SNPs in DNA repair genes associated to meningitis and host immune response

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 713, Issue 1-2, 2011, Pages 39-47

  da Silva, Thayse Azevedo ^a   Fontes, Fabrícia Lima ^a   Coutinho, Leonam Gomes ^a   de Souza, Fladjule Rejane Soares ^a   de Melo, Julliane Tamara Araújo ^a   de Souto, Janeusa Trindade ^a   Leib, Stephen L ^b   Agnez Lima, Lucymara Fassarella ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Base excision repair; Inflammatory response; Meningitis; Polymorphism

Indexed keywords

GENOMIC DNA; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADULT; APE1 GENE; ARTICLE; BINDING SITE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DNA REPAIR; EXCISION REPAIR; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; MAJOR CLINICAL STUDY; MALE; MENINGITIS; OGG1 GENE; PARP 1 GENE; PRIORITY JOURNAL; PROTEIN BINDING; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; DNA DAMAGE; DNA REPAIR; FEMALE; GENOTYPE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOMODULATION; MALE; MENINGITIS; POLYMORPHISM, SINGLE NUCLEOTIDE;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 79960279208     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2011.05.012     Document Type: Article

References (85)

1. Mace S.E. Central nervous system infections as a cause of an altered mental statusŽ What is the pathogen growing in your central nervous systemž. Emerg. Med. Clin. North Am. 2010, 28:535-570.
2. Greenfield S., Sheehe P.R., Feldman H.A. Meningococcal carriage in a population of "normal" families. J. Infect. Dis. 1971, 123:67-73.
3. Hausdorff W.P., Siber G., Paradiso P.R. Geographical differences in invasive pneumococcal disease rates and serotype frequency in young children. Lancet 2001, 357:950-952.
4. Rotbart H.A. Viral meningitis. Semin. Neurol. 2000, 20:277-292.
5. Brouwer M.C., de Gans J., Heckenberg S.G., Zwinderman A.H., van der Poll T., van de Beek D. Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. Lancet Infect. Dis. 2009, 9:31-44.
6. Emonts M., Hazelzet J.A., de Groot R., Hermans P.W. Host genetic determinants of Neisseria meningitidis infections. Lancet Infect. Dis. 2003, 3:565-577.
7. Leib S.L., Kim Y.S., Chow L.L., Sheldon R.A., Tauber M.G. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J. Clin. Invest. 1996, 98:2632-2639.
8. Klein M., Koedel U., Pfister H.W. Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapyž. Prog. Neurobiol. 2006, 80:269-280.
9. Auer M., Pfister L.A., Leppert D., Tauber M.G., Leib S.L. Effects of clinically used antioxidants in experimental pneumococcal meningitis. J. Infect. Dis. 2000, 182:347-350.
10. Fishel M.L., Vasko M.R., Kelley M.R. DNA repair in neurons: so if they don't divide what's to repairž. Mutat. Res. 2007, 614:24-36.
11. Wilson D.M., McNeill D.R. Base excision repair and the central nervous system. Neuroscience 2007, 145:1187-1200.
12. Lin L.H., Cao S., Yu L., Cui J., Hamilton W.J., Liu P.K. Up-regulation of base excision repair activity for 8-hydroxy-2′-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion. J. Neurochem. 2000, 74:1098-1105.
13. Lan J., Li W., Zhang F., Sun F.Y., Nagayama T., O'Horo C., Chen J. Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion. J. Cereb. Blood Flow Metab. 2003, 23:1324-1339.
14. Klungland A., Bjelland S. Oxidative damage to purines in DNA: role of mammalian Ogg1. DNA Repair 2007, 6:481-488.
15. Tsukahara H., Haruta T., Ono N., Kobata R., Fukumoto Y., Hiraoka M., Mayumi M. Oxidative stress in childhood meningitis: measurement of 8-hydroxy-2′-deoxyguanosine concentration in cerebrospinal fluid. Redox Rep. 2000, 5:295-298.
