Progression of heart failure: Is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor?

Circulation

Volumn 105, Issue 3, 2002, Pages 272-275

  Marks, Andrew R ^a   Reiken, Steven ^a   Marx, Steven O ^a  

^a Columbia Univ College of Physicians ^*  (United States)

Author keywords

Calcium; Contractility; Editorials; Excitation; Sarcoplasmic reticulum

Indexed keywords

CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; RYANODINE RECEPTOR;

ADRENERGIC SYSTEM; CALCIUM TRANSPORT; CATECHOLAMINERGIC SYSTEM; EDITORIAL; HEART FAILURE; HEART OUTPUT; HEART VENTRICLE TACHYCARDIA; HUMAN; LIPID BILAYER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; STOICHIOMETRY;

EID: 0037154319     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/circ.105.3.272     Document Type: Editorial

References (24)

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2. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia
3. Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia
4. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)
5. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum
6. Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes
7. Cardiac intracellular calcium release channels: Role in heart failure
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10. Phosphorylation modulates the function of the calcium release channel of sarcoplasmic reticulum from cardiac muscle
11. Phosphorylation of the purified cardiac ryanodine receptor by exogenous and endogenous protein kinases
12. In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation
13. Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism
14. Phosphorylation of the cardiac ryanodine receptor by cAMP-dependent protein kinase
15. Regulation of the cardiac ryanodine receptor by protein kinase-dependent phosphorylation
16. 2+ and phosphorylation
17. Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation
18. 2+ release channels (ryanodine receptors)
19. Coupled gating between cardiac calcium release channels (ryanodine receptors)
20. 2+: Simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes
21. Dyssynchronous Ca(2+) sparks in myocytes from infarcted hearts
22. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure
23. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure
24. Beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure