Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 511-518

  Thiry, Anne ^a   Delayen, Aurélie ^b   Goossens, Laurence ^b   Houssin, Raymond ^b   Ledecq, Marie ^a   Frankart, Aurélie ^a   Dogné, Jean Michel ^a   Wouters, Johan ^a   Supuran, Claudiu T ^c   Hénichart, Jean Pierre ^b   Masereel, Bernard ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase; Molecular modeling; Sulfonamide; Tumor associated isoform

Indexed keywords

ANTI 3 [4 (AMINOSULFONYL)ANILINO] 2 HYDROXY 3 PHENYLPROPANOIC ACID; ANTI 3 [4 (AMINOSULFONYL)ANILINO] 2 HYDROXY 3 PHENYLPROPANOIC ACID HYDROXYAMIDE POTASSIUM SALT; ANTI 4 [(2,3 DIHYDROXY 1 PHENYLPROPYL)AMINO] 1 BENZENESULFONAMIDE; ANTI 4 [[2 (BENZYLOXY) 3 HYDROXY 1 PHENYLPROPYL]AMINO]BENZENESULFONAMIDE; ANTI BENZYLANILINOSULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE IX INHIBITOR; COBALT CHLORIDE; ETHYL ANTI 3 [4 (AMINOSULFONYL)ANILINO] 2 BENZYLOXY 3 PHENYLPROPANOATE; ETHYL ANTI 3 [4 (AMINOSULFONYL)ANILINO] 2 HYDROXY 3 PHENYLPROPANOATE; ETHYLPHENYLGLYCIDATE; GLYCINE DERIVATIVE; ISOENZYME; SULFANILAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; DERIVATIZATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; MOLECULAR MODEL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTIGENS, NEOPLASM; BINDING SITES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFANILAMIDES; SULFONAMIDES;

EID: 60149101971     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.03.034     Document Type: Article

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