Cardiovascular and metabolic alterations in mice lacking both β1- and β2-adrenergic receptors

Journal of Biological Chemistry

Volumn 274, Issue 24, 1999, Pages 16701-16708

  Rohrer, Daniel K ^a   Chruscinski, Andrzej ^b   Schauble, Eric H ^b   Bernstein, Daniel ^b   Kobilka, Brian K ^b  

^a ROCHE BIOSCIENCE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ADRENALIN; ANGIOTENSIN; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; DOPAMINE; HISTAMINE; ISOPRENALINE; PHENYLEPHRINE; SEROTONIN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR FUNCTION; CHRONOTROPISM; CONTROLLED STUDY; EXERCISE; GENE DISRUPTION; HEART LEFT VENTRICLE CONTRACTILITY; HEART RATE; INOTROPISM; KNOCKOUT MOUSE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY;

ANIMALS; BLOOD PRESSURE; CARBON DIOXIDE; CARDIOVASCULAR PHYSIOLOGY; CROSSES, GENETIC; EPINEPHRINE; HEART RATE; HEART VENTRICLES; HETEROZYGOTE; HOMOZYGOTE; ISOPROTERENOL; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2;

ANIMALIA;

EID: 0033546313     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.24.16701     Document Type: Article

References (48)

1. Strader, C. D., Fong, T. M., Graziano, M. P., and Tota, M. R. (1995) FASEB J. 9, 745-754
2. Pepperl, D. J., and Regan, J. W. (1994) in Handbook of Receptors and Channels, (Peroutka, S. J., ed) pp. 45-78, CRC Press, Inc., Boca Raton, FL
3. Dixon, R. A., Kobilka, B. K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. E., Mumford, R. A., Slater, E. E., Sigal, I. S., Caron, M. G., Lefkowitz, R. J., and Strader, C. D. (1986) Nature 321, 75-79
4. Frielle, T., Collins, S., Daniel, K. W., Caron, M. G., Lefkowitz, R. J., and Kobilka, B. K. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 7920-7924
5. Emorine, L. J., Marullo, S., Briend-Sutren, M., Patey, G., Tate, K., Delavier-Klutchko, C., and Strosberg, A. D. (1989) Science 245, 1118-1121
6. Strosberg, A. D. (1995) Obes. Res., Suppl. 4, 501S-505S
7. Rohrer, D. K. (1998) in From Hypertension to Heart Failure, (Bohm, M., Laragh, J. H., and Zehender, M., eds) pp. 129-158, Springer-Verlag, Berlin
8. Lands, A. M., Luduena, F. P., and Buzzo, H. J. (1967) Life Sci. 6, 2241-2249
9. Lands, A. M., Arnold, A., McAuliff, J. P., Luduena, F. P., and Brown, T. J. (1967) Nature 214, 597-598
10. Malinowska, B., and Schlicker, E. (1997) Br. J. Pharmacol. 122, 1307-1314
11. Link, R. E., Stevens, M. S., Kulatunga, M., Scheinin, M., Barsh, G. S., and Kobilka, B. K. (1995) Mol. Pharmacol. 48, 48-55
12. Susulic, V. S., Frederich, R. C., Lawitts, J., Tozzo, E., Kahn, B. B., Harper, M. E., Himms-Hagen, J., Flier, J. S., and Lowell, B. B. (1995) J. Biol. Chem. 270, 29483-29492
13. Rohrer, D. K., Desai, K. H., Jasper, J. R., Stevens, M. E., Regula, D. J., Barsh, G. S., Bernstein, D., and Kobilka, B. K. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7375-7380
14. Link, R. E., Desai, K., Hein, L., Stevens, M. E., Chruscinski, A., Bernstein, D., Barsh, G. S., and Kobilka, B. K. (1996) Science 273, 803-805
15. MacMillan, L. B., Hein, L., Smith, M. S., Piascik, M. T., and Limbird, L. E. (1996) Science 273, 801-803
16. Cavalli, A., Lattion, A., Hummler, E., Nenninger, M., Pedrazzini, T., Aubert, J., Michel, M. C., Yang, M., Lembo, G., Vecchione, C., Mostardim, M., Schmidt, A., Beermann, F., and Cotecchia, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11589-11594
