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Volumn 8, Issue 4, 2011, Pages 593-603

Molecular imaging of hypoxia: Strategies for probe design and application

Author keywords

Cancer; Carbonic anhydrase ix; Copper 64; Fluorescence; Fluorination; Fluorine 18; HIF 1; Hypoxia; Molecular imaging; Positron emission tomography; Radiosynthesis; Single photon emission computed tomography

Indexed keywords


EID: 79959986431     PISSN: 15701794     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017911796117179     Document Type: Article
Times cited : (42)

References (82)
  • 1
    • 84966192535 scopus 로고
    • The histological structure of some humanlung cancers and the possible implications for radiotherapy
    • Thomlinson, R. H., Gray, L. H. The histological structure of some humanlung cancers and the possible implications for radiotherapy. Br. J. Cancer 1955, 9, 539-549.
    • (1955) Br. J. Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 2
    • 32144435353 scopus 로고
    • Mode of action of x-ray doses given with different oxygen concentrations
    • Read, J. Mode of action of x-ray doses given with different oxygenconcentrations. Br. J. Radiol. 1952, 25, 651-661.
    • (1952) Br. J. Radiol , vol.25 , pp. 651-661
    • Read, J.1
  • 3
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as afactor in radiotherapy
    • Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., Scott, O. C. A. The concentration of oxygen dissolved in tissues at the time of irradiation as afactor in radiotherapy. Br. J. Radiol. 1953, 26, 638-648.
    • (1953) Br. J. Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.A.5
  • 4
    • 0003131689 scopus 로고
    • The influence of oxygen on the radiosensitivity of mammalian tissues
    • Wright, E. A., Howard-Flanders, P. The influence of oxygen on the radiosensitivity of mammalian tissues. Acta Radiol. 1957, 48, 26-32.
    • (1957) Acta Radiol , vol.48 , pp. 26-32
    • Wright, E.A.1    Howard-Flanders, P.2
  • 5
    • 0035925098 scopus 로고    scopus 로고
    • Tumor Hypoxia, Definitions and Current Clinical,Biologic, and Molecular Aspects
    • Höckel, M., Vaupel, P. Tumor Hypoxia, Definitions and Current Clinical,Biologic, and Molecular Aspects. J. Natl. Cancer Inst. 2001, 93, 266-276.
    • (2001) J. Natl. Cancer Inst , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 6
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumor hypoxia in cancer treatment
    • Brown, J. M., Wilson, W. R. Exploiting tumor hypoxia in cancer treatment. Nat. Rev. Cancer 2004, 4, 437-447.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 7
    • 0019349297 scopus 로고
    • Classification of antineoplasticagents by their selective toxicities toward oxygenated and hypoxic tumorcells
    • Teicher, B. A., Lazo, J. S., Sartorelli, A. C. Classification of antineoplasticagents by their selective toxicities toward oxygenated and hypoxic tumorcells. Cancer Res. 1981, 41, 73-81.
    • (1981) Cancer Res , vol.41 , pp. 73-81
    • Teicher, B.A.1    Lazo, J.S.2    Sartorelli, A.C.3
  • 8
    • 0025354292 scopus 로고
    • Classification of antineoplastic treatments by their differential toxicity toward putativeoxygenated and hypoxic tumor subpopulations in vivo in the FSaII murinefibrosarcoma
    • Teicher, B. A., Holden, S. A., al-Achi, A., Herman, T. S. Classification of antineoplastic treatments by their differential toxicity toward putativeoxygenated and hypoxic tumor subpopulations in vivo in the FSaII murinefibrosarcoma. Cancer Res. 1990, 50, 3339-3344.
    • (1990) Cancer Res , vol.50 , pp. 3339-3344
    • Teicher, B.A.1    Holden, S.A.2    Al-Achi, A.3    Herman, T.S.4
  • 9
    • 0010170555 scopus 로고
    • Hypoxia induces DNAoverreplication and enhances metastatic potential of murine tumor cells
    • Young, S. D., Marshall, R. S., Hill, R. P. Hypoxia induces DNAoverreplication and enhances metastatic potential of murine tumor cells. Proc. Natl. Acad. Sci. U. S. A. 1988, 85, 9533-9537.
