Novel antitumor L-arabinose derivative of indolocarbazole with high affinity to DNA

ChemMedChem

Volumn 4, Issue 10, 2009, Pages 1641-1648

  Kaluzhny, Dmitry N ^a   Tatarskiy Jr , Victor V ^b   Dezhenkova, Lyubov G ^c   Plikhtyak, Irina L ^b   Miniker, Tatyana D ^b   Shchyolkina, Anna K ^a   Strel'tsov, Sergey A ^a   Chilov, Ghermes G ^d   Novikov, Fedor N ^d   Kubasova, Irina Yu ^b   Smirnova, Zoya S ^b   Mel'nik, Stalina Ya ^b   Livshits, Mikhail A ^a   Borisova, Olga F ^a   Shtil, Alexander A ^b  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^d MolTech Ltd   (Russian Federation)

Author keywords

Antitumor agents; Binding constants; DNA; Indolocarbazoles; Intercalation

Indexed keywords

12 (ALPHA LEVO ARABINOPYRANOSYL)INDOLO[2,3 ALPHA]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; ANTINEOPLASTIC AGENT; ARABINOSE DERIVATIVE; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER GRAFT; CELL DEATH; CELL STRAIN HCT116; CONTROLLED STUDY; DRUG DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; ENERGY TRANSFER; ENZYME INHIBITION; FEMALE; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; INTERCALATION COMPLEX; LEWIS CARCINOMA; LINEAR DICHROISM; LYMPHATIC LEUKEMIA; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSACTIVATION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARABINOSE; CARBAZOLES; CELL LINE, TUMOR; DNA; FEMALE; HUMANS; INTERCALATING AGENTS; MICE; MICE, INBRED STRAINS; SPECTROMETRY, FLUORESCENCE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 70349764512     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900227     Document Type: Article

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