메뉴 건너뛰기




Volumn 13, Issue 7, 2007, Pages 1399-1412

Stem/progenitor cell sources of insulin-producing cells for the treatment of diabetes

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; INSULIN; PATIENT TREATMENT; TRANSPLANTATION (SURGICAL);

EID: 34547134956     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2007.0047     Document Type: Review
Times cited : (80)

References (135)
  • 1
    • 0043244907 scopus 로고    scopus 로고
    • Economic costs of diabetes in the US in 2002
    • Hogan, P., Dall, T. and Nikolov, P. Economic costs of diabetes in the US in 2002. Diabetes Care 26, 917, 2003.
    • (2003) Diabetes Care , vol.26 , pp. 917
    • Hogan, P.1    Dall, T.2    Nikolov, P.3
  • 2
    • 34547116556 scopus 로고    scopus 로고
    • National Diabetes Fact Sheet:, Atlanta, GA: Centers for Disease Control and Prevention, U.S. Department of Health and Human Services
    • National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States. Atlanta, GA: Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 2003.
    • (2003) General Information and National Estimates on Diabetes in the United States
  • 5
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P.A. and Wollheim, C.B. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130, 167, 1992.
    • (1992) Endocrinology , vol.130 , pp. 167
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 6
    • 0022447894 scopus 로고
    • Five new insulin- producing cell lines with differing secretory properties
    • Carrington, C.A., Rubery, E.D., Pearson, E.C. and Hales, C.N. Five new insulin- producing cell lines with differing secretory properties. J Endocrinol 109, 193, 1986.
    • (1986) J Endocrinol , vol.109 , pp. 193
    • Carrington, C.A.1    Rubery, E.D.2    Pearson, E.C.3    Hales, C.N.4
  • 7
    • 0027360242 scopus 로고
    • Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets
    • Ishihara, H., Asano, T., Tsukuda, K., Katagiri, H., Inukai, K., Anai, M., Kikuchi, M., Yazaki, Y., Miyazaki, J.I. and Oka, Y. Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia 36, 1139, 1993.
    • (1993) Diabetologia , vol.36 , pp. 1139
    • Ishihara, H.1    Asano, T.2    Tsukuda, K.3    Katagiri, H.4    Inukai, K.5    Anai, M.6    Kikuchi, M.7    Yazaki, Y.8    Miyazaki, J.I.9    Oka, Y.10
  • 9
    • 0027299925 scopus 로고
    • Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: A potentially general technique for isolating physiologically representative cell lines
    • Radvanyi, F., Christgau, S., Baekkeskov, S., Jolicoeur, C. and Hanahan, D. Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines. Mol Cell Biol 13, 4223, 1993.
    • (1993) Mol Cell Biol , vol.13 , pp. 4223
    • Radvanyi, F.1    Christgau, S.2    Baekkeskov, S.3    Jolicoeur, C.4    Hanahan, D.5
  • 10
    • 0025783174 scopus 로고
    • Glucose induces insulin gene transcription in a murine pancreatic beta-cell line
    • Efrat, S., Surana, M. and Fleischer, N. Glucose induces insulin gene transcription in a murine pancreatic beta-cell line. J Biol Chem 266, 11141, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 11141
    • Efrat, S.1    Surana, M.2    Fleischer, N.3
  • 11
    • 0028938747 scopus 로고
    • Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene
    • Efrat, S., Fusco-DeMane, D., Lemberg, H., al Emran, O. and Wang, X. Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc Natl Acad Sci U S A 92, 3576, 1995.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3576
    • Efrat, S.1    Fusco-DeMane, D.2    Lemberg, H.3    al Emran, O.4    Wang, X.5
  • 13
    • 0026342259 scopus 로고
    • Transport and metabolism of glucose in an insulin-secreting cell line, beta TC-1
    • Whitesell, R.R., Powers, A.C., Regen, D.M. and Abumrad, N.A. Transport and metabolism of glucose in an insulin-secreting cell line, beta TC-1. Biochemistry 30, 11560, 1991.
    • (1991) Biochemistry , vol.30 , pp. 11560
    • Whitesell, R.R.1    Powers, A.C.2    Regen, D.M.3    Abumrad, N.A.4
  • 14
    • 0027132228 scopus 로고
    • Differential expression of non-allelic insulin genes in rodent islet tumour cells
    • Lund, K., Blume, N., Michelsen, B.K., Bucchini, D. and Madsen, O.D. Differential expression of non-allelic insulin genes in rodent islet tumour cells. J Mol Endocrinol 11, 305, 1993.