17. Chruscinski, A. J., Rohrer, D. K., Schauble, E., Desai, K. H., Bernstein, D., and Kobilka, B. K. (1999) J. Biol. Chem. 274, 16694-16700 (acc art 568292)
18. Rohrer, D. K., Schauble, E. H., Desai, K. H., Kobilka, B. K., and Bernstein, D. (1998) Am. J. Physiol. 274, H1184-H1193
19. Desai, K. H., Sato, R., Schauble, E., Barsh, G. S., Kobilka, B. K., and Bernstein, D. (1997) Am. J. Physiol. 272, H1053-H1061
20. Shen, Y. T., Cervoni, P., Claus, T., and Vatner, S. F. (1996) J. Pharmacol. Exp. Ther. 278, 1435-1443
21. Cline, W. J. (1981) J. Pharmacol. Exp. Ther. 216, 104-110
22. Davy, M., Grandcourt, O., Midol-Monnet, M., and Cohen, Y. (1997) Cell. Mol. Life Sci. 53, 263-266
23. Zaizen, H., Imanishi, S., Nasu, M., and Arita, M. (1996) Heart Vessels 11, 10-17
24. Gauthier, C., Tavernier, G., Charpentier, F., Langin, D., and Le, M. H. (1996) J. Clin. Invest. 98, 556-562
25. Rohrer, D. K., and Kobilka, B. K. (1998) Annu. Rev. Pharmacol. Toxicol. 38, 35-73
26. Endoh, M. (1989) Basic Res. Cardiol. 1, 69-83
27. Eschenhagen, T., Mende, U., Diederich, M., Hertle, B., Memmesheimer, C., Pohl, A., Schmitz, W., Scholz, H., Steinfath, M., Bohm, M., Michel, M. C., Brodde, O. E., and Raap, A. (1996) Circulation 93, 763-771
28. Glaubiger, G., and Lefkowitz, R. J. (1977) Biochem. Biophys. Res. Commun. 78, 720-725
29. Boudoulas, H., Lewis, R. P., Kates, R. E., and Dalamangas, G. (1977) Ann. Intern. Med. 87, 433-436
30. Brodde, O. E., Michel, M. C., Wang, X. L., and Zerkowski, H. R. (1988) J. Hypertens. 6, (suppl.) 497-500
31. Opie, L. H. (1985) Am. J. Cardiol. 55, 95D-100D
32. Galbo, H., Holst, J. J., Christensen, N. J., and Hilsted, J. (1976) J. Appl. Physiol. 40, 855-863
33. Juhlin, D. A. (1983) Acta Med. Scand. 672, (suppl.) 49-54
34. Bogus, E. M., Cheng, L. C., and Zierler, K. (1977) Biochim. Biophys. Acta 464, 347-355
35. Clausen, T., and Flatman, J. A. (1977) J. Physiol. (Lond.) 270, 383-414
36. Ellingsen, O., Sejersted, O. M., Leraand, S., and Ilebekk, A. (1987) Circ. Res. 60, 540-550
37. Uusitupa, M., Siitonen, O., Harkonen, M., Gordin, A., Aro, A., Hersio, K., Johansson, G., Korhonen, T., and Rauramaa, R. (1982) Ann. Clin. Res. 34, 165-167
38. McLeod, A. A., Brown, J. E., Kuhn, C., Kitchell, B. B., Sedor, F. A., Williams, R. S., and Shand, D. G. (1983) Circulation 67, 1076-1084
39. Bristow, M. R., Cubicciotti, R., Ginsburg, R., Stinson, E. B., and Johnson, C. (1982) Mol. Pharmacol. 21, 671-679
40. Brodde, O. E., Broede, A., Daul, A., Kunde, K., and Michel, M. C. (1992) Basic Res. Cardiol. 1, 1-14
41. Desai, K. H., Rohrer, D. K., Kobilka, B. K., and Bernstein, D. (1996) Circulation. 94, Suppl. 1, I-288
42. Kemmotsu, O., Hashimoto, Y., and Shimosato, S. (1973) Anesthesiology 39, 470-477
43. Lynch, C. D. (1986) Anesthesiology 64, 620-631
44. Bosnjak, Z. J., Supan, F. D., and Rusch, N. J. (1991) Anesthesiology 74, 340-345
45. Bevilacqua, M., Savonitto, S., Bosisio, E., Chebat, E., Bertora, P. L., Sardina, M., and Norbiato, G. (1989) Am. J. Cardiol. 63, 853-857
46. Gotshall, R. W., Bauer, T. A., and Fahrner, S. L. (1996) Int. J. Sports Med. 17, 17-21
47. Di Bello, V., Talarico, L., Di, M. C., Santoro, G., Bertini, A., Giorgi, D., Caputo, M. T., Bianchi, M., Cecchini, L., and Giusti, C. (1995) Int. J. Sports Med. 16, 498-506
48. Thomas, A. J., Davis, G. M., and Sutton, J. R. (1997) Methods Inf. Med. 36, 372-375