-
1
-
-
45149106841
-
Application of combinatorial chemistry science on modern drug discovery
-
Kennedy, J. P.; Williams, L.; Bridges, T. M.; Daniels, R. N.; Weaver, D.; Lindsley, C. W. Application of combinatorial chemistry science on modern drug discovery J. Comb. Chem. 2008, 10, 345-354
-
(2008)
J. Comb. Chem.
, vol.10
, pp. 345-354
-
-
Kennedy, J.P.1
Williams, L.2
Bridges, T.M.3
Daniels, R.N.4
Weaver, D.5
Lindsley, C.W.6
-
2
-
-
54449102045
-
Group efficiency: A guideline for hits-to-leads chemistry
-
Verdonk, M. L.; Rees, D. C. Group efficiency: A guideline for hits-to-leads chemistry ChemMedChem 2008, 3, 1179-1180
-
(2008)
ChemMedChem
, vol.3
, pp. 1179-1180
-
-
Verdonk, M.L.1
Rees, D.C.2
-
3
-
-
48149083026
-
Pharmaceutical strategy and innovation: An academics perspective
-
Baxendale, I. R.; Hayward, J. J.; Ley, S. V.; Tranmer, G. K. Pharmaceutical strategy and innovation: An academics perspective ChemMedChem 2007, 2, 768-788
-
(2007)
ChemMedChem
, vol.2
, pp. 768-788
-
-
Baxendale, I.R.1
Hayward, J.J.2
Ley, S.V.3
Tranmer, G.K.4
-
4
-
-
0442310496
-
High-throughput experimentation: A powerful enabling technology for the chemicals and materials industry
-
Dar, Y. L. High-throughput experimentation: A powerful enabling technology for the chemicals and materials industry Macromol. Rapid Commun. 2004, 25, 34-47
-
(2004)
Macromol. Rapid Commun.
, vol.25
, pp. 34-47
-
-
Dar, Y.L.1
-
5
-
-
6444234760
-
The role of the medicinal chemist in drug discovery - Then and now
-
DOI 10.1038/nrd1523
-
Lombardino, J. G.; Lowe, J. A., III. The role of the medicinal chemist in drug discovery-Then and now Nat. Rev. Drug Discovery 2004, 3, 853-862 (Pubitemid 39405946)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.10
, pp. 853-862
-
-
Lombardino, J.G.1
Lowe III, J.A.2
-
6
-
-
0037235881
-
Virtual screening to enrich hit lists from high-throughput screening: A case study on small-molecule inhibitors of angiogenin
-
DOI 10.1002/prot.10270
-
Jenkins, J. L.; Kao, R. Y. T.; Shapiro, R. Virtual screening to enrich hit lists from high-throughput screening: A case study on small-molecule inhibitors of angiogenin Prot. Struct. Funct. Genet. 2003, 50, 81-93 (Pubitemid 36090610)
-
(2003)
Proteins: Structure, Function and Genetics
, vol.50
, Issue.1
, pp. 81-93
-
-
Jenkins, J.L.1
Kao, R.Y.T.2
Shapiro, R.3
-
7
-
-
0033863669
-
High-throughput screening: New technology for the 21st century
-
DOI 10.1016/S1367-5931(00)00110-1
-
Hertzberg, R. P.; Pope, A. J. High-throughput screening: new technology for the 21st century Curr. Opin. Chem. Biol. 2000, 4, 445-451 (Pubitemid 30621048)
-
(2000)
Current Opinion in Chemical Biology
, vol.4
, Issue.4
, pp. 445-451
-
-
Hertzberg, R.P.1
Pope, A.J.2
-
8
-
-
70350462347
-
Relieving the first bottleneck in the drug discovery pipeline: Using array technologies to rationalize membrane protein production
-
Bonander, N.; Bill, R. M. Relieving the first bottleneck in the drug discovery pipeline: Using array technologies to rationalize membrane protein production Expert Rev. Proteomics 2009, 6, 501-505
-
(2009)
Expert Rev. Proteomics
, vol.6
, pp. 501-505
-
-
Bonander, N.1
Bill, R.M.2
-
9
-
-
67849090676
-
Organic Synthesis Scavengers in full flow
-
Seeberger, P. H. Organic Synthesis Scavengers in full flow Nat. Chem. 2009, 1, 258-260
-
(2009)
Nat. Chem.
, vol.1
, pp. 258-260
-
-
Seeberger, P.H.1
-
10
-
-
67849113794
-
The rise of fragment-based drug discovery
-
Murray, C. W.; Rees, D. C. The rise of fragment-based drug discovery Nat. Chem. 2009, 1, 187-192
-
(2009)
Nat. Chem.
, vol.1
, pp. 187-192
-
-
Murray, C.W.1
Rees, D.C.2
-
11
-
-
77950313887
-
Welcome to the future of medicinal chemistry
-
Ojima, I.; Thurston, D. E. Welcome to the future of medicinal chemistry Future Med. Chem. 2009, 1, 1-2
-
(2009)
Future Med. Chem.
, vol.1
, pp. 1-2
-
-
Ojima, I.1
Thurston, D.E.2
-
12
-
-
42349099366
-
The changing face of organic synthesis
-
Ley, S. V.; Baxendale, I. R. The changing face of organic synthesis Chimia 2008, 62, 162-168
-
(2008)
Chimia
, vol.62
, pp. 162-168
-
-
Ley, S.V.1
Baxendale, I.R.2
-
13
-
-
21744441328
-
Accelerating lead development by microwave-enhanced medicinal chemistry
-
DOI 10.1016/j.ddtec.2005.05.002, PII S1740674905000077
-
Shipe, W. D.; Wolkenberg, S. E.; Lindsley, C. W. Accelerating lead development by microwave-enhanced medicinal chemistry Drug Discovery Today Technol. 2005, 2, 155-161 (Pubitemid 40946323)
-
(2005)
Drug Discovery Today: Technologies
, vol.2
, Issue.2
, pp. 155-161
-
-
Shipe, W.D.1
Wolkenberg, S.E.2
Lindsley, C.W.3
-
14
-
-
79955604516
-
A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing
-
Lange, H.; Carter, C. F.; Hopkin, M. D.; Burke, A.; Goode, J. G.; Baxendale., I. R.; Ley, S. V. A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing Chem. Sci. 2011, 2, 765-769
-
(2011)
Chem. Sci.
, vol.2
, pp. 765-769
-
-
Lange, H.1
Carter, C.F.2
Hopkin, M.D.3
Burke, A.4
Goode, J.G.5
Baxendale, I.R.6
Ley, S.V.7
-
15
-
-
79952122285
-
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3- triazoles
-
Smith, C. J.; Nikbin, N.; Ley, S. V.; Lange, H.; Baxendale, I. R. A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles Org. Biomol. Chem. 2011, 9, 1938-1947
-
(2011)
Org. Biomol. Chem.
, vol.9
, pp. 1938-1947
-
-
Smith, C.J.1
Nikbin, N.2
Ley, S.V.3
Lange, H.4
Baxendale, I.R.5
-
16
-
-
77949853471
-
A flow-based synthesis of Imatinib: The API of Gleevec
-
Hopkin, M. D.; Baxendale, I. R.; Ley, S. V. A flow-based synthesis of Imatinib: the API of Gleevec Chem. Commun. 2010, 46, 2450-2452
-
(2010)
Chem. Commun.
, vol.46
, pp. 2450-2452
-
-
Hopkin, M.D.1
Baxendale, I.R.2
Ley, S.V.3
-
17
-
-
78149447862
-
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor
-
Malet-Sanz, L.; Madrzak, J.; Ley, S. V.; Baxendale, I. R. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor Org. Biomol. Chem. 2010, 8, 5324-5332
-
(2010)
Org. Biomol. Chem.
, vol.8
, pp. 5324-5332
-
-
Malet-Sanz, L.1
Madrzak, J.2
Ley, S.V.3
Baxendale, I.R.4
-
19
-
-
77950124624
-
ReactIR Flow Cell: A new analytical tool for continuous flow chemical processing
-
Carter, C. F.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode, J. G.; Gaunt, N. L. ReactIR Flow Cell: A new analytical tool for continuous flow chemical processing Org. Process Dev. Res. 2010, 14, 393-404
-
(2010)
Org. Process Dev. Res.
, vol.14
, pp. 393-404
-
-
Carter, C.F.1
Lange, H.2
Ley, S.V.3
Baxendale, I.R.4
Wittkamp, B.5
Goode, J.G.6
Gaunt, N.L.7
-
20
-
-
78249258386
-
A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N, N -diethyl-4-(3-fluorophenylpiperidin-4- ylidenemethyl)benzamide as a potent and highly selective delta-opioid receptor agonist
-
Qian, Z. Z.; Baxendale, I. R.; Ley, S. V. A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N, N -diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective delta-opioid receptor agonist Chem.-Eur. J. 2010, 16, 12342-12348
-
(2010)
Chem.-Eur. J.
, vol.16
, pp. 12342-12348
-
-
Qian, Z.Z.1
Baxendale, I.R.2
Ley, S.V.3
-
21
-
-
33745191890
-
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly
-
Baxendale, I. R.; Deeley, C. M.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K. A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly Chem. Commun. 2006, 24, 2566-2568
-
(2006)
Chem. Commun.
, vol.24
, pp. 2566-2568
-
-
Baxendale, I.R.1
Deeley, C.M.2
Griffiths-Jones, C.M.3
Ley, S.V.4
Saaby, S.5
Tranmer, G.K.6
-
22
-
-
33751328966
-
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
-
DOI 10.1039/b612197g
-
Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K. A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols Chem. Commun. 2006, 4835-4837 (Pubitemid 44808939)
-
(2006)
Chemical Communications
, Issue.46
, pp. 4835-4837
-
-
Baxendale, I.R.1
Ley, S.V.2
Smith, C.D.3
Tranmer, G.K.4
-
23
-
-
33344468928
-
Preparation of the neolignan natural product grossamide by a continuous-flow process
-
DOI 10.1055/s-2006-926244
-
Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S. V.; Tranmer, G. K. Preparation of the neolignan natural product grossamide by a continuous-flow process Synlett 2006, 427-430 (Pubitemid 43288580)
-
(2006)
Synlett
, Issue.3
, pp. 427-430
-
-
Baxendale, I.R.1
Griffiths-Jones, C.M.2
Ley, S.V.3
Tranmer, G.K.4
-
24
-
-
79955633732
-
Palladium-catalyzed amination reactions in flow: Overcoming the challenges of clogging via acoustic irradiation
-
Noël, T.; Naber, J. R.; Hartman, R. L.; McMullen, J. P.; Jensen, K. F.; Buchwald, S. L. Palladium-catalyzed amination reactions in flow: Overcoming the challenges of clogging via acoustic irradiation Chem. Sci. 2011, 2, 287-290
-
(2011)
Chem. Sci.
, vol.2
, pp. 287-290
-
-
Noël, T.1
Naber, J.R.2
Hartman, R.L.3
McMullen, J.P.4
Jensen, K.F.5
Buchwald, S.L.6
-
25
-
-
79551473940
-
Inductive Heating with Magnetic Materials inside Flow Reactors
-
Ceylan, S.; Coutable, L.; Wegner, J.; Kirschning, A. Inductive Heating with Magnetic Materials inside Flow Reactors Chem.-Eur. J. 2011, 17, 1884-1893
-
(2011)
Chem.-Eur. J.
