Synthesis and biological activities of NB-506 analogues modified at the glucose group

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 5, 2000, Pages 419-422

  Ohkubo, Mitsuru ^a   Nishimura, Teruyuki ^a   Kawamoto, Hiroshi ^a   Nakano, Masato ^a   Honma, Teruki ^a   Yoshinari, Tomoko ^a   Arakawa, Hiroharu ^a   Suda, Hiroyuki ^a   Morishima, Hajime ^a   Nishimura, Susumu ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE; FURAN DERIVATIVE; GLUCOPYRANOSIDE; GLUCOSE DERIVATIVE; RIBOFURANOSIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CYTOTOXICITY; DRUG POTENCY; DRUG SAFETY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; GLYCOSYLATION; MOUSE; NONHUMAN;

ANTINEOPLASTIC AGENTS; CARBAZOLES; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; GLUCOSE; GLUCOSIDES; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; STEREOISOMERISM; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034611438     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00004-4     Document Type: Article

References (16)

1. Morham S.G., Kluckman K.D., Voulomanos N., Smithies O. Mol. Cell. Biol. 16:1996;6804.
2. Husain I., Mohler J.L., Seigler H.F., Besterman J.M. Cancer Res. 54:1994;539.
3. Arakawa H., Iguchi T., Morita M., Yoshinari T., Kojiri K., Suda H., Okura A., Nishimura S. Cancer Res. 55:1995;1316.
4. Yoshinari T., Matsumoto M., Arakawa H., Okada H., Noguchi K., Suda H., Okura A., Nishimura S. Cancer Res. 55:1995;1310.
5. Fukasawa K., Komatani H., Hara Y., Suda H., Okura A., Nishimura S., Yoshinari T. Int. J. Cancer. 75:1998;145.
6. Kojiri K., Kondo H., Yoshinari T., Arakawa H., Nakajima S., Satoh F., Kawamura K., Okura A., Suda H., Okanishi M. J. Antibiot. 44:1991;723.
7. Ohkubo M., Kojiri K., Kondo H., Tanaka S., Kawamoto H., Nishimura T., Nishimura I., Yoshinari T., Arakawa H., Suda H., Morishima H., Nishimura S. Bioorg. Med. Chem. Lett. 9:1999;1219.
8. Ohkubo M., Nishimura T., Honma T., Nishimura I., Ito S., Yoshinari T., Arakawa H., Suda H., Morishima H., Nishimura S. Bioorg. Med. Chem. Lett. 9:1999;3307.
9. Yoshinari T., Ohkubo M., Fukasawa K., Egashira S., Hara Y., Matsumoto M., Nakai K., Arakawa H., Morishima H., Nishimura S. Cancer Res. 59:1999;4271.
10. Arakawa H., Morita M., Kodera T., Okura A., Ohkubo M., Morishima H., Nishimura S. Jpn. J. Cancer Res. 90:1999;1163.
11. Ohkubo M., Kawamoto H., Ohno T., Nakano M., Morishima H. Tetrahedron. 53:1997;585.
12. Ohkubo M., Nishimura T., Jona H., Honma T., Ito S., Morishima H. Tetrahedron. 53:1997;5937.
13. Compounds 5 and 6 were prepared from 6-benzyloxyindole and 2, 3-dibromo-N-methylmaleimide, see ref.: Ohkubo, M.; Nishimura, T.; Jona, H.; Honma, T.; Morishima, H. Tetrahedron 1996, 52, 8099.
14. Iversen T., Bundle D.R. Carbohydr. Res. 103:1982;29.
15. Ireland R.E., Thaisrivongs S., Vanier N., Wilcox C.S. J. Org. Chem. 45:1980;48.
16. 10 578.1649, found 578.1655.