Expansion of human neural precursor cells in large-scale bioreactors for the treatment of neurodegenerative disorders

Biotechnology Progress

Volumn 24, Issue 4, 2008, Pages 859-870

  Baghbaderani, Behnam A ^a   Behie, Leo A ^a   Sen, Arindom ^a   Mukhida, Karim ^b   Hong, Murray ^b   Mendez, Ivar ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOREACTORS; CELLS; CHEMICAL REACTORS; CYTOLOGY; INDUSTRIAL CHEMICALS;

COMPUTER-CONTROLLED; HUMAN CELLS; IN-VITRO; LIQUID SHEAR; NEURAL PRECURSOR CELLS; NEURODEGENERATIVE DISORDERS; PARKINSON'S DISEASE; SCALE-UP; SERUM-FREE MEDIUM; TARGET VALUE;

HEALTH;

OXYGEN;

BIOREACTOR; CELL AGGREGATION; CELL CULTURE; CELL DIFFERENTIATION; CONFERENCE PAPER; CULTURE TECHNIQUE; CYTOLOGY; DEGENERATIVE DISEASE; EVALUATION; HUMAN; METABOLISM; METHODOLOGY; NERVE CELL; PHYSIOLOGY; STEM CELL;

BIOREACTORS; CELL AGGREGATION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; NEURODEGENERATIVE DISEASES; NEURONS; OXYGEN; STEM CELLS;

RATTUS;

EID: 51849126825     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp.070324s     Document Type: Conference Paper

References (49)