    • (1988) Proc. Natl. Acad. Sci. U. S. A , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 11
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advancedcancer of the uterine cervix
    • Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U., Vaupel, P. Association between tumor hypoxia and malignant progression in advancedcancer of the uterine cervix. Cancer Res. 1996, 56, 4509-4915.
    • (1996) Cancer Res , vol.56 , pp. 4509-4915
    • Höckel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 13
    • 0031059664 scopus 로고    scopus 로고
    • Exposure to hypoxia, glucose starvation andacidosis: Effect on invasive capacity of murine tumor cells and correlationwith cathepsin (L + B) secretion. Clin. Exp
    • Cuvier, C., Jang, A., Hill, R. P. Exposure to hypoxia, glucose starvation andacidosis: effect on invasive capacity of murine tumor cells and correlationwith cathepsin (L + B) secretion. Clin. Exp. Metastasis 1997, 15, 19-25.
    • (1997) Metastasis , vol.15 , pp. 19-25
    • Cuvier, C.1    Jang, A.2    Hill, R.P.3
  • 14
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular densityas predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • Sundfor, K., Lyng, H., Rof stad, E. K. Tumour hypoxia and vascular densityas predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br. J. Cancer 1998, 78, 822-827.
    • (1998) Br. J. Cancer , vol.78 , pp. 822-827
    • Sundfor, K.1    Lyng, H.2    Rof Stad, E.K.3
  • 15
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxic cervical cancerswith low apoptotic index are highly aggressive
    • Höckel, M., Schlenger, K., Höckel, S., Vaupel, P. Hypoxic cervical cancerswith low apoptotic index are highly aggressive. Cancer Res. 1999, 59, 4525-4528.
    • (1999) Cancer Res , vol.59 , pp. 4525-4528
    • Höckel, M.1    Schlenger, K.2    Höckel, S.3    Vaupel, P.4
  • 16
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in humancervical cancers
    • Walenta, S., Wetterling, M., Lehrke, M., Schwickert, G., Sundfor, K., Rof stad, E. K., Mueller-Klieser, W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in humancervical cancers. Cancer Res. 2000, 60, 916-921.
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rof Stad, E.K.6    Mueller-Klieser, W.7
  • 17
    • 22544464403 scopus 로고    scopus 로고
    • Coordinate regulationof the oxygen-dependent degradation domains of hypoxia-inducible factor1a
    • Chan, D. A., Sutphin, P. D., Yen, S. E., Giaccia, A. J. Coordinate regulationof the oxygen-dependent degradation domains of hypoxia-inducible factor1a. Mol. Cell. Biol. 2005, 25, 6415-6426.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 6415-6426
    • Chan, D.A.1    Sutphin, P.D.2    Yen, S.E.3    Giaccia, A.J.4
  • 23
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a is a marker for anunfavorable prognosis in early-stage cervical cancer
    • Birner, P., Schindl, M., Obermair, A., Plank, C., Breitnecker, G., Oberhuber, G. Overexpression of hypoxia-inducible factor 1a is a marker for anunfavorable prognosis in early-stage cervical cancer. Cancer Res. 2000, 60,4693-4696.
    • (2000) Cancer Res , vol.60 , pp. 4693-4696
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Plank, C.4    Breitnecker, G.5    Oberhuber, G.6
  • 26
    • 3843107242 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor (HIF)-1a isassociated with vascular endothelial growth factor expression and tumorangiogenesis in human oesophageal squamous cell carcinoma
    • Kimura, S., Kitadai, Y., Tanaka, S., Kuwai, T., Hihara, J., Yoshida, K., Toge, T., Chayama, K. Expression of hypoxia-inducible factor (HIF)-1a isassociated with vascular endothelial growth factor expression and tumorangiogenesis in human oesophageal squamous cell carcinoma. Eur. J.Cancer 2004, 40, 1904-1912.
    • (2004) Eur. J.Cancer , vol.40 , pp. 1904-1912
    • Kimura, S.1    Kitadai, Y.2    Tanaka, S.3    Kuwai, T.4    Hihara, J.5    Yoshida, K.6    Toge, T.7    Chayama, K.8
  • 27
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1a: A novelpredictive and prognostic parameter in the radiotherapy of oropharyngealcancer
    • Aebersold, D. M., Burri, P., Beer, K. T., Laissue, J., Djonov, V., Greiner, R.H., Semenza, G. L. Expression of hypoxia-inducible factor-1a: a novelpredictive and prognostic parameter in the radiotherapy of oropharyngealcancer. Cancer Res. 2001, 61, 2911-2916.
    • (2001) Cancer Res , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3    Laissue, J.4    Djonov, V.5    Greiner, R.H.6    Semenza, G.L.7
  • 29
    • 0036721256 scopus 로고    scopus 로고
    • Association of hypoxia-inducible factors 1a and 2a with activatedangiogenic pathways and prognosis in patients with endometrial carcinoma
    • Sivridis, E., Giatromanolaki, A., Gatter, K. C., Harris, A. L., Koukourakis, M. I. Association of hypoxia-inducible factors 1a and 2a with activatedangiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 2002, 95, 1055-1063.
    • (2002) Cancer , vol.95 , pp. 1055-1063
    • Sivridis, E.1    Giatromanolaki, A.2    Gatter, K.C.3    Harris, A.L.4    Koukourakis, M.I.5
  • 30
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for Cancer Therapy
    • Semenza, G. L. Targeting HIF-1 for Cancer Therapy. Nat. Rev. Cancer 2003,3, 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 33
    • 0032780848 scopus 로고    scopus 로고
    • The OxyLite: A fibre-optic oxygen sensor
    • Griffiths, J. R., Robinson, S. P. The OxyLite: a fibre-optic oxygen sensor. Br.J. Radiol. 1999, 72, 627-630.
    • (1999) Br.J. Radiol , vol.72 , pp. 627-630
    • Griffiths, J.R.1    Robinson, S.P.2
  • 34
    • 46749143345 scopus 로고    scopus 로고
    • Molecular imaging of hypoxia
    • Krohn, K. A., Link, J. M., Mason, R. P. Molecular imaging of hypoxia. J.Nucl. Med. 2008, 49, 129S-48S.
    • (2008) J.Nucl. Med , vol.49 , pp. 129-148
    • Krohn, K.A.1    Link, J.M.2    Mason, R.P.3
  • 40
    • 0028785458 scopus 로고
    • Evidence thathypoxia markers detect oxygen gradients in liver: Pimonidazole andretrograde perfusion of rat liver
    • Arteel, G. E., Thurman, R. G., Yates, J. M., Raleigh, J. A. Evidence thathypoxia markers detect oxygen gradients in liver: pimonidazole andretrograde perfusion of rat liver. Br. J. Cancer 1995, 72, 889-895.
    • (1995) Br. J. Cancer , vol.72 , pp. 889-895
    • Arteel, G.E.1    Thurman, R.G.2    Yates, J.M.3    Raleigh, J.A.4
  • 41
    • 0030032543 scopus 로고    scopus 로고
    • 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9Ls.c. tumors
    • Evans, S. M., Jenkins, W. T., Joiner, B., Lord, E. M., Koch, C. J. 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9Ls.c. tumors. Cancer Res. 1996, 56, 405-411.
    • (1996) Cancer Res , vol.56 , pp. 405-411
    • Evans, S.M.1    Jenkins, W.T.2    Joiner, B.3    Lord, E.M.4    Koch, C.J.5
  • 44
    • 49849087072 scopus 로고    scopus 로고
    • Chemistry with [18F]fluoride ion
    • Cai, L., Lu, S., Pike, V. W. Chemistry with [18F]fluoride ion. Eur. J. Org.Chem. 2008, 2853-2873.
    • (2008) Eur. J. Org.Chem , pp. 2853-2873
    • Cai, L.1    Lu, S.2    Pike, V.W.3
  • 45
    • 32644435100 scopus 로고    scopus 로고
    • Automatedradiosynthesis of [18F]SPA-RQ for imaging human brain NK1 receptorswith PET
    • Chin, F. T., Morse, C. L., Shetty, H. U., Pike, V. W. Automatedradiosynthesis of [18F]SPA-RQ for imaging human brain NK1 receptorswith PET. J. Labelled Compd. Rad. 2006, 49, 17-31.
    • (2006) J. Labelled Compd. Rad , vol.49 , pp. 17-31
    • Chin, F.T.1    Morse, C.L.2    Shetty, H.U.3    Pike, V.W.4
  • 46
    • 0022651142 scopus 로고
    • No-carrieraddedfluorine-18-labeling of aliphatic compounds in high yields viaaminopolyether-supported nucleophilic substitution
    • Block, D., Klatte, B., Knochel, A., Beckmann, R., Holm, U. No-carrieraddedfluorine-18-labeling of aliphatic compounds in high yields viaaminopolyether-supported nucleophilic substitution. J. Labelled Compd.Rad. 1986, 23, 467-477.
    • (1986) J. Labelled Compd.Rad , vol.23 , pp. 467-477
    • Block, D.1    Klatte, B.2    Knochel, A.3    Beckmann, R.4    Holm, U.5
  • 47
    • 61449112099 scopus 로고    scopus 로고
    • Single-Step High-YieldRadiosynthesis and Evaluation of a Sensitive 18F-Labeled Ligand forImaging Brain Peripheral Benzodiazepine Receptors with PET
    • Briard, E., Zoghbi, S. S., Simeon, F. G., Imaizumi, M., Gourley, J. P., Shetty, H. U., Lu, S., Fujita, M., Innis, R. B., Pike, V. W. Single-Step High-YieldRadiosynthesis and Evaluation of a Sensitive 18F-Labeled Ligand forImaging Brain Peripheral Benzodiazepine Receptors with PET. J. Med.Chem. 2009, 52, 688-699.
    • (2009) J. Med.Chem , vol.52 , pp. 688-699
    • Briard, E.1    Zoghbi, S.S.2    Simeon, F.G.3    Imaizumi, M.4    Gourley, J.P.5    Shetty, H.U.6    Lu, S.7    Fujita, M.8    Innis, R.B.9    Pike, V.W.10
  • 49
    • 34548162135 scopus 로고    scopus 로고
    • Simple and highly efficient synthesis of 3'-deoxy-3'-[18F]fluorothymidineusing nucleophilic fluorination catalyzed by protic solvent
    • Lee, S. J., Oh, S. J., Chi, D. Y., Kil, H. S., Kim, E. N., Ryu, J. S., Moon, D.H. Simple and highly efficient synthesis of 3'-deoxy-3'-[18F]fluorothymidineusing nucleophilic fluorination catalyzed by protic solvent. Eur. J. Nucl.Med. Mol. Imaging 2007, 34, 1406-1409.
    • (2007) Eur. J. Nucl.Med. Mol. Imaging , vol.34 , pp. 1406-1409
    • Lee, S.J.1    Oh, S.J.2    Chi, D.Y.3    Kil, H.S.4    Kim, E.N.5    Ryu, J.S.6    Moon, D.H.7
  • 50
    • 68149154419 scopus 로고    scopus 로고
    • Recent applications of click chemistryfor the synthesis of radiotracers for molecular imaging
    • Mamat, C., Ramenda, T., Wuest, F. R. Recent applications of click chemistryfor the synthesis of radiotracers for molecular imaging. Mini Rev. Org.Chem. 2009, 6, 21-34.
    • (2009) Mini Rev. Org.Chem , vol.6 , pp. 21-34
    • Mamat, C.1    Ramenda, T.2    Wuest, F.R.3
  • 51
    • 0024551844 scopus 로고
    • No-carrier-addedsynthesis of 3-[18F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol. A potentialPET agent for detecting hypoxic but viable tissues
    • Hwang, D. R., Dence, C. S., Bonasera, T. A., Welch, M. J. No-carrier-addedsynthesis of 3-[18F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol. A potentialPET agent for detecting hypoxic but viable tissues. Appl. Radiat. Isot. 1989,40, 117-126.
    • (1989) Appl. Radiat. Isot , vol.40 , pp. 117-126
    • Hwang, D.R.1    Dence, C.S.2    Bonasera, T.A.3    Welch, M.J.4
  • 53
    • 27844583946 scopus 로고    scopus 로고
    • A new synthesis of thelabeling precursor for [18F]-fluoromisonidazole
    • Adamsen, T. C. H., Grierson, J. R., Krohn, K. A. A new synthesis of thelabeling precursor for [18F]-fluoromisonidazole. J. Labelled Compd. Rad.2005, 48, 923-927.
    • (2005) J. Labelled Compd. Rad , vol.48 , pp. 923-927
    • Adamsen, T.C.H.1    Grierson, J.R.2    Krohn, K.A.3
  • 54
    • 0035503276 scopus 로고    scopus 로고
    • [18F]-EF5, a marker for PET detection of hypoxia: Synthesis of precursor and anew fluorination procedure
    • Dolbier, W. R., Jr., Li, A. R., Koch, C. J., Shiue, C. Y., Kachur, A. V. [18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and anew fluorination procedure. Appl. Radiat. Isot. 2001, 54, 73-80.
    • (2001) Appl. Radiat. Isot , vol.54 , pp. 73-80
    • Dolbier Jr., W.R.1    Li, A.R.2    Koch, C.J.3    Shiue, C.Y.4    Kachur, A.V.5
  • 56
    • 35548962244 scopus 로고    scopus 로고
    • Cu-ATSM: A radiopharmaceutical for the PETimaging of hypoxia
    • Vavere, A. L., Lewis, J. S. Cu-ATSM: A radiopharmaceutical for the PETimaging of hypoxia. Dalton Trans. 2007, 4893-4902.
    • (2007) Dalton Trans , pp. 4893-4902
    • Vavere, A.L.1    Lewis, J.S.2
  • 57
    • 0001032885 scopus 로고
    • Preparation of somethiosemicarbazones and their copper complexes. III
    • Gingras, B. A., Suprunchuk, T., Bayley, C. H. Preparation of somethiosemicarbazones and their copper complexes. III. Can. J. Chem. 1962, 40,1053-1059.
    • (1962) Can. J. Chem , vol.40 , pp. 1053-1059
    • Gingras, B.A.1    Suprunchuk, T.2    Bayley, C.H.3
  • 58
    • 43949134198 scopus 로고    scopus 로고
    • In vitro and invivo evaluation of bifunctional bisthiosemicarbazone 64Cu-complexes forthe positron emission tomography imaging of hypoxia
    • Bonnitcha, P. D., Vavere, A. L., Lewis, J. S., Dilworth, J. R. In vitro and invivo evaluation of bifunctional bisthiosemicarbazone 64Cu-complexes forthe positron emission tomography imaging of hypoxia. J. Med. Chem. 2008,51, 2985-2991.
    • (2008) J. Med. Chem , vol.51 , pp. 2985-2991
    • Bonnitcha, P.D.1    Vavere, A.L.2    Lewis, J.S.3    Dilworth, J.R.4
  • 59
    • 0033413164 scopus 로고    scopus 로고
    • Chemistry of technetiumradiopharmaceuticals 1: Chemistry behind the development of technetium-99m compounds to determine kidney function
    • Nosco, D. L., Beaty-Nosco, J. A. Chemistry of technetiumradiopharmaceuticals 1: Chemistry behind the development of technetium-99m compounds to determine kidney function. Coordin. Chem. Rev. 1999,184, 91-123.
    • (1999) Coordin. Chem. Rev , vol.184 , pp. 91-123
    • Nosco, D.L.1    Beaty-Nosco, J.A.2
  • 60
    • 0031929644 scopus 로고    scopus 로고
    • Technetium-99mlabeledHL91 to identify tumor hypoxia: Correlation with fluorine-18-FDG
    • Cook, G. J., Houston, S., Barrington, S. F., Fogelman, I. Technetium-99mlabeledHL91 to identify tumor hypoxia: correlation with fluorine-18-FDG.J. Nucl. Med. 1998, 39, 99-103.
    • (1998) J. Nucl. Med , vol.39 , pp. 99-103
    • Cook, G.J.1    Houston, S.2    Barrington, S.F.3    Fogelman, I.4
  • 61
    • 0031597439 scopus 로고    scopus 로고
    • Studies of 99mTc-BnAO(HL-91): A non-nitroaromatic compound for hypoxic cell detection
    • Zhang, X., Melo, T., Ballinger, J. R., Rauth, A. M. Studies of 99mTc-BnAO(HL-91): a non-nitroaromatic compound for hypoxic cell detection. Int. J.Radiat. Oncol. Biol. Phys. 1998, 42, 737-740.