    • (1993) J Mol Endocrinol , vol.11 , pp. 305
    • Lund, K.1    Blume, N.2    Michelsen, B.K.3    Bucchini, D.4    Madsen, O.D.5
  • 15
    • 0030948732 scopus 로고    scopus 로고
    • Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression
    • Clark, S.A., Quaade, C., Constandy, H., Hansen, P., Halban, P., Ferber, S., Newgard, C.B. and Normington, K. Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. Diabetes 46, 958, 1997.
    • (1997) Diabetes , vol.46 , pp. 958
    • Clark, S.A.1    Quaade, C.2    Constandy, H.3    Hansen, P.4    Halban, P.5    Ferber, S.6    Newgard, C.B.7    Normington, K.8
  • 17
    • 0028286784 scopus 로고
    • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity
    • Ferber, S., Beltran del Rio, H., Johnson, J.H., Noel, R.J., Cassidy, L.E., Clark, S., Becker, T.C., Hughes, S.D. and Newgard, C.B. GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. J Biol Chem 269, 11523, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 11523
    • Ferber, S.1    Beltran del Rio, H.2    Johnson, J.H.3    Noel, R.J.4    Cassidy, L.E.5    Clark, S.6    Becker, T.C.7    Hughes, S.D.8    Newgard, C.B.9
  • 18
    • 0030016231 scopus 로고    scopus 로고
    • Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts
    • Klug, M.G., Soonpaa, M.H., Koh, G.Y. and Field, L.J. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 98, 216, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 216
    • Klug, M.G.1    Soonpaa, M.H.2    Koh, G.Y.3    Field, L.J.4
  • 20
    • 0034705056 scopus 로고    scopus 로고
    • Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation
    • Liu, S., Qu, Y., Stewart, T.J., Howard, M.J., Chakrabortty, S., Holekamp, T.F. and McDonald, J.W. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci U S A 97, 6126, 2000.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6126
    • Liu, S.1    Qu, Y.2    Stewart, T.J.3    Howard, M.J.4    Chakrabortty, S.5    Holekamp, T.F.6    McDonald, J.W.7
  • 22
    • 0042453495 scopus 로고    scopus 로고
    • Analysis of insulin- producing cells during in vitro differentiation from feeder-free embryonic stem cells
    • Moritoh, Y., Yamato, E., Yasui, Y., Miyazaki, S. and Miyazaki, J. Analysis of insulin- producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes 52, 1163, 2003.
    • (2003) Diabetes , vol.52 , pp. 1163
    • Moritoh, Y.1    Yamato, E.2    Yasui, Y.3    Miyazaki, S.4    Miyazaki, J.5
  • 23
    • 0042767581 scopus 로고    scopus 로고
    • Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: An in vitro model to study islet differentiation
    • Kahan, B.W., Jacobson, L.M., Hullett, D.A., Ochoada, J.M., Oberley, T.D., Lang, K.M. and Odorico, J.S. Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes 52, 2016, 2003.
    • (2003) Diabetes , vol.52 , pp. 2016
    • Kahan, B.W.1    Jacobson, L.M.2    Hullett, D.A.3    Ochoada, J.M.4    Oberley, T.D.5    Lang, K.M.6    Odorico, J.S.7
  • 24
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R. and McKay, R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292, 1389, 2001.
    • (2001) Science , vol.292 , pp. 1389
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3    Velasco, I.4    Ravin, R.5    McKay, R.6
  • 25
    • 0037058934 scopus 로고    scopus 로고
    • Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    • Hori, Y., Rulifson, I.C., Tsai, B.C., Heit, J.J., Cahoy, J.D. and Kim, S.K. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 99, 16105, 2002.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16105
    • Hori, Y.1    Rulifson, I.C.2    Tsai, B.C.3    Heit, J.J.4    Cahoy, J.D.5    Kim, S.K.6
  • 28
    • 23844453346 scopus 로고    scopus 로고
    • Sequestration and synthesis: The source of insulin in cell clusters differentiated from murine embryonic stem cells
    • Paek, H.J., Morgan, J.R. and Lysaght, M.J. Sequestration and synthesis: the source of insulin in cell clusters differentiated from murine embryonic stem cells. Stem Cells 23, 862, 2005.
