A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4- ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist

Chemistry - A European Journal

Volumn 16, Issue 41, 2010, Pages 12342-12348

  Qian, Zizheng ^a   Baxendale, Ian R ^a   Ley, Steven V ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

flow chemistry; IR spectroscopy; microreactors; solid phase synthesis

Indexed keywords

ANALYTICAL PROTOCOLS; ASTRA ZENECA; BENZAMIDES; CONTINUOUS FLOWS; CONTINUOUS-FLOW PROCESS; FLOW CELLS; FLOW CHEMISTRY; FLOW STREAMS; IN-LINE; INPUT STREAMS; IR ANALYSIS; IR SPECTROSCOPY; MICRO REACTOR; MONITORING DEVICE; OPIOID RECEPTORS; OPTIMISATIONS; REACTIVE COMPONENTS; SOLID-PHASE SYNTHESIS; STEP FLOW; SUPPORTED REAGENTS; TO EFFECT;

AMIDES; HYDRAULICS; PUMPS;

CHEMICAL REACTORS;

BENZAMIDE DERIVATIVE; DELTA OPIATE RECEPTOR; N,N DIETHYL 4 (3 FLUOROPHENYLPIPERIDIN 4 YLIDENEMETHYL)BENZAMIDE; N,N-DIETHYL-4-(3-FLUOROPHENYLPIPERIDIN-4-YLIDENEMETHYL)BENZAMIDE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; INFRARED SPECTROPHOTOMETRY; SYNTHESIS;

BENZAMIDES; MOLECULAR STRUCTURE; PIPERAZINES; PIPERIDINES; RECEPTORS, OPIOID, DELTA; SPECTROPHOTOMETRY, INFRARED;

EID: 78249258386     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201002147     Document Type: Article

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