    • (1998) Int. J.Radiat. Oncol. Biol. Phys , vol.42 , pp. 737-740
    • Zhang, X.1    Melo, T.2    Ballinger, J.R.3    Rauth, A.M.4
  • 62
    • 0026654515 scopus 로고
    • Bioreductive fluorescent markers for hypoxic cells: A study of 2-nitroimidazoles with 1-substituents containing fluorescent, bridgeheadnitrogen,bicyclic systems
    • Hodgkiss, R. J., Middleton, R. W., Parrick, J., Rami, H. K., Wardman, P., Wilson, G. D. Bioreductive fluorescent markers for hypoxic cells: a study of 2-nitroimidazoles with 1-substituents containing fluorescent, bridgeheadnitrogen,bicyclic systems. J. Med. Chem. 1992, 35, 1920-1926.
    • (1992) J. Med. Chem , vol.35 , pp. 1920-1926
    • Hodgkiss, R.J.1    Middleton, R.W.2    Parrick, J.3    Rami, H.K.4    Wardman, P.5    Wilson, G.D.6
  • 63
    • 33644983345 scopus 로고    scopus 로고
    • Novelfluorescent markers for hypoxic cells of naphthalimides with twoheterocyclic side chains for bioreductive binding
    • Liu, Y., Xu, Y., Qian, X., Liu, J., Shen, L., Li, J., Zhang, Y. Novelfluorescent markers for hypoxic cells of naphthalimides with twoheterocyclic side chains for bioreductive binding. Bioorg. Med. Chem. 2006,14, 2935-2941.
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 2935-2941
    • Liu, Y.1    Xu, Y.2    Qian, X.3    Liu, J.4    Shen, L.5    Li, J.6    Zhang, Y.7
  • 65
    • 23844485492 scopus 로고    scopus 로고
    • Reducedexpression of hypoxia-inducible factor-1a in perinecrotic regions of solidtumors
    • Sobhanifar, S., Aquino-Parsons, C., Stanbridge, E. J., Olive, P. Reducedexpression of hypoxia-inducible factor-1a in perinecrotic regions of solidtumors. Cancer Res. 2005, 65, 7259-7266.
    • (2005) Cancer Res , vol.65 , pp. 7259-7266
    • Sobhanifar, S.1    Aquino-Parsons, C.2    Stanbridge, E.J.3    Olive, P.4
  • 73
    • 4644286773 scopus 로고    scopus 로고
    • Pharmacokinetics and Tumor Targeting of 131I-Labeled F(ab')2Fragments of the Chimeric Monoclonal Antibody G250: Preclinical andClinical Pilot Studies. Cancer Biother
    • Brouwers, A., Mulders, P., Oosterwijk, E., Buijs, W., Corstens, F., Boerman, O., Oyen, W. Pharmacokinetics and Tumor Targeting of 131I-Labeled F(ab')2Fragments of the Chimeric Monoclonal Antibody G250: Preclinical andClinical Pilot Studies. Cancer Biother. Radiopharm. 2004, 19, 466-477.
    • (2004) Radiopharm , vol.19 , pp. 466-477
    • Brouwers, A.1    Mulders, P.2    Oosterwijk, E.3    Buijs, W.4    Corstens, F.5    Boerman, O.6    Oyen, W.7
  • 74
    • 0038118505 scopus 로고    scopus 로고
    • Biodistribution and Pharmacokinetics of 125IlabeledMonoclonal Antibody M75 Specific for Carbonic Anhydrase IX, anIntrinsic Marker of Hypoxia, in Nude Mice Xenografted with HumanColorectal Carcinoma
    • Chrastina, A., Závada, J., Parkkila, S., Kaluz, Š., Kaluzová, M., Rajcáni, J., Pastorek, J., Pastoreková, S. Biodistribution and Pharmacokinetics of 125IlabeledMonoclonal Antibody M75 Specific for Carbonic Anhydrase IX, anIntrinsic Marker of Hypoxia, in Nude Mice Xenografted with HumanColorectal Carcinoma. Int. J. Cancer 2003, 105, 873-881.