    • (2005) Stem Cells , vol.23 , pp. 862
    • Paek, H.J.1    Morgan, J.R.2    Lysaght, M.J.3
  • 29
    • 0037417958 scopus 로고    scopus 로고
    • Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
    • Blyszczuk, P., Czyz, J., Kania, G., Wagner, M., Roll, U., St-Onge, L. and Wobus, A.M. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci U S A 100, 998, 2003.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 998
    • Blyszczuk, P.1    Czyz, J.2    Kania, G.3    Wagner, M.4    Roll, U.5    St-Onge, L.6    Wobus, A.M.7
  • 31
    • 4544310572 scopus 로고    scopus 로고
    • In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells
    • Leon-Quinto, T., Jones, J., Skoudy, A., Burcin, M. and Soria, B. In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 47, 1442, 2004.
    • (2004) Diabetologia , vol.47 , pp. 1442
    • Leon-Quinto, T.1    Jones, J.2    Skoudy, A.3    Burcin, M.4    Soria, B.5
  • 32
    • 0033979603 scopus 로고    scopus 로고
    • Insulin- secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    • Soria, B., Roche, E., Berna, G., Leon-Quinto, T., Reig, J.A. and Martin, F. Insulin- secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49, 157, 2000.
    • (2000) Diabetes , vol.49 , pp. 157
    • Soria, B.1    Roche, E.2    Berna, G.3    Leon-Quinto, T.4    Reig, J.A.5    Martin, F.6
  • 33
    • 0035057914 scopus 로고    scopus 로고
    • From stem cells to beta cells: New strategies in cell therapy of diabetes mellitus
    • Soria, B., Skoudy, A. and Martin, F. From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 44, 407, 2001.
    • (2001) Diabetologia , vol.44 , pp. 407
    • Soria, B.1    Skoudy, A.2    Martin, F.3
  • 34
    • 0038692109 scopus 로고    scopus 로고
    • PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells
    • Noguchi, H., Kaneto, H., Weir, G.C. and Bonner-Weir, S. PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes 52, 1732, 2003.
    • (2003) Diabetes , vol.52 , pp. 1732
    • Noguchi, H.1    Kaneto, H.2    Weir, G.C.3    Bonner-Weir, S.4
  • 35
    • 25844477198 scopus 로고    scopus 로고
    • BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence
    • Noguchi, H., Bonner-Weir, S., Wei, F.Y., Matsushita, M. and Matsumoto, S. BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes 54, 2859, 2005.
    • (2005) Diabetes , vol.54 , pp. 2859
    • Noguchi, H.1    Bonner-Weir, S.2    Wei, F.Y.3    Matsushita, M.4    Matsumoto, S.5
  • 36
    • 14644427763 scopus 로고    scopus 로고
    • TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro
    • Dominguez-Bendala, J., Klein, D., Ribeiro, M., Ricordi, C., Inverardi, L., Pastori, R. and Edlund, H. TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro. Diabetes 54, 720, 2005.
    • (2005) Diabetes , vol.54 , pp. 720
    • Dominguez-Bendala, J.1    Klein, D.2    Ribeiro, M.3    Ricordi, C.4    Inverardi, L.5    Pastori, R.6    Edlund, H.7
  • 42
    • 0037213351 scopus 로고    scopus 로고
    • Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis
    • Gu, G., Brown, J.R. and Melton, D.A. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev 120, 35, 2003.
    • (2003) Mech Dev , vol.120 , pp. 35
    • Gu, G.1    Brown, J.R.2    Melton, D.A.3
  • 43
    • 27744603796 scopus 로고    scopus 로고
    • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration?
    • Meier, J.J., Bhushan, A., Butler, A.E., Rizza, R.A. and Butler, P.C. Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48, 2221, 2005.
    • (2005) Diabetologia , vol.48 , pp. 2221
    • Meier, J.J.1    Bhushan, A.2    Butler, A.E.3    Rizza, R.A.4    Butler, P.C.5
  • 44
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir, S., Baxter, L.A., Schuppin, G.T. and Smith, F.E. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42, 1715, 1993.
    • (1993) Diabetes , vol.42 , pp. 1715
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 45
    • 0034100823 scopus 로고    scopus 로고
    • Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
    • Ramiya, V.K., Maraist, M., Arfors, K.E., Schatz, D.A., Peck, A.B. and Cornelius, J.G. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 6, 278, 2000.
    • (2000) Nat Med , vol.6 , pp. 278
    • Ramiya, V.K.1    Maraist, M.2    Arfors, K.E.3    Schatz, D.A.4    Peck, A.B.5    Cornelius, J.G.6
  • 47
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor, Y., Brown, J., Martinez, O.I. and Melton, D.A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41, 2004.