, vol.17
, pp. 1884-1893
-
-
Ceylan, S.1
Coutable, L.2
Wegner, J.3
Kirschning, A.4
-
26
-
-
77952331743
-
The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow
-
Ngamsom, B.; Hickey, A. M.; Greenway, G. M.; Littlechild, J. A.; McCreedy, T.; Watts, P.; Wiles, C. The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow Org. Biomol. Chem. 2010, 8, 2419-2424
-
(2010)
Org. Biomol. Chem.
, vol.8
, pp. 2419-2424
-
-
Ngamsom, B.1
Hickey, A.M.2
Greenway, G.M.3
Littlechild, J.A.4
McCreedy, T.5
Watts, P.6
Wiles, C.7
-
27
-
-
77951136872
-
Continuous flow processing from microreactors to mesoscale: The Bohlmann-Rahtz cyclodehydration reaction
-
Bagley, M. C.; Fusillo, V.; Jenkins, R. L.; Lubinu, M. C.; Mason, C. Continuous flow processing from microreactors to mesoscale: The Bohlmann-Rahtz cyclodehydration reaction Org. Biomol. Chem. 2010, 8, 2245-2251
-
(2010)
Org. Biomol. Chem.
, vol.8
, pp. 2245-2251
-
-
Bagley, M.C.1
Fusillo, V.2
Jenkins, R.L.3
Lubinu, M.C.4
Mason, C.5
-
28
-
-
77955368979
-
Inductively heated oxides inside microreactors-Facile oxidations under flow conditions
-
Wegner, J.; Ceylan, S.; Friese, C.; Kirschning, A. Inductively heated oxides inside microreactors-Facile oxidations under flow conditions Eur. J. Org. Chem. 2010, 23, 4372-4375
-
(2010)
Eur. J. Org. Chem.
, vol.23
, pp. 4372-4375
-
-
Wegner, J.1
Ceylan, S.2
Friese, C.3
Kirschning, A.4
-
29
-
-
77955122762
-
The scale-up of organic synthesis using micro reactors
-
Wiles, C.; Watts, P. The scale-up of organic synthesis using micro reactors Chimica oggi - Chemistry Today 2010, 28, 3-5
-
(2010)
Chimica Oggi - Chemistry Today
, vol.28
, pp. 3-5
-
-
Wiles, C.1
Watts, P.2
-
30
-
-
78649582899
-
Toward a continuous-flow synthesis of boscalid (R)
-
Glasnov, T. N.; Kappe, C. O. Toward a continuous-flow synthesis of boscalid (R) Adv. Syn. Catal. 2010, 352, 3089-3097
-
(2010)
Adv. Syn. Catal.
, vol.352
, pp. 3089-3097
-
-
Glasnov, T.N.1
Kappe, C.O.2
-
31
-
-
78650915976
-
Intelligent microflow: Development of self-optimizing reaction systems
-
Rasheed, M.; Wirth, T. Intelligent microflow: Development of self-optimizing reaction systems Angew. Chem., Int. Ed. 2010, 50, 357-358
-
(2010)
Angew. Chem., Int. Ed.
, vol.50
, pp. 357-358
-
-
Rasheed, M.1
Wirth, T.2
-
32
-
-
77949915742
-
Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions
-
Riva, E.; Gagliardi, S.; Martinelli, M.; Passarella, D.; Vigo, D.; Rencurosi, A. Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions Tetrahedron 2010, 66, 3242-3247
-
(2010)
Tetrahedron
, vol.66
, pp. 3242-3247
-
-
Riva, E.1
Gagliardi, S.2
Martinelli, M.3
Passarella, D.4
Vigo, D.5
Rencurosi, A.6
-
33
-
-
77955662268
-
Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids
-
Brasholz, M.; Johnson, B. A.; Macdonald, J. M.; Polyzos, A.; Tsanaktsidis, J.; Saubern, S.; Holmes, A. B.; Ryan, J. H. Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids Tetrahedron 2010, 66, 6445-6449
-
(2010)
Tetrahedron
, vol.66
, pp. 6445-6449
-
-
Brasholz, M.1
Johnson, B.A.2
MacDonald, J.M.3
Polyzos, A.4
Tsanaktsidis, J.5
Saubern, S.6
Holmes, A.B.7
Ryan, J.H.8
-
34
-
-
77949536400
-
A highly efficient flow reactor process for the synthesis of N -Boc-3,4-dehydro- l -proline methyl ester
-
Tamborini, L.; Conti, P.; Pinto, A.; Micheli, C. D. A highly efficient flow reactor process for the synthesis of N -Boc-3,4-dehydro- l -proline methyl ester Tetrahedron: Asymmetry 2010, 21, 222-225
-
(2010)
Tetrahedron: Asymmetry
, vol.21
, pp. 222-225
-
-
Tamborini, L.1
Conti, P.2
Pinto, A.3
Micheli, C.D.4
-
35
-
-
75749106169
-
Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2- A ] Heterocycles
-
Herath, A.; Dahl, R.; Cosford, N. D. P. Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2- a ] Heterocycles Org. Lett. 2010, 12, 412-415
-
(2010)
Org. Lett.
, vol.12
, pp. 412-415
-
-
Herath, A.1
Dahl, R.2
Cosford, N.D.P.3
-
36
-
-
78449301674
-
One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert -butyl esters
-
Herath, A.; Cosford, N. D. P. One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert -butyl esters Org. Lett. 2010, 12, 5182-5185
-
(2010)
Org. Lett.
, vol.12
, pp. 5182-5185
-
-
Herath, A.1
Cosford, N.D.P.2
-
37
-
-
77950499570
-
Chemoselective reaction system using a two inlet micro-flow reactor: Application to carbonyl allylation
-
Amemiya, F.; Fuse, K.; Fuchigami, T.; Atobe, M. Chemoselective reaction system using a two inlet micro-flow reactor: application to carbonyl allylation Chem. Commun. 2010, 46, 2730-2732
-
(2010)
Chem. Commun.
