Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors: Investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity

Journal of Medicinal Chemistry

Volumn 54, Issue 14, 2011, Pages 4937-4953

  Peterson, Katherine E ^a   Cinelli, Maris A ^a   Morrell, Andrew E ^a   Mehta, Akhil ^a   Dexheimer, Thomas S ^b   Agama, Keli ^b   Antony, Smitha ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 6 (1' HYDROXY 2' METHYLETHYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (2' HYDROXYPROPYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (2',3' DIHYDROXYPROPYL) 2,3 DIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (2',3' DIHYDROXYPROPYL) 3 NITRO 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (2',3',4',5' TETRAHYDROXYPENTYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (2',3',4',5',6' PENTAHYDROXYHEXYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (3' AMINO 2' HYDROXYPROPYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (3' HYDROXY 1' METHYLETHYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (3' HYDROXY 2' METHYLETHYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 (3' HYDROXY 2' OXOPROPYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 [(2',3' DIHYDROPROPYL)] 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 [2' HYDROXY 3' TERT (BUTYLDIPHENYLSILYLOXY)PROPYL] 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 5,6 DIHYDRO 6 [2' OXO 3' TERT (BUTYLDIPHENYLSILYLOXY)PROPYL] 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; ALCOHOL; CARBOHYDRATE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; INDENOISOQUINOLINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ASSAY; BIOLOGICAL ACTIVITY; DNA BINDING; DNA PROTEIN COMPLEX; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; EVALUATION; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; STEREOCHEMISTRY;

ALCOHOLS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HEXOSES; HUMANS; HYDROGEN BONDING; INDENES; MODELS, MOLECULAR; PENTOSES; QUINOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 79960651736     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101338z     Document Type: Article

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