    • (2004) Nature , vol.429 , pp. 41
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 48
    • 33646580071 scopus 로고    scopus 로고
    • Are there pancreatic progenitor cells from which new islets form after birth? Nat Clin Pract
    • Bonner-Weir, S. and Sharma, A. Are there pancreatic progenitor cells from which new islets form after birth? Nat Clin Pract Endocrinol Metab 2, 240, 2006.
    • (2006) Endocrinol Metab , vol.2 , pp. 240
    • Bonner-Weir, S.1    Sharma, A.2
  • 49
    • 0025190642 scopus 로고
    • CNS stem cells express a new class of intermediate filament protein
    • Lendahl, U., Zimmerman, L.B. and McKay, R.D. CNS stem cells express a new class of intermediate filament protein. Cell 60, 585, 1990.
    • (1990) Cell , vol.60 , pp. 585
    • Lendahl, U.1    Zimmerman, L.B.2    McKay, R.D.3
  • 50
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
    • Zulewski, H., Abraham, E.J., Gerlach, M.J., Daniel, P.B., Moritz, W., Muller, B., Vallejo, M., Thomas, M.K. and Habener, J.F. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50, 521, 2001.
    • (2001) Diabetes , vol.50 , pp. 521
    • Zulewski, H.1    Abraham, E.J.2    Gerlach, M.J.3    Daniel, P.B.4    Moritz, W.5    Muller, B.6    Vallejo, M.7    Thomas, M.K.8    Habener, J.F.9
  • 51
    • 0037394382 scopus 로고    scopus 로고
    • Phenotypic determination and characterization of nestin-positive precursors derived from human fetal pancreas
    • Huang, H. and Tang, X. Phenotypic determination and characterization of nestin-positive precursors derived from human fetal pancreas. Lab Invest 83, 539, 2003.
    • (2003) Lab Invest , vol.83 , pp. 539
    • Huang, H.1    Tang, X.2
  • 52
    • 0036315648 scopus 로고    scopus 로고
    • Beta-cell differentiation during human development does not rely on nestin-positive precursors: Implications for stem cell-derived replacement therapy
    • Piper, K., Ball, S.G., Turnpenny, L.W., Brickwood, S., Wilson, D.I. and Hanley, N.A. Beta-cell differentiation during human development does not rely on nestin-positive precursors: implications for stem cell-derived replacement therapy. Diabetologia 45, 1045, 2002.
    • (2002) Diabetologia , vol.45 , pp. 1045
    • Piper, K.1    Ball, S.G.2    Turnpenny, L.W.3    Brickwood, S.4    Wilson, D.I.5    Hanley, N.A.6
  • 55
    • 0032533441 scopus 로고    scopus 로고
    • Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas
    • Bouwens, L. Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microsc Res Tech 43, 332, 1998.
    • (1998) Microsc Res Tech , vol.43 , pp. 332
    • Bouwens, L.1
  • 56
    • 1042288598 scopus 로고    scopus 로고
    • Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas
    • Lardon, J., Huyens, N., Rooman, I. and Bouwens, L. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch 444, 61, 2004.
    • (2004) Virchows Arch , vol.444 , pp. 61
    • Lardon, J.1    Huyens, N.2    Rooman, I.3    Bouwens, L.4
  • 59
    • 12944327377 scopus 로고    scopus 로고
    • In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
    • Baeyens, L., De Breuck, S., Lardon, J., Mfopou, J.K., Rooman, I. and Bouwens, L. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 48, 49, 2005.
    • (2005) Diabetologia , vol.48 , pp. 49
    • Baeyens, L.1    De Breuck, S.2    Lardon, J.3    Mfopou, J.K.4    Rooman, I.5    Bouwens, L.6
  • 60
    • 33749590993 scopus 로고    scopus 로고
    • Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/ STAT pathway
    • Baeyens, L., Bonne, S., German, M.S., Ravassard, P., Heimberg, H. and Bouwens, L. Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/ STAT pathway. Cell Death Differ 13, 1892, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 1892
    • Baeyens, L.1    Bonne, S.2    German, M.S.3    Ravassard, P.4    Heimberg, H.5    Bouwens, L.6
  • 63
    • 0037062515 scopus 로고    scopus 로고
    • In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
    • Yang, L., Li, S., Hatch, H., Ahrens, K., Cornelius, J.G., Petersen, B.E. and Peck, A.B. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci U S A 99, 8078, 2002.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8078
    • Yang, L.1    Li, S.2    Hatch, H.3    Ahrens, K.4    Cornelius, J.G.5    Petersen, B.E.6    Peck, A.B.7
  • 64
    • 9444255761 scopus 로고    scopus 로고
    • High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells
    • Cao, L.Z., Tang, D.Q., Horb, M.E., Li, S.W. and Yang, L.J. High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells. Diabetes 53, 3168, 2004.