, vol.46
, pp. 2730-2732
-
-
Amemiya, F.1
Fuse, K.2
Fuchigami, T.3
Atobe, M.4
-
38
-
-
75949097498
-
Generation and reactions of alpha-silyloxiranyllithium in a microreactor
-
Nagaki, A.; Takabayasi, N.; Tomida, Y.; Yoshida, J. Generation and reactions of alpha-silyloxiranyllithium in a microreactor Beilstein J. Org. Chem. 2009, 5, No. 16
-
(2009)
Beilstein J. Org. Chem.
, vol.5
, pp. 16
-
-
Nagaki, A.1
Takabayasi, N.2
Tomida, Y.3
Yoshida, J.4
-
39
-
-
39749134078
-
Fluorination reactions in microreactors
-
Gustafsson, T.; Pontén, F.; Seeberger, P. H. Fluorination reactions in microreactors Chem. Commun. 2008, 26, 1100-1102
-
(2008)
Chem. Commun.
, vol.26
, pp. 1100-1102
-
-
Gustafsson, T.1
Pontén, F.2
Seeberger, P.H.3
-
40
-
-
77957577062
-
Cross-coupling in a flow microreactor: Space integration of lithiation and Murahashi coupling
-
Nagaki, A.; Kenmoku, A.; Moriwaki, Y.; Hayashi, A.; Yoshida, J. Cross-coupling in a flow microreactor: Space integration of lithiation and Murahashi coupling Angew. Chem., Int. Ed. 2010, 49, 7543-7547
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 7543-7547
-
-
Nagaki, A.1
Kenmoku, A.2
Moriwaki, Y.3
Hayashi, A.4
Yoshida, J.5
-
41
-
-
78651250721
-
Efficient access to new chemical space through flow-Construction of druglike macrocycles through copper-surface-catalyzed azide-alkyne cycloaddition reactions
-
Bogdan, A. R.; James, K. Efficient access to new chemical space through flow-Construction of druglike macrocycles through copper-surface-catalyzed azide-alkyne cycloaddition reactions Chem.-Eur. J. 2010, 16, 14506-14512
-
(2010)
Chem.-Eur. J.
, vol.16
, pp. 14506-14512
-
-
Bogdan, A.R.1
James, K.2
-
42
-
-
59049088745
-
A strategic, "green" approach to organic chemistry with microwave assistance and predictive yield optimization as core, enabling technologies
-
Strauss, C. R. A strategic, "green" approach to organic chemistry with microwave assistance and predictive yield optimization as core, enabling technologies Aust. J. Chem. 2009, 62, 3-15
-
(2009)
Aust. J. Chem.
, vol.62
, pp. 3-15
-
-
Strauss, C.R.1
-
44
-
-
40849116347
-
Microwave reactions under continuous flow conditions
-
DOI 10.2174/138620707783220374
-
Baxendale, I. R.; Hayward, J. J.; Ley, S. V. Microwave reactions under continuous flow conditions Comb. Chem. High Throughput Screening 2007, 10, 802-836 (Pubitemid 351396401)
-
(2007)
Combinatorial Chemistry and High Throughput Screening
, vol.10
, Issue.10
, pp. 802-836
-
-
Baxendale, I.R.1
Hayward, J.J.2
Ley, S.V.3
-
45
-
-
33746283173
-
Microwave flow chemistry: The next evolutionary step in synthetic chemistry?
-
Baxendale, I. R.; Pitts, M. R. Microwave flow chemistry: The next evolutionary step in synthetic chemistry? Chim. Oggi-Chem. Today 2006, 24, 41-45 (Pubitemid 44105478)
-
(2006)
Chimica Oggi
, vol.24
, Issue.3
, pp. 41-45
-
-
Baxendale, I.R.1
Pitts, M.R.2
-
46
-
-
33747189999
-
Combining enabling techniques in organic synthesis: Continuous flow processes with heterogenized catalysts
-
DOI 10.1002/chem.200600236
-
Kirschning, A.; Solodenko, W.; Mennecke, K. Combining enabling techniques in organic synthesis: Continuous flow processes with heterogenized catalysts Chem.-Eur. J. 2006, 12, 5972-5990 (Pubitemid 44231023)
-
(2006)
Chemistry - A European Journal
, vol.12
, Issue.23
, pp. 5972-5990
-
-
Kirschning, A.1
Solodenko, W.2
Mennecke, K.3
-
47
-
-
80051586082
-
The flow synthesis of heterocycles for natural product and medicinal chemistry applications
-
10.1007/s11030-010-9282-1
-
Baumann, M.; Baxendale, I. R.; Ley, S. V. The flow synthesis of heterocycles for natural product and medicinal chemistry applications Mol. Diversity 2011, 10.1007/s11030-010-9282-1
-
(2011)
Mol. Diversity
-
-
Baumann, M.1
Baxendale, I.R.2
Ley, S.V.3
-
48
-
-
84880559014
-
Organic synthesis in mini flow reactors using immobilized catalysts
-
In; Benaglia, M., Ed.; John Wiley & Sons; New York,; pp.
-
Ceylan, S.; Kirschning, A. Organic synthesis in mini flow reactors using immobilized catalysts. In Recoverable and Recyclable Catalysts; Benaglia, M., Ed.; John Wiley & Sons; New York, 2009; pp 379-410.
-
(2009)
Recoverable and Recyclable Catalysts
, pp. 379-410
-
-
Ceylan, S.1
Kirschning, A.2
-
49
-
-
53149129111
-
Review on patents in microreactor and micro process engineering
-
Hessel, V.; Knobloch, C.; Löwe, H. Review on patents in microreactor and micro process engineering Recent Pat. Chem. Eng. 2008, 1, 1-16
-
(2008)
Recent Pat. Chem. Eng.
