Computational and experimental investigation of flow and fluid mixing in the roller bottle bioreactor

Biotechnology and Bioengineering

Volumn 70, Issue 2, 2000, Pages 117-130

  Unger, D R ^a   Muzzio, F J ^a   Aunins, J G ^b   Singhvi, R ^b  

^a The State University of New Jersey   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bioreactor; CFD; Mixing; Roller bottle

Indexed keywords

AXIAL FLOW; COMPUTATIONAL FLUID DYNAMICS; FINITE ELEMENT METHOD; FLOW PATTERNS; FLOW VISUALIZATION; STREAM FLOW; VELOCITY MEASUREMENT;

PARTICLE IMAGING VELOCIMETRY (PIV); ROLLER BOTTLES;

BIOREACTORS;

GLYCEROL; TRACER; WATER;

APPARATUS; ARTICLE; BIOREACTOR; CALCULATION; CULTURE MEDIUM; DYNAMICS; FLOW MEASUREMENT; FLOW RATE; FLUID FLOW; MOTION; SIMULATION; VELOCITY;

EID: 0034693458     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0290(20001020)70:2<117::AID-BIT1>3.0.CO;2-8     Document Type: Article

References (17)

1. Particle-imaging techniques for experimental fluid mechanics
2. Using flow perturbations to enhance mixing of dry powders in V-blenders
3. Reduction of NO(x) formation in natural gas burner flames
4. Interferon production in microcarrier culture of human fibroblast cells
5. The Kenics static mixer: A three-dimensional chaotic flow
6. Numerical characterization of low Reynolds number flow in the Kenics static mixer
7. Using time-dependent RPM to enhance mixing in stirred vessels
8. Effect of idealized asymmetric inhibitor stubs on circumferential flow in the space shuttle
9. Computational and experimental investigation of flow and particle settling in a roller bottle bioreactor
10. Effect of convection on the microstructure of a lamellar eutectic growing with a stepped interface
11. A comparative computational and experimental study of chaotic mixing and viscous fluids
12. Dynamics of fluid mixing induced at a T-junction. 3. Experimental characterization and fluid dynamic computation of temperature distribution in space
13. Experimental and numerical characterization of viscous flow and mixing in an impinging jet contactor
14. Mixing of granular material in a drum mixer undergoing rotational and rocking motions. 1. Uniform particles
15. Mixing of granular material in a drum mixer undergoing rotational and rocking motions. 2. Segregating particles
16. The structure of mixtures of particles generated by time-dependent flows