    • (2004) Diabetes , vol.53 , pp. 3168
    • Cao, L.Z.1    Tang, D.Q.2    Horb, M.E.3    Li, S.W.4    Yang, L.J.5
  • 65
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M. and Chan, L. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 9, 596, 2003.
    • (2003) Nat Med , vol.9 , pp. 596
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3    Younan, P.4    Imaeda, H.5    Maeda, M.6    Chan, L.7
  • 67
    • 0346099384 scopus 로고    scopus 로고
    • Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury
    • Mathews, V., Hanson, P.T., Ford, E., Fujita, J., Polonsky, K.S. and Graubert, T.A. Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes 53, 91, 2004.
    • (2004) Diabetes , vol.53 , pp. 91
    • Mathews, V.1    Hanson, P.T.2    Ford, E.3    Fujita, J.4    Polonsky, K.S.5    Graubert, T.A.6
  • 68
    • 0141615656 scopus 로고    scopus 로고
    • Insulin-positive cells in vitro generated from rat bone marrow stromal cells
    • Jahr, H. and Bretzel, R.G. Insulin-positive cells in vitro generated from rat bone marrow stromal cells. Transplant Proc 35, 2140, 2003.
    • (2003) Transplant Proc , vol.35 , pp. 2140
    • Jahr, H.1    Bretzel, R.G.2
  • 69
    • 4644310257 scopus 로고    scopus 로고
    • Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells
    • Chen, L.B., Jiang, X.B. and Yang, L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World J Gastroenterol 10, 3016, 2004.
    • (2004) World J Gastroenterol , vol.10 , pp. 3016
    • Chen, L.B.1    Jiang, X.B.2    Yang, L.3
  • 70
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus, A., Holz, G.G., Theise, N.D. and Hussain, M.A. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111, 843, 2003.
    • (2003) J Clin Invest , vol.111 , pp. 843
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Hussain, M.A.4
  • 72
    • 1442326000 scopus 로고    scopus 로고
    • No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo
    • Lechner, A., Yang, Y.G., Blacken, R.A., Wang, L., Nolan, A.L. and Habener, J.F. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 53, 616, 2004.
    • (2004) Diabetes , vol.53 , pp. 616
    • Lechner, A.1    Yang, Y.G.2    Blacken, R.A.3    Wang, L.4    Nolan, A.L.5    Habener, J.F.6
  • 73
    • 0020394658 scopus 로고
    • Hemopoietic colony-forming cells in umbilical cord blood with extensive capability to generate mono- and multipotential hemopoietic progenitors
    • Nakahata, T. and Ogawa, M. Hemopoietic colony-forming cells in umbilical cord blood with extensive capability to generate mono- and multipotential hemopoietic progenitors. J Clin Invest 70, 1324, 1982.
    • (1982) J Clin Invest , vol.70 , pp. 1324
    • Nakahata, T.1    Ogawa, M.2
  • 75
    • 33646234957 scopus 로고    scopus 로고
    • No longer a biological waste product: Umbilical cord blood
    • O'Brien, T.A., Tiedemann, K. and Vowels, M.R. No longer a biological waste product: umbilical cord blood. Med J Aust 184, 407, 2006.
    • (2006) Med J Aust , vol.184 , pp. 407
    • O'Brien, T.A.1    Tiedemann, K.2    Vowels, M.R.3
  • 77
    • 33745868355 scopus 로고    scopus 로고
    • Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics
    • Zhao, Y., Wang, H. and Mazzone, T. Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res 312, 2454, 2006.
    • (2006) Exp Cell Res , vol.312 , pp. 2454
    • Zhao, Y.1    Wang, H.2    Mazzone, T.3
  • 78
    • 0242582180 scopus 로고    scopus 로고
    • Islet regeneration during the reversal of autoimmune diabetes in NOD mice
    • Kodama, S., Kuhtreiber, W., Fujimura, S., Dale, E.A. and Faustman, D.L. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 302, 1223, 2003.
