpyridinium and 6-hydroxydopamine
    • Lee C. S., Park W. J., Ko H. H. Han E. S. (2006) Differential involvement of mitochondrial permeability transition in cytotoxicity of 1-methyl-4-phenylpyridinium and 6-hydroxydopamine. Mol.Cell Biochem. 289, 193 200.
    • (2006) Mol.Cell Biochem. , vol.289 , pp. 193-200
    • Lee, C.S.1    Park, W.J.2    Ko, H.H.3    Han, E.S.4
  • 38
    • 0035895803 scopus 로고    scopus 로고
    • SB 239063, a novel p38 inhibitor,attenuates early neuronal injury following ischemia
    • 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia.
    • Legos J. J., Erhardt J. A., White R. F., Lenhard S. C., Chandra S., Parsons A. A., Tuma R. F. Barone F. C. (2001) SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia. Brain Res. 892, 70 77.
    • (2001) Brain Res. , vol.892 , pp. 70-77
    • Legos, J.J.1    Erhardt, J.A.2    White, R.F.3    Lenhard, S.C.4    Chandra, S.5    Parsons, A.A.6    Tuma, R.F.7    Barone, F.C.8
  • 39
    • 0037163110 scopus 로고    scopus 로고
    • Involvement of protein kinase C activation and cell survival / cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action
    • Levites Y., Amit T., Youdim M. B. H. Mandel S. (2002) Involvement of protein kinase C activation and cell survival / cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action. J. Biol. Chem. 34, 30574 30580.
    • (2002) J. Biol. Chem. , vol.34 , pp. 30574-30580
    • Levites, Y.1    Amit, T.2    Youdim, M.B.H.3    Mandel, S.4
  • 40
    • 0033547434 scopus 로고    scopus 로고
    • Protein kinase C overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal
    • Li W., Zhang J., Flechner L., Hyun T., Yam A., Franke F. Pierce J. H. (1999) Protein kinase C overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene 18, 6564 6572.
    • (1999) Oncogene , vol.18 , pp. 6564-6572
    • Li, W.1    Zhang, J.2    Flechner, L.3    Hyun, T.4    Yam, A.5    Franke, F.6    Pierce, J.H.7
  • 41
    • 0042817922 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    • Li B. S., Ma W., Jaffe H., Zheng Y., Takahashi S., Ahang L., Kulkarni A. B. Pant H. C. (2003) Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J. Biol. Chem. 278, 35702 35709.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35702-35709
    • Li, B.S.1    Ma, W.2    Jaffe, H.3    Zheng, Y.4    Takahashi, S.5    Ahang, L.6    Kulkarni, A.B.7    Pant, H.C.8
  • 42
    • 0030598917 scopus 로고    scopus 로고
    • Dopamine, 6-hydroxydopamine, iron and dioxygen: Their mutual interacions and possible implication in the development of Parkinson's disease
    • Linert W., Herlinger E., Jameson R. F., Kienzl E., Jellinger K. Youdim M. B. (1996) Dopamine, 6-hydroxydopamine, iron and dioxygen: their mutual interacions and possible implication in the development of Parkinson's disease. Biochim. Biophys. Acta 1316, 160 168.
    • (1996) Biochim. Biophys. Acta , vol.1316 , pp. 160-168
    • Linert, W.1    Herlinger, E.2    Jameson, R.F.3    Kienzl, E.4    Jellinger, K.5    Youdim, M.B.6
  • 43
    • 0031786125 scopus 로고    scopus 로고
    • The sevenfold way of PKC regulation
    • Liu W. S. Heckman C. A. (1998) The sevenfold way of PKC regulation. Cell. Signal. 10, 529 542.
    • (1998) Cell. Signal. , vol.10 , pp. 529-542
    • Liu, W.S.1    Heckman, C.A.2
  • 44
    • 21844442345 scopus 로고    scopus 로고
    • Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
    • Lotharius J., Falsig J., Beek J. V., Payne S., Dringen R., Brundin P. Leist M. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J. Neurosci. 25, 6329 6342.
    • (2005) J. Neurosci. , vol.25 , pp. 6329-6342
    • Lotharius, J.1    Falsig, J.2    Beek, J.V.3    Payne, S.4    Dringen, R.5    Brundin, P.6    Leist, M.7
  • 46
    • 0032488992 scopus 로고    scopus 로고
    • Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway
    • Luo Y., Umegaki H., Wang X., Abe R. Roth G. S. (1998) Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J. Biol. Chem. 273, 3756 3764.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3756-3764
    • Luo, Y.1    Umegaki, H.2    Wang, X.3    Abe, R.4    Roth, G.S.5
  • 48
    • 12144290127 scopus 로고    scopus 로고
    • Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells
    • Mathiansen J. R., McKenna B. A., Saporito M. S. et al. (2004) Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells. Brain Res. 1003, 86 97.