, vol.1
, pp. 1-16
-
-
Hessel, V.1
Knobloch, C.2
Löwe, H.3
-
51
-
-
77950214357
-
Flow ozonolysis using a semipermeable teflon AF-2400 membrane to effect gas-liquid contact
-
O'Brien, M.; Baxendale, I. R.; Ley, S. V. Flow ozonolysis using a semipermeable teflon AF-2400 membrane to effect gas-liquid contact Org. Lett. 2010, 12, 1596-1598
-
(2010)
Org. Lett.
, vol.12
, pp. 1596-1598
-
-
O'Brien, M.1
Baxendale, I.R.2
Ley, S.V.3
-
52
-
-
78650116079
-
Safe and efficient Ritter reactions in flow
-
Brandt, J. C.; Elmore, S. C.; Robinson, R. I.; Wirth, T. Safe and efficient Ritter reactions in flow Synlett 2010, 20, 3099-3103
-
(2010)
Synlett
, vol.20
, pp. 3099-3103
-
-
Brandt, J.C.1
Elmore, S.C.2
Robinson, R.I.3
Wirth, T.4
-
53
-
-
70449337540
-
Continuous flow nitration of benzaldehyde
-
Kulkami, A. A.; Kalyani, V. S.; Joshi, R. A.; Joshi, R. R. Continuous flow nitration of benzaldehyde Org. Process Res. Dev. 2009, 13, 999-1002
-
(2009)
Org. Process Res. Dev.
, vol.13
, pp. 999-1002
-
-
Kulkami, A.A.1
Kalyani, V.S.2
Joshi, R.A.3
Joshi, R.R.4
-
54
-
-
51149088558
-
The use of diethylaminosulfur trifluoride (DAST) for fluorination in a continuous-flow microreactor
-
Baumann, M.; Baxendale, I. R.; Ley, S. V. The use of diethylaminosulfur trifluoride (DAST) for fluorination in a continuous-flow microreactor Synlett 2008, 14, 2111-2114
-
(2008)
Synlett
, vol.14
, pp. 2111-2114
-
-
Baumann, M.1
Baxendale, I.R.2
Ley, S.V.3
-
55
-
-
42349114723
-
A modular flow reactor for performing Curtius rearrangements as a continuous flow process
-
DOI 10.1039/b801631n
-
Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.; Tierney, J. P. A modular flow reactor for performing Curtius rearrangements as a continuous flow process Org. Biomol. Chem. 2008, 6, 1577-1586 (Pubitemid 351555196)
-
(2008)
Organic and Biomolecular Chemistry
, vol.6
, Issue.9
, pp. 1577-1586
-
-
Baumann, M.1
Baxendale, I.R.2
Ley, S.V.3
Nikbin, N.4
Smith, C.D.5
Tierney, J.P.6
-
56
-
-
70350650698
-
Harsh reaction conditions in continuous-flow microreactors for pharmaceutical production
-
Kockmann, N.; Roberge, D. M. Harsh reaction conditions in continuous-flow microreactors for pharmaceutical production Chem. Eng. Technol. 2009, 32, 1682-1694
-
(2009)
Chem. Eng. Technol.
, vol.32
, pp. 1682-1694
-
-
Kockmann, N.1
Roberge, D.M.2
-
57
-
-
78651474657
-
Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor
-
Martin, L. J.; Marzinzik, A. L.; Ley, S. V.; Baxendale, I. R. Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor Org. Lett. 2011, 13, 320-323
-
(2011)
Org. Lett.
, vol.13
, pp. 320-323
-
-
Martin, L.J.1
Marzinzik, A.L.2
Ley, S.V.3
Baxendale, I.R.4
-
58
-
-
77950319440
-
The application of flow microreactors to the preparation of a family of casein kinase i inhibitors
-
Venturoni, F.; Nikbin, N.; Ley, S. V.; Baxendale, I. R. The application of flow microreactors to the preparation of a family of casein kinase I inhibitors Org. Biomol. Chem. 2010, 8, 1798-1806
-
(2010)
Org. Biomol. Chem.
, vol.8
, pp. 1798-1806
-
-
Venturoni, F.1
Nikbin, N.2
Ley, S.V.3
Baxendale, I.R.4
-
59
-
-
77949803605
-
The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors
-
Carter, C. F.; Baxendale, I. R.; Pavey, J. B. J.; Ley, S. V. The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors Org. Biomol. Chem. 2010, 8, 1588-1595
-
(2010)
Org. Biomol. Chem.
, vol.8
, pp. 1588-1595
-
-
Carter, C.F.1
Baxendale, I.R.2
Pavey, J.B.J.3
Ley, S.V.4
-
60
-
-
57549112435
-
A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor
-
Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tamborini, L.; Voica, A.-F. A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor J. Comb. Chem. 2008, 10, 851-857
-
(2008)
J. Comb. Chem.
, vol.10
, pp. 851-857
-
-
Baxendale, I.R.1
Ley, S.V.2
Smith, C.D.3
Tamborini, L.4
Voica, A.-F.5
-
61
-
-
34547914483
-
Flow and batch mode focused microwave synthesis of 5-amino-4- cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines
-
DOI 10.1039/b709043a
-
Smith, C. J.; Iglesias-Sigüenza, F. J.; Baxendale, I. R.; Ley, S. V. Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines Org. Biomol. Chem. 2007, 5, 2758-2761 (Pubitemid 47258233)
-
(2007)
Organic and Biomolecular Chemistry
, vol.5
, Issue.17
, pp. 2758-2761
-
-
Smith, C.J.1
Iglesias-Siguenza, F.J.2
Baxendale, I.R.3
Ley, S.V.4
-
62
-
-
34250726632
-
[3+27] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor
-
DOI 10.1039/b702995k
-
Smith, C. D.; Baxendale, I. R.; Lanners, S.; Hayward, J. J.; Smith, S. C.; Ley, S. V. [3 + 2]-Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor Org. Biomol. Chem. 2007, 5, 1559-1561 (Pubitemid 46959424)
-
(2007)
Organic and Biomolecular Chemistry
, vol.5
, Issue.10
, pp. 1559-1561
-
-
Smith, C.D.1
Baxendale, I.R.2
Lanners, S.3
Hayward, J.J.4
Smith, S.C.5
Ley, S.V.6
-
63
-
-
33845236565
-
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
-
DOI 10.1021/ol061975c
-
Baumann, M.; Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K. Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles Org. Lett. 2006, 8, 5231-5234 (Pubitemid 44861535)
-
(2006)
Organic Letters
, vol.8
, Issue.23
, pp. 5231-5234
-
-
Baumann, M.1
Baxendale, I.R.2
Ley, S.V.3
Smith, C.D.4
Tranmer, G.K.5
-
64
-
-
77749293066
-
Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor
-
Baumann, M.; Baxendale, I. R.; Ley, S. V. Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor Synlett 2010, 5, 749-752
-
(2010)
Synlett
, vol.5
, pp. 749-752
-
-
Baumann, M.1
Baxendale, I.R.2
Ley, S.V.3
-
65
-
-
79952761078
-
Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor
-
Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J. Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor Heterocycles 2011, 82, 1297-1316
-
(2011)
Heterocycles
, vol.82
, pp. 1297-1316
-
-
Baumann, M.1
Baxendale, I.R.2
Kirschning, A.3
Ley, S.V.4
Wegner, J.5
-
66
-
-
73649097576
-
[3 + 2]-Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions
-
Grafton, M.; Mansfield, A. C.; Fray, J. M. [3 + 2]-Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions Tetrahedron Lett. 2010, 51, 1026-1029
-
(2010)
Tetrahedron Lett.
, vol.51
, pp. 1026-1029
-
-
Grafton, M.1
Mansfield, A.C.2
Fray, J.M.3
-
67
-
-
78049513527
-
Synthesis of 3-Aryl/benzyl-4,5,6,6 a -tetrahydro-3 aH -pyrrolo[3,4- d ]isoxazole derivatives: A comparison between conventional, microwave-assisted and flow-based methodologies
-
Castellano, S.; Tamborini, L.; Viviano, M.; Pinto, A.; Sbardella, G.; Conti, P. Synthesis of 3-Aryl/benzyl-4,5,6,6 a -tetrahydro-3 aH -pyrrolo[3,4- d ]isoxazole derivatives: A comparison between conventional, microwave-assisted and flow-based methodologies J. Org. Chem. 2010, 75, 7439-7442
-
(2010)
J. Org. Chem.
, vol.75
, pp. 7439-7442
-
-
Castellano, S.1
Tamborini, L.2
Viviano, M.3
Pinto, A.4
Sbardella, G.5
Conti, P.6
-
68
-
-
84857121979
-
-
The H-Cube flow hydrogenator and the H-Cube Midi are both commercially available from ThalesNano. Website
-
The H-Cube flow hydrogenator and the H-Cube Midi are both commercially available from ThalesNano. Website: http://www.thalesnano.com.
-
-
-
-
69
-
-
77955663098
-
Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-Difluoro-ethyl)- pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide]-4-{[2- fluoro-4-(2-oxo-2 H -pyridin-1-yl)-phenyl]-amide} as a clinical candidate
-
Anselm, L.; Banner, D. W.; Benz, J.; Groebke Zbinden, K.; Himber, J.; Hilpert, H.; Huber, W.; Kuhn, B.; Mary, J.-L.; Otteneder, M. B.; Panday, N.; Ricklin, F.; Stahl, M.; Thomi, S.; Haap, W. Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-Difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide]-4-{[2-fluoro-4-(2-oxo-2 H -pyridin-1-yl)- phenyl]-amide} as a clinical candidate Bioorg. Med. Chem. Lett. 2010, 20, 5313-5319
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 5313-5319
-
-
Anselm, L.1
Banner, D.W.2
Benz, J.3
Groebke Zbinden, K.4
Himber, J.5
Hilpert, H.6
Huber, W.7
Kuhn, B.8
Mary, J.-L.9
Otteneder, M.B.10
Panday, N.11
Ricklin, F.12
Stahl, M.13
Thomi, S.14
Haap, W.15
-
70
-
-
79960265109
-
-
PCT Int. Appl. WO2009019163
-
Jablonski, P.; Kawasaki, K.; Knust, H.; Limberg, A.; Nettekoven, M.; Ratni, H.; Riemer, C.; Wu, X. PCT Int. Appl. WO2009019163
-
-
-
Jablonski, P.1
Kawasaki, K.2
Knust, H.3
Limberg, A.4
Nettekoven, M.5
Ratni, H.6
Riemer, C.7
Wu, X.8
-
71
-
-
79960269903
-
-
Chem. Abstr. 2007, 147, 118261.
-
(2007)
Chem. Abstr.
, vol.147
, pp. 118261
-
-
-
72
-
-
33847628449
-
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
-
DOI 10.1016/j.bmcl.2007.01.026, PII S0960894X07000753
-
Backes, B. J.; Longenecker, K.; Hamilton, G. L.; Stewart, K.; Lai, C.; Kopecka, H.; von Geldern, T. W.; Madar, D. J.; Pei, Z.; Lubben, T. H.; Zinker, B. A.; Tian, Z.; Ballaron, S. J.; Stashko, M. A.; Mika, A. K.; Beno, D. W. A.; Kempf-Grote, A. J.; Black-Schaefer, C.; Sham, H. L.; Trevillyan, J. M. Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit Bioorg. Med. Chem. Lett. 2007, 17, 2005-2012 (Pubitemid 46367663)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.7
, pp. 2005-2012
-
-
Backes, B.J.1
Longenecker, K.2
Hamilton, G.L.3
Stewart, K.4
Lai, C.5
Kopecka, H.6
Von Geldern, T.W.7
Madar, D.J.8
Pei, Z.9
Lubben, T.H.10
Zinker, B.A.11
Tian, Z.12
Ballaron, S.J.13
Stashko, M.A.14
Mika, A.K.15
Beno, D.W.A.16
Kempf-Grote, A.J.17
Black-Schaefer, C.18
Sham, H.L.19
Trevillyan, J.M.20
more..
