LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription

Oncogene

Volumn 29, Issue 25, 2010, Pages 3691-3702

  Amente, S ^a,b   Bertoni, A ^a   Morano, A ^a   Lania, L ^a,b   Avvedimento, E V ^a,b   Majello, B ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

histone; LSD1; methylation; Myc; oxidative burst; transcription

Indexed keywords

8 OXO GUANINE DNA GLYCOSYLASE; APE1; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA GLYCOSYLTRANSFERASE; GUANINE; HISTONE H3; HYDROGEN PEROXIDE; LYSINE; LYSINE 4; LYSINE DEMETHYLATING ENZYME; MYC PROTEIN; NUCLEASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DEMETHYLATION; E BOX ELEMENT; GENE SILENCING; GENE TARGETING; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE; CHROMATIN; DNA; DNA REPAIR ENZYMES; E-BOX ELEMENTS; HISTONE DEMETHYLASES; HISTONES; LYSINE; METHYLATION; MITOGENS; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS C-MYC; RATS; TRANSCRIPTION, GENETIC;

EID: 77954053278     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.120     Document Type: Article

References (41)

1. Anand R, Marmorstein R. (2007). Structure and mechanism of lysine-specific demethylase enzymes. J Biol Chem 282: 35425-35429.
2. Berger SL. (2007). The complex language of chromatin regulation during transcription. Nature 447: 407-412.
3. Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S. (2003a). Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO J 22: 6299-6309.
4. Bhakat KK, Mantha AK, Mitra S. (2008). Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid Redox Signal 11: 621-638.
5. Bhakat KK, Yang SH, Mitra S. (2003b). Acetylation of human AP-endonuclease 1, a critical enzyme in DNA repair and transcription regulation. Methods Enzymol 371: 292-300.
6. Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK et al. (2008). Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol 28: 7066-7080.
7. Chen D, Lucey MJ, Phoenix F, Lopez-Garcia J, Hart SM, Losson R et al. (2003). T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. J Biol Chem 278: 38586-38592.
8. Cloos PA, Christensen J, Agger K, Helin K. (2008). Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 22: 1115-1140.
9. Cowling VH, Cole MD. (2006). Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol 16: 242-252.
10. Eilers M, Eisenman RN. (2008). Myc's broad reach. Genes Dev 22: 2755-2766.
11. Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J et al. (2003). Genomic targets of the human c-Myc protein. Genes Dev 17: 1115-1129.
12. Forneris F, Binda C, Battaglioli E, Mattevi A. (2008). LSD1: oxidative chemistry for multifaceted functions in chromatin regulation. Trends Biochem Sci 33: 181-189.
13. Forneris F, Binda C, Vanoni MA, Mattevi A, Battaglioli E. (2005). Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett 579: 2203-2207.
14. Frank SR, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan HM et al. (2003). MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep 4: 575-580.
15. Frank SR, Schroeder M, Fernandez P, Taubert S, Amati B. (2001). Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev 15: 2069-2082.
16. Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS et al. (2007). Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell 128: 505-518.
17. Gargano B, Amente S, Majello B, Lania L. (2007). P-TEFb is a crucial co-factor for Myc transactivation. Cell Cycle 6: 2031-2037.
18. Guccione E, Martinato F, Finocchiaro G, Luzi L, Tizzoni L, Dall' Olio V et al. (2006). Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol 8: 764-770.
19. Kim MS, Kondo T, Takada I, Youn MY, Yamamoto Y, Takahashi S et al. (2009). DNA demethylation in hormone-induced transcrip-tional derepression. Nature 461: 1007-1012.
20. Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Green RD, Kouzarides T. (2009). Distinct transcriptional outputs associated with mono-and dimethylated histone H3 arginine 2. Nat Struct Mol Biol 16: 449-451.
21. Kouzarides T. (2007). Chromatin modifications and their function. Cell 128: 693-705.
22. Lan F, Nottke AC, Shi Y. (2008). Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol 20: 316-325.
23. Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evan GI. (1995). A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 23: 1686-1690.
24. Mantha AK, Oezguen N, Bhakat KK, Izumi T, Braun W, Mitra S. (2008). Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1. J Mol Biol 379: 28-37.
25. Martinato F, Cesaroni M, Amati B, Guccione E. (2008). Analysis of Myc-induced histone modifications on target chromatin. PLoS ONE 3: e3650.
26. McMahon SB, Wood MA, Cole MD. (2000). The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol 20: 556-562.
27. Metzger E, Schule R. (2007). The expanding world of histone lysine demethylases. Nat Struct Mol Biol 14: 252-254.
28. Metzger E, Wissmann M, Yin N, Muller JM, Schneider R, Peters AH et al. (2005). LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437: 436-439.
29. Meyer N, Penn LZ. (2008). Reflecting on 25 years with MYC. Nat Rev Cancer 8: 976-990.
30. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127: 635-648.
31. Perillo B, Ombra MN, Bertoni A, Cuozzo C, Sacchetti S, Sasso A et al. (2008). DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 319: 202-206.
32. Schlosser I, Holzel M, Hoffmann R, Burtscher H, Kohlhuber F, Schuhmacher M et al. (2005). Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line. Oncogene 24: 520-524.
33. Secombe J, Li L, Carlos L, Eisenman RN. (2007). The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev 21: 537-551.
34. Shi Y. (2007). Histone lysine demethylases: emerging roles in development, physiology and disease. Nat Rev Genet 8: 829-833.
35. Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA et al. (2004). Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119: 941-953.
36. Sidorenko VS, Nevinsky GA, Zharkov DO. (2007). Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease. DNA Repair (Amst) 6: 317-328.
37. Tell G, Quadrifoglio F, Tiribelli C, Kelley MR. (2008). The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal 11: 601-620.
38. Vervoorts J, Luscher-Firzlaff JM, Rottmann S, Lilischkis R, Walsemann G, Dohmann K et al. (2003). Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep 4: 484-490.
39. Wissmann M, Yin N, Muller JM, Greschik H, Fodor BD, Jenuwein T et al. (2007). Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol 9: 347-353.
40. Wu K-J, Mattioli M, Morse HC, Dalla Favera R. (2002). c-Myc activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cb) gene. Oncogene 21: 7872-7882.
41. Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT et al. (2006). Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci USA 103: 17834-17839.