    • (2004) Brain Res. , vol.1003 , pp. 86-97
    • Mathiansen, J.R.1    McKenna, B.A.2    Saporito, M.S.3
  • 49
    • 0031981649 scopus 로고    scopus 로고
    • Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: Implications for Parkinson's disease
    • Mayo J. C., Sainz R. M., Uría H., Antolín I., Esteban M. M. Rodriguez C. (1998a) Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease. J. Pineal Res. 24, 179 192.
    • (1998) J. Pineal Res. , vol.24 , pp. 179-192
    • Mayo, J.C.1    Sainz, R.M.2    Uría, H.3    Antolín, I.4    Esteban, M.M.5    Rodriguez, C.6
  • 50
    • 0031827090 scopus 로고    scopus 로고
    • Inhibition of cell proliferation: A mechanism likely to mediate the prevention of neuronal cell death by melatonin
    • Mayo J. C., Sainz R. M., Uria H., Antolin I., Esteban M. M. Rodriguez C. (1998b) Inhibition of cell proliferation: a mechanism likely to mediate the prevention of neuronal cell death by melatonin. J. Pineal Res. 25, 12 18.
    • (1998) J. Pineal Res. , vol.25 , pp. 12-18
    • Mayo, J.C.1    Sainz, R.M.2    Uria, H.3    Antolin, I.4    Esteban, M.M.5    Rodriguez, C.6
  • 51
    • 0034281386 scopus 로고    scopus 로고
    • Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase
    • Namqunq U. Xia Z. (2000) Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J. Neurosci. 20, 6442 6451.
    • (2000) J. Neurosci. , vol.20 , pp. 6442-6451
    • Namqunq, U.1    Xia, Z.2
  • 53
    • 0032569019 scopus 로고    scopus 로고
    • Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase
    • Nemoto S., Xiang J., Huang S. Lin A. (1998) Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J. Biol. Chem. 273, 16415 16420.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16415-16420
    • Nemoto, S.1    Xiang, J.2    Huang, S.3    Lin, A.4
  • 54
    • 2442671608 scopus 로고    scopus 로고
    • Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells
    • Newhouse K., Hsuan S.-L., Chang S. H., Cai B., Wang Y. Xia Z. (2004) Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells. Toxicol. Sci. 79, 137 146.
    • (2004) Toxicol. Sci. , vol.79 , pp. 137-146
    • Newhouse, K.1    Hsuan, S.-L.2    Chang, S.H.3    Cai, B.4    Wang, Y.5    Xia, Z.6
  • 55
    • 0035194849 scopus 로고    scopus 로고
    • Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice
    • Noshita N., Lewen A., Sugawara T. Chan P. H. (2001) Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 21, 1442 1450.
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 1442-1450
    • Noshita, N.1    Lewen, A.2    Sugawara, T.3    Chan, P.H.4
  • 56
    • 0031775603 scopus 로고    scopus 로고
    • Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells
    • Ochu E. E., Rothwell N. J. Waters C. M. (1998) Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. J. Neurochem. 70, 2637 2640.
    • (1998) J. Neurochem. , vol.70 , pp. 2637-2640
    • Ochu, E.E.1    Rothwell, N.J.2    Waters, C.M.3
  • 57
    • 0028129498 scopus 로고
    • Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
    • Pagano M., Theodoras A. M., Tam S. W. Draetta G. F. (1994) Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 8, 1627 1639.
    • (1994) Genes Dev. , vol.8 , pp. 1627-1639
    • Pagano, M.1    Theodoras, A.M.2    Tam, S.W.3    Draetta, G.F.4
  • 58
    • 0242582865 scopus 로고    scopus 로고
    • Hydrogen peroxide signalling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase
    • Pantano C., Shrivastava P., McElhinney B. Janssen-Heininger Y. M. (2003) Hydrogen peroxide signalling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase. J. Biol. Chem. 278, 44091 44096.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44091-44096
    • Pantano, C.1    Shrivastava, P.2    McElhinney, B.3    Janssen-Heininger, Y.M.4
  • 59
    • 0028072520 scopus 로고
    • Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle
    • Peter M. Herskowitz I. (1994) Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 79, 181 184.
    • (1994) Cell , vol.79 , pp. 181-184
    • Peter, M.1    Herskowitz, I.2
  • 60
    • 0032055973 scopus 로고    scopus 로고
    • Neuronal cell death
    • Pettmann B. Henderson C. E. (1998) Neuronal cell death. Neuron 20, 633 647.