16. Bernstein C., Bernstein H., Payne C.M., Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 2002, 511:145-178.
17. Yu S.W., Wang H., Dawson T.M., Dawson V.L. Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. Neurobiol. Dis. 2003, 14:303-317.
18. Altmeyer M., Hottiger M.O. Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging (Milano) 2009, 1:458-469.
19. Peralta-Leal A., Rodríguez-Vargas J.M., Aguilar-Quesada R., Rodríguez M.I., Linares J.L., de Almodóvar M.R., Oliver F.J. PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases. Free Radic. Biol. Med. 2009, 47:13-26.
20. Koedel U., Winkler F., Angele B., Fontana A., Pfister H.W. Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. J. Cereb. Blood Flow Metab. 2002, 22:39-49.
21. Tell G., Quadrifoglio F., Tiribelli C., Kelley M.R. The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid. Redox Signal. 2009, 11:601-620.
22. Guikema J.E., Linehan E.K., Tsuchimoto D., Nakabeppu Y., Strauss P.R., Stavnezer J., Schrader C.E. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J. Exp. Med. 2007, 204:3017-3026.
23. Xanthoudakis S., Miao G.G., Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:23-27.
24. Hill J.W., Evans M.K. Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Nucleic Acids Res. 2006, 34:1620-1632.
25. Kauppinen T.M. Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease. Neurochem. Int. 2007, 50:954-958.
26. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988, 16:1215.
27. Ke X., Collins A., Ye S. PIRA PCR designer for restriction analysis of single nucleotide polymorphisms. Bioinformatics 2001, 17:838-839.
28. Vodicka P., Stetina R., Polakova V., Tulupova E., Naccarati A., Vodickova L., Kumar R., Hanova M., Pardini B., Slyskova J., Musak L., De Palma G., Soucek P., Hemminki K. Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. Carcinogenesis 2007, 28:657-664.
29. Sanguinetti C.J., Dias Neto E., Simpson A.J. Rapid silver staining and recovery of PCR products separated on polyacrylamide gels. Biotechniques 1994, 17:914-921.
30. Frosina G. Prophylaxis of oxidative DNA damage by formamidopyrimidine-DNA glycosylase. Int. J. Cancer 2006, 119:1-7.
31. D'Ambrosio S.M., Gibson-D'Ambrosio R.E., Brady T., Oberyszyn A.S., Robertson F.M. Mechanisms of nitric oxide-induced cytotoxicity in normal human hepatocytes. Environ. Mol. Mutagen. 2001, 37:46-54.
32. Hirano T. Repair system of 7, 8-dihydro-8-oxoguanine as a defense line against carcinogenesis. J. Radiat. Res. 2008, 49:329-340.
33. Sweasy J.B., Lang T., DiMaio D. Is base excision repair a tumor suppressor mechanismž. Cell Cycle 2006, 5:250-259.
34. Masutani M., Nakagama H., Sugimura T. Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. Cell. Mol. Life Sci. 2005, 62:769-783.
35. Hill J.W., Hazra T.K., Izumi T., Mitra S. Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair. Nucleic Acids Res. 2001, 29:430-438.
36. Vidal A.E., Hickson I.D., Boiteux S., Radicella J.P. Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step. Nucleic Acids Res. 2001, 29:1285-1292.
37. Malanga M., Althaus F.R. The role of poly (ADP-ribose) in the DNA damage signaling network. Biochem. Cell Biol. 2005, 83:354-364.
38. Koedel U., Scheld W.M., Pfister H.W. Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect. Dis. 2002, 2:721-736.
39. Janoff E.N., Rubins J.B. Invasive pneumococcal disease in the immunocompromised host. Microb. Drug Resist. 1997, 3:215-232.
40. Maul R.W., Gearhart P.J. Controlling somatic hypermutation in immunoglobulin variable and switch regions. Immunol. Res. 2010, 47:113-122.
41. Schrader C.E., Guikema J.E., Wu X., Stavnezer J. The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:645-652.
42. Merluzzi S., Gri G., Gattei V., Pagano M., Pucillo C. APE/Ref-1 makes fine-tuning of CD40-induced B cell proliferation. Mol. Immunol. 2008, 45:3731-3739.
43. Winter D.B., Phung Q.H., Zeng X., Seeberg E., Barnes D.E., Lindahl T., Gearhart P.J. Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase. J. Immunol. 2003, 170:5558-5562.
44. Ambrose H.E., Willimott S., Beswick R.W., Dantzer F., de Murcia J.M., Yelamos J., Wagner S.D. Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses. Immunology 2009, 127:178-186.
45. Robert I., Dantzer F., Reina-San-Martin B. PARP-1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination. J. Exp. Med. 2009, 206:1047-1056.
46. Loh R.K, Thong Y.H., Ferrante A. Deficiency of IgG subclasses and IgA, and elevation of IgE in children with a past history of bacterial meningitis. Acta Paediatr. Scand. 1991, 80:654-658.
47. Kurosaki T., Aiba Y., Kometani K., Moriyama S., Takahashi Y. Unique properties of memory B cells of different isotypes. Immunol. Rev. 2010, 237:104-116.
48. Yachie A., Konno A., Ohta K., Wada T., Seki H., Taniguchi N., Miyawaki T. Delineation of producing ability of IgG and IgA subclasses by naive B cells in newborn infants and adult individuals. Clin. Exp. Immunol. 1995, 102:204-209.
49. Nouri-Aria K.T., Lobo-Yeo A., Vergani D., Mieli-Vergani G., Mowat A.P., Eddleston A.L. Immunoregulation of immunoglobulin production in normal infants and children. Clin. Exp. Immunol. 1985, 59:679-686.
50. Weksler M.E., Goodhardt M., Szabo P. The effect of age on B cell development and humoral immunity. Springer Semin. Immunopathol. 2002, 24:35-52.
51. Luning Prak E.T., Ross J., Sutter J., Sullivan K.E. Age-related trends in pediatric B-cell subsets. Pediatr. Dev. Pathol. 2011, 14:45-52.
52. Frasca D., Blomberg B.B. Effects of aging on B cell function. Curr. Opin. Immunol. 2009, 21:425-430.
53. Frasca D., Landin A.M., Lechner S.C., Ryan J.G., Schwartz R., Riley R.L., Blomberg B.B. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J. Immunol. 2008, 180:5283-5290.
54. Shockett P., Stavnezer J. Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene. J. Immunol. 1991, 147:4374-4383.
55. Grahnert A., Grahnert A., Klein C., Schilling E., Wehrhahn J., Hauschildt S. NAD+: a modulator of immune functions. Innate Immun. 2011, 17:212-233.
56. Ridderstad A., Tarlinton D.M. Kinetics of establishing the memory B cell population as revealed by CD38 expression. J. Immunol. 1998, 160:4688-4695.
57. Yasue T., Nishizumi H., Aizawa S., Yamamoto T., Miyake K., Mizoguchi C., Uehara S., Kikuchi Y., Takatsu K. A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:10307-10312.
58. Aiba Y., Kometani K., Hamadate M., Moriyama S., Sakaue-Sawano A., Tomura M., Luche H., Fehling H.J., Casellas R., Kanagawa O., Miyawaki A., Kurosaki T. Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:12192-12197.
59. Cockayne D.A., Muchamuel T., Grimaldi J.C., Muller-Steffner H., Randall T.D., Lund F.E., Murray R., Schuber F., Howard M.C. Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses. Blood 1998, 92:1324-1333.
60. Bhakat K.K., Mantha A.K., Mitra S. Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid. Redox Signal. 2009, 11:621-638.
61. Lindberg K, Rynnel-Dagoo B., Sundqvist K.G. Cytokines in nasopharyngeal secretions; evidence for defective IL-1beta production in children with recurrent episodes of acute otitis media. Clin. Exp. Immunol. 1994, 97:396-402.
62. Dinarello C.A. Proinflammatory cytokines. Chest 2000, 118:503-508.
63. Endler G., Marculescu R., Starkl P., Binder A., Geishofer G., Muller M., Zohrer B., Resch B., Zenz W., Mannhalter C. Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. Clin. Chem. 2006, 52:511-514.