    • (2003) Science , vol.302 , pp. 1223
    • Kodama, S.1    Kuhtreiber, W.2    Fujimura, S.3    Dale, E.A.4    Faustman, D.L.5
  • 80
    • 1542410323 scopus 로고    scopus 로고
    • Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages
    • Hisatomi, Y., Okumura, K., Nakamura, K., Matsumoto, S., Satoh, A., Nagano, K., Yamamoto, T. and Endo, F. Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages. Hepatology 39, 667, 2004.
    • (2004) Hepatology , vol.39 , pp. 667
    • Hisatomi, Y.1    Okumura, K.2    Nakamura, K.3    Matsumoto, S.4    Satoh, A.5    Nagano, K.6    Yamamoto, T.7    Endo, F.8
  • 83
    • 19344362213 scopus 로고    scopus 로고
    • Differentiation of insulin-producing cells from human neural progenitor cells
    • Hori, Y., Gu, X., Xie, X. and Kim, S.K. Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med 2, e103, 2005.
    • (2005) PLoS Med , vol.2
    • Hori, Y.1    Gu, X.2    Xie, X.3    Kim, S.K.4
  • 85
    • 33645223082 scopus 로고    scopus 로고
    • Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells
    • Suri, A., Calderon, B., Esparza, T.J., Frederick, K., Bittner, P. and Unanue, E.R. Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science 311, 1778, 2006.
    • (2006) Science , vol.311 , pp. 1778
    • Suri, A.1    Calderon, B.2    Esparza, T.J.3    Frederick, K.4    Bittner, P.5    Unanue, E.R.6
  • 86
    • 33645221626 scopus 로고    scopus 로고
    • Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution
    • Nishio, J., Gaglia, J.L., Turvey, S.E., Campbell, C., Benoist, C. and Mathis, D. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 311, 1775, 2006.
    • (2006) Science , vol.311 , pp. 1775
    • Nishio, J.1    Gaglia, J.L.2    Turvey, S.E.3    Campbell, C.4    Benoist, C.5    Mathis, D.6
  • 87
    • 33645226291 scopus 로고    scopus 로고
    • Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration
    • Chong, A.S., Shen, J., Tao, J., Yin, D., Kuznetsov, A., Hara, M. and Philipson, L.H. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science 311, 1774, 2006.
    • (2006) Science , vol.311 , pp. 1774
    • Chong, A.S.1    Shen, J.2    Tao, J.3    Yin, D.4    Kuznetsov, A.5    Hara, M.6    Philipson, L.H.7
  • 88
    • 0028987251 scopus 로고
    • Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
    • Finegood, D.T., Scaglia, L. and Bonner-Weir, S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44, 249, 1995.
    • (1995) Diabetes , vol.44 , pp. 249
    • Finegood, D.T.1    Scaglia, L.2    Bonner-Weir, S.3
  • 90
    • 0038155702 scopus 로고    scopus 로고
    • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    • Bruning, J.C., Winnay, J., Bonner-Weir, S., Taylor, S.I., Accili, D. and Kahn, C.R. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561, 1997.
    • (1997) Cell , vol.88 , pp. 561
    • Bruning, J.C.1    Winnay, J.2    Bonner-Weir, S.3    Taylor, S.I.4    Accili, D.5    Kahn, C.R.6
  • 91
    • 0037219411 scopus 로고    scopus 로고
    • Beta- cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler, A.E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R.A. and Butler, P.C. Beta- cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102, 2003.
    • (2003) Diabetes , vol.52 , pp. 102
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 92
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • Bonner-Weir, S., Trent, D.F. and Weir, G.C. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 71, 1544, 1983.
    • (1983) J Clin Invest , vol.71 , pp. 1544
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 93
    • 0023860467 scopus 로고
    • Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats
    • Brockenbrough, J.S., Weir, G.C. and Bonner-Weir, S. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes 37, 232, 1988.
    • (1988) Diabetes , vol.37 , pp. 232
    • Brockenbrough, J.S.1    Weir, G.C.2    Bonner-Weir, S.3
  • 94
    • 0018182423 scopus 로고
    • A morphological study of the endocrine pancreas in human pregnancy
    • Van Assche, F.A., Aerts, L. and De Prins, F. A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol 85, 818, 1978.
    • (1978) Br J Obstet Gynaecol , vol.85 , pp. 818
    • Van Assche, F.A.1    Aerts, L.2    De Prins, F.3
  • 95
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Farilla, L., Hui, H., Bertolotto, C., Kang, E., Bulotta, A., Di Mario, U. and Perfetti, R. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143, 4397, 2002.
