Differentiation of pluripotent embryonic stem cells into cardiomyocytes

Circulation Research

Volumn 91, Issue 3, 2002, Pages 189-201

  Boheler, Kenneth R ^a   Czyz, Jaroslaw ^a   Tweedie, David ^a   Yang, Huang Tian ^a   Anisimov, Sergey V ^a   Wobus, Anna M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Cardiomyocytes; Embryonic carcinoma; Embryonic germ; Embryonic stem; In vitro differentiation

Indexed keywords

CELL PROTEIN; HEART RECEPTOR; ION CHANNEL;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL REGENERATION; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; GENE TARGETING; GENETIC MANIPULATION; GERM LAYER; HEART DEVELOPMENT; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; EMBRYO; GENOMICS; HEART; HUMANS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUTATION; MYOCARDIUM; STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 0037047695     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000027865.61704.32     Document Type: Review

References (90)

1. Potential of embryonic stem cells
2. The evolving concept of a stem cell: Entity or function?
3. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
4. Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells
5. Establishment in culture of pluripotential cells from mouse embryos
6. Embryonic stem cell lines derived from human blastocysts
7. Derivation of pluripotent stem cells from cultured human primordial germ cells
8. Cardiac and skeletal muscle development in P19 embryonal carcinoma cells
9. The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium
10. 2+ channel blockers
11. Primordial germ cell-derived mouse embryonic germ (EG) cells in vitro resemble undifferentiated stem cells with respect to differentiation capacity and cell cycle distribution
12. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
13. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
14. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation
15. Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis
16. Ultrastructure and cell-cell coupling of cardiac myocytes differentiating in embryonic stem cell cultures
17. 1 integrin
18. Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro
19. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts
20. Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro
21. Myocardial aging and stem cell biology
22. Troponin I isoform expression is developmentally regulated in differentiating embryonic stem cell-derived cardiac myocytes
23. Embryonic stem cell cardiogenesis: Applications for cardiovascular research
24. Establishment of ionic channels and signaling cascades in the embryonic stem cell-derived primitive endoderm and cardiovascular system
25. 2+ current in the early stages of cardiomyocyte development
26. 2+ channels
27. Embryonic stem cell-derived cardiac differentiation: Modulation of differentiation and "loss-of-function" analysis in vitro
28. Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor
29. Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAKI and cardiac transcription factors Csx/Nkx-2.5 and GATA-4
30. Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro
31. Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes
32. Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent protein
33. A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells
34. Selection of ventricular-like cardiomyocytes from ES cells in vitro
35. Leukemia inhibitory factor: Part of a large ingathering family
36. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
37. Leukemia inhibitory factor modulates cardiogenesis in embryoid bodies in opposite fashions
38. Paracrine promotion of cardiomyogenesis in embryoid bodies by LIF modulated endoderm
39. Molecular characterization of a gene of the "EGF family" expressed in undifferentiated human NTERA2 teratocarcinoma cells
40. Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes
41. Cell biology of cardiac development
42. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
43. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
44. Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells
45. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1
46. Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos
47. Bidirectional signaling between the cytoskeleton and integrins
48. Cytoskeletal control of myogenesis: A desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation
49. Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene
50. Defective pro α2(I) collagen synthesis in a recessive mutation in mice: A model of human osteogenesis imperfecta
51. 1 integrin gene expression in mice
52. 1 integrin
53. 1 integrin-deficient embryonic stem cell-derived cardiac cells
54. Calreticulin is essential for integrin-mediated calcium signaling and cell adhesion
55. Heart, brain, and body wall defects in mice lacking calreticulin
56. Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2
57. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development
58. 2+ exchanger: Molecular partners in pacemaker regulation
59. The gene trap approach in embryonic stem cells: The potential for genetic screens in mice
60. A gene trap approach in mouse embryonic stem cells: The lacZ reporter is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice
61. In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse
62. Efficient gene trap screening for novel developmental genes using IRESβgeo vector and in vitro preselection
63. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro
64. Expression trapping: Identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells
65. Discovering altered genomic expression patterns in heart: Transcriptome determination by serial analysis of gene expression
66. SAGE identification of differentiation responsive genes in P19 embryonic cells induced to form cardiomyocytes in vitro
67. Feeder-free growth of undifferentiated human embryonic stem cells
68. Blastocyst transfer in human in vitro fertilization: The use of embryo co-culture
69. Isolation and culture of inner cell mass cells from human blastocysts
70. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers
71. Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
72. Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro
73. Multilineage differentiation from human embryonic stem cell lines
74. Can exogenous stem cells be used in transplantation?
75. Changing potency by spontaneous fusion
76. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
77. Embryonic stem cells as an in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies: Present state and future prospects
78. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice
79. Gene trap integrations expressed in the developing heart: Insertion site affects splicing of the PT1-ATG vector
80. Bodenin: A novel murine gene expressed in restricted areas of the brain
81. Efficient poly A trap approach allows the capture of genes specifically active in differentiated embryonic stem cells and in mouse embryos
82. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
83. Jumonji, a nuclear protein that is necessary for normal heart development
84. A retroviral gene trap insertion into the histone 3.3A gene causes partial neonatal lethality, stunted growth, neuromuscular deficits and male sub-fertility in transgenic mice
85. Identification of a differentially expressed RNA helicase by gene trapping
86. Gene trap screening using negative selection: Identification of two tandem, differentially expressed loci with potential hematopoietic function
87. Expression and genetic analysis of prtb, a gene that encodes a highly conserved proline-rich protein expressed in the brain
88. Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells
89. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation