-
1
-
-
0003394220
-
-
Wiley-Interscience Publication: New York, NY
-
Doyle, M. P., McKervey, M. A., and Ye, T. Modern Catalytic Methods for Organic Synthesis with Diazo Compounds; Wiley-Interscience Publication: New York, NY, 1998.
-
(1998)
Modern Catalytic Methods for Organic Synthesis with Diazo Compounds
-
-
Doyle, M.P.1
McKervey, M.A.2
Ye, T.3
-
3
-
-
77955666187
-
-
Pace, V.; Verniest, G.; Sinisterra, J.-V.; Alcantara, A. R.; De Kimpe, N. J. Org. Chem. 2010, 75, 5760-5763
-
(2010)
J. Org. Chem.
, vol.75
, pp. 5760-5763
-
-
Pace, V.1
Verniest, G.2
Sinisterra, J.-V.3
Alcantara, A.R.4
De Kimpe, N.5
-
4
-
-
37049086756
-
-
Kennedy, M.; McKervey, M. A.; Maguire, A. R.; Tuladhar, S. M.; Twohig, M. F. J. Chem. Soc., Perkin Trans. 1 1990, 1047-1054
-
(1990)
J. Chem. Soc., Perkin Trans. 1
, pp. 1047-1054
-
-
Kennedy, M.1
McKervey, M.A.2
Maguire, A.R.3
Tuladhar, S.M.4
Twohig, M.F.5
-
5
-
-
78651507839
-
-
e-EROS Encyclopedia of Reagents for Organic Synthesis
-
Shiori, T.; Aoyama, T.; Snowden, T. e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001.
-
(2001)
-
-
Shiori, T.1
Aoyama, T.2
Snowden, T.3
-
6
-
-
78651501136
-
-
http://www.canadaeast.com/front/article/666039.
-
-
-
-
8
-
-
53849095703
-
-
Kockmann, N.; Gottsponer, M.; Zimmermann, B.; Roberge, D. M. Chem.-Eur. J. 2008, 14, 7470-7477
-
(2008)
Chem.-Eur. J.
, vol.14
, pp. 7470-7477
-
-
Kockmann, N.1
Gottsponer, M.2
Zimmermann, B.3
Roberge, D.M.4
-
10
-
-
33745191890
-
-
Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K. J. Chem. Soc., Chem. Commun. 2006, 24, 2566-2568
-
(2006)
J. Chem. Soc., Chem. Commun.
, vol.24
, pp. 2566-2568
-
-
Baxendale, I.R.1
Deeley, J.2
Griffiths-Jones, C.M.3
Ley, S.V.4
Saaby, S.5
Tranmer, G.K.6
-
11
-
-
33344468928
-
-
Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S. V.; Tranmer, G. K. Synlett 2006, 3, 427-430
-
(2006)
Synlett
, vol.3
, pp. 427-430
-
-
Baxendale, I.R.1
Griffiths-Jones, C.M.2
Ley, S.V.3
Tranmer, G.K.4
-
12
-
-
58149105608
-
-
Van Alsten, J. G.; Reeder, L. M.; Stanchina, C. L.; Knoechel, D. J. Org. Process Res. Dev. 2008, 12, 989-994
-
(2008)
Org. Process Res. Dev.
, vol.12
, pp. 989-994
-
-
Van Alsten, J.G.1
Reeder, L.M.2
Stanchina, C.L.3
Knoechel, D.J.4
-
13
-
-
70449337540
-
-
Kulkarni, A. A.; Kalyani, V. S.; Joshi, R. A.; Josh, R. R. Org. Process Res. Dev. 2009, 13, 999-1002
-
(2009)
Org. Process Res. Dev.
, vol.13
, pp. 999-1002
-
-
Kulkarni, A.A.1
Kalyani, V.S.2
Joshi, R.A.3
Josh, R.R.4
-
14
-
-
67650311641
-
-
Baumann, M.; Baxendale, I. R.; Martin, L. J.; Ley, S. V. Tetrahedron 2009, 65, 6611-6625
-
(2009)
Tetrahedron
, vol.65
, pp. 6611-6625
-
-
Baumann, M.1
Baxendale, I.R.2
Martin, L.J.3
Ley, S.V.4
-
15
-
-
70349782205
-
-
Baxendale, I. R.; Ley, S. V.; Mansfield, A. C.; Smith, C. D. Angew. Chem., Int. Ed. 2009, 48, 4017-4021
-
(2009)
Angew. Chem., Int. Ed.
