Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue

Molecular Pharmacology

Volumn 55, Issue 2, 1999, Pages 377-385

  Bailly, Christian ^a,e   Qu, Xiaogang ^b   Anizon, Fabrice ^d   Prudhomme, Michelle ^d   Riou, Jean François ^c   Chaires, Jonathan B ^b  

^a INSERM   (France)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^c SANOFI   (France)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

^e U 124 Inst Natl S la Rech Med   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A][PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; 7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC ANTIBIOTIC; GYRASE INHIBITOR; PROTEIN KINASE C INHIBITOR; REBECCAMYCIN; STAUROSPORINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG SYNTHESIS; ENZYME INHIBITION; LEUKEMIA CELL; LEUKEMIA P 388; NONHUMAN; PRIORITY JOURNAL;

EID: 0033049569     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.2.377     Document Type: Article

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