-
73
-
-
77955424784
-
Discovery of potent, selective, and orally bioavailable 3 H -spiro[isobenzofuran-1,4′-piperidine]-based melanocortin subtype-4 receptor agonists
-
Guo, L.; Ye, Z.; Liu, J.; He, S.; Bakshi, R. K.; Sebhat, I. K.; Dobbelaar, P. H.; Hong, Q.; Jian, T.; Dellureficio, J. P.; Tsou, N. N.; Ball, R. G.; Weinberg, D. H.; MacNeil, T.; Tang, R.; Tamvakopoulos, C.; Peng, Q.; Chen, H. Y.; Chen, A. S.; Martin, W. J.; MacIntyre, D. E.; Strack, A. M.; Fong, T. M.; Wyvratt, M. J.; Nargund, R. P. Discovery of potent, selective, and orally bioavailable 3 H -spiro[isobenzofuran-1,4′-piperidine]-based melanocortin subtype-4 receptor agonists Bioorg. Med. Chem. Lett. 2010, 20, 4895-4900
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 4895-4900
-
-
Guo, L.1
Ye, Z.2
Liu, J.3
He, S.4
Bakshi, R.K.5
Sebhat, I.K.6
Dobbelaar, P.H.7
Hong, Q.8
Jian, T.9
Dellureficio, J.P.10
Tsou, N.N.11
Ball, R.G.12
Weinberg, D.H.13
MacNeil, T.14
Tang, R.15
Tamvakopoulos, C.16
Peng, Q.17
Chen, H.Y.18
Chen, A.S.19
Martin, W.J.20
MacIntyre, D.E.21
Strack, A.M.22
Fong, T.M.23
Wyvratt, M.J.24
Nargund, R.P.25
more..
-
74
-
-
33751157028
-
Kinetic control of pore formation in macroporous polymers-Formation of molded porous materials with high-flow characteristics for seperations or catalysis
-
For references on monoliths see
-
For references on monoliths see: Svec, F.; Frechet, J. M. J. Kinetic control of pore formation in macroporous polymers-Formation of molded porous materials with high-flow characteristics for seperations or catalysis Chem. Mater. 1995, 7, 707-715
-
(1995)
Chem. Mater.
, vol.7
, pp. 707-715
-
-
Svec, F.1
Frechet, J.M.J.2
-
75
-
-
0026876899
-
Polymeric porogens used in the preparation of novel monodispersed macroporous polymeric seperation media for high-performance liquid- chromatography
-
Svec, F.; Frechet, J. M. J. Polymeric porogens used in the preparation of novel monodispersed macroporous polymeric seperation media for high-performance liquid-chromatography Anal. Chem. 1992, 64, 1232-1238
-
(1992)
Anal. Chem.
, vol.64
, pp. 1232-1238
-
-
Svec, F.1
Frechet, J.M.J.2
-
76
-
-
33747189999
-
Combining enabling techniques in organic synthesis: Continuous flow processes with heterogenized catalysts
-
For recent applications of ion-exchange monoliths see:;; Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions Org. Biomol. Chem. 2008, 6, 1587-1593
-
Kirschning, A.; Solodenko, W.; Mennecke, K. Combining enabling techniques in organic synthesis: Continuous flow processes with heterogenized catalysts Chem.-Eur. J. 2006, 12, 5927-5990 For recent applications of ion-exchange monoliths see: Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D. Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions Org. Biomol. Chem. 2008, 6, 1587-1593
-
(2006)
Chem.-Eur. J.
, vol.12
, pp. 5927-5990
-
-
Kirschning, A.1
Solodenko, W.2
Mennecke, K.3
Baumann, M.4
Baxendale, I.R.5
Ley, S.V.6
Nikbin, N.7
Smith, C.D.8
-
77
-
-
34547877321
-
Continuous flow ligand-free Heck reactions using monolithic Pd[0] nanoparticles
-
Nikbin, N.; Ladlow, M.; Ley, S. V. Continuous flow ligand-free Heck reactions using monolithic Pd[0] nanoparticles Org. Process Res. Dev. 2007, 11, 458-462
-
(2007)
Org. Process Res. Dev.
, vol.11
, pp. 458-462
-
-
Nikbin, N.1
Ladlow, M.2
Ley, S.V.3
-
78
-
-
67650311641
-
Development of fluorination methods using continuous-flow microreactors
-
Baumann, M.; Baxendale, I. R.; Martin, L. J.; Ley, S. V. Development of fluorination methods using continuous-flow microreactors Tetrahedron 2009, 65, 6611-6625
-
(2009)
Tetrahedron
, vol.65
, pp. 6611-6625
-
-
Baumann, M.1
Baxendale, I.R.2
Martin, L.J.3
Ley, S.V.4
-
79
-
-
79953029329
-
Oxidation reactions in segmented and continuous flow chemical processing using an N -(tert -butyl)phenylsulfinimidoyl chloride monolith
-
For a recent application of covalent reagent see
-
For a recent application of covalent reagent see: Lange, H.; Capener, M. J.; Jones, A. X.; Smith, C. J.; Nikbin, N.; Baxendale, I. R.; Ley, S. V. Oxidation reactions in segmented and continuous flow chemical processing using an N -(tert -butyl)phenylsulfinimidoyl chloride monolith Synlett 2011, 869-873
-
(2011)
Synlett
, pp. 869-873
-
-
Lange, H.1
Capener, M.J.2
Jones, A.X.3
Smith, C.J.4
Nikbin, N.5
Baxendale, I.R.6
Ley, S.V.7
-
80
-
-
79952151592
-
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent
-
Smith, C. J.; Smith, C. D.; Nikbin, N.; Ley, S. V.; Baxendale., I. R. Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent Org. Biomol. Chem. 2011, 9, 1927-1937
-
(2011)
Org. Biomol. Chem.