, vol.48
, pp. 4017-4021
-
-
Baxendale, I.R.1
Ley, S.V.2
Mansfield, A.C.3
Smith, C.D.4
-
16
-
-
78651518595
-
-
Industrial scale continuous diazomethane production is carried out by Phoenix Chemicals: US6962983. This is achieved by feeding a base and diazomethane precursor into a reactor vessel that generates diazomethane which can be removed using a diluent gas
-
Industrial scale continuous diazomethane production is carried out by Phoenix Chemicals: US6962983. This is achieved by feeding a base and diazomethane precursor into a reactor vessel that generates diazomethane which can be removed using a diluent gas.
-
-
-
-
17
-
-
37849015691
-
-
Struempel, M.; Ondruschka, B.; Daute, R.; Stark, A. Green Chem. 2008, 10, 41-43
-
(2008)
Green Chem.
, vol.10
, pp. 41-43
-
-
Struempel, M.1
Ondruschka, B.2
Daute, R.3
Stark, A.4
-
18
-
-
70449435071
-
-
Struempel, M.; Ondruschka, B.; Stark, A. Org. Process Res. Dev. 2009, 13, 1014-1021
-
(2009)
Org. Process Res. Dev.
, vol.13
, pp. 1014-1021
-
-
Struempel, M.1
Ondruschka, B.2
Stark, A.3
-
19
-
-
78651486257
-
-
PS-Diazald was prepared from a commercially available polymer-supported tosyl chloride in two steps: see Supporting Information
-
PS-Diazald was prepared from a commercially available polymer-supported tosyl chloride in two steps: see Supporting Information.
-
-
-
-
20
-
-
78651469217
-
-
Flow Liquid Liquid Extraction machine, available from Syrris
-
Flow Liquid Liquid Extraction machine, available from Syrris, http://www.syrris.com.
-
-
-
-
21
-
-
78651496926
-
-
http://www.vapourtec.co.uk.
-
-
-
-
23
-
-
78651470037
-
-
Similar results were obtained starting from 3-phenyl propionyl chloride 1a; we observed formation of the expected diazoketone 2a (62%) and the TMS-protected diazoketone (31%)
-
Similar results were obtained starting from 3-phenyl propionyl chloride 1a; we observed formation of the expected diazoketone 2a (62%) and the TMS-protected diazoketone (31%).
-
-
-
-
24
-
-
78651510350
-
-
A23: 2-3 mmol, commercially available from Sigma-Aldrich
-
A23: 2-3 mmol, commercially available from Sigma-Aldrich.
-
-
-
-
25
-
-
78651510048
-
-
Except for 2e, 2g, 2h, and 2i: crude reaction mixtures gave purities >85%; a batch purification was carried out for these compounds (see footnote Scheme 2)
-
Except for 2e, 2g, 2h, and 2i: crude reaction mixtures gave purities >85%; a batch purification was carried out for these compounds (see footnote Scheme 2).
-
-
-
-
28
-
-
84906440607
-
-
Estevan, F.; Lahuerta, P.; Pérez-Prieto, J.; Stiriba, S.-E.; Ubeda, M. A. Synlett 1995, 1121-1122
-
(1995)
Synlett
, pp. 1121-1122
-
-
Estevan, F.1
Lahuerta, P.2
Pérez-Prieto, J.3
Stiriba, S.-E.4
Ubeda, M.A.5
-
29
-
-
40649104514
-
-
Yadav, J. S.; Subba Reddy, B. V.; Gopala Rao, Y.; Narsaiah, A. V. Tetratrahedron Lett. 2008, 49, 2381-2383
-
(2008)
Tetratrahedron Lett.
, vol.49
, pp. 2381-2383
-
-
Yadav, J.S.1
Subba Reddy, B.V.2
Gopala Rao, Y.3
Narsaiah, A.V.4
-
30
-
-
42049100636
-
-
Yadav, J. S.; Subba Reddy, B. V.; Gopala Rao, Y.; Narsaiah, A. V. Chem. Lett. 2008, 37, 348-349
-
(2008)
Chem. Lett.