    • (1998) Neuron , vol.20 , pp. 633-647
    • Pettmann, B.1    Henderson, C.E.2
  • 61
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T. Nebreda A. R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027 1037.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.R.8
  • 62
    • 0024465402 scopus 로고
    • Cell cycle-specific action of nerve growth factor in PC12 cells: Differentiation without proliferation
    • Rudkin B. B., Lazarovici P., Levi B.-Z., Abe Y., Fujita K. Guroff G. (1989) Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation. EMBO J. 8, 3319 3325.
    • (1989) EMBO J. , vol.8 , pp. 3319-3325
    • Rudkin, B.B.1    Lazarovici, P.2    Levi, B.-Z.3    Abe, Y.4    Fujita, K.5    Guroff, G.6
  • 63
    • 1242274413 scopus 로고    scopus 로고
    • Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: Relationships with nerve growth factor
    • Saito A., Narasimhan P., Hayashi T., Okuno S., Ferrand-Drake M. Chan P. H. (2004) Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. J. Neurosci. 24, 1584 1593.
    • (2004) J. Neurosci. , vol.24 , pp. 1584-1593
    • Saito, A.1    Narasimhan, P.2    Hayashi, T.3    Okuno, S.4    Ferrand-Drake, M.5    Chan, P.H.6
  • 64
    • 0038529681 scopus 로고    scopus 로고
    • Nerve growth factor portects against 6-hydroxydopamine-induced oxidative stress by increassing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner
    • Salinas M., Diaz R., Abraham N. G., de Galarreta C. M. R. Cuadrado A. (2003) Nerve growth factor portects against 6-hydroxydopamine-induced oxidative stress by increassing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner. J. Biol. Chem. 278, 13898 13904.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13898-13904
    • Salinas, M.1    Diaz, R.2    Abraham, N.G.3    De Galarreta, C.M.R.4    Cuadrado, A.5
  • 66
    • 22844445441 scopus 로고    scopus 로고
    • Mixed lineage kinase-c-jun N-terminal kinase signalling pathway: A new therapeutic target in Parkinson's disease
    • Silva R. M., Kuan C.Y., Rakic P. Burke R. E. (2005) Mixed lineage kinase-c-jun N-terminal kinase signalling pathway: a new therapeutic target in Parkinson's disease. Mov. Disord. 20, 653 664.
    • (2005) Mov. Disord. , vol.20 , pp. 653-664
    • Silva, R.M.1    Kuan, C.Y.2    Rakic, P.3    Burke, R.E.4
  • 67
    • 0033538078 scopus 로고    scopus 로고
    • FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line
    • Sonoda Y., Watanabe S., Matsumoto Y., Aizu-Yokota E. Kasahara T. (1999) FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J. Biol. Chem. 274, 10566 10570.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10566-10570
    • Sonoda, Y.1    Watanabe, S.2    Matsumoto, Y.3    Aizu-Yokota, E.4    Kasahara, T.5
  • 69
    • 0034697364 scopus 로고    scopus 로고
    • Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
    • Stanciu M., Wang Y., Kentor R. et al. (2000) Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J. Biol. Chem. 275, 12200 12206.
    • (2000) J. Biol. Chem. , vol.275 , pp. 12200-12206
    • Stanciu, M.1    Wang, Y.2    Kentor, R.3
  • 73
    • 0028127058 scopus 로고
    • Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis
    • Walkinshaw G. Waters C. M. (1994) Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience 63, 975 987.
    • (1994) Neuroscience , vol.63 , pp. 975-987
    • Walkinshaw, G.1    Waters, C.M.2
  • 74
    • 0032820452 scopus 로고    scopus 로고
    • Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
    • Wang H. Joseph J. A. (1999) Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Rad. Biol. Med. 27, 612 616.
    • (1999) Free Rad. Biol. Med. , vol.27 , pp. 612-616
    • Wang, H.1    Joseph, J.A.2
  • 75
    • 0028326907 scopus 로고
    • Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts
    • Wymann M. Arcaro A. (1994) Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts. Biochem. J. 298 Pt 3, 517 520.
    • (1994) Biochem. J. 298 Pt , vol.3 , pp. 517-520
    • Wymann, M.1    Arcaro, A.2
  • 76
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R. J. Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326 1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 78
    • 0029052834 scopus 로고
    • NGF regulates the PC12 cell cycle machinery through specific inhibition of the cdk kinases and induction of cyclin D1
    • Yan G.-Z. Ziff E. B. (1995) NGF regulates the PC12 cell cycle machinery through specific inhibition of the cdk kinases and induction of cyclin D1. J. Neurosci. 15, 6200 6212.
    • (1995) J. Neurosci. , vol.15 , pp. 6200-6212
    • Yan, G.-Z.1    Ziff, E.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.