    • (2002) Endocrinology , vol.143 , pp. 4397
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3    Kang, E.4    Bulotta, A.5    Di Mario, U.6    Perfetti, R.7
  • 96
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers, D.A., Kieffer, T.J., Hussain, M.A., Drucker, D.J., Bonner-Weir, S., Habener, J.F. and Egan, J.M. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49, 741, 2000.
    • (2000) Diabetes , vol.49 , pp. 741
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6    Egan, J.M.7
  • 97
    • 1842855402 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
    • Wang, Q., Li, L., Xu, E., Wong, V., Rhodes, C. and Brubaker, P.L. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia 47, 478, 2004.
    • (2004) Diabetologia , vol.47 , pp. 478
    • Wang, Q.1    Li, L.2    Xu, E.3    Wong, V.4    Rhodes, C.5    Brubaker, P.L.6
  • 98
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu, G., Stoffers, D.A., Habener, J.F. and Bonner-Weir, S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48, 2270, 1999.
    • (1999) Diabetes , vol.48 , pp. 2270
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 99
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall, D.M., Riddle, M.C., Rosenstock, J., Zhuang, D., Kim, D.D., Fineman, M.S. and Baron, A.D. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28, 1083, 2005.
    • (2005) Diabetes Care , vol.28 , pp. 1083
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6    Baron, A.D.7
  • 100
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo, R.A., Ratner, R.E., Han, J., Kim, D.D., Fineman, M.S. and Baron, A.D. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 28, 1092, 2005.
    • (2005) Diabetes Care , vol.28 , pp. 1092
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 101
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    • Ahren, B., Pacini, G., Foley, J.E. and Schweizer, A. Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care 28, 1936, 2005.
    • (2005) Diabetes Care , vol.28 , pp. 1936
    • Ahren, B.1    Pacini, G.2    Foley, J.E.3    Schweizer, A.4
  • 102
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    • Pratley, R.E., Jauffret-Kamel, S., Galbreath, E. and Holmes, D. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res 38, 423, 2006.
    • (2006) Horm Metab Res , vol.38 , pp. 423
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3    Holmes, D.4
  • 105
    • 7044241260 scopus 로고    scopus 로고
    • A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice
    • Rosenberg, L., Lipsett, M., Yoon, J.W., Prentki, M., Wang, R., Jun, H.S., Pittenger, G.L., Taylor-Fishwick, D. and Vinik, A.I. A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice. Ann Surg 240, 875, 2004.
    • (2004) Ann Surg , vol.240 , pp. 875
    • Rosenberg, L.1    Lipsett, M.2    Yoon, J.W.3    Prentki, M.4    Wang, R.5    Jun, H.S.6    Pittenger, G.L.7    Taylor-Fishwick, D.8    Vinik, A.I.9
  • 107
    • 0037414812 scopus 로고    scopus 로고
    • Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death
    • Garcia-Ocana, A., Takane, K.K., Reddy, V.T., Lopez-Talavera, J.C., Vasavada, R.C. and Stewart, A.F. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem 278, 343, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 343
    • Garcia-Ocana, A.1    Takane, K.K.2    Reddy, V.T.3    Lopez-Talavera, J.C.4    Vasavada, R.C.5    Stewart, A.F.6
  • 108
    • 0033954474 scopus 로고    scopus 로고
    • Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
    • Garcia-Ocana, A., Takane, K.K., Syed, M.A., Philbrick, W.M., Vasavada, R.C. and Stewart, A.F. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 275, 1226, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 1226
    • Garcia-Ocana, A.1    Takane, K.K.2    Syed, M.A.3    Philbrick, W.M.4    Vasavada, R.C.5    Stewart, A.F.6
  • 109
    • 0033323812 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia
    • Petrik, J., Pell, J.M., Arany, E., McDonald, T.J., Dean, W.L., Reik, W. and Hill, D.J. Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia. Endocrinology 140, 2353, 1999.
    • (1999) Endocrinology , vol.140 , pp. 2353
    • Petrik, J.1    Pell, J.M.2    Arany, E.3    McDonald, T.J.4    Dean, W.L.5    Reik, W.6    Hill, D.J.7
  • 111
    • 0031763478 scopus 로고    scopus 로고
    • Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: Identification of betacellulin as a novel beta-cell mitogen
    • Huotari, M.A., Palgi, J. and Otonkoski, T. Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen. Endocrinology 139, 1494, 1998.