, vol.37
, pp. 348-349
-
-
Yadav, J.S.1
Subba Reddy, B.V.2
Gopala Rao, Y.3
Narsaiah, A.V.4
-
31
-
-
77950037732
-
-
Pissot-Soldermann, C.; Gerspacher, M.; Furet, P.; Gaul, C.; Holzer, P.; McCarthy, C.; Radimerski, T.; Regnier, C. H.; Baffert, F.; Drueckes, P.; Tavares, G. A.; Vangrevelinghe, E.; Blasco, F.; Ottaviani, G.; Ossola, F.; Scesa, J.; Reetz, J. Bioorg. Med. Chem. Lett. 2010, 20, 2609-2613
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 2609-2613
-
-
Pissot-Soldermann, C.1
Gerspacher, M.2
Furet, P.3
Gaul, C.4
Holzer, P.5
McCarthy, C.6
Radimerski, T.7
Regnier, C.H.8
Baffert, F.9
Drueckes, P.10
Tavares, G.A.11
Vangrevelinghe, E.12
Blasco, F.13
Ottaviani, G.14
Ossola, F.15
Scesa, J.16
Reetz, J.17
-
32
-
-
61349113364
-
-
Corona, P.; Carta, A.; Loriga, M.; Vitale, G.; Paglietti, G. Eur. J. Med. Chem. 2009, 44, 1579-1591
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 1579-1591
-
-
Corona, P.1
Carta, A.2
Loriga, M.3
Vitale, G.4
Paglietti, G.5
-
33
-
-
67649993442
-
-
Tanimori, S.; Nishimura, T.; Kirihata, M. Bioorg. Med. Chem. Lett. 2009, 19, 4119-4121
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 4119-4121
-
-
Tanimori, S.1
Nishimura, T.2
Kirihata, M.3
-
34
-
-
57549094425
-
-
Yadav, J. S.; Subba Redi, B. V.; Premalatha, K.; Shiva Shankar, K. Synthesis 2008, 23, 3787-3792
-
(2008)
Synthesis
, vol.23
, pp. 3787-3792
-
-
Yadav, J.S.1
Subba Redi, B.V.2
Premalatha, K.3
Shiva Shankar, K.4
-
35
-
-
77953001153
-
-
Hou, J.-T.; Liu, Y.-H.; Zhang, Z.-H. J. Heterocycl. Chem. 2010, 47, 703-706
-
(2010)
J. Heterocycl. Chem.
, vol.47
, pp. 703-706
-
-
Hou, J.-T.1
Liu, Y.-H.2
Zhang, Z.-H.3
-
36
-
-
77950344170
-
-
Meshram, H. M.; Sanosh Kumar, G.; Ramesh, P.; Chennakesava Redy, B. Tetrahedron Lett. 2010, 51, 2580-2585
-
(2010)
Tetrahedron Lett.
, vol.51
, pp. 2580-2585
-
-
Meshram, H.M.1
Sanosh Kumar, G.2
Ramesh, P.3
Chennakesava Redy, B.4
-
38
-
-
78651502781
-
-
With cupric acetylacetonate or rhodium octanoate dimer: only recovered diazoketone was obsereved. With rhodium acetate dimer, numerous side products were identified starting from 2a
-
With cupric acetylacetonate or rhodium octanoate dimer: only recovered diazoketone was obsereved. With rhodium acetate dimer, numerous side products were identified starting from 2a.
-
-
-
-
39
-
-
78651508699
-
-
Crude mixture 4a -4d presented an unidentified impurity which could not be removed using scavengers. Purification was carried out by a catch and release technique: see Supporting Information
-
Crude mixture 4a -4d presented an unidentified impurity which could not be removed using scavengers. Purification was carried out by a catch and release technique: see Supporting Information.
-
-
-
-
40
-
-
78651488596
-
-
Attempts to preferentially form one of the regioisomers by forming one imine as a first step by dehydration of the flow stream failed
-
Attempts to preferentially form one of the regioisomers by forming one imine as a first step by dehydration of the flow stream failed.
-
-
-
|