Preparation of the neolignan natural product grossamide by a continuous-flow process

Synlett

Volumn , Issue 3, 2006, Pages 427-430

  Baxendale, Ian R ^a   Griffiths Jones, Charlotte M ^a   Ley, Steven V ^a   Tranmer, Geoffrey K ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Enzymes; Flow synthesis; Natural products; Polymer supported reagents

Indexed keywords

GROSSAMIDE; NEOLIGNAN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; CONTINUOUS FLOW REACTOR; CYCLIZATION; ENANTIOSELECTIVITY; FLOW MEASUREMENT; SYNTHESIS;

EID: 33344468928     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-926244     Document Type: Article

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59. With DMF followed by THF.
60. The exact amount was highly dependant on flow rates, scale and specific dimensions of the column. Optimum conditions could be rapidly determined in an automated screening fashion.
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