    • (1998) Endocrinology , vol.139 , pp. 1494
    • Huotari, M.A.1    Palgi, J.2    Otonkoski, T.3
  • 112
    • 1542284736 scopus 로고    scopus 로고
    • Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57B16/J mice treated with alloxan
    • Rooman, I. and Bouwens, L. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57B16/J mice treated with alloxan. Diabetologia 47, 259, 2004.
    • (2004) Diabetologia , vol.47 , pp. 259
    • Rooman, I.1    Bouwens, L.2
  • 118
    • 0024496119 scopus 로고
    • Separation of pancreatic islets by fluorescence-activated sorting
    • Gray, D.W., Gohde, W., Carter, N., Heiden, T. and Morris, P.J. Separation of pancreatic islets by fluorescence-activated sorting. Diabetes 38 Suppl 1, 133, 1989.
    • (1989) Diabetes , vol.38 , Issue.SUPPL. 1 , pp. 133
    • Gray, D.W.1    Gohde, W.2    Carter, N.3    Heiden, T.4    Morris, P.J.5
  • 119
    • 33749856483 scopus 로고    scopus 로고
    • Rehabilitation of adaptive immunity and regeneration of beta cells
    • Pasquali, L., Fan, Y., Trucco, M. and Ringquist, S. Rehabilitation of adaptive immunity and regeneration of beta cells. Trends Biotechnol 24, 516, 2006.
    • (2006) Trends Biotechnol , vol.24 , pp. 516
    • Pasquali, L.1    Fan, Y.2    Trucco, M.3    Ringquist, S.4
  • 120
    • 33646537145 scopus 로고    scopus 로고
    • Truong, W., Hancock, W.W., Anderson, C.C., Merani, S. and Shapiro, A.M. Coinhibitory T-cell signaling in islet allograft rejection and tolerance. Cell Transplant 15, 105, 2006.
    • Truong, W., Hancock, W.W., Anderson, C.C., Merani, S. and Shapiro, A.M. Coinhibitory T-cell signaling in islet allograft rejection and tolerance. Cell Transplant 15, 105, 2006.
  • 124
    • 0028954224 scopus 로고
    • Immune responses in MHC class II-deficient mice
    • Grusby, M.J. and Glimcher, L.H. Immune responses in MHC class II-deficient mice. Annu Rev Immunol 13, 417, 1995.
    • (1995) Annu Rev Immunol , vol.13 , pp. 417
    • Grusby, M.J.1    Glimcher, L.H.2
  • 125
    • 0035797898 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
    • Tada, M., Takahama, Y., Abe, K., Nakatsuji, N. and Tada, T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol 11, 1553, 2001.
    • (2001) Curr Biol , vol.11 , pp. 1553
    • Tada, M.1    Takahama, Y.2    Abe, K.3    Nakatsuji, N.4    Tada, T.5
  • 126
    • 23944457397 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells
    • Cowan, C.A., Atienza, J., Melton, D.A. and Eggan, K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 309, 1369, 2005.
    • (2005) Science , vol.309 , pp. 1369
    • Cowan, C.A.1    Atienza, J.2    Melton, D.A.3    Eggan, K.4
  • 130
  • 131
    • 27144526161 scopus 로고    scopus 로고
    • Shear-controlled single-step mouse embryonic stem cell expansion and embryoid body-based differentiation
    • Fok, E.Y. and Zandstra, P.W. Shear-controlled single-step mouse embryonic stem cell expansion and embryoid body-based differentiation. Stem Cells 23, 1333, 2005.
    • (2005) Stem Cells , vol.23 , pp. 1333
    • Fok, E.Y.1    Zandstra, P.W.2
  • 132
    • 33751563297 scopus 로고    scopus 로고
    • Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors
    • Oct 1; [Epub ahead of print
    • Cormier, J.T., Nieden, N.I., Rancourt, D.E. and Kallos, M.S. Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors. Tissue Eng 2006 Oct 1; [Epub ahead of print].
    • (2006) Tissue Eng
    • Cormier, J.T.1    Nieden, N.I.2    Rancourt, D.E.3    Kallos, M.S.4
  • 135
    • 2942615532 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into insulin-producing clusters
    • Segev, H., Fishman, B., Ziskind, A., Shulman, M. and Itskovitz-Eldor, J. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 22, 265, 2004.
    • (2004) Stem Cells , vol.22 , pp. 265
    • Segev, H.1    Fishman, B.2    Ziskind, A.3    Shulman, M.4    Itskovitz-Eldor, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.