    • (2003) Int. J. Cancer , vol.105 , pp. 873-881
    • Chrastina, A.1    Závada, J.2    Parkkila, S.3    Kaluz, S.4    Kaluzová, M.5    Rajcáni, J.6    Pastorek, J.7    Pastoreková, S.8
  • 76
    • 33646446585 scopus 로고    scopus 로고
    • Indanesulfonamides as carbonic anhydrase inhibitors. Towardstructure-based design of selective inhibitors of the tumor-associatedisozyme CA IX
    • Thiry, A., Ledecq, M., Cecchi, A., Dogne, J. M., Wouters, J., Supuran, C. T., Masereel, B. Indanesulfonamides as carbonic anhydrase inhibitors. Towardstructure-based design of selective inhibitors of the tumor-associatedisozyme CA IX. J. Med. Chem. 2006, 49, 2743-2749.
    • (2006) J. Med. Chem , vol.49 , pp. 2743-2749
    • Thiry, A.1    Ledecq, M.2    Cecchi, A.3    Dogne, J.M.4    Wouters, J.5    Supuran, C.T.6    Masereel, B.7
  • 78
    • 0348147633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent,potently inhibits cytosolic isozymes I and II, and transmembrane, tumorassociatedisozyme IX
    • Abbate, F., Casini, A., Owa, T., Scozzafava, A., Supuran Claudiu, T. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent,potently inhibits cytosolic isozymes I and II, and transmembrane, tumorassociatedisozyme IX. Bioorg. Med. Chem. Lett. 2004, 14, 217-23.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 217-223
    • Abbate, F.1    Casini, A.2    Owa, T.3    Scozzafava, A.4    Supuran, C.T.5
  • 79
    • 0842281270 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: The first selective, membraneimpermeantinhibitors targeting the tumor-associated isozyme IX
    • Pastorekova, S., Casini, A., Scozzafava, A., Vullo, D., Pastorek, J., SupuranClaudiu, T. Carbonic anhydrase inhibitors: the first selective, membraneimpermeantinhibitors targeting the tumor-associated isozyme IX. Bioorg. Med. Chem. Lett. 2004, 14, 869-73.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 869-873
    • Pastorekova, S.1    Casini, A.2    Scozzafava, A.3    Vullo, D.4    Pastorek, J.5    Supuranclaudiu, T.6
  • 80
    • 1842790839 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IXwith fluorine-containing sulfonamides. The first subnanomolar CA IXinhibitor discovered
    • Vullo, D., Scozzafava, A., Pastorekova, S., Pastorek, J., Supuran, C. T.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IXwith fluorine-containing sulfonamides. The first subnanomolar CA IXinhibitor discovered. Bioorg. Med. Chem. Lett. 2004, 14, 2351-2356.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 2351-2356
    • Vullo, D.1    Scozzafava, A.2    Pastorekova, S.3    Pastorek, J.4    Supuran, C.T.5
  • 81
    • 79959979994 scopus 로고    scopus 로고
    • In 4th AnnualMeeting of the Society for Molecular Imaging Cologne, Germany
    • Zhang, L., Cecic, I., Cheng, Z., Gambhir, S. S., Graves, E. E. In 4th AnnualMeeting of the Society for Molecular Imaging Cologne, Germany, 2005.
    • (2005)
    • Zhang, L.1    Cecic, I.2    Cheng, Z.3    Gambhir, S.S.4    Graves, E.E.5
  • 82
    • 69949128698 scopus 로고    scopus 로고
    • Imaging of CA IX withfluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenatedcells in a xenograft tumour model
    • Dubois, L., Lieuwes, N. G., Maresca, A., Thiry, A., Supuran, C. T., Scozzafava, A., Wouters, B. G., Lambin, P. Imaging of CA IX withfluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenatedcells in a xenograft tumour model. Radiother. Oncol. 2009, 92, 423-428.
    • (2009) Radiother. Oncol , vol.92 , pp. 423-428
    • Dubois, L.1    Lieuwes, N.G.2    Maresca, A.3    Thiry, A.4    Supuran, C.T.5    Scozzafava, A.6    Wouters, B.G.7    Lambin, P.8


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