64. Arnalich F., López-Maderuelo D., Codoceo R., Lopez J., Solis-Garrido L.M., Capiscol C., Fernandez-Capitán C., Madero R., Montiel C. Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. Clin. Exp. Immunol. 2002, 127:331-336.
65. Lahrtz F., Piali L., Spanaus K.S., Seebach J., Fontana A. Chemokines and chemotaxis of leukocytes in infectious meningitis. J. Neuroimmunol. 1998, 85:33-43.
66. Mukaida N. Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am. J. Physiol. Lung Cell Mol. Physiol. 2003, 284:L566-577.
67. Amano H., Morimoto K., Senba M., Wang H., Ishida Y., Kumatori A., Yoshimine H., Oishi K., Mukaida N., Nagatake T. Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia. J. Immunol. 2004, 172:398-409.
68. O'Hara A.M., Bhattacharyya A., Mifflin R.C., Smith M.F., Ryan K.A., Scott K.G., Naganuma M., Casola A., Izumi T., Mitra S., Ernst P.B., Crowe S.E. Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. J. Immunol. 2006, 177:7990-7999.
69. Xie J.Y., Li M.X., Xiang D.B., Mou J.H., Qing Y., Zeng L.L., Yang Z.Z., Guan W., Wang D. Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma. Clin. Lymphoma Myeloma Leuk. 2010, 10:385-393.
70. Jedinak A., Dudhgaonkar S., Kelley M.R., Sliva D. Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages. Anticancer Res. 2011, 3:379-385.
71. Gloire G., Legrand-Poels S., Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 2006, 72:1493-1505.
72. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 2009, 27:693-733.
73. Sjölinder H., Mogensen T.H., Kilian M., Jonsson A.B., Paludan S.R. Important role for Toll-like receptor 9 in host defense against meningococcal sepsis. Infect. Immun. 2008, 76:5421-5428.
74. Koedel U., Klein M., Pfister H.W. New understandings on the pathophysiology of bacterial meningitis. Curr. Opin. Infect. Dis. 2010, 23:217-223.
75. Schubert-Unkmeir A., Slanina H., Frosch M. Mammalian cell transcriptome in response to meningitis-causing pathogens. Expert Rev. Mol. Diagn. 2009, 9:833-842.
76. Mabley J.G., Pacher P., Deb A., Wallace R., Elder R.H., Szabo C. Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation. FASEB J. 2005, 19:290-292.
77. Kauppinen T.M., Swanson R.A. Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. J. Immunol. 2005, 174:2288-2296.
78. Ando K., Hirao S., Kabe Y., Ogura Y., Sato I., Yamaguchi Y., Wada T., Handa H. A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res. 2008, 36:4327-4336.
79. Lee H.M, Yuk J.M., Shin D.M., Yang C.S., Kim K.K., Choi D.K., Liang Z.L., Kim J.M., Jeon B.H., Kim C.D., Lee J.H., Jo E.K. Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses. J. Immunol. 2009, 183:6839-6848.
80. Perillo B., Ombra M.N., Bertoni A., Cuozzo C., Sacchetti S., Sasso A., Chiariotti L., Malorni A., Abbondanza C., Avvedimento E.V. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 2008, 319:202-206.
81. Amente S., Bertoni A., Morano A., Lania L., Avvedimento E.V., Majello B. LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Oncogene 2010, 29:3691-3702.
82. Chiarugi A. Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. Br. J. Pharmacol. 2002, 137:761-770.
83. Chang W.J., Alvarez-Gonzalez R. The sequence-specific DNA binding of NF-kappa B is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase 1. J. Biol. Chem. 2001, 276:47664-47670.
84. Hasko G., Mabley J.G., Nemeth Z.H., Pacher P., Deitch E.A., Szabo C. Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. Mol. Med. 2002, 8:283-289.
85. Chiarugi A., Moskowitz M.A. Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. J. Neurochem. 2003, 85:306-317.