1. Mukhida K, Mendez I, McLeod M, Kobayashi N, Haughn C, Milne B, Baghbaderani B, Sen A, Behie LA, Hong M. Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain. Stem Cells. 2007; DOI 10.1634/stemcells.2007-0326.
2. Kallos MS, Sen A, Behie LA. Large-scale expansion of mammalian neural stem cells: a review. Med Biol Eng Comput. 2003;41:271-282.
3. Storch A, Schwarz J. Neural stem cells and neurodegeneration. Curr Opin Investig Drugs. 2002;3:774-781.
4. Freed CR, Breeze RE, Rosenberg NL, Schneck SA. Kriek E, Qi JX, Lone T, Zhang YB, Snyder JA, Wells TH, Ramig LO, Thomson L, Mazziotta JC, Huang SC, ST G, Brooks D, Sawle G, Schroter G, Ansari AA. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N Engl J Med. 1992; 327:1549-1555.
5. Lindvall O, Brundin P, Widner H, Rehncrona S, Gustavii B, Frackowiak R, Leenders KL, Sawle G, Rothwell JC, Marsden CD, Bjorklund A. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science. 1990;247:574-577.
6. Lindvall O, Sawle G, Widner H, Rothwell JC, Bjorklund A, Brooks D, Brundin P, Frackowiak R, Marsden CD, Odin P, Rehncrona S. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol. 1994;35:172-180.
7. Piccini P, Brooks DJ, Bjorklund A, Gunn RN, Grasby PM, Rimoldi O, Brundin P, Hagell P, Rehncrona S, Widner H, Lindvall O. Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat Neurosci. 1999;2:1137-1140.
8. Piccini P, Lindvall O, Bjorklund A, Brundin P, Hagell P, Ceravolo R, Oertel W, Quinn N, Samuel M, Rehncrona S, Widner H, Brooks DJ. Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts. Ann Neurol. 2000;48:689-695.
9. Bachoud-Levi A-C, Bourdet C, Brugieres P, Nguyen J-P, Grandmougin T, Haddad B, Jeny R, Bartolomeo P, Boisse M-F, Barba GD. Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease. Exp Neurol. 2000;161:194-202.
10. Bachoud-Levi A-C, Gaura V, Brugieres P, Lefaucheur J-P, Boisse M-F, Maison P, Baudic S, Ribeiro M-J, Bourdet C, Remy P. Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study. Lancet Neurol. 2006;5:303-309.
11. Bachoud-Levi A-C, Remy P, Nguyen J-P, Brugieres P, Lefaucheur J-P, Bourdet C, Baudic S, Gaura V, Maison P, Haddad B. Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet. 2000;356: 1975-1979.
12. Philpott LM, Kopyov OV, Lee AJ, Jacques S, Duma CM, Caine S, Yang M. Eagle KS. Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: Three case presentations. Cell Transplant. 1997;6:203-212.
13. Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med. 2001;344: 710-719.
14. Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, Freeman TB. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol. 2003;54: 403-414.
15. Mendez I, Dagher A, Hong M, Gaudet P, Weerasinghe S, McAlister V, King D, Desrosiers J, Darvesh S, Acorn T, Robertson H. Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases. J Neurosurg. 2002;96:589-596.
16. Mendez I, Sanchez-Pernaute R, Cooper O, Vinuela A, Ferrari D, Bjorklund L, Dagher A, Isacson O. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain. 2005;128:1498-1510.
17. Kopyov OV, Jacques S, Lieberman A, Duma CM, Eagle KS. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp Neurol. 1998;149:97-108.
18. Rosser AE, Barker RA, Harrower T, Watts C, Farrington M, Ho AK, Burnstein RM, Menon DK, Gillard JH, Pickard J, Dunnett SB. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475. J Neurol Neurosurg Psychiatry. 2002;73:678-685.
19. Dunnett SB, Rosser AE. Cell transplantation for Huntington's disease: Should we continue? Brain Res Bull. 2007;72:132-147.
20. Dunnett SB, Rosser AE. Cell therapy in Huntington's disease. NeuroRx. 2004;1:394-405.
21. Carpenter MK, Cui X, Hu Z-y, Jackson J, Sherman S, Seiger A, Wahlberg LU. In vitro expansion of a multipotent population of human neural progenitor cells. Exp Neurol. 1999;158:265-278.
22. Storch A, Paul G, Csete M, Boehm BO, Carvey PM, Kupsch A, Schwarz J. Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells. Exp Neurol. 2001;170:317-325.
23. Suzuki M, Wright LS, Marwah P, Lardy HA, Svendsen CN. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA). on human neural stem cell cultures derived from the fetal cortex. Proc Natl Acad Sci USA. 2004;101:3202-3207.
24. Svendsen CN, ter Borg MG, Armstrong RJE, Rosser AE, Chandran S, Ostenfeld T, Caldwell MA. A new method for the rapid and long term growth of human neural precursor cells. J Neurosci Methods. 1998;85:141-152.
25. Vescovi AL, Parati EA, Gritti A, Poulin P, Ferrario M, Wanke E; Frolichsthal- Schoeller P, Cova L, Arcellana-Panlilio M, Colombo A, Galli R. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp Neurol. 1999;156:71-83.
26. Mukhida K, Hong M, Behie LA, Mendez I. Co-grafting with bioreactor-expanded human neural precursor cells enhances survival of fetal dopaminergic transplants in Hemiparkinsonian rodents. Exp Neurol. 2006;198:582.
27. Butler M Animal Cell Culture and Technology, 2nd ed. London: BIOS Scientific Publishers, 2004; pp 75-97.
28. Sen A, Kallos MS, Behie LA. Effects of hydrodynamic on extended cultures of mammalian neural stem cell aggregates in suspension culture. Ind Eng Chem Res. 2001;40:5350-5357.
29. Gilbertson JA, Sen A, Behie LA, Kallos MS. Scaled-up production of mammalian neural precursor cell aggregates in computer-controlled suspension bioreactors. Biotechnol Bioeng. 2006;94:783-792.
30. Kallos MS, Behie LA. Inoculation and growth conditions for high-cell-density expansion of mammalian neural stem cells in suspension bioreactors. Biotechnol Bioeng. 1999;63:473-483.
31. Kallos MS, Behie LA, Vescovi AL. Extended serial passaging of mammalian neural stem cells in suspension bioreactors. Biotechnol Bioeng. 1999;65:589-599.
32. Sen A, Kallos MS, Behie LA. Expansion of mammalian neural stem cells in bioreactors: effect of power input and medium viscosity. Brain Res Dev Brain Res. 2002;134:103-113.
33. Sen A, Kallos MS. Behie LA. Passaging protocols for mammalian neural stem cells in suspension bioreactors. Biotechnol Prog. 2002;18:337-345.
34. Youn BS, Sen A, Kallos MS. Behie LA, Girgis-Gabardo A, Kurpios N, Barcelon M, Hassell JA. Large-scale expansion of mammary epithelial stem cell aggregates in suspension bioreactors. Biotechnol Prog. 2005;21:984-993.
35. Youn BS, Sen A, Behie LA, Girgis-Gabardo A, Hassell JA. Scale-up of breast cancer stem cell aggregate cultures to suspension bioreactors. Biotechnol Prog. 2006;22:801-810.
36. Aunins JG, Woodson BA, Hale LC, Wang DIC. Effects of paddle impeller geometry on power input and mass transfer in small-scale animal cell culture vessels. Biotechnol Bioeng. 1989;43:1127-1132.
37. Cherry RS, Kwon K-Y. Transient shear stresses on a suspension cell in turbulence. Biotechnol Bioeng. 1990;36:563-571.
38. Nagata S Mixing: Principles and Applications; New York: Wiley, 1975; p 458.
39. Gooch KJ, Kwon JH, Blunk T, Langer R, Freed LE, Vunjak-Novakovic G. Effects of mixing intensity on tissueengineered cartilage. Biotechnol Bioeng. 2001;72:402-407.
40. Sucosky P, Osorio DF, Brown JB, Neitzel GP. Fluid mechanics of a spinner-flask bioreactor. Biotechnol Bioeng. 2004;85:34-46.
41. Moreira JL, Aunins JG, Carrondo MJ. Hydrodynamics effects on BHK cells grown as suspended natural aggregates. Biotechnol Bioeng. 1995;46:351-360.
42. Ozturk SS, Thrift JC, Blackie JD, Naveh D. Real-time monitoring and control of glucose and lactate concentrations in a mammalian cell perfusion reactor. Biotechnol Bioeng. 1997;53:372-378.
43. Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN. Gene expression in human neural stem cells: effects of leukemia inhibitory factor. J Neurochem. 2003;86:179-95.
44. Buc-Caron M-H. Neuroepithelial progenitor cells explanted from human fetal brain proliferate and differentiatein vitro. NeurohiolDis. 1995;2:37-47.
45. Chalmers-Redman RME, Priestley T, Kemp JA, Fine A. In vitro propagation and inducible differentiation of multipotential progenitor cells from human fetal brain. Neuroscience. 1997;76:1121-1128.
46. Duittoz AH, Hevor T. Primary culture of neural precursors from the ovine central nervous system (CNS). J Neurosci Methods. 2001;107:131-140.
47. Gritti A, Parati E, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti D, Roisen F, Nickel D, Vescovi A. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J Neurosci. 1996;16:1091-1100.
48. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med. 2004;10(Suppl):S42-S50.
49. Storch A, Sabolek M, Milosevic J, Schwarz SC, Schwarz J. Midbrain-derived neural stem cells: from basic science to therapeutic approaches. Cell Tissue Res. 2004;318:15-22.