, vol.9
, pp. 1927-1937
-
-
Smith, C.J.1
Smith, C.D.2
Nikbin, N.3
Ley, S.V.4
Baxendale, I.R.5
-
81
-
-
84857121977
-
-
The Vapourtec R2+/R4 flow system is commercially available from Vapourtec. Website
-
The Vapourtec R2+/R4 flow system is commercially available from Vapourtec. Website: http://www.vapourtec.co.uk.
-
-
-
-
83
-
-
49049100663
-
Maximizing efficiency in the production of compound libraries
-
Koppitz, M. Maximizing efficiency in the production of compound libraries J. Comb. Chem. 2008, 10, 573-579
-
(2008)
J. Comb. Chem.
, vol.10
, pp. 573-579
-
-
Koppitz, M.1
-
84
-
-
85004462669
-
A definate evidence on the ambivalent azomethine ylide intermediate in trifluoroacetic acid promoted and fluoride anion-promoted 1,3-cycloadditions involving the silicon-carbon bond-cleavage
-
Terao, Y.; Kotaki, H.; Imai, N.; Achiwa, K. A definate evidence on the ambivalent azomethine ylide intermediate in trifluoroacetic acid promoted and fluoride anion-promoted 1,3-cycloadditions involving the silicon-carbon bond-cleavage Chem. Pharm. Bull. 1985, 33, 896-898
-
(1985)
Chem. Pharm. Bull.
, vol.33
, pp. 896-898
-
-
Terao, Y.1
Kotaki, H.2
Imai, N.3
Achiwa, K.4
-
85
-
-
0003592435
-
N -Benzyl- N -methoxymethyl- N -(trimethylsilyl)methylamine as an azomethine ylide equivalent: 2,6-dioxo-1-phenyl-4-benzyl-1,4-diazabicyclo[3.3.0] octane
-
Padwa, A.; Dent, W. N -Benzyl- N -methoxymethyl- N -(trimethylsilyl) methylamine as an azomethine ylide equivalent: 2,6-dioxo-1-phenyl-4-benzyl-1,4- diazabicyclo[3.3.0]octane Org. Synth. 1989, 67, 133-139
-
(1989)
Org. Synth.
, vol.67
, pp. 133-139
-
-
Padwa, A.1
Dent, W.2
-
86
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
-
Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Delivery Rev. 2001, 46, 3-26 (Pubitemid 33653411)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
87
-
-
0032568397
-
Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes
-
DOI 10.1021/jm970530e
-
Kansy, M.; Senner, F.; Gubernator, K. Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes J. Med. Chem. 1998, 41, 1007-1010 (Pubitemid 28207375)
-
(1998)
Journal of Medicinal Chemistry
, vol.41
, Issue.7
, pp. 1007-1010
-
-
Kansy, M.1
Senner, F.2
Gubernator, K.3
-
88
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
DOI 10.1038/nrd2445, PII NRD2445
-
Leeson, P. D.; Springthorpe, B. The influence of drug-like concepts on decision-making in medicinal chemistry Nat. Rev. Drug Discovery 2007, 6, 881-890 (Pubitemid 350042396)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.11
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
89
-
-
0141958109
-
In silico prediction of blood-brain barrier permeation
-
DOI 10.1016/S1359-6446(03)02827-7, PII S1359644603028277
-
Clark, D. E. In silico prediction of blood-brain barrier permeation Drug Discovery Today 2003, 8, 927-933 (Pubitemid 37230012)
-
(2003)
Drug Discovery Today
, vol.8
, Issue.20
, pp. 927-933
-
-
Clark, D.E.1
-
90
-
-
0032714220
-
Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs
-
DOI 10.1023/A:1015040217741
-
Kelder, J.; Grootenhuis, P. D. J.; Bayada, D. M.; Delbressine, L. P.; Ploemen, J. P. Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs Pharm. Res. 1999, 16, 1514-1519 (Pubitemid 29510546)
-
(1999)
Pharmaceutical Research
, vol.16
, Issue.10
, pp. 1514-1519
-
-
Kelder, J.1
Grootenhuis, P.D.J.2
Bayada, D.M.3
Delbressine, L.P.C.4
Ploemen, J.-P.5
-
91
-
-
27344459398
-
Virtual computational chemistry laboratory - Design and description
-
DOI 10.1007/s10822-005-8694-y
-
Tetko, I. V.; Gasteiger, J.; Todeschini, R.; Mauri, A.; Livingstone, D.; Ertl, P.; Palyulin, V. A.; Radchenko, E. V.; Zefirov, N. S.; Makarenko, A. S.; Tanchuk, V. Y.; Prokopenko, V. V. Virtual computational chemistry laboratory-Design and description J. Comput.-Aided Mol. Des. 2005, 19, 453-463 (Pubitemid 41613292)
-
(2005)
Journal of Computer-Aided Molecular Design
, vol.19
, Issue.6
, pp. 453-463
-
-
Tetko, I.V.1
Gasteiger, J.2
Todeschini, R.3
Mauri, A.4
Livingstone, D.5
Ertl, P.6
Palyulin, V.A.7
Radchenko, E.V.8
Zefirov, N.S.9
Makarenko, A.S.10
Tanchuk, V.Yu.11
Prokopenko, V.V.12
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