Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22α-targeted overexpression of the serotonin transporter

FASEB Journal

Volumn 23, Issue 12, 2009, Pages 4135-4147

  Guignabert, Christophe ^a,b   Tu, Ly ^a,b   Izikki, Mohamed ^a,b   Dewachter, Laurence ^a   Zadigue, Patricia ^b   Humbert, Marc ^a,d   Adnot, Serge ^b   Fadel, Elie ^a,c   Eddahibi, Saadia ^a,b  

^a INSERM   (France)

^b INSERM U955   (France)

^c CENTRE CHIRURGICAL MARIE LANNELONGUE   (France)

^d HÔPITAL ANTOINE BÉCLÈRE   (France)

Author keywords

Bcl 2 Bax ratio; NFAT Kv1.5 axis; PDK inhibitor; Pulmonary vascular remodeling; Serotonin pathway

Indexed keywords

CYCLOSPORIN A; DEOXYCORTICOSTERONE ACETATE; DICHLOROACETIC ACID; FLUOXETINE; POTASSIUM CHANNEL KV1.5; PROTEIN SUBUNIT; SEROTONIN; SEROTONIN TRANSPORTER; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC2; TRANSGELIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY MUSCLE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; LUNG HEMODYNAMICS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; STRAIN DIFFERENCE; T LYMPHOCYTE; WILD TYPE;

MUS;

EID: 72749086606     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-131